tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Cristillo AD et al. | Cloning and characterization of N4WBP5A, an inducible, cyclosporine-sensitive, Nedd4-binding protein in human T lymphocytes. | 2003 | J. Biol. Chem. | pmid:12796489 |
| Ikegame K et al. | Successful treatment of bcr/abl-positive acute mixed lineage leukemia by unmanipulated bone marrow transplantation from an HLA-haploidentical (3-antigen-mismatched) cousin. | 2003 | Bone Marrow Transplant. | pmid:12796797 |
| Peattie DA et al. | Expression and characterization of human FKBP52, an immunophilin that associates with the 90-kDa heat shock protein and is a component of steroid receptor complexes. | 1992 | Proc. Natl. Acad. Sci. U.S.A. | pmid:1279700 |
| Lhoëst G et al. | Isolation and mass spectrometric identification of two metabolites of FK 506 from rat liver microsomal incubation media. | 1992 | Pharm Acta Helv | pmid:1279730 |
| Benigni A et al. | The acute effect of FK506 and cyclosporine on endothelial cell function and renal vascular resistance. | 1992 | Transplantation | pmid:1279848 |
| Mor E et al. | Late-onset acute rejection in orthotopic liver transplantation--associated risk factors and outcome. | 1992 | Transplantation | pmid:1279849 |
| Hirano Y et al. | The effects of FK506 and cyclosporine on the exocrine function of the rat pancreas. | 1992 | Transplantation | pmid:1279850 |
| Takaya S et al. | Liver transplantation in positive cytotoxic crossmatch cases using FK506, high-dose steroids, and prostaglandin E1. | 1992 | Transplantation | pmid:1279851 |
| Partaledis JA et al. | Saccharomyces cerevisiae contains a homolog of human FKBP-13, a membrane-associated FK506/rapamycin binding protein. | 1992 | Yeast | pmid:1279908 |
| Graham-Brown RA and Grassberger M | Pimecrolimus: a review of pre-clinical and clinical data. | 2003 | Int. J. Clin. Pract. | pmid:12800465 |
| Ozawa K et al. | An appraisal of pediatric liver transplantation from living relatives. Initial clinical experiences in 20 pediatric liver transplantations from living relatives as donors. | 1992 | Ann. Surg. | pmid:1280074 |
| Akutsu I et al. | [Inhibitory effects of cyclosporin A and FK-506 on eosinophil chemotactic factor activity in culture supernatants of mononuclear cells from asthmatics]. | 1992 | Arerugi | pmid:1280086 |
| Tomari S et al. | Pranlukast, a cysteinyl leukotriene receptor 1 antagonist, attenuates allergen-specific tumour necrosis factor alpha production and nuclear factor kappa B nuclear translocation in peripheral blood monocytes from atopic asthmatics. | 2003 | Clin. Exp. Allergy | pmid:12801315 |
| Kiji T et al. | Enhancement of cell viability in cryopreserved rat vascular grafts by administration of regenerating gene (REG) inducers. | 2003 Mar-Apr | J. Vasc. Res. | pmid:12808349 |
| Murphy GJ et al. | Randomized clinical trial of the effect of microemulsion cyclosporin and tacrolimus on renal allograft fibrosis. | 2003 | Br J Surg | pmid:12808614 |
| Middleton SJ et al. | Adult small intestinal transplantation in England and Wales. | 2003 | Br J Surg | pmid:12808622 |
| Bergstrand H and Lundquist B | Human basophil histamine release is differently affected by inhibitors of calmodulin, diacylglycerol kinase and peptidyl prolyl cis-trans isomerase in a secretagogue specific manner. | 1992 | Allergy | pmid:1280915 |
| Laffitte E et al. | Erosive pustular dermatosis of the scalp: treatment with topical tacrolimus. | 2003 | Arch Dermatol | pmid:12810500 |
