| MeSH term | MeSH ID | Detail |
|---|---|---|
| Connective Tissue Diseases | D003240 | 2 associated lipids |
| Corneal Diseases | D003316 | 13 associated lipids |
| Cough | D003371 | 19 associated lipids |
| Crigler-Najjar Syndrome | D003414 | 1 associated lipids |
| Crohn Disease | D003424 | 12 associated lipids |
| Cryptococcosis | D003453 | 3 associated lipids |
| Cutis Laxa | D003483 | 1 associated lipids |
| Cystic Fibrosis | D003550 | 65 associated lipids |
| Cystitis | D003556 | 23 associated lipids |
| Phyllodes Tumor | D003557 | 1 associated lipids |
| Hearing Loss, Sudden | D003639 | 1 associated lipids |
| Deglutition Disorders | D003680 | 2 associated lipids |
| Dehydration | D003681 | 11 associated lipids |
| Demyelinating Diseases | D003711 | 15 associated lipids |
| Dental Enamel Hypoplasia | D003744 | 2 associated lipids |
| Dental Pulp Calcification | D003784 | 2 associated lipids |
| Dermatitis | D003872 | 30 associated lipids |
| Drug Eruptions | D003875 | 30 associated lipids |
| Dermatitis, Atopic | D003876 | 19 associated lipids |
| Dermatitis, Contact | D003877 | 59 associated lipids |
tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Sheiner PA et al. | Acute renal failure associated with the use of ibuprofen in two liver transplant recipients on FK506. | 1994 | Transplantation | pmid:7513099 |
| Neuhaus PJ | Optimised first-line FK506-based protocols in liver transplantation: experience from the University Hospital Rudolf Virchow, Berlin. | 1994 | Transplant. Proc. | pmid:7527961 |
| Sewing KF | Pharmacokinetics, dosing principles, and blood level monitoring of FK506. | 1994 | Transplant. Proc. | pmid:7527962 |
| Frei U and Wagner K | Renal function in liver transplant patients receiving FK506 or cyclosporin A immunosuppressive therapy. | 1994 | Transplant. Proc. | pmid:7527963 |
| Morris R | Modes of action of FK506, cyclosporin A, and rapamycin. | 1994 | Transplant. Proc. | pmid:7527964 |
| Ericzon BG | Early graft function in liver transplantation patients. | 1994 | Transplant. Proc. | pmid:7527965 |
| Ricordi C et al. | Donor bone marrow cell infusion without recipient cytoablation induces acceptance of rat islet allografts. | 1994 | Transplant. Proc. | pmid:7527967 |
| Tsugita M et al. | Hepatocytes or liver nonparenchymal cells plus FK 506 prolong liver xenograft survival. | 1994 | Transplant. Proc. | pmid:7527969 |
| Asselin I et al. | Polymerase chain reaction-based assay to assess the success of myoblast transplantation in mdx mice. | 1994 | Transplant. Proc. | pmid:7527970 |
| Rao US and Scarborough GA | Direct demonstration of high affinity interactions of immunosuppressant drugs with the drug binding site of the human P-glycoprotein. | 1994 | Mol. Pharmacol. | pmid:7514263 |
| Lieberman DN and Mody I | Regulation of NMDA channel function by endogenous Ca(2+)-dependent phosphatase. | 1994 | Nature | pmid:7514273 |
| Burdmann EA et al. | Urinary enzymes as biomarkers of renal injury in experimental nephrotoxicity of immunosuppressive drugs. | 1994 | Ren Fail | pmid:7514309 |
| Jindal RM et al. | Serum lipid changes in liver transplant recipients in a prospective trial of cyclosporine versus FK506. | 1994 | Transplantation | pmid:7514317 |
| Haddy A and Rusnak F | Overexpression and characterization of a recombinant form of rat calcineurin A. | 1994 | Biochem. Biophys. Res. Commun. | pmid:7514397 |
| Borel JF and Baumann G | Molecular mechanisms of immunosuppressive agents. | 1994 | Bull. Mem. Acad. R. Med. Belg. | pmid:7531051 |
