tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Chen YS et al. | Population pharmacokinetic analysis of tacrolimus in Chinese myasthenia gravis patients. | 2017 | Acta Pharmacol. Sin. | pmid:28552913 |
| Luo X et al. | Prediction of tacrolimus metabolism and dosage requirements based on CYP3A4 phenotype and CYP3A5(*)3 genotype in Chinese renal transplant recipients. | 2016 | Acta Pharmacol. Sin. | pmid:26924289 |
| Lu YX et al. | A population pharmacokinetic study of tacrolimus in healthy Chinese volunteers and liver transplant patients. | 2015 | Acta Pharmacol. Sin. | pmid:25500866 |
| Chen JC and Ma P | Mechanism of FK506-induced renal hypoperfusion and its reversion in rats. | 2001 | Acta Pharmacol. Sin. | pmid:11749797 |
| Bienemann K et al. | Topical tacrolimus is effective against eczema in Wiskott-Aldrich syndrome (WAS). | 2007 | Acta Paediatr. | pmid:17429928 |
| Sinha R and Marks SD | Tacrolimus toxicity secondary to diarrhoea in nephrotic syndrome. | 2013 | Acta Paediatr. | pmid:23573873 |
| Isidor B et al. | Hyperzincemia and hypercalprotectinemia: unsuccessful treatment with tacrolimus. | 2009 | Acta Paediatr. | pmid:18983438 |
| Marlaka JR et al. | Tacrolimus without or with the addition of conventional immunosuppressive treatment in juvenile autoimmune hepatitis. | 2012 | Acta Paediatr. | pmid:22646819 |
| Gradman J and Wolthers OD | Short-term growth in children with eczema during treatment with topical mometasone furoate and tacrolimus. | 2007 | Acta Paediatr. | pmid:17590198 |
| Puzik A et al. | Effects of ciclosporin A, tacrolimus and sirolimus on cytokine production in neonatal immune cells. | 2007 | Acta Paediatr. | pmid:17880416 |
| Azuma H et al. | Atypical Epstein-Barr virus infection during and after intermittent FK506 therapy. | 1997 | Acta Paediatr Jpn | pmid:9141259 |
| Matsui A et al. | Apparently increased trough levels of tacrolimus caused by acute infantile diarrhea in two infants with biliary atresia after liver transplantation. | 1996 | Acta Paediatr Jpn | pmid:9002314 |
| Bas E et al. | An experimental comparative study of dexamethasone, melatonin and tacrolimus in noise-induced hearing loss. | 2009 | Acta Otolaryngol. | pmid:19051071 |
| Fukunaga T et al. | Osteogenesis in xenogeneic bone transplantation, using an immunosuppressant. Rabbit-rat experiments. | 1995 | Acta Orthop Scand | pmid:8553828 |
| Muramatsu K et al. | Longer survival of rat limb allograft. Combined immunosuppression of FK-506 and 15-deoxyspergualin. | 1997 | Acta Orthop Scand | pmid:9462361 |
| Ikebe S et al. | Immunosuppressive effect of tacrolimus (FK-506). Bone xenografts in rabbits. | 1996 | Acta Orthop Scand | pmid:8792745 |
| Shibatani M et al. | Degree of corticosteroid treatment within the first 2 months of renal transplantation has a strong influence on the incidence of osteonecrosis of the femoral head. | 2008 | Acta Orthop | pmid:18839369 |
| Virtanen HM et al. | Effect of 0.03% tacrolimus ointment on conjunctival cytology in patients with severe atopic blepharoconjunctivitis: a retrospective study. | 2006 | Acta Ophthalmol Scand | pmid:16965503 |
| Remitz A et al. | Tacrolimus ointment in atopic blepharoconjunctivitis does not seem to elevate intraocular pressure. | 2011 | Acta Ophthalmol | pmid:20064110 |
| Hellström VC et al. | Malignancies in transplanted patients: Multidisciplinary evaluation and switch to mTOR inhibitors after kidney transplantation - experiences from a prospective, clinical, observational study. | 2016 | Acta Oncol | pmid:26824275 |