| MeSH term | MeSH ID | Detail |
|---|---|---|
| Infection | D007239 | 6 associated lipids |
| Abnormalities, Multiple | D000015 | 13 associated lipids |
| Hypersensitivity, Delayed | D006968 | 43 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Bone Diseases | D001847 | 4 associated lipids |
| Leukemia P388 | D007941 | 43 associated lipids |
| Ulcer | D014456 | 16 associated lipids |
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Obesity | D009765 | 29 associated lipids |
| Thrombosis | D013927 | 49 associated lipids |
| Bradycardia | D001919 | 13 associated lipids |
| Hemorrhage | D006470 | 15 associated lipids |
| Proteinuria | D011507 | 30 associated lipids |
| Lymphoma | D008223 | 18 associated lipids |
| Femur Head Necrosis | D005271 | 5 associated lipids |
| Alzheimer Disease | D000544 | 76 associated lipids |
| Drug Hypersensitivity | D004342 | 20 associated lipids |
| Eye Diseases | D005128 | 12 associated lipids |
| Arteriosclerosis | D001161 | 86 associated lipids |
tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Burke GW et al. | Use of FK 506 in simultaneous pancreas/kidney transplantation: lack of impairment of glycemic or lipid metabolism. | 1995 | Transplant. Proc. | pmid:8539872 |
| Burke GW et al. | The use of FK506 in simultaneous pancreas/kidney transplantation: rescue, induction, and maintenance immunosuppression. | 1995 | Transplant. Proc. | pmid:8539874 |
| Wennberg L et al. | Immunosuppression with leflunomide and cyclosporine prevents pig-to-rat islet xenograft rejection. | 1995 | Transplant. Proc. | pmid:8539967 |
| Tai J et al. | In vivo function of pig islet xenografts in immunosuppressed diabetic mice. | 1995 | Transplant. Proc. | pmid:8539968 |
| Felldin M et al. | Rescue therapy with Tacrolimus (FK506) in renal transplant recipients--a multicenter analysis. | 1995 | Transplant. Proc. | pmid:8540032 |
| Bersztel A et al. | Deoxyspergualin is synergistic with cyclosporin A, but not with FK506 in a rat heart allograft transplantation model. | 1995 | Transplant. Proc. | pmid:8540095 |
| Echigo Y et al. | Effects of cyclosporine and tacrolimus (FK 506) on acute pancreatitis in mice. | 1995 | Arch Surg | pmid:7528496 |
| Lemster BH et al. | IL-8/IL-8 receptor expression in psoriasis and the response to systemic tacrolimus (FK506) therapy. | 1995 | Clin. Exp. Immunol. | pmid:7531627 |
| Chaudhuri B et al. | The interaction between the catalytic A subunit of calcineurin and its autoinhibitory domain, in the yeast two-hybrid system, is disrupted by cyclosporin A and FK506. | 1995 | FEBS Lett. | pmid:7528690 |
| Timerman AP et al. | Characterization of an exchange reaction between soluble FKBP-12 and the FKBP.ryanodine receptor complex. Modulation by FKBP mutants deficient in peptidyl-prolyl isomerase activity. | 1995 | J. Biol. Chem. | pmid:7531689 |
| Richter A et al. | Growth inhibitory effects of FK506 and cyclosporin A independent of inhibition of calcineurin. | 1995 | Biochem. Pharmacol. | pmid:7531976 |
| Porayko MK et al. | Comparing nephrotoxicity of FK 506 and cyclosporine regimens after liver transplantation: preliminary results from US Multicenter trial. U.S. Multicenter Liver Study Group. | 1995 | Transplant. Proc. | pmid:7533358 |
| Mueller AR et al. | The superior immunosuppressant according to diagnosis: FK 506 or cyclosporine A. | 1995 | Transplant. Proc. | pmid:7533359 |
| Abouljoud MS et al. | Hyperlipidemia after liver transplantation: long-term results of the FK506/cyclosporine A US Multicenter Trial. US Multicenter Study Group. | 1995 | Transplant. Proc. | pmid:7533360 |
| Bäckman L et al. | Whole-blood and plasma levels of FK 506 after liver transplantation: results from the US Multicenter Trial. FK506 Multicenter Study Group. | 1995 | Transplant. Proc. | pmid:7533361 |