| Woerly G et al. | Demonstration of ternary immunophilin-calcineurin complexes with the immunosuppressants cyclosporin and macrolide FK506. | 1994 | Biochem. Pharmacol. | pmid:7514409 |
| Whiting PH | Acute and chronic nephrotoxicity associated with immunosuppressive drugs. | 1994 | Curr. Opin. Nephrol. Hypertens. | pmid:7531104 |
| Lauerma AI and Maibach HI | Topical FK506--clinical potential or laboratory curiosity? | 1994 | Dermatology (Basel) | pmid:7514460 |
| Chen TS et al. | Microbial transformation of immunosuppressive compounds. IV. Hydroxylation and hemiketal formation of ascomycin (immunomycin) by Streptomyces sp. MA 6970 (ATCC No. 55281). | 1994 | J. Antibiot. | pmid:7531195 |
| Brillantes AB et al. | Stabilization of calcium release channel (ryanodine receptor) function by FK506-binding protein. | 1994 | Cell | pmid:7514503 |
| Morozumi K and Takeda A | [Kidney disorders induced by immunosuppressive agents]. | 1994 | Nippon Naika Gakkai Zasshi | pmid:7529294 |
| Alamartine E et al. | In-vitro effects of cyclosporin A, FK506, 6-mercaptopurine, and prednisolone on lymphokine-activated killer cells. | 1994 | Nephrol. Dial. Transplant. | pmid:7529381 |
| Krentz AJ et al. | Postoperative glucose metabolism in liver transplant recipients. A two-year prospective randomized study of cyclosporine versus FK506. | 1994 | Transplantation | pmid:7516590 |
| Ludwig B et al. | Characterization of Mip proteins of Legionella pneumophila. | 1994 | FEMS Microbiol. Lett. | pmid:7516906 |
| Atcherson MM and Trifillis AL | Cytotoxic effects of FK506 on human renal proximal tubule cells in culture. | 1994 | In Vitro Cell. Dev. Biol. Anim. | pmid:7529625 |
| Maruyama K et al. | FK 506 for vascular permeability factor production in minimal change nephrotic syndrome. | 1994 | Nephron | pmid:7517020 |
| High KP | The antimicrobial activities of cyclosporine, FK506, and rapamycin. | 1994 | Transplantation | pmid:7517076 |
| Peattie DA et al. | Three distinct messenger RNAs can encode the human immunosuppressant-binding protein FKBP12. | 1994 | Gene | pmid:7529739 |
| Yoshimura N et al. | The direct effect of FK506 and rapamycin on interleukin 1(beta) and immunoglobulin production in vitro. | 1994 | Transplantation | pmid:7517078 |
| Shipston MJ et al. | Glucocorticoid negative feedback in pituitary corticotropes. Pivotal role for calcineurin inhibition of adenylyl cyclase. | 1994 | Ann. N. Y. Acad. Sci. | pmid:7529975 |
| Firdaous I et al. | Pediatric intravenous FK506--how much are we really infusing? | 1994 | Transplantation | pmid:7517079 |
| Manez R et al. | Rejection and hepatitis in liver transplants. | 1994 | Transplantation | pmid:7517080 |
| Igarashi T et al. | Central nervous system toxicity related to FK506 in patients with Behçet's disease. | 1994 | Ann. Rheum. Dis. | pmid:7517134 |
| Spada M et al. | Monitoring of intestinal myoelectrical activity after isolated small bowel transplantation in FK 506 immunosuppressed pigs. | 1994 | Transplant. Proc. | pmid:7518141 |
| Spada M et al. | Morphology of acute rejection and observation of lymphoproliferative hyperplastic reaction in FK 506 treated pigs after small bowel transplantation. | 1994 | Transplant. Proc. | pmid:7518142 |
| Vischi S et al. | The maltose absorption test does not predict allograft rejection of small bowel transplantation in FK 506 immunosuppressed pigs. | 1994 | Transplant. Proc. | pmid:7518143 |
