Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with tacrolimus
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Rivelli RF et al. | Early withdrawal of calcineurin inhibitor from a sirolimus-based immunosuppression stabilizes fibrosis and the transforming growth factor-β signalling pathway in kidney transplant. | 2015 | Nephrology (Carlton) | pmid:25404086 |
Nakagawa K et al. | Immunosuppression with tacrolimus improved reproductive outcome of women with repeated implantation failure and elevated peripheral blood TH1/TH2 cell ratios. | 2015 | Am. J. Reprod. Immunol. | pmid:25394810 |
Farnik H et al. | Telaprevir drug monitoring during antiviral therapy of hepatitis C graft infection after liver transplantation. | 2015 | Liver Int. | pmid:24649882 |
Prinz V et al. | MRI heralds secondary nigral lesion after brain ischemia in mice: a secondary time window for neuroprotection. | 2015 | J. Cereb. Blood Flow Metab. | pmid:26126863 |
Cantaluppi V et al. | Neutrophil Gelatinase Associated Lipocalin Is an Early and Accurate Biomarker of Graft Function and Tissue Regeneration in Kidney Transplantation from Extended Criteria Donors. | 2015 | PLoS ONE | pmid:26125566 |
Fukahori H et al. | Effect of novel PKCθ selective inhibitor AS2521780 on acute rejection in rat and non-human primate models of transplantation. | 2015 | Int. Immunopharmacol. | pmid:26122135 |
Langone A et al. | Switching STudy of Kidney TRansplant PAtients with Tremor to LCP-TacrO (STRATO): an open-label, multicenter, prospective phase 3b study. | 2015 | Clin Transplant | pmid:26113208 |
Eidens M et al. | Development and validation of a rapid and reliable real-time PCR method for CYP3A5 genotyping. | 2015 | Clin. Lab. | pmid:25975003 |
Castaneda J and Matzuk MM | DEVELOPMENTAL BIOLOGY. Toward a rapid and reversible male pill. | 2015 | Science | pmid:26494747 |
Safa K et al. | Eculizumab for drug-induced de novo posttransplantation thrombotic microangiopathy: A case report. | 2015 | Clin. Nephrol. | pmid:24495904 |
Gordon P and Gooptu B | Tacrolimus in idiopathic inflammatory myopathy-associated interstitial lung disease: defining roles and responders. | 2015 | Rheumatology (Oxford) | pmid:25342374 |
Milam EC et al. | Treatment of Scarring Alopecia in Discoid Variant of Chronic Cutaneous Lupus Erythematosus With Tacrolimus Lotion, 0.3. | 2015 | JAMA Dermatol | pmid:26039539 |
Shi WL et al. | Effects of the CYP3A4*1B Genetic Polymorphism on the Pharmacokinetics of Tacrolimus in Adult Renal Transplant Recipients: A Meta-Analysis. | 2015 | PLoS ONE | pmid:26039043 |
Wozniak LJ et al. | Donor-specific HLA Antibodies Are Associated With Late Allograft Dysfunction After Pediatric Liver Transplantation. | 2015 | Transplantation | pmid:26038872 |
Staatz CE and Tett SE | Clinical Pharmacokinetics of Once-Daily Tacrolimus in Solid-Organ Transplant Patients. | 2015 | Clin Pharmacokinet | pmid:26038096 |
Migita K et al. | Pneumococcal polysaccharide vaccination in rheumatoid arthritis patients receiving tacrolimus. | 2015 | Arthritis Res. Ther. | pmid:26036592 |
Miyata H et al. | Sperm calcineurin inhibition prevents mouse fertility with implications for male contraceptive. | 2015 | Science | pmid:26429887 |
Jin S et al. | Exposure to Radiocontrast Agents Induces Pancreatic Inflammation by Activation of Nuclear Factor-κB, Calcium Signaling, and Calcineurin. | 2015 | Gastroenterology | pmid:25980752 |
Wiseman AC | Induction Therapy in Renal Transplantation: Why? What Agent? What Dose? We May Never Know. | 2015 | Clin J Am Soc Nephrol | pmid:25979977 |
