tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Kuo CJ et al. | Rapamycin selectively inhibits interleukin-2 activation of p70 S6 kinase. | 1992 | Nature | pmid:1614535 |
| Moutabarrik A et al. | In vitro FK506 kidney tubular cell toxicity. | 1992 | Transpl. Int. | pmid:14621743 |
| Okamura N et al. | Enhanced liver regeneration by FK 506 can be blocked by interleukin-1 alpha and interleukin-2. | 1992 | Transplant. Proc. | pmid:1371624 |
| Moutabarrik A et al. | FK506 mechanism of nephrotoxicity: stimulatory effect on endothelin secretion by cultured kidney cells. | 1992 | Transpl. Int. | pmid:14621744 |
| Sakr M et al. | Effect of renal ischemia on plasma levels of FK 506 in rats. | 1992 | Transplant. Proc. | pmid:1371625 |
| Kusne S et al. | Infections during a randomized trial comparing cyclosporine to FK 506 immunosuppression in liver transplantation. | 1992 | Transplant. Proc. | pmid:1371626 |
| Lee C et al. | FK-506 binding protein from Tolypocladium inflatum: resistance of FKBP/FK-506 complex against proteolysis. | 1992 | Biochem. Biophys. Res. Commun. | pmid:1371677 |
| Edkins RD et al. | Comparison of cyclosporine and FK506 effects on glutathione levels in rat cochlea, brain, liver and kidney. | 1992 | Biochem. Pharmacol. | pmid:1371687 |
| Galat A et al. | A rapamycin-selective 25-kDa immunophilin. | 1992 | Biochemistry | pmid:1371698 |
| Hanawa H et al. | An immunosuppressant compound, FK-506, prevents the progression of autoimmune myocarditis in rats. | 1992 | Clin. Immunol. Immunopathol. | pmid:1371730 |
| Asako H et al. | Reduction of leukocyte adherence and emigration by cyclosporine and L683,590 (FK506) in postcapillary venules. | 1992 | Transplantation | pmid:1384191 |
| Yamada K et al. | New morphological changes induced by FK506 in a short period in the rat kidney and the effect of superoxide dismutase and OKY-046 on THEM: the relationship of FK506 nephrotoxicity to lipid peroxidation and change in production of thromboxane A2 in the kidney. | 1992 | Transpl. Int. | pmid:14621878 |
| Demetris AJ et al. | Conversion of liver allograft recipients from cyclosporine to FK506 immunosuppressive therapy--a clinicopathologic study of 96 patients. | 1992 | Transplantation | pmid:1374944 |
| Bundick RV et al. | FK506 as an agonist to induce inhibition of interleukin 2 production. | 1992 | Transplantation | pmid:1374947 |
| Sakr M et al. | The protective effect of FK506 pretreatment against renal ischemia/reperfusion injury in rats. | 1992 | Transplantation | pmid:1374948 |
| Lepre CA et al. | Solution structure of FK506 bound to FKBP-12. | 1992 | FEBS Lett. | pmid:1375171 |
| Ruff VA et al. | FKBP-12 is not an inhibitor of protein kinase C. | 1992 | Immunol. Invest. | pmid:1375189 |
| Kawaguchi S | [Effects of FK506 on aminonucleoside-induced nephrotic rats]. | 1992 | Nihon Jinzo Gakkai Shi | pmid:1375300 |
| de Paulis A et al. | Anti-inflammatory effect of FK-506 on human skin mast cells. | 1992 | J. Invest. Dermatol. | pmid:1281861 |
| Santiago SF et al. | Effect of short-term immunosuppressive therapy with FK 506 or CyA on the donor in small intestine allotransplantation in rats. | 1992 | Transplant. Proc. | pmid:1376520 |
| Utsunomiya H et al. | Effect of FK 506 on orthotopic small bowel transplantation in rats. | 1992 | Transplant. Proc. | pmid:1376521 |
| Yagihashi A et al. | Changes in cell surface markers in human small bowel transplantation with FK 506. | 1992 | Transplant. Proc. | pmid:1376522 |
| Abu-Elmagd K et al. | Management of intestinal transplantation in humans. | 1992 | Transplant. Proc. | pmid:1376523 |
| Takaori K et al. | Basic study on immunologic effects of cyclosporine and FK 506 for application to pancreatic transplantation. | 1992 | Transplant. Proc. | pmid:1376531 |
| Ohtsuka S et al. | The effect of short-term FK 506 therapy on pancreas transplantation using the cuff technique in rats. | 1992 | Transplant. Proc. | pmid:1376532 |
| Kamei T et al. | Established intraportal islet allograft is rejected despite the acceptance of donor-specific second cardiac allograft. | 1992 | Transplant. Proc. | pmid:1281579 |