| Okamoto M et al. | Detection of allograft rejection in rat small bowel transplantation by analysing the in situ distribution of S-phase lymphocytes. | 1994 | Transplant. Proc. | pmid:7518145 |
| Ippoliti G et al. | Serum cytokine levels after small bowel transplantation in pigs. | 1994 | Transplant. Proc. | pmid:7518146 |
| Orita T et al. | Effect of FK 506 in combination with prednisolone on the graft-vs-host reaction after small bowel transplantation in rats. | 1994 | Transplant. Proc. | pmid:7518147 |
| Alessiani M et al. | Total orthotopic small bowel transplantation in swine under FK 506. | 1994 | Transplant. Proc. | pmid:7518148 |
| Jain A et al. | FK 506 in small bowel transplant recipients: pharmacokinetics and dosing. | 1994 | Transplant. Proc. | pmid:7518149 |
| Yoshikawa N et al. | Effect of FK-506 on xenografted human Graves' thyroid tissue is severe combined immunodeficient mice. | 1994 | Clin. Endocrinol. (Oxf) | pmid:7519528 |
| Porayko MK et al. | Nephrotoxic effects of primary immunosuppression with FK-506 and cyclosporine regimens after liver transplantation. | 1994 | Mayo Clin. Proc. | pmid:7508536 |
| Kao PN et al. | Cloning and expression of cyclosporin A- and FK506-sensitive nuclear factor of activated T-cells: NF45 and NF90. | 1994 | J. Biol. Chem. | pmid:7519613 |
| Martin MF | Nephrotoxic effects of immunosuppression. | 1994 | Mayo Clin. Proc. | pmid:7508537 |
| Jindal RM et al. | Diabetogenicity of FK506 versus cyclosporine in liver transplant recipients. | 1994 | Transplantation | pmid:7519799 |
| Mor E et al. | Reversal of severe FK506 side effects by conversion to cyclosporine-based immunosuppression. | 1994 | Transplantation | pmid:7519800 |
| Erden E et al. | Plasma FK506 levels in patients with histopathologically documented renal allograft rejection. | 1994 | Transplantation | pmid:7519801 |
| Randomised trial comparing tacrolimus (FK506) and cyclosporin in prevention of liver allograft rejection. European FK506 Multicentre Liver Study Group. | 1994 | Lancet | pmid:7520105 | |
| Funauchi M et al. | Effects of an inhibitor for calcium/calmodulin-dependent protein phosphatase, calcineurin, on induction of long-term potentiation in rat visual cortex. | 1994 | Neurosci. Res. | pmid:7520143 |
| Ito T et al. | Protective effects of gabexate mesilate on acute pancreatitis induced by tacrolimus (FK-506) in rats in which the pancreas was stimulated by caerulein. | 1994 | J. Gastroenterol. | pmid:7520321 |
| Gonschior AK et al. | Measurement of blood concentrations of FK506 (tacrolimus) and its metabolites in seven liver graft patients after the first dose by h.p.l.c.-MS and microparticle enzyme immunoassay (MEIA). | 1994 | Br J Clin Pharmacol | pmid:7534100 |
| Connelly PR et al. | Enthalpy of hydrogen bond formation in a protein-ligand binding reaction. | 1994 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7510408 |
| Kim YI et al. | FK 506 prevents critical warm ischemia damage to the pig liver and improves hepatic microcirculation. | 1994 | Transplant. Proc. | pmid:7520636 |
| Shiraga T et al. | Metabolism of FK506, a potent immunosuppressive agent, by cytochrome P450 3A enzymes in rat, dog and human liver microsomes. | 1994 | Biochem. Pharmacol. | pmid:7510480 |
| Hirai T et al. | A short course of FK506 can induce limited donor-specific graft acceptance. | 1994 | Ann. Thorac. Surg. | pmid:7520685 |
| Hossain M et al. | Effects of various drugs (staurosporine, herbimycin A, ketotifen, theophylline, FK506 and cyclosporin A) on eosinophil viability. | 1994 | Arerugi | pmid:7520689 |
