tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Mollison KW et al. | Nephrotoxicity studies of the immunosuppressants tacrolimus (FK506) and ascomycin in rat models. | 1998 | Toxicology | pmid:9570331 |
| Salerno A et al. | The effect of cyclosporin A, FK506 and rapamycin on the murine contact sensitivity reaction. | 1998 | Clin. Exp. Immunol. | pmid:9566798 |
| Pizzolato GP et al. | Cerebral vasculitis during FK 506 treatment in a liver transplant patient. | 1998 | Neurology | pmid:9566415 |
| Kennedy AP et al. | Polyomavirus middle T antigen as a probe for T cell antigen receptor-coupled signaling pathways. | 1998 | J. Biol. Chem. | pmid:9565564 |
| Yuzawa K and Fukao K | Topical FK506 ointment for skin grafting. | 1998 | Transplantation | pmid:9565111 |
| Hayashi M et al. | Allograft rejection after liver transplantation for autoimmune liver diseases. | 1998 | Liver Transpl Surg | pmid:9563959 |
| Jain A et al. | Incidence and severity of acute allograft rejection in liver transplant recipients treated with alfa interferon. | 1998 | Liver Transpl Surg | pmid:9563957 |
| Fernández-Miranda C et al. | Lipid abnormalities in stable liver transplant recipients--effects of cyclosporin, tacrolimus, and steroids. | 1998 | Transpl. Int. | pmid:9561680 |
| Cicalese L et al. | Phenotypic and functional characteristics of intestinal intraepithelial lymphocytes during acute rejection of small intestinal allografts. | 1998 | Transpl. Int. | pmid:9561676 |
| Takaoka Y et al. | Cyclosporin A and FK-506 inhibit development of superantigen-potentiated collagen-induced arthritis in mice. | 1998 | Gen. Pharmacol. | pmid:9559334 |
| Main ER et al. | Context-dependent nature of destabilizing mutations on the stability of FKBP12. | 1998 | Biochemistry | pmid:9558354 |
| Taylor PJ et al. | Therapeutic drug monitoring of tacrolimus (FK506) using tandem mass spectrometry. | 1998 | Ther Drug Monit | pmid:9558142 |
| Jubran RF and Dinndorf PA | Successful therapy of refractory graft versus host disease with tacrolimus and Psoralen plus ultraviolet light. | 1998 | Ther Drug Monit | pmid:9558141 |
| Ku YM and Min DI | An abbreviated area-under-the-curve monitoring for tacrolimus in patients with liver transplants. | 1998 | Ther Drug Monit | pmid:9558138 |
| Antonysamy MA et al. | Flt-3 ligand increases microchimerism but can prevent the therapeutic effect of donor bone marrow in transiently immunosuppressed cardiac allograft recipients. | 1998 | J. Immunol. | pmid:9558122 |
| D'Incà R et al. | Tacrolimus to treat pyoderma gangrenosum resistant to cyclosporine. | 1998 | Ann. Intern. Med. | pmid:9556483 |
| Terashima A et al. | Single-channel activity of the Ca2+-dependent K+ channel is modulated by FK506 and rapamycin. | 1998 | Brain Res. | pmid:9555045 |
| Wiederrecht GJ et al. | Mechanism of action of rapamycin: new insights into the regulation of G1-phase progression in eukaryotic cells. | 1995 | Prog Cell Cycle Res | pmid:9552353 |
| Hashimoto T et al. | [Involvement of calcineurin A alpha and A beta in neuronal death in a gerbil model of cerebral ischemia]. | 1998 | Nippon Yakurigaku Zasshi | pmid:9551469 |
| Matsuda T and Baba A | [Response of Na+/Ca2+ antiporter to ischemia and glial/neuronal death]. | 1998 | Nippon Yakurigaku Zasshi | pmid:9551468 |
| Epstein A et al. | Cyclosporine, but not FK506, selectively induces renal and coronary artery smooth muscle contraction. | 1998 | Surgery | pmid:9551073 |
| ten Berge RJ and Schellekens PT | [Immunology in clinical practice. VI. Current immunosuppressive drugs]. | 1997 | Ned Tijdschr Geneeskd | pmid:9550813 |
| Trull AK | Therapeutic monitoring of tacrolimus. | 1998 | Ann. Clin. Biochem. | pmid:9547889 |
| Endrich MM and Gehring H | The V3 loop of human immunodeficiency virus type-1 envelope protein is a high-affinity ligand for immunophilins present in human blood. | 1998 | Eur. J. Biochem. | pmid:9546659 |
| Matsuoka S et al. | [Severe hepatic veno-occlusive disease (VOD) which was successfully treated with supportive therapy, but subsequently developed late-recurrence]. | 1998 | Rinsho Ketsueki | pmid:9545827 |