| Söderdahl G et al. | FK 506 improves recovery of bile secretion following orthotopic liver transplantation in man. | 1995 | Transplant. Proc. | pmid:7533362 |
| Mor E et al. | Weight gain and lipid profile changes in liver transplant recipients: long-term results of the American FK506 Multicenter Study. | 1995 | Transplant. Proc. | pmid:7533363 |
| Hemenway CS et al. | vph6 mutants of Saccharomyces cerevisiae require calcineurin for growth and are defective in vacuolar H(+)-ATPase assembly. | 1995 | Genetics | pmid:8582630 |
| Tanabe M et al. | Therapeutic synergism between low-dose FK 506 and antimetabolites in rat allogeneic heart transplantation. | 1995 | Transplant. Proc. | pmid:7533411 |
| Abu-Elmagd K et al. | The current status of hepatic transplantation at the University of Pittsburgh. | 1995 | Clin Transpl | pmid:8794262 |
| Masri MA | Comparative study of toxicity and efficacy of cyclosporine, cyclosporine G (OG37), FK 506, and rapamycin in BALB/c mice with fitted skin grafts. | 1995 | Transplant. Proc. | pmid:7533412 |
| Shapiro R et al. | The superiority of tacrolimus in renal transplant recipients -- the Pittsburgh experience. | 1995 | Clin Transpl | pmid:8794266 |
| Jiang H et al. | Immunosuppressive effects of FK 506 on rat renal allograft survival, in comparison with cyclosporine. | 1995 | Transplant. Proc. | pmid:7533413 |
| Bismuth H | Comparison of FK 506- and cyclosporine-based immunosuppression: FK 506 therapy significantly reduces the incidence of acute, steroid-resistant, refractory, and chronic rejection whilst possessing a comparable safety profile. European FK 506 Multicenter Liver Study Group. | 1995 | Transplant. Proc. | pmid:7533415 |
| Ochiai T et al. | Japanese multicenter studies of FK 506 in renal transplantation. Japanese FK 506 Study Group. | 1995 | Transplant. Proc. | pmid:7533419 |
| Saito S et al. | The pattern of rejection and susceptibility to different kinds of immunosuppression after combined liver, duodenum, and pancreas transplantation in swine--immunosuppressive drugs versus ex vivo immunomodulation of the allograft. | 1995 | Transplant. Proc. | pmid:7533420 |
| Hadley S et al. | Major infectious complications after orthotopic liver transplantation and comparison of outcomes in patients receiving cyclosporine or FK506 as primary immunosuppression. | 1995 | Transplantation | pmid:7535482 |
| Bakhtiar R and Stearns RA | Studies on non-covalent associations of immunosuppressive drugs with serum albumin using pneumatically assisted electrospray ionization mass spectrometry. | 1995 | Rapid Commun. Mass Spectrom. | pmid:7535601 |
| Kaufman DB et al. | The successful use of tacrolimus (FK506) in a pancreas/kidney transplant recipient with recurrent cyclosporine-associated hemolytic uremic syndrome. | 1995 | Transplantation | pmid:7541579 |
| McDiarmid SV et al. | The treatment of intractable rejection with tacrolimus (FK506) in pediatric liver transplant recipients. | 1995 | J. Pediatr. Gastroenterol. Nutr. | pmid:7541834 |
| Koehler MT et al. | FK506 (tacrolimus) in the treatment of steroid-resistant acute graft-versus-host disease in children undergoing bone marrow transplantation. | 1995 | Bone Marrow Transplant. | pmid:7581088 |
| Dix SP et al. | Re: Severe interaction between methotrexate and a macrolide-like antibiotic. | 1995 | J. Natl. Cancer Inst. | pmid:7563209 |
| Reisman L et al. | Modulation of interleukin-1 secretion by immunosuppressive drugs, alone and in combination. | 1995 | Transpl. Immunol. | pmid:7551978 |
| Woo J et al. | Effects of FK 506 on chimerism and the induction of donor-specific unresponsiveness following fully allogeneic bone marrow transplantation in mice. | 1995 | Transpl. Immunol. | pmid:7551985 |
| Kelly PA et al. | Tacrolimus: a new immunosuppressive agent. | 1995 | Am J Health Syst Pharm | pmid:7552894 |