Ratanatharathorn V et al. | Low-dose antithymocyte globulin enhanced the efficacy of tacrolimus and mycophenolate for GVHD prophylaxis in recipients of unrelated SCT. | 2015 | Bone Marrow Transplant. | pmid:25285804 |
Tanriover B et al. | Induction Therapies in Live Donor Kidney Transplantation on Tacrolimus and Mycophenolate With or Without Steroid Maintenance. | 2015 | Clin J Am Soc Nephrol | pmid:25979971 |
Meyer C et al. | Impact of irradiation and immunosuppressive agents on immune system homeostasis in rhesus macaques. | 2015 | Clin. Exp. Immunol. | pmid:25902927 |
Sassi MB et al. | Involvement of CYP 3A5 In the Interaction Between Tacrolimus and Nicardipine: A Case Report. | 2015 | Curr Drug Saf | pmid:25968921 |
Wang CY et al. | Analysis of tacrolimus blood concentrations in renal transplant patients. | 2015 | Genet. Mol. Res. | pmid:25966149 |
Bedi M and Taylor AL | Recalcitrant Hailey-Hailey disease responds to oral tacrolimus and botulinum toxin type A. | 2015 | Cutis | pmid:26761940 |
Kang YZ et al. | Autoimmune hepatitis-primary biliary cirrhosis concurrent with biliary stricture after liver transplantation. | 2015 | World J. Gastroenterol. | pmid:25717264 |
Hategan A and Bourgeois JA | Tacrolimus neurotoxicity and the role of the Renin-Angiotensin system. | 2015 | J Neuropsychiatry Clin Neurosci | pmid:25923858 |
Blasco-Morente G et al. | Long-Standing Presternal Plaque. | 2015 | Actas Dermosifiliogr | pmid:25917959 |
Ferraresso M et al. | Relationship between mRNA expression levels of CYP3A4, CYP3A5 and SXR in peripheral mononuclear blood cells and aging in young kidney transplant recipients under tacrolimus treatment. | 2015 | Pharmacogenomics | pmid:25916520 |
Nagaya M et al. | A new system to evaluate the influence of immunosuppressive drugs on pancreatic islets using epigenetic analysis in a 3-dimensional culture. | 2015 | Pancreas | pmid:25906448 |
Wang M et al. | Enteric polymer based on pH-responsive aliphatic polycarbonate functionalized with vitamin E to facilitate oral delivery of tacrolimus. | 2015 | Biomacromolecules | pmid:25714622 |
Gallon L et al. | Differential Effects of Calcineurin and Mammalian Target of Rapamycin Inhibitors on Alloreactive Th1, Th17, and Regulatory T Cells. | 2015 | Transplantation | pmid:25905982 |
Gajzlerska W et al. | Use of three-carbon chain compounds as biosynthesis precursors to enhance tacrolimus production in Streptomyces tsukubaensis. | 2015 | N Biotechnol | pmid:25152525 |
Josephson MA et al. | American society of Nephrology Quiz and Questionnaire 2014: transplantation. | 2015 | Clin J Am Soc Nephrol | pmid:25862775 |
Yu Z et al. | IL-15 is decreased upon CsA and FK506 treatment of acute rejection following heart transplantation in mice. | 2015 | Mol Med Rep | pmid:25333459 |
Peña C et al. | [Secondary acute myeloid leukemia in a lung allograft recipient. Report of one case]. | 2015 | Rev Med Chil | pmid:25860370 |
Selk A | A Survey of Experts Regarding the Treatment of Adult Vulvar Lichen Sclerosus. | 2015 | J Low Genit Tract Dis | pmid:25853633 |
Watanabe K et al. | The participation of insulin-like growth factor-binding protein 3 released by astrocytes in the pathology of Alzheimer's disease. | 2015 | Mol Brain | pmid:26637371 |
Hurst AL et al. | Supra-therapeutic tacrolimus concentrations associated with concomitant nicardipine in pediatric liver transplant recipients. | 2015 | Pediatr Transplant | pmid:25850753 |
Tajdaran K et al. | A novel polymeric drug delivery system for localized and sustained release of tacrolimus (FK506). | 2015 | Biotechnol. Bioeng. | pmid:25850693 |
Wang L et al. | Effect of CYP3A5 gene polymorphisms on tacrolimus concentration/dosage ratio in adult liver transplant patients. | 2015 | Genet. Mol. Res. | pmid:26634478 |
