tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Carobbi A et al. | Effect of splenectomy in combination with FK 506 and 15-deoxyspergualin on cardiac xenograft survival. | 1991 | Transplant. Proc. | pmid:1703704 |
| Diekmann F et al. | Conversion to rapamycin in renal allograft recipients with biopsy-proven calcineurin inhibitor-induced nephrotoxicity. | 2001 Nov-Dec | Transplant. Proc. | pmid:11750386 |
| Lauzurica R et al. | Subclinical inflammation in renal transplant recipients: impact of cyclosporine microemulsion versus tacrolimus. | 2007 | Transplant. Proc. | pmid:17889127 |
| Manzanares C et al. | Influence of hepatitis C virus infection on FK 506 blood levels in renal transplant patients. | 1998 | Transplant. Proc. | pmid:9636513 |
| Ramos-Cebrián M et al. | Conversion from tacrolimus to cyclosporine could improve control of posttransplant diabetes mellitus after renal transplantation. | 2007 | Transplant. Proc. | pmid:17889154 |
| van Duijnhoven E et al. | Tacrolimus dosing requirements in diabetic and nondiabetic patients calculated from pretransplantation data. | 1998 | Transplant. Proc. | pmid:9636514 |
| GarcÃa Meseguer C et al. | Anti-HLA antibodies posttransplantation in children: do we know what it means? | 2009 Jul-Aug | Transplant. Proc. | pmid:19715846 |
| Kedzierska K et al. | Oxidative stress indices in rats under immunosuppression. | 2011 | Transplant. Proc. | pmid:22172876 |
| Pascual J and Ortuño J | Simple tacrolimus-based immunosuppressive regimens following renal transplantation: a large multicenter comparison between double and triple therapy. | 2002 | Transplant. Proc. | pmid:11959198 |
| Soda M et al. | Association Between Tacrolimus