| Koch K et al. | The C-32 triacetyl-L-rhamnose derivative of ascomycin: a potent, orally active macrolactone immunosuppressant. | 1995 | J. Med. Chem. | pmid:7537331 |
| MacDonald AS and Sketris IS | Tacrolimus in transplantation. | 1995 | Am J Health Syst Pharm | pmid:7552906 |
| Kawasaki M et al. | [Immunosuppression and the problems in partial liver transplantation]. | 1995 | Nihon Rinsho Meneki Gakkai Kaishi | pmid:8963785 |
| Torii N et al. | An inhibitor for calcineurin, FK506, blocks induction of long-term depression in rat visual cortex. | 1995 | Neurosci. Lett. | pmid:7537357 |
| Holmes JA and Twentyman PR | The activity of deoxyspergualin in multidrug-resistant cells. | 1995 | Cancer Chemother. Pharmacol. | pmid:7554042 |
| Miyazawa H et al. | Hamster to rat kidney xenotransplantation. Effects of FK 506, cyclophosphamide, organ perfusion, and complement inhibition. | 1995 | Transplantation | pmid:7537396 |
| Pockley AG et al. | Effect of cyclosporin A, FK506 and rapamycin on proliferation and soluble IL-2 receptor release from mitogenically stimulated rat spleen cells. | 1995 | Biochem. Soc. Trans. | pmid:8654800 |
| Furlan V et al. | Interactions between FK506 and rifampicin or erythromycin in pediatric liver recipients. | 1995 | Transplantation | pmid:7537398 |
| Mañez R et al. | Anomalous pattern of IgG antibody response to primary cytomegalovirus infection after solid organ retransplantation. | 1995 | Transplantation | pmid:7537400 |
| Van Thiel DH et al. | Tacrolimus: a potential new treatment for autoimmune chronic active hepatitis: results of an open-label preliminary trial. | 1995 | Am. J. Gastroenterol. | pmid:7537444 |
| Lam E et al. | Isolation of a cDNA encoding a novel human FK506-binding protein homolog containing leucine zipper and tetratricopeptide repeat motifs. | 1995 | Gene | pmid:7543869 |
| Minamoto A et al. | Suppression of corneal graft rejection by subconjunctival injection of FK-506 in a rat model of penetrating keratoplasty. | 1995 | Jpn. J. Ophthalmol. | pmid:7543958 |
| Ueda M et al. | A proposal of FK506 optimal dosing in living related liver transplantations. | 1995 | Transplantation | pmid:7544035 |
| Muthukkumar S et al. | Rapamycin, a potent immunosuppressive drug, causes programmed cell death in B lymphoma cells. | 1995 | Transplantation | pmid:7544036 |
| Fisher A et al. | FK506 hepatotoxicity in liver allograft recipients. | 1995 | Transplantation | pmid:7539961 |
| Muraki T et al. | Antithrombotic effect of FK506 versus prothrombotic effect of cyclosporine in vivo. | 1995 | Transplantation | pmid:7544038 |
| Nash RA et al. | Tacrolimus (FK506) alone or in combination with methotrexate or methylprednisolone for the prevention of acute graft-versus-host disease after marrow transplantation from HLA-matched siblings: a single-center study. | 1995 | Blood | pmid:7540071 |
| Bennett WM | The nephrotoxicity of immunosuppressive drugs. | 1995 | Clin. Nephrol. | pmid:7540121 |
| Moro A et al. | Secretion by Trypanosoma cruzi of a peptidyl-prolyl cis-trans isomerase involved in cell infection. | 1995 | EMBO J. | pmid:7540135 |
| Zweifach A and Lewis RS | Slow calcium-dependent inactivation of depletion-activated calcium current. Store-dependent and -independent mechanisms. | 1995 | J. Biol. Chem. | pmid:7540169 |
| Hattori Y and Nakanishi N | Effects of cyclosporin A and FK506 on nitric oxide and tetrahydrobiopterin synthesis in bacterial lipopolysaccharide-treated J774 macrophages. | 1995 | Cell. Immunol. | pmid:7545550 |
| Han JW et al. | Rapamycin, wortmannin, and the methylxanthine SQ20006 inactivate p70s6k by inducing dephosphorylation of the same subset of sites. | 1995 | J. Biol. Chem. | pmid:7545671 |