Jacobo-Cabral CO et al. | Population pharmacokinetic analysis of tacrolimus in Mexican paediatric renal transplant patients: role of CYP3A5 genotype and formulation. | 2015 | Br J Clin Pharmacol | pmid:25846845 |
Wang L et al. | Gq signaling causes glomerular injury by activating TRPC6. | 2015 | J. Clin. Invest. | pmid:25844902 |
Bowman LJ et al. | Tacrolimus-Induced Cardiomyopathy in an Adult Renal Transplant Recipient. | 2015 | Pharmacotherapy | pmid:26616582 |
Miguel-Gómez L et al. | [Peristomal pyoderma gangrenosum associated with colon cancer]. | 2015 | Med Clin (Barc) | pmid:25659860 |
Romanowski M et al. | Adiponectin and leptin gene polymorphisms in patients with post-transplant diabetes mellitus. | 2015 | Pharmacogenomics | pmid:26282401 |
Girdlestone J et al. | Enhancement of the immunoregulatory potency of mesenchymal stromal cells by treatment with immunosuppressive drugs. | 2015 | Cytotherapy | pmid:26276002 |
Solomon SR et al. | Total Body Irradiation-Based Myeloablative Haploidentical Stem Cell Transplantation Is a Safe and Effective Alternative to Unrelated Donor Transplantation in Patients Without Matched Sibling Donors. | 2015 | Biol. Blood Marrow Transplant. | pmid:25797174 |
Dedinská I et al. | Waist circumference as an independent risk factor for NODAT. | 2015 | Ann. Transplant. | pmid:25791039 |
Suzuki N et al. | In vivo regulation of erythropoiesis by chemically inducible dimerization of the erythropoietin receptor intracellular domain. | 2015 | PLoS ONE | pmid:25790231 |
Ross A and Kirsner RS | JID VisualDx Quiz: April 2015. | 2015 | J. Invest. Dermatol. | pmid:25785952 |
Heneberg P et al. | Pimecrolimus Is a Potent Inhibitor of Allergic Reactions to Hymenopteran Venom Extracts and Birch Pollen Allergen In Vitro. | 2015 | PLoS ONE | pmid:26562153 |
Yang CJ et al. | Differential Large-Amplitude Breathing Motions in the Interface of FKBP12-Drug Complexes. | 2015 | Biochemistry | pmid:26561008 |
Marcus EA et al. | Successful term pregnancy in an intestine-pancreas transplant recipient with chronic graft dysfunction and parenteral nutrition dependence: a case report. | 2015 | Transplant. Proc. | pmid:25724255 |
Dias PH et al. | Effects of immunosuppression with tacrolimus and mycophenolate mofetil on renal histology and function in single kidney rats submitted to ischemia and reperfusion. | 2015 | Acta Cir Bras | pmid:25714692 |
Fan J et al. | Donor IL-18 rs5744247 polymorphism as a new biomarker of tacrolimus elimination in Chinese liver transplant patients during the early post-transplantation period: results from two cohort studies. | 2015 | Pharmacogenomics | pmid:25712187 |
San Miguel C et al. | Immunosuppression Strategies in the Treatment of Hepatocellular Carcinoma in Virgen de las Nieves University Hospital. | 2015 | Transplant. Proc. | pmid:26518930 |
Jia N et al. | Collapsing focal segmental glomerulosclerosis following long-term treatment with oral ibandronate: case report and review of literature. | 2015 | BMC Cancer | pmid:26197890 |
Duong SQ et al. | Transition from brand to generic tacrolimus is associated with a decrease in trough blood concentration in pediatric heart transplant recipients. | 2015 | Pediatr Transplant | pmid:26497983 |
Jóźwiak-Bębenista M et al. | The cyclic AMP effects and neuroprotective activities of PACAP and VIP in cultured astrocytes and neurons exposed to oxygen-glucose deprivation. | 2015 | Pharmacol Rep | pmid:25712659 |
Kadlub N et al. | The calcineurin inhibitor tacrolimus as a new therapy in severe cherubism. | 2015 | J. Bone Miner. Res. | pmid:25491283 |