| Lopez-Ilasaca M et al. | Effects of FK506-binding protein 12 and FK506 on autophosphorylation of epidermal growth factor receptor. | 1998 | J. Biol. Chem. | pmid:9545268 |
| Bassing CH et al. | FKBP12 is not required for the modulation of transforming growth factor beta receptor I signaling activity in embryonic fibroblasts and thymocytes. | 1998 | Cell Growth Differ. | pmid:9543388 |
| Hiroi J et al. | Effect of tacrolimus hydrate (FK506) ointment on spontaneous dermatitis in NC/Nga mice. | 1998 | Jpn. J. Pharmacol. | pmid:9541280 |
| Anderson PO | Tacrolimus and breastfeeding. | 1998 | Transplantation | pmid:9539100 |
| Schäffer MR et al. | Tacrolimus impairs wound healing: a possible role of decreased nitric oxide synthesis. | 1998 | Transplantation | pmid:9539093 |
| Cichon G and Strauss M | Transient immunosuppression with 15-deoxyspergualin prolongs reporter gene expression and reduces humoral immune response after adenoviral gene transfer. | 1998 | Gene Ther. | pmid:9536268 |
| Mattoo AK | Peptidylprolyl cis-trans-isomerases from plant organelles. | 1998 | Meth. Enzymol. | pmid:9534153 |
| Wiederrecht G and Siekierka JJ | Yeast immunophilins: purification and assay of yeast FKBP12. | 1998 | Meth. Enzymol. | pmid:9534152 |
| Ochiai M et al. | Islet toxicity of FK506 measured in canine autografts. | 1998 | Transplant. Proc. | pmid:9532224 |
| Burke GW et al. | Tacrolimus-related microangiopathy in kidney and simultaneous pancreas-kidney recipients: evidence of endothelin and cytokine involvement. | 1998 | Transplant. Proc. | pmid:9532223 |
| Elmer DS et al. | Metabolic effects of FK 506 (tacrolimus) versus cyclosporine in portally drained pancreas allografts. | 1998 | Transplant. Proc. | pmid:9532159 |
| Corry RJ et al. | Tacrolimus without antilymphocyte induction therapy prevents pancreas loss from rejection in 123 consecutive patients. | 1998 | Transplant. Proc. | pmid:9532157 |
| Gruessner RW et al. | Mycophenolate mofetil and tacrolimus for induction and maintenance therapy after pancreas transplantation. | 1998 | Transplant. Proc. | pmid:9532156 |
| Büsing M et al. | Mycophenolate mofetil/tacrolimus/single-shot versus azathioprine/cyclosporine/ATG in pancreas-kidney transplantation: results of a prospective randomized single-center study. | 1998 | Transplant. Proc. | pmid:9532155 |
| Burke GW et al. | Cholesterol control: long-term benefit of pancreas-kidney transplantation with FK 506 immunosuppression. | 1998 | Transplant. Proc. | pmid:9532153 |
| Peddi VR et al. | Tacrolimus eliminates acute rejection as a major complication following simultaneous kidney and pancreas transplantation. | 1998 | Transplant. Proc. | pmid:9532151 |
| Bruce DS et al. | Effects of tacrolimus, mycophenolate mofetil, and cyclosporine microemulsion on rejection incidence in synchronous pancreas-kidney transplantation. | 1998 | Transplant. Proc. | pmid:9532150 |
| Kahl A et al. | First results with a quadruple therapy regimen including tacrolimus and mycophenolate mofetil in patients after combined pancreas and kidney transplantation. | 1998 | Transplant. Proc. | pmid:9532149 |
| Corry RJ et al. | Pancreas transplantation without antibody therapy. | 1998 | Transplant. Proc. | pmid:9532050 |
| First MR | Clinical application of immunosuppressive agents in renal transplantation. | 1998 | Surg. Clin. North Am. | pmid:9531936 |
| Walensky LD et al. | The 13-kD FK506 binding protein, FKBP13, interacts with a novel homologue of the erythrocyte membrane cytoskeletal protein 4.1. | 1998 | J. Cell Biol. | pmid:9531554 |
| Venkataraman C et al. | Activation of lyn, blk, and btk but not syk in CD72-stimulated B lymphocytes. | 1998 | J. Immunol. | pmid:9531290 |
| Briffa N and Morris RE | Immunosuppressive drugs after lung transplantation. | 1998 | BMJ | pmid:9529396 |
| Matsuda T et al. | Immunosuppressants decrease neutrophil chemoattractant and attenuate ischemia/reperfusion injury of the liver in rats. | 1998 | J Trauma | pmid:9529174 |
| Mizunuma M et al. | Role of calcineurin and Mpk1 in regulating the onset of mitosis in budding yeast. | 1998 | Nature | pmid:9521328 |