| Ruff VA and Leach KL | Direct demonstration of NFATp dephosphorylation and nuclear localization in activated HT-2 cells using a specific NFATp polyclonal antibody. | 1995 | J. Biol. Chem. | pmid:7545680 |
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| Jain AB et al. | Capillary blood versus arterial or venous blood for tacrolimus monitoring in liver transplantation. | 1995 | Transplantation | pmid:7545836 |
| Lampen A et al. | Metabolism of the immunosuppressant tacrolimus in the small intestine: cytochrome P450, drug interactions, and interindividual variability. | 1995 | Drug Metab. Dispos. | pmid:8689938 |
| Lake JR et al. | The impact of immunosuppressive regimens on the cost of liver transplantation--results from the U.S. FK506 multicenter trial. | 1995 | Transplantation | pmid:7482713 |
| Bolman RM | Advantage--FK 506: reduced chronic rejection for lung transplant recipients. | 1995 | Ann. Thorac. Surg. | pmid:7545888 |
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| Kawahara K et al. | Effects of deoxyspergualin on bronchial anastomosis healing in canine pulmonary allografts. | 1995 Jul-Aug | J. Heart Lung Transplant. | pmid:7578196 |
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| Su Q et al. | Nephrotoxicity of cyclosporin A and FK506: inhibition of calcineurin phosphatase. | 1995 May-Jun | Ren. Physiol. Biochem. | pmid:7542793 |
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| Pham SM et al. | Tacrolimus (FK 506) in clinical cardiac transplantation: a five-year experience. | 1996 | Transplant. Proc. | pmid:8623208 |
| Ketel BL et al. | Tacrolimus-based vs cyclosporine-based immunotherapy in combined kidney-pancreas transplantation. | 1996 | Transplant. Proc. | pmid:8623453 |
| Kyo M et al. | Results with histological diagnosis in kidney transplant rejections treated with 15-deoxyspergualin. | 1996 | Transplant. Proc. | pmid:8623457 |
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| Guérette B et al. | Increased interferon-gamma mRNA expression following alloincompatible myoblast transplantation is inhibited by FK506. | 1996 | Muscle Nerve | pmid:8965835 |
| Tanabe K et al. | Diabetes mellitus after renal transplantation under FK 506 (tacrolimus) as primary immunosuppression. | 1996 | Transplant. Proc. | pmid:8658670 |
| Sugito K et al. | A comparative study of clinicopathologic characteristics of renal allografts under cyclosporine and FK506 immunosuppression. | 1996 | Transplant. Proc. | pmid:8658683 |
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| Rokaw MD et al. | Rapamycin inhibits protein kinase C activity and stimulates Na+ transport in A6 cells. | 1996 | J. Biol. Chem. | pmid:8943313 |
| Matsui A et al. | Apparently increased trough levels of tacrolimus caused by acute infantile diarrhea in two infants with biliary atresia after liver transplantation. | 1996 | Acta Paediatr Jpn | pmid:9002314 |
| Jordan ML et al. | The use of tacrolimus in renal transplantation. | 1996 | World J Urol | pmid:8873438 |
| Wada Y et al. | BCX-34: a novel T-cell selective immunosuppressant: purine nucleoside phosphorylase (PNP) inhibitor. | 1996 | Artif Organs | pmid:8853794 |
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| Lochmüller H et al. | Transient immunosuppression by FK506 permits a sustained high-level dystrophin expression after adenovirus-mediated dystrophin minigene transfer to skeletal muscles of adult dystrophic (mdx) mice. | 1996 | Gene Ther. | pmid:8854096 |
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| Schmaldienst S and Horl WH | Bacterial infections during immunosuppression - immunosuppressive agents interfere not only with immune response, but also with polymorphonuclear cell function. | 1996 | Nephrol. Dial. Transplant. | pmid:8672015 |
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