| Chu J et al. | Topical tacrolimus is a useful adjunctive therapy for bullous pemphigoid. | 2003 | Arch Dermatol | pmid:12810523 |
| Barry JM | Immunosuppressive drugs in renal transplantation. A review of the regimens. | 1992 | Drugs | pmid:1281071 |
| Reutzel-Selke A et al. | Short-term immunosuppressive treatment of the donor ameliorates consequences of ischemia/ reperfusion injury and long-term graft function in renal allografts from older donors. | 2003 | Transplantation | pmid:12811235 |
| Molano RD et al. | Long-term islet allograft survival in nonobese diabetic mice treated with tacrolimus, rapamycin, and anti-interleukin-2 antibody. | 2003 | Transplantation | pmid:12811239 |
| Bilolo KK et al. | Synergistic effects of malononitrilamides (FK778, FK779) with tacrolimus (FK506) in prevention of acute heart and kidney allograft rejection and reversal of ongoing heart allograft rejection in the rat. | 2003 | Transplantation | pmid:12811249 |
| Kramer D et al. | Calcineurin controls the expression of numerous genes in cerebellar granule cells. | 2003 | Mol. Cell. Neurosci. | pmid:12812763 |
| Rodriguez-Hernandez CJ et al. | The immunosuppressant FK506 uncovers a positive regulatory cross-talk between the Hog1p and Gcn2p pathways. | 2003 | J. Biol. Chem. | pmid:12813040 |
| Stiff DD et al. | Metabolism of FK 506 in differentially induced rat liver microsomes. | 1992 | Res. Commun. Chem. Pathol. Pharmacol. | pmid:1281332 |
| Kurtz J et al. | Lack of role for CsA-sensitive or Fas pathways in the tolerization of CD4 T cells via BMT and anti-CD40L. | 2003 | Am. J. Transplant. | pmid:12814472 |
| Foor F et al. | Calcineurin mediates inhibition by FK506 and cyclosporin of recovery from alpha-factor arrest in yeast. | 1992 | Nature | pmid:1281518 |
| Goldfeld AE et al. | Transcription of the tumor necrosis factor alpha gene is rapidly induced by anti-immunoglobulin and blocked by cyclosporin A and FK506 in human B cells. | 1992 | Proc. Natl. Acad. Sci. U.S.A. | pmid:1281550 |
| Morikawa K et al. | The distinct effects of FK506 on the activation, proliferation, and differentiation of human B lymphocytes. | 1992 | Transplantation | pmid:1281561 |
| Moutabarrik A et al. | FK506-induced kidney tubular cell injury. | 1992 | Transplantation | pmid:1281562 |
| Yagihashi A et al. | HLA matching effect in liver transplantation. | 1992 | Transplant. Proc. | pmid:1281569 |
| Kobayashi M et al. | Posttransplant donor-specific T-lymphocytotoxic antibody in liver transplant patients with a positive crossmatch. | 1992 | Transplant. Proc. | pmid:1281570 |
| Lemster B et al. | Cytokine gene expression in murine lymphocytes activated in the presence of FK 506, bredinin, mycophenolic acid, or brequinar sodium. | 1992 | Transplant. Proc. | pmid:1281576 |
| Tze WJ et al. | FK 506: an effective immunosuppressant for islet xenotransplantation. | 1992 | Transplant. Proc. | pmid:1281577 |
| Kamei T et al. | Established intraportal islet allograft is rejected despite the acceptance of donor-specific second cardiac allograft. | 1992 | Transplant. Proc. | pmid:1281579 |
| Woo J et al. | FK 506 treatment following syngeneic bone marrow transplantation does not inhibit clonal deletion of V beta 5+ or V beta 11+ T cells. | 1992 | Transplant. Proc. | pmid:1281583 |
| Souza ER et al. | Acute effects of FK 506 on glomerular hemodynamics. | 1992 | Transplant. Proc. | pmid:1281585 |
| Reitamo S and Remitz A | [Tacrolimus and pimecrolimus ointments in the treatment of atopic eczema]. | 2003 | Duodecim | pmid:12815980 |