| Bell A et al. | Roles of peptidyl-prolyl cis-trans isomerase and calcineurin in the mechanisms of antimalarial action of cyclosporin A, FK506, and rapamycin. | 1994 | Biochem. Pharmacol. | pmid:7520696 |
| Paslaru L et al. | GRP78 induction by cyclosporin A in human HeLa cells. | 1994 | FEBS Lett. | pmid:7520875 |
| Gailliot FP et al. | Isolation and characterization of the major equilibrium product of FK-520. | 1994 | J. Antibiot. | pmid:7520900 |
| Stancato LF et al. | The native v-Raf.hsp90.p50 heterocomplex contains a novel immunophilin of the FK506 binding class. | 1994 | J. Biol. Chem. | pmid:7520912 |
| Hirano Y et al. | Mechanism of FK506-induced glucose intolerance in rats. | 1994 | J Toxicol Sci | pmid:7520947 |
| Okamoto S et al. | The interleukin-8 AP-1 and kappa B-like sites are genetic end targets of FK506-sensitive pathway accompanied by calcium mobilization. | 1994 | J. Biol. Chem. | pmid:7510691 |
| Nakagawa H et al. | Tacrolimus ointment for atopic dermatitis. | 1994 | Lancet | pmid:7522297 |
| Sharkey J and Butcher SP | Immunophilins mediate the neuroprotective effects of FK506 in focal cerebral ischaemia. | 1994 | Nature | pmid:7522303 |
| Bram RJ and Crabtree GR | Calcium signalling in T cells stimulated by a cyclophilin B-binding protein. | 1994 | Nature | pmid:7522304 |
| Tanaka A et al. | Living related liver transplantation across ABO blood groups. | 1994 | Transplantation | pmid:7522363 |
| Devlin J et al. | Nitric oxide generation. A predictive parameter of acute allograft rejection. | 1994 | Transplantation | pmid:7522365 |
| Todo S et al. | Single-center experience with primary orthotopic liver transplantation with FK 506 immunosuppression. | 1994 | Ann. Surg. | pmid:7522431 |
| Lebeau MC et al. | Rabbit FKBP-59/HBI does not inhibit calcineurin activity in vitro. | 1994 | Biochem. Biophys. Res. Commun. | pmid:7522447 |
| Lemster B et al. | Influence of FK 506 (tacrolimus) on circulating CD4+ T cells expressing CD25 and CD45RA antigens in 19 patients with chronic progressive multiple sclerosis participating in an open label drug safety trial. | 1994 | Autoimmunity | pmid:7539635 |
| Wakabayashi H et al. | The effect of FK506 on warm ischemia and reperfusion injury in the rat liver. | 1994 | Surg. Today | pmid:7539646 |
| Apanay DC et al. | Cyclosporine increases the oxidizability of low-density lipoproteins in renal transplant recipients. | 1994 | Transplantation | pmid:7524202 |
| Steinmüller TM et al. | The effect of FK506 versus cyclosporine on glucose and lipid metabolism--a randomized trial. | 1994 | Transplantation | pmid:7524203 |
| Singh N et al. | Infectious complications in liver transplant recipients on tacrolimus. Prospective analysis of 88 consecutive liver transplants. | 1994 | Transplantation | pmid:7524204 |
| Takahara S et al. | Clinical evaluation of trough levels and area under the curve in cyclosporine- and FK 506-treated kidney transplant recipients. | 1994 | Transplant. Proc. | pmid:7524219 |
| Heitman J et al. | Antifungal effects of cyclosporine and FK 506 are mediated via immunophilin-dependent calcineurin inhibition. | 1994 | Transplant. Proc. | pmid:7524220 |
| Yoshimura R et al. | Effect of immunosuppressive drugs (CsA, FK 506, rapamycin) on the kidney microsomal cytochrome P-450 system in the rat. | 1994 | Transplant. Proc. | pmid:7524223 |
| Kupferman JC et al. | Activation of the renal renin-angiotensin system by cyclosporine A and FK 506 in the rat. | 1994 | Transplant. Proc. | pmid:7524224 |
