| MeSH term | MeSH ID | Detail |
|---|---|---|
| Connective Tissue Diseases | D003240 | 2 associated lipids |
| Corneal Diseases | D003316 | 13 associated lipids |
| Cough | D003371 | 19 associated lipids |
| Crigler-Najjar Syndrome | D003414 | 1 associated lipids |
| Crohn Disease | D003424 | 12 associated lipids |
| Cryptococcosis | D003453 | 3 associated lipids |
| Cutis Laxa | D003483 | 1 associated lipids |
| Cystic Fibrosis | D003550 | 65 associated lipids |
| Cystitis | D003556 | 23 associated lipids |
| Phyllodes Tumor | D003557 | 1 associated lipids |
| Hearing Loss, Sudden | D003639 | 1 associated lipids |
| Deglutition Disorders | D003680 | 2 associated lipids |
| Dehydration | D003681 | 11 associated lipids |
| Demyelinating Diseases | D003711 | 15 associated lipids |
| Dental Enamel Hypoplasia | D003744 | 2 associated lipids |
| Dental Pulp Calcification | D003784 | 2 associated lipids |
| Dermatitis | D003872 | 30 associated lipids |
| Drug Eruptions | D003875 | 30 associated lipids |
| Dermatitis, Atopic | D003876 | 19 associated lipids |
| Dermatitis, Contact | D003877 | 59 associated lipids |
tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Jha AK et al. | Dermoscopy as an evolving tool to assess vitiligo activity. | 2018 | J. Am. Acad. Dermatol. | pmid:29229577 |
| De Lemos-Bonotto M et al. | A systematic review and meta-analysis of second-line immunosuppressants for autoimmune hepatitis treatment. | 2018 | Eur J Gastroenterol Hepatol | pmid:29227329 |
| Lamanna JJ et al. | Peripheral blood detection of systemic graft-specific xeno-antibodies following transplantation of human neural progenitor cells into the porcine spinal cord. | 2018 | J Clin Neurosci | pmid:29089163 |
| Butler KV et al. | Targeted Gene Repression Using Novel Bifunctional Molecules to Harness Endogenous Histone Deacetylation Activity. | 2018 | ACS Synth Biol | pmid:29073761 |
| Watanabe N et al. | The possible clinical impact of risperidone on P-glycoprotein-mediated transport of tacrolimus: A case report and in vitro study. | 2018 | Biopharm Drug Dispos | pmid:29055041 |
| Altieri M et al. | Conversion From Once-Daily Prolonged-Release Tacrolimus to Once-Daily Extended-Release Tacrolimus in Stable Liver Transplant Recipients. | 2018 | Exp Clin Transplant | pmid:28697715 |
| Sakai R et al. | Efficacy and safety of multitarget therapy with cyclophosphamide and tacrolimus for lupus nephritis: a prospective, single-arm, single-centre, open label pilot study in Japan. | 2018 | Lupus | pmid:28683654 |
| Almeida-Paulo GN et al. | Weight of ABCB1 and POR genes on oral tacrolimus exposure in CYP3A5 nonexpressor pediatric patients with stable kidney transplant. | 2018 | Pharmacogenomics J. | pmid:28094348 |
| Lancia P et al. | Adverse Events under Tacrolimus and Cyclosporine in the First 3 Years Post-Renal Transplantation in Children. | 2018 | Clin Drug Investig | pmid:29236209 |
| Zaman M et al. | Application of quasi-emulsification and modified double emulsification techniques for formulation of tacrolimus microsponges. | 2018 | Int J Nanomedicine | pmid:30127605 |
| Asano T et al. | The utility of FDG-PET/CT imaging in the evaluation of multicentric reticulohistiocytosis: A case report. | 2018 | Medicine (Baltimore) | pmid:30113451 |
| Belaiche S et al. | Factors associated with the variability of calcineurin inhibitor blood levels in kidney recipients grafted for more than 1Â year. | 2018 | Fundam Clin Pharmacol | pmid:29069531 |
| Wang JL et al. | Delivery of tacrolimus with cationic lipid-assisted nanoparticles for ulcerative colitis therapy. | 2018 | Biomater Sci | pmid:29850666 |
| Ling G et al. | Mycophenolate Mofetil Alone and in Combination with Tacrolimus Inhibits the Proliferation of HT-29 Human Colonic Adenocarcinoma Cell Line and Might Interfere with Colonic Tumorigenesis. | 2018 | Anticancer Res. | pmid:29848681 |