Pucci N et al. | Tacrolimus vs. cyclosporine eyedrops in severe cyclosporine-resistant vernal keratoconjunctivitis: A randomized, comparative, double-blind, crossover study. | 2015 | Pediatr Allergy Immunol | pmid:25712437 |
Katayama K et al. | Inhibition of radiographic joint damage in rheumatoid arthritis patients in DAS28 remission using single- or combined with methotrexate non biological disease-modifying antirheumatic drug therapy in routine clinical practice. | 2015 | Mod Rheumatol | pmid:24983407 |
Kim KW et al. | The effect of mammalian target of rapamycin inhibition on T helper type 17 and regulatory T cell differentiation in vitro and in vivo in kidney transplant recipients. | 2015 | Immunology | pmid:24974886 |
Yessayan L et al. | Race, Calcineurin Inhibitor Exposure, and Renal Function After Solid Organ Transplantation. | 2015 | Transplant. Proc. | pmid:26707323 |
Dumortier T et al. | Estimating the contribution of everolimus to immunosuppressive efficacy when combined with tacrolimus in liver transplantation: a model-based approach. | 2015 | Clin. Pharmacol. Ther. | pmid:25669933 |
Yoon NY et al. | Topical glucocorticoid or pimecrolimus treatment suppresses thymic stromal lymphopoietin-related allergic inflammatory mechanism in an oxazolone-induced atopic dermatitis murine model. | 2015 | Arch. Dermatol. Res. | pmid:25786383 |
Tanaka M et al. | Corticosteroid and tacrolimus treatment in neuromyelitis optica related disorders. | 2015 | Mult. Scler. | pmid:25662352 |
Van der Perren A et al. | FK506 reduces neuroinflammation and dopaminergic neurodegeneration in an α-synuclein-based rat model for Parkinson's disease. | 2015 | Neurobiol. Aging | pmid:25660193 |
Dai DS et al. | Protective Effect of Salvia Przewalskii Extract on Puromycin-Induced Podocyte Injury. | 2015 | Am. J. Nephrol. | pmid:26439819 |
Ayala E et al. | Myeloablative intravenous pharmacokinetically targeted busulfan plus fludarabine as conditioning for allogeneic hematopoietic cell transplantation in patients with non-Hodgkin lymphoma. | 2015 | Clin Lymphoma Myeloma Leuk | pmid:25659459 |
Wu SC et al. | Identification of Circulating miRNAs in a Mouse Model of Nerve Allograft Transplantation under FK506 Immunosuppression by Illumina Small RNA Deep Sequencing. | 2015 | Dis. Markers | pmid:26435568 |
Okechuku G et al. | Anorexia nervosa in a pediatric renal transplant recipient and its reversal with cyclosporine. | 2015 | Pediatr Transplant | pmid:25661468 |
Xie X et al. | mTOR inhibitor versus mycophenolic acid as the primary immunosuppression regime combined with calcineurin inhibitor for kidney transplant recipients: a meta-analysis. | 2015 | BMC Nephrol | pmid:26126806 |
Kume K et al. | Screening for a gene deletion mutant whose temperature sensitivity is suppressed by FK506 in budding yeast and its application for a positive screening for drugs inhibiting calcineurin. | 2015 | Biosci. Biotechnol. Biochem. | pmid:25614218 |
Garnock-Jones KP | Tacrolimus prolonged release (Envarsus®): a review of its use in kidney and liver transplant recipients. | 2015 | Drugs | pmid:25613762 |
Li CJ and Li L | Tacrolimus in preventing transplant rejection in Chinese patients--optimizing use. | 2015 | Drug Des Devel Ther | pmid:25609922 |
Oguni H and Hayashi M | [Topics for authorization of new intravenous antiepileptic drugs and tacrolimus for autoimmune epilepsy]. | 2015 | No To Hattatsu | pmid:26349372 |
Uemoto S et al. | Early coupled up-regulation of interleukin-12 receptor beta-1 in CD8+ central memory and effector T cells for better clinical outcomes in liver transplant recipients. | 2015 | Clin. Exp. Immunol. | pmid:25603847 |