| Kattner A et al. | Conversion from CyA to CyA-NOF in a cholestatic liver grafted patient with CyA malabsorption. | 1994 | Transplant. Proc. | pmid:7524225 |
| Ishioka M et al. | FK506 treatment of noninfectious uveitis. | 1994 | Am. J. Ophthalmol. | pmid:7526689 |
| Carroll PB et al. | Effect of tacrolimus (FK506) in dystrophic epidermolysis bullosa: rationale and preliminary results. | 1994 | Arch Dermatol | pmid:7526802 |
| Lauerma AI et al. | Topical FK506: suppression of allergic and irritant contact dermatitis in the guinea pig. | 1994 | Arch. Dermatol. Res. | pmid:7526805 |
| Bush KT et al. | Induction of the FK506-binding protein, FKBP13, under conditions which misfold proteins in the endoplasmic reticulum. | 1994 | Biochem. J. | pmid:7526846 |
| Kahan BD | New immunosuppressive drugs--pharmacologic approaches to alter immunoregulation. | 1994 | Ther Immunol | pmid:7584478 |
| Akamine S et al. | Monitoring canine lung allograft rejection using Ia antigen expression by bronchoalveolar lymphocytes. | 1994 | Surg. Today | pmid:7526914 |
| Tsuchida M et al. | The effects of FK506 and dexamethasone on rat thymocyte differentiation. | 1994 | Ther Immunol | pmid:7584489 |
| Lemoine A et al. | FK 506 renal toxicity and lack of detectable cytochrome P-450 3A in the liver graft of a patient undergoing liver transplantation. | 1994 | Hepatology | pmid:7527003 |
| Alnemri ES et al. | FKBP46, a novel Sf9 insect cell nuclear immunophilin that forms a protein-kinase complex. | 1994 | J. Biol. Chem. | pmid:7527037 |
| Rosenwirth B et al. | Inhibition of human immunodeficiency virus type 1 replication by SDZ NIM 811, a nonimmunosuppressive cyclosporine analog. | 1994 | Antimicrob. Agents Chemother. | pmid:7527198 |
| Devlin J et al. | FK 506 primary immunosuppression following emergency liver transplantation for fulminant hepatic failure. European FK 506 Study Liver Group. | 1994 | Transpl. Int. | pmid:11271328 |
| Otto G et al. | Corticosteroids and concomitant medication in the European multicentre study of FK 506 and cyclosporin in primary liver transplantation. | 1994 | Transpl. Int. | pmid:11271338 |
| Wilson JR et al. | Sensorimotor neuropathy resembling CIDP in patients receiving FK506. | 1994 | Muscle Nerve | pmid:7512691 |
| Wong P et al. | FK 506 rescue therapy for intractable liver allograft rejection. | 1994 | Transpl. Int. | pmid:11271339 |
| Lyons WE et al. | Immunosuppressant FK506 promotes neurite outgrowth in cultures of PC12 cells and sensory ganglia. | 1994 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7512727 |
| Mor E et al. | Comparison of short and long-term renal function in liver transplant patients receiving cyclosporin or FK 506. | 1994 | Transpl. Int. | pmid:11271340 |
| Uemoto S et al. | Long-term use of FK 506 in living related liver transplantation. | 1994 | Transpl. Int. | pmid:11271341 |
| Dmitrewski J et al. | Steroid withdrawal 3 months after liver transplantation--does FK 506 confer any advantage over cyclosporin? | 1994 | Transpl. Int. | pmid:11271342 |
| Yasunami Y and Ikeda S | Induction of donor specific unresponsiveness in rat islet allografts by intraportal grafting and FK506. | 1994 | Cell Transplant | pmid:7512877 |
| Mor E et al. | Reversal of gastrointestinal toxicity associated with long-term FK506 immunosuppression by conversion to cyclosporine in liver transplant recipients. | 1994 | Transplantation | pmid:7513098 |