| Hanke JH et al. | FK506 and rapamycin selectively enhance degradation of IL-2 and GM-CSF mRNA. | 1992 | Lymphokine Cytokine Res. | pmid:1281674 |
| Logan TM et al. | Side chain and backbone assignments in isotopically labeled proteins from two heteronuclear triple resonance experiments. | 1992 | FEBS Lett. | pmid:1281793 |
| de Paulis A et al. | Anti-inflammatory effect of FK-506 on human skin mast cells. | 1992 | J. Invest. Dermatol. | pmid:1281861 |
| Bergstrand H et al. | Modulation of neutrophil superoxide generation by inhibitors of protein kinase C, calmodulin, diacylglycerol and myosin light chain kinases, and peptidyl prolyl cis-trans isomerase. | 1992 | J. Pharmacol. Exp. Ther. | pmid:1281879 |
| Artz MA et al. | Improved cardiovascular risk profile and renal function in renal transplant patients after randomized conversion from cyclosporine to tacrolimus. | 2003 | J. Am. Soc. Nephrol. | pmid:12819249 |
| Anglicheau D et al. | Association of the multidrug resistance-1 gene single-nucleotide polymorphisms with the tacrolimus dose requirements in renal transplant recipients. | 2003 | J. Am. Soc. Nephrol. | pmid:12819250 |
| Ravaioli M et al. | Speech disorder related to tacrolimus-induced pontine myelinolysis after orthotopic liver transplantation. | 2003 | Transpl. Int. | pmid:12819864 |
| Bakri R et al. | Serious interaction between tacrolimus FK506 and chloramphenicol in a kidney-pancreas transplant recipient. | 2003 | Transpl. Int. | pmid:12819878 |
| DiLella AG et al. | Chromosomal band assignments of the genes encoding human FKBP12 and FKBP13. | 1992 | Biochem. Biophys. Res. Commun. | pmid:1281998 |
| Sawada M et al. | Down regulation of CD4 expression in cultured microglia by immunosuppressants and lipopolysaccharide. | 1992 | Biochem. Biophys. Res. Commun. | pmid:1282000 |
| Kalas W et al. | FK506 restores sensitivity of thymic lymphomas to calcium-mediated apoptosis and the inducible expression of Fas ligand. | 2003 Mar-Apr | Anticancer Res. | pmid:12820430 |
| Rosenstiel P et al. | Differential effects of immunophilin-ligands (FK506 and V-10,367) on survival and regeneration of rat retinal ganglion cells in vitro and after optic nerve crush in vivo. | 2003 | J. Neurotrauma | pmid:12820684 |
| Endo K et al. | Improvement of Satoyoshi syndrome with tacrolimus and corticosteroids. | 2003 | Neurology | pmid:12821760 |
| Minoda M et al. | Effects of gamma-interferon and FK506 on resting B cell proliferation of New Zealand black/white F1 mice. | 1992 | Microbiol. Immunol. | pmid:1282197 |
| Kang H et al. | [Combined immunosuppression of FK506 and RS-61443 in rat limb allotransplantation]. | 2003 | Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi | pmid:12822367 |
| Mallipeddi R and Evans AV | Refractory pityriasis lichenoides chronica successfully treated with topical tacrolimus. | 2003 | Clin. Exp. Dermatol. | pmid:12823321 |
| Wong R et al. | Tacrolimus-associated posterior reversible encephalopathy syndrome after allogeneic haematopoietic stem cell transplantation. | 2003 | Br. J. Haematol. | pmid:12823354 |
| Bowman H and Lennard TW | Immunosuppressive drugs. | 1992 Nov 4-17 | Br J Hosp Med | pmid:1282440 |
| Karamperis N et al. | Comparison of the pharmacokinetics of tacrolimus and cyclosporine at equivalent molecular doses. | 2003 | Transplant. Proc. | pmid:12826146 |
| Soltero L et al. | Coadministration of tacrolimus and ketoconazole in renal transplant recipients: cost analysis and review of metabolic effects. | 2003 | Transplant. Proc. | pmid:12826147 |