Dave CN et al. | Innovative use of intravesical tacrolimus for hemorrhagic radiation cystitis. | 2015 | Int Urol Nephrol | pmid:26347076 |
Wu J et al. | MicroRNA-30 family members regulate calcium/calcineurin signaling in podocytes. | 2015 | J. Clin. Invest. | pmid:26436650 |
Overk CR et al. | Differential calcium alterations in animal models of neurodegenerative disease: Reversal by FK506. | 2015 | Neuroscience | pmid:26341908 |
de Jonge H et al. | Progressive decline in tacrolimus clearance after renal transplantation is partially explained by decreasing CYP3A4 activity and increasing haematocrit. | 2015 | Br J Clin Pharmacol | pmid:26114223 |
Kallscheuer N et al. | Single-Domain Peptidyl-Prolyl cis/trans Isomerase FkpA from Corynebacterium glutamicum Improves the Biomass Yield at Increased Growth Temperatures. | 2015 | Appl. Environ. Microbiol. | pmid:26341203 |
Bhadauria D et al. | Cryptosporidium infection after renal transplantation in an endemic area. | 2015 | Transpl Infect Dis | pmid:25620388 |
Luger T et al. | Pimecrolimus in atopic dermatitis: consensus on safety and the need to allow use in infants. | 2015 | Pediatr Allergy Immunol | pmid:25557211 |
Schnitzbauer AA et al. | Delayed bottom-up and amended simple method of dosing with once-daily tacrolimus application to achieve stable trough levels in liver transplantation. | 2015 | Ann. Transplant. | pmid:25553853 |
Burke MT et al. | Genetics and nonmelanoma skin cancer in kidney transplant recipients. | 2015 | Pharmacogenomics | pmid:25616102 |
Schnitzler F et al. | Solid Organ Transplantation in Patients with Inflammatory Bowel Diseases (IBD): Analysis of Transplantation Outcome and IBD Activity in a Large Single Center Cohort. | 2015 | PLoS ONE | pmid:26288187 |
Aruch DB and Renteria A | Simultaneous PRES and TMA secondary to tacrolimus after allogeneic bone marrow transplant. | 2015 | Blood | pmid:26287041 |
Pagliarello C et al. | Calcipotriol/betamethasone dipropionate ointment compared with tacrolimus ointment for the treatment of erosive pustular dermatosis of the scalp: a split-lesion comparison. | 2015 | Eur J Dermatol | pmid:25786341 |
Hauch A et al. | Generics: are all immunosuppression agents created equally? | 2015 | Surgery | pmid:26206317 |
Gong N et al. | Immunoregulatory effects of sirolimus vs. tacrolimus treatment in kidney allograft recipients. | 2015 | Cell. Immunol. | pmid:26205091 |
Chamani G et al. | Efficacy of tacrolimus and clobetasol in the treatment of oral lichen planus: a systematic review and meta-analysis. | 2015 | Int. J. Dermatol. | pmid:26204904 |
Muduma G et al. | Evaluating the economic implications of non-adherence and antibody-mediated rejection in renal transplant recipients: the role of once-daily tacrolimus in the UK. | 2015 | J Med Econ | pmid:26201252 |
Mizuno K et al. | Dexamethasone but not tacrolimus suppresses TNF-α-induced thymic stromal lymphopoietin expression in lesional keratinocytes of atopic dermatitis model. | 2015 | J. Dermatol. Sci. | pmid:26198442 |
Rathi M et al. | Conversion from tacrolimus to cyclosporine in patients with new-onset diabetes after renal transplant: an open-label randomized prospective pilot study. | 2015 | Transplant. Proc. | pmid:26036543 |
Mohsin N et al. | Pharmacokinetics of mycophenolate mofetil in Omani patients on cyclosporine or tacrolimus. | 2015 | Transplant. Proc. | pmid:26036534 |
Türkoğlu O et al. | Are antimicrobial peptides related to cyclosporine A-induced gingival overgrowth? | 2015 | Arch. Oral Biol. | pmid:25555253 |
Rivinius R et al. | Analysis of malignancies in patients after heart transplantation with subsequent immunosuppressive therapy. | 2015 | Drug Des Devel Ther | pmid:25552900 |