| Woo J et al. | FK 506 treatment following syngeneic bone marrow transplantation does not inhibit clonal deletion of V beta 5+ or V beta 11+ T cells. | 1992 | Transplant. Proc. | pmid:1281583 |
| Souza ER et al. | Acute effects of FK 506 on glomerular hemodynamics. | 1992 | Transplant. Proc. | pmid:1281585 |
| Hanke JH et al. | FK506 and rapamycin selectively enhance degradation of IL-2 and GM-CSF mRNA. | 1992 | Lymphokine Cytokine Res. | pmid:1281674 |
| Logan TM et al. | Side chain and backbone assignments in isotopically labeled proteins from two heteronuclear triple resonance experiments. | 1992 | FEBS Lett. | pmid:1281793 |
| Bergstrand H et al. | Modulation of neutrophil superoxide generation by inhibitors of protein kinase C, calmodulin, diacylglycerol and myosin light chain kinases, and peptidyl prolyl cis-trans isomerase. | 1992 | J. Pharmacol. Exp. Ther. | pmid:1281879 |
| DiLella AG et al. | Chromosomal band assignments of the genes encoding human FKBP12 and FKBP13. | 1992 | Biochem. Biophys. Res. Commun. | pmid:1281998 |
| Aldape RA et al. | Charged surface residues of FKBP12 participate in formation of the FKBP12-FK506-calcineurin complex. | 1992 | J. Biol. Chem. | pmid:1379588 |
| Langrehr JM et al. | Nitric oxide production in host-versus-graft and graft-versus-host reactions in the rat. | 1992 | J. Clin. Invest. | pmid:1379617 |
| Kumano K et al. | [Functional and morphological changes in rat kidney induced by FK506 and its reversal by various vasodilators]. | 1992 | Nippon Hinyokika Gakkai Zasshi | pmid:1379657 |
| Woodle ES et al. | FK506: inhibition of humoral mechanisms of hepatic allograft rejection. | 1992 | Transplantation | pmid:1379749 |
| Sato K et al. | Effectiveness of triple drug immunosuppression for pancreaticoduodenal allotransplantation in dogs. | 1992 | Transplant. Proc. | pmid:1379753 |
| Kobayashi N et al. | Abdominal organ cluster transplantation in pigs receiving FK 506. | 1992 | Transplant. Proc. | pmid:1379754 |
| Bolton C | The efficacy of cyclosporin A, FK-506 and prednisolone to modify the adoptive transfer of experimental allergic encephalomyelitis (EAE). | 1992 | Agents Actions | pmid:1380765 |
| Terada N et al. | Rapamycin inhibits the phosphorylation of p70 S6 kinase in IL-2 and mitogen-activated human T cells. | 1992 | Biochem. Biophys. Res. Commun. | pmid:1380801 |
| Friccius H et al. | The effects of the antifungal azoles itraconazole, fluconazole, ketoconazole and miconazole on cytokine gene expression in human lymphoid cells. | 1992 | Int. J. Immunopharmacol. | pmid:1380951 |
| Dumont FJ et al. | The immunosuppressive and toxic effects of FK-506 are mechanistically related: pharmacology of a novel antagonist of FK-506 and rapamycin. | 1992 | J. Exp. Med. | pmid:1380976 |
| Norris AA et al. | Protective effects of cyclophosphamide, cyclosporin A and FK506 against antigen-induced lung eosinophilia in guinea-pigs. | 1992 | Clin. Exp. Immunol. | pmid:1381297 |
| Todo S et al. | Intestinal transplantation in composite visceral grafts or alone. | 1992 | Ann. Surg. | pmid:1384443 |
| Massol N et al. | Rabbit FKBP59-heat shock protein binding immunophillin (HBI) is a calmodulin binding protein. | 1992 | Biochem. Biophys. Res. Commun. | pmid:1384470 |
| Siekierka JJ and Sigal NH | FK-506 and cyclosporin A: immunosuppressive mechanism of action and beyond. | 1992 | Curr. Opin. Immunol. | pmid:1384551 |
| Hultsch T et al. | The effect of the immunophilin ligands rapamycin and FK506 on proliferation of mast cells and other hematopoietic cell lines. | 1992 | Mol. Biol. Cell | pmid:1384815 |
| Petros AM et al. | Identification of solvent-exposed regions of an FK-506 analog, ascomycin, bound to FKBP using a paramagnetic probe. | 1992 | J. Biomol. NMR | pmid:1384850 |
| Liu J et al. | The effects of FK-506 and cyclosporin A on the proliferation of PHA-stimulated T cells in response to IL-2, IL-4 or IL-6. | 1992 | Int. Arch. Allergy Immunol. | pmid:1384862 |
| Mochizuki M et al. | Preclinical and clinical study of FK506 in uveitis. | 1992 | Curr. Eye Res. | pmid:1385045 |