| Langer RM et al. | De novo tumors after kidney transplantation: the Budapest experience. | 2003 | Transplant. Proc. | pmid:12826170 |
| Braun N et al. | Impairment of renal function following liver transplantation. | 2003 | Transplant. Proc. | pmid:12826191 |
| Meloni F et al. | Monocyte chemoattractant protein-1 levels in bronchoalveolar lavage fluid of lung-transplanted patients treated with tacrolimus as rescue treatment for refractory acute rejection. | 2003 | Transplant. Proc. | pmid:12826211 |
| Mabuchi M et al. | Insulin-like growth factor-I enhances choleretic action of FK506 in rats. | 2003 | Transplant. Proc. | pmid:12826230 |
| Mogayzel PJ and Wagner TL | Cyclosporin and tacrolimus do not potentiate oxidative damage in pulmonary epithelial cells. | 2003 | Transpl. Int. | pmid:12827228 |
| Iglesias J et al. | Rapamycin-based rescue therapy after chronic rejection in a pediatric liver transplant patient. | 2003 | Transpl. Int. | pmid:12827229 |
| van Duijnhoven EM et al. | Increase in tacrolimus trough levels after steroid withdrawal. | 2003 | Transpl. Int. | pmid:12827231 |
| O'Carroll RE et al. | Psychological outcome and quality of life following liver transplantation: a prospective, national, single-center study. | 2003 | Liver Transpl. | pmid:12827558 |
| Levitsky J et al. | The effect of immunosuppressive regimens on the recurrence of primary biliary cirrhosis after liver transplantation. | 2003 | Liver Transpl. | pmid:12827561 |
| Min DI et al. | Visual compatibility of tacrolimus with commonly used drugs during simulated Y-site injection. | 1992 | Am J Hosp Pharm | pmid:1282779 |
| Sato Y et al. | Repeating intraportal donor-specific transfusion may induce tolerance following adult living-related donor liver transplantation. | 2003 May-Jun | Hepatogastroenterology | pmid:12828042 |
| Braza TJ et al. | Tacrolimus 0.1% ointment for seborrhoeic dermatitis: an open-label pilot study. | 2003 | Br. J. Dermatol. | pmid:12828755 |
| Lanford RE et al. | An infectious clone of woolly monkey hepatitis B virus. | 2003 | J. Virol. | pmid:12829821 |
| van Hooff JP et al. | A prospective randomized multicenter study of tacrolimus in combination with sirolimus in renal-transplant recipients. | 2003 | Transplantation | pmid:12829890 |
| Heffron TG et al. | Pediatric liver transplantation with daclizumab induction. | 2003 | Transplantation | pmid:12829908 |
| Gonwa T et al. | Randomized trial of tacrolimus + mycophenolate mofetil or azathioprine versus cyclosporine + mycophenolate mofetil after cadaveric kidney transplantation: results at three years. | 2003 | Transplantation | pmid:12829910 |
| Briggs D et al. | Effects of immediate switch from cyclosporine microemulsion to tacrolimus at first acute rejection in renal allograft recipients. | 2003 | Transplantation | pmid:12829912 |
| Mochizuki M | [Immunotherapy in ocular diseases]. | 1992 | Nippon Ganka Gakkai Zasshi | pmid:1283052 |
| McLaughlin GE et al. | Reversal of acute tacrolimus-induced renal vasoconstriction by theophylline in rats. | 2003 | Pediatr Crit Care Med | pmid:12831420 |
| Lanford RE et al. | Comparison of tamarins and marmosets as hosts for GBV-B infections and the effect of immunosuppression on duration of viremia. | 2003 | Virology | pmid:12832204 |
| Meshkinpour A et al. | An open pilot study using tacrolimus ointment in the treatment of seborrheic dermatitis. | 2003 | J. Am. Acad. Dermatol. | pmid:12833030 |
| Ellis RA et al. | Use of mixed lymphocyte reaction to identify subimmunosuppressive FK-506 levels in mice. | 2003 | Microsurgery | pmid:12833332 |
| Olejniczak ET et al. | A 4D HCCH-TOCSY experiment for assigning the side chain 1H and 13C resonances of proteins. | 1992 | J. Biomol. NMR | pmid:1283353 |
| Bauer S et al. | The effect of the new immunosuppressive drug FK506 on the formation of secondary metabolites of cyclosporin A. | 1992 | Int J Clin Pharmacol Ther Toxicol | pmid:1283385 |
| Abou-Jaoude MM and Almawi WY | Single-center experience with tacrolimus-based immunosuppressive regimens in renal transplantation. | 2003 | Mol. Immunol. | pmid:12835078 |
| Abou-Jaoude MM et al. | Tacrolimus (FK506) versus cyclosporin A microemulsion (Neoral) maintenance immunosuppression: effects on graft survival and function, infection, and metabolic profile following kidney transplantation (KT). | 2003 | Mol. Immunol. | pmid:12835083 |
| Thaçi D et al. | Occlusive treatment of chronic hand dermatitis with pimecrolimus cream 1% results in low systemic exposure, is well tolerated, safe, and effective. An open study. | 2003 | Dermatology (Basel) | pmid:12835546 |
| McLaughlin GE et al. | Benefit of theophylline administration in tacrolimus-induced nephrotoxicity in rats. | 2003 | Pediatr. Nephrol. | pmid:12836095 |
| Butcher RA and Schreiber SL | A small molecule suppressor of FK506 that targets the mitochondria and modulates ionic balance in Saccharomyces cerevisiae. | 2003 | Chem. Biol. | pmid:12837385 |
| Leamey CA et al. | Role of calcineurin in activity-dependent pattern formation in the dorsal lateral geniculate nucleus of the ferret. | 2003 | J. Neurobiol. | pmid:12838580 |
| Meingassner JG et al. | Pimecrolimus inhibits the elicitation phase but does not suppress the sensitization phase in murine contact hypersensitivity, in contrast to tacrolimus and cyclosporine A. | 2003 | J. Invest. Dermatol. | pmid:12839566 |
| Magari K et al. | Calcineurin inhibitors exert rapid reduction of inflammatory pain in rat adjuvant-induced arthritis. | 2003 | Br. J. Pharmacol. | pmid:12839866 |
| Renoir JM et al. | [Effect of immunosuppressants FK506 and rapamycin on the function of progesterone receptor: protein "p59-HBI", intersection between immunology and endocrinology?]. | 1992 | C. R. Acad. Sci. III, Sci. Vie | pmid:1284044 |
| Thomas NJ and Carcillo JA | Theophylline for acute renal vasoconstriction associated with tacrolimus: a new indication for an old therapeutic agent? | 2003 | Pediatr Crit Care Med | pmid:12840610 |
| Levi DM et al. | Transplantation of the abdominal wall. | 2003 | Lancet | pmid:12842369 |
| Dumortier J et al. | [Graft versus host disease following liver transplantation. Favorable outcome after treatment with tacrolimus]. | 2003 | Gastroenterol. Clin. Biol. | pmid:12843926 |
| Pariente A | [Auto-immune hepatitis: therapeutic management]. | 2003 | Gastroenterol. Clin. Biol. | pmid:12843932 |
| Kuhné MR et al. | Linker for activation of T cells, zeta-associated protein-70, and Src homology 2 domain-containing leukocyte protein-76 are required for TCR-induced microtubule-organizing center polarization. | 2003 | J. Immunol. | pmid:12847255 |
| Kon OM | Novel immunosuppressants in asthma. | 2000 | Chem. Immunol. | pmid:12847724 |
| Natazuka T | FK506 reverses adriamycin resistance in a multidrug-resistant human leukemia cell line. | 1992 | Kobe J Med Sci | pmid:1284834 |
| Baran DA and Galin ID | "One size fits all": immunosuppression in cardiac transplantation. | 2003 | Ann. Transplant. | pmid:12848376 |