| Geng L et al. | Lower tacrolimus trough levels in the late period after living donor liver transplantation contribute to improvements in long-term clinical outcomes. | 2018 | HBPD INT | pmid:29807766 |
| Ding CG et al. | Early Immunosuppressive Exposure of Enteric-Coated-Mycophenolate Sodium Plus Tacrolimus Associated with Acute Rejection in Expanded Criteria Donor Kidney Transplantation. | 2018 | Chin. Med. J. | pmid:29786042 |
| Malakasioti G et al. | Converting immunosuppression from an oral suspension to a granule formulation of tacrolimus in pediatric renal transplant recipients. | 2018 | Pediatr Transplant | pmid:29767471 |
| Wang DD et al. | Population pharmacokinetics of tacrolimus in paediatric systemic lupus erythematosus based on real-world study. | 2018 | J Clin Pharm Ther | pmid:29766530 |
| Grenzi PC et al. | Influence of immunosuppressive drugs on the CD30 molecule in kidney transplanted patients. | 2018 | Hum. Immunol. | pmid:29656112 |
| Altwegg R et al. | Effectiveness and safety of anti-TNF therapy for inflammatory bowel disease in liver transplant recipients for primary sclerosing cholangitis: A nationwide case series. | 2018 | Dig Liver Dis | pmid:29655972 |
| Freriksen JJM et al. | Placental disposition of the immunosuppressive drug tacrolimus in renal transplant recipients and in ex vivo perfused placental tissue. | 2018 | Eur J Pharm Sci | pmid:29655601 |
| Udomkarnjananun S et al. | An Unusual Manifestation of Calcineurin Inhibitor-Induced Pain Syndrome in Kidney Transplantation: A Case Report and Literature Review. | 2018 | Am J Case Rep | pmid:29654227 |
| Krzyżowska K et al. | Which Kidney Transplant Recipients Can Benefit from the Initial Tacrolimus Dose Reduction? | 2018 | Biomed Res Int | pmid:29651435 |
| Nakagita K et al. | Effect of fluconazole on the pharmacokinetics of everolimus and tacrolimus in a heart transplant recipient: Case report. | 2018 | Int J Clin Pharmacol Ther | pmid:29648533 |
| Takeuchi K et al. | Comparison of Safety and Efficacy of Tacrolimus versus Infliximab for Active Ulcerative Colitis. | 2018 | Dig Dis | pmid:29050007 |
| Gupta AS et al. | Pyoderma Gangrenosum of the Scalp: A Rare Clinical Variant. | 2018 | Wounds | pmid:29481333 |
| Romano P et al. | UPLC-MS/MS assay validation for tacrolimus quantitative determination in peripheral blood T CD4+ and B CD19+ lymphocytes. | 2018 | J Pharm Biomed Anal | pmid:29471254 |
| Lloberas N et al. | Detection of a rare CYP3A4 variant in a transplant patient characterized by a tacrolimus poor metabolizer phenotype. | 2018 | Pharmacogenomics | pmid:29469606 |
| Brooks EK et al. | Evaluation of Multiple Linear Regression-Based Limited Sampling Strategies for Enteric-Coated Mycophenolate Sodium in Adult Kidney Transplant Recipients. | 2018 | Ther Drug Monit | pmid:29461443 |
| Chen X et al. | A case report of lupus erythematosus tumidus converted from discoid lupus erythematosus. | 2018 | Medicine (Baltimore) | pmid:29668590 |
| Mashiah J et al. | Topical pimecrolimus for paediatric cutaneous mastocytosis. | 2018 | Clin. Exp. Dermatol. | pmid:29460435 |
| Li A et al. | Atopic keratoconjunctivitis: A diagnostic dilemma-a case report. | 2018 | Medicine (Baltimore) | pmid:29668589 |
| Li Y and Feng X | Efficacy and safety of tacrolimus in systemic lupus erythematosus patients with refractory thrombocytopenia: a retrospective study. | 2018 | Lupus | pmid:28566017 |
| Wojarski J et al. | Immunosuppressive Treatment and Its Effect on the Occurrence of Pneumocystis jiroveci, Mycoplasma pneumoniae, Chlamydophila pnemoniae, and Legionella pneumophila Infections/Colonizations Among Lung Transplant Recipients. | 2018 | Transplant. Proc. | pmid:30177108 |
| Yoshizawa S et al. | Exosomal miRNA Signatures for Late-Onset Acute Graft-Versus-Host Disease in Allogenic Hematopoietic Stem Cell Transplantation. | 2018 | Int J Mol Sci | pmid:30142940 |
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| Lindström L et al. | Risk factors and prognosis for recurrent primary sclerosing cholangitis after liver transplantation: a Nordic Multicentre Study. | 2018 | Scand. J. Gastroenterol. | pmid:29301479 |
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| Wang HD et al. | Desensitization and Prevention of Antibody-Mediated Rejection in Vascularized Composite Allotransplantation by Syngeneic Hematopoietic Stem Cell Transplantation. | 2018 | Transplantation | pmid:29298238 |
| Kono M et al. | False Elevation of the Blood Tacrolimus Concentration, as Assessed by an Affinity Column-mediated Immunoassay (ACMIA), Led to Acute T Cell-mediated Rejection after Kidney Transplantation. | 2018 | Intern. Med. | pmid:29279473 |
| Heppt MV et al. | Frontal Fibrosing Alopecia: A Retrospective Analysis of 72 Patients from a German Academic Center. | 2018 | Facial Plast Surg | pmid:29278862 |
| Dheer D et al. | Tacrolimus: An updated review on delivering strategies for multifarious diseases. | 2018 | Eur J Pharm Sci | pmid:29277665 |
| Ng YZ et al. | Fluorescence Polarization Assay for Small Molecule Screening of FK506 Biosynthesized in 96-Well Microtiter Plates. | 2017 | Biochemistry | pmid:28841306 |
| Epperla N et al. | Impact of treatment and outcomes for patients with posttransplant drug-associated thrombotic microangiopathy. | 2017 | Transfusion | pmid:28836275 |
| Müller EG et al. | Tacrolimus eye drops as monotherapy for vernal keratoconjunctivitis: a randomized controlled trial. | 2017 | Arq Bras Oftalmol | pmid:28832739 |
| van der Merwe Y et al. | An Elastomeric Polymer Matrix, PEUU-Tac, Delivers Bioactive Tacrolimus Transdurally to the CNS in Rat. | 2017 | EBioMedicine | pmid:29208469 |
| Wiebe C et al. | Class II Eplet Mismatch Modulates Tacrolimus Trough Levels Required to Prevent Donor-Specific Antibody Development. | 2017 | J. Am. Soc. Nephrol. | pmid:28729289 |
| Tolkachjov SN et al. | Frontal fibrosing alopecia among men: AÂ clinicopathologic study of 7 cases. | 2017 | J. Am. Acad. Dermatol. | pmid:28716436 |
| Ahn SW et al. | A multicenter prospective observational study on the safety and efficacy of tacrolimus in patients with myasthenia gravis. | 2017 | J. Neurol. Sci. | pmid:28716258 |
| Montenovo MI et al. | Superior Patient and Graft Survival in Adult Liver Transplant with Rabbit Antithymocyte Globulin Induction: Experience with 595 Patients. | 2017 | Exp Clin Transplant | pmid:27309029 |
| Das B et al. | Alemtuzumab (Campath-1H) therapy for refractory rejections in pediatric heart transplant recipients. | 2017 | Pediatr Transplant | pmid:27862703 |
| Kita K and Mano Y | Application of volumetric absorptive microsampling device for quantification of tacrolimus in human blood as a model drug of high blood cell partition. | 2017 | J Pharm Biomed Anal | pmid:28601765 |
| Abongwa C et al. | Successful treatment of tacrolimus-related pure red cell aplasia and autoimmune hemolytic anemia with rituximab in a pediatric cardiac transplant patient. | 2017 | Pediatr Blood Cancer | pmid:28598573 |
| Wu Z et al. | FOXP3 rs3761548 polymorphism is associated with tacrolimus-induced acute nephrotoxicity in renal transplant patients. | 2017 | Eur. J. Clin. Pharmacol. | pmid:27747372 |
| Tamashiro EY et al. | Influence of CYP3A4 and CYP3A5 polymorphisms on tacrolimus and sirolimus exposure in stable kidney transplant recipients. | 2017 | Drug Metab Pers Ther | pmid:28593920 |
| Srinivas NR | Letter: sublingual dosing of tacrolimus in transplant patients-interesting concept to overcome first pass effects. | 2017 | Aliment. Pharmacol. Ther. | pmid:28589592 |
| Gerlach UA et al. | Intragraft and Systemic Immune Parameters Discriminating Between Rejection and Long-Term Graft Function in a Preclinical Model of Intestinal Transplantation. | 2017 | Transplantation | pmid:27607529 |
| Torres IB et al. | Tacrolimus and mycophenolate regimen and subclinical tubulo-interstitial inflammation in low immunological risk renal transplants. | 2017 | Transpl. Int. | pmid:28667664 |
| Fai D et al. | Duration of response in vitiligo lesions after narrowband UVB phototherapy combined with tacrolimus ointment. | 2017 | G Ital Dermatol Venereol | pmid:28621124 |
| Efe C et al. | Efficacy and Safety of Mycophenolate Mofetil and Tacrolimus as Second-line Therapy for Patients With Autoimmune Hepatitis. | 2017 | Clin. Gastroenterol. Hepatol. | pmid:28603052 |
| Nakagawa K et al. | Immunosuppressive treatment using tacrolimus promotes pregnancy outcome in infertile women with repeated implantation failures. | 2017 | Am. J. Reprod. Immunol. | pmid:28466977 |
| Ramirez R et al. | Posterior Reversible Encephalopathy Syndrome After Orthotopic Heart Transplantation: A Case Report. | 2017 | Am J Case Rep | pmid:28465499 |
| Aguiar D et al. | Real-World Multicenter Experience of Immunosuppression Minimization Among 661 Liver Transplant Recipients. | 2017 | Ann. Transplant. | pmid:28461684 |
| Ikebe T et al. | Hemophagocytic lymphohistiocytosis following influenza vaccination in a patient with aplastic anemia undergoing allogeneic bone marrow stem cell transplantation. | 2017 | Int. J. Hematol. | pmid:28054244 |
| Harada S et al. | Complete remission of angiolymphoid hyperplasia with eosinophilia using topical tacrolimus. | 2017 | Eur J Dermatol | pmid:28007668 |
| Zhang L et al. | Characterization of calcineurin from Cryptococcus humicola and the application of calcineurin in aluminum tolerance. | 2017 | BMC Biotechnol. | pmid:28356086 |
| Zheng X et al. | Effect of FK-506 (tacrolimus) therapy on bone healing of titanium implants: a histometric and biomechanical study in mice. | 2017 | Eur. J. Oral Sci. | pmid:27935130 |
| Song K et al. | Engineering of the LysR family transcriptional regulator FkbR1 and its target gene to improve ascomycin production. | 2017 | Appl. Microbiol. Biotechnol. | pmid:28349163 |
| Ikeguchi R et al. | Recipient bone marrow-derived stromal cells prolong graft survival in a rat hind limb allotransplantation model. | 2017 | Microsurgery | pmid:27859595 |
| Wan T et al. | Effects of nanoparticles with hydrotropic nicotinamide on tacrolimus: permeability through psoriatic skin and antipsoriatic and antiproliferative activities. | 2017 | Int J Nanomedicine | pmid:28260894 |
| Bellon H et al. | The Effect of Immunosuppression on Airway Integrity. | 2017 | Transplantation | pmid:28471870 |
| Ferjani H et al. | Beneficial effects of mycophenolate mofetil on cardiotoxicity induced by tacrolimus in wistar rats. | 2017 | Exp. Biol. Med. (Maywood) | pmid:26582055 |
| Solari S et al. | Sublingual tacrolimus administration provides similar drug exposure to per-oral route employing lower doses in liver transplantation: a pilot study. | 2017 | Aliment. Pharmacol. Ther. | pmid:28261844 |
| Moes AD et al. | Chlorthalidone Versus Amlodipine for Hypertension in Kidney Transplant Recipients Treated With Tacrolimus: A Randomized Crossover Trial. | 2017 | Am. J. Kidney Dis. | pmid:28259499 |
| Moiseev IS et al. | Pharmacokinetic comparison of cyclosporin A and tacrolimus in graft-versus-host disease prophylaxis. | 2017 | Ann. Hematol. | pmid:28343273 |
| Cui W et al. | Therapy of tacrolimus combined with corticosteroids in idiopathic membranous nephropathy. | 2017 | Braz. J. Med. Biol. Res. | pmid:28355356 |
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| Siponen M et al. | Topical tacrolimus, triamcinolone acetonide, and placebo in oral lichen planus: a pilot randomized controlled trial. | 2017 | Oral Dis | pmid:28168769 |
| Vanhove T et al. | Response to: 'Bodyweight-adjustments introduce significant correlations between CYP3A metrics and tacrolimus clearance'. | 2017 | Br J Clin Pharmacol | pmid:28168728 |
| Dobbels F et al. | Efficacy of a medication adherence enhancing intervention in transplantation: The MAESTRO-Tx trial. | 2017 | J. Heart Lung Transplant. | pmid:28162931 |
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| Aschauer C et al. | Positioning of Tacrolimus for the Treatment of Diabetic Nephropathy Based on Computational Network Analysis. | 2017 | PLoS ONE | pmid:28060893 |
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| Dong Y et al. | Risk Factors, Clinical Features, and Treatment Outcomes of Recurrent Mooren Ulcers in China. | 2017 | Cornea | pmid:28060068 |
| de Oliveira JTP et al. | Variability index of tacrolimus serum levels in pediatric liver transplant recipients younger than 12Â years: Non-adherence or risk of non-adherence? | 2017 | Pediatr Transplant | pmid:29034612 |
| Kim YK et al. | New tablet formulation of tacrolimus with smaller interindividual variability may become a better treatment option than the conventional capsule formulation in organ transplant patients. | 2017 | Drug Des Devel Ther | pmid:29033547 |
| Noda K et al. | Tacrolimus-induced hypertrophic cardiomyopathy in a patient with dermatomyositis. | 2017 | Rheumatology (Oxford) | pmid:28977571 |
| Tamura M et al. | [A case of anti-PL-7 antibody positive polymyositis with thrombotic microangiopathy]. | 2017 | Nihon Rinsho Meneki Gakkai Kaishi | pmid:29367529 |
| Jia Y et al. | Estimation of Mycophenolic Acid Area Under the Curve With Limited-Sampling Strategy in Chinese Renal Transplant Recipients Receiving Enteric-Coated Mycophenolate Sodium. | 2017 | Ther Drug Monit | pmid:27941535 |
| Kaneko T et al. | Effectiveness of Measuring Genetic Polymorphisms in Metabolizing Enzymes of Tacrolimus within One Medical Facility. | 2017 | J Nippon Med Sch | pmid:29279557 |
| Dutta D et al. | Recruitment of calcineurin to the TCR positively regulates T cell activation. | 2017 | Nat. Immunol. | pmid:27941787 |
| Terakura S et al. | Exploratory research for optimal GvHD prophylaxis after single unit CBT in adults: short-term methotrexate reduced the incidence of severe GvHD more than mycophenolate mofetil. | 2017 | Bone Marrow Transplant. | pmid:27941766 |
| Perez LE et al. | Visilizumab with tacrolimus and methotrexate for GvHD prevention after allogeneic hematopoietic cell transplantation from mismatched unrelated donors. | 2017 | Bone Marrow Transplant. | pmid:27991896 |
| Naicker D et al. | Nationwide conversion to generic tacrolimus in pediatric kidney transplant recipients. | 2017 | Pediatr. Nephrol. | pmid:28660366 |
| Kannegieter NM et al. | Pharmacodynamic Monitoring of Tacrolimus-Based Immunosuppression in CD14+ Monocytes After Kidney Transplantation. | 2017 | Ther Drug Monit | pmid:28640063 |
| Andrade LM et al. | Improved tacrolimus skin permeation by co-encapsulation with clobetasol in lipid nanoparticles: Study of drug effects in lipid matrix by electron paramagnetic resonance. | 2017 | Eur J Pharm Biopharm | pmid:28627400 |
| Qi H et al. | Integration of parallel C-labeling experiments and in silico pathway analysis for enhanced production of ascomycin. | 2017 | Biotechnol. Bioeng. | pmid:27869289 |
| Gatault P et al. | Reduction of Extended-Release Tacrolimus Dose in Low-Immunological-Risk Kidney Transplant Recipients Increases Risk of Rejection and Appearance of Donor-Specific Antibodies: A Randomized Study. | 2017 | Am. J. Transplant. | pmid:27862923 |
| Vanhove T et al. | Effect of the Direct Oral Anticoagulants Rivaroxaban and Apixaban on the Disposition of Calcineurin Inhibitors in Transplant Recipients. | 2017 | Ther Drug Monit | pmid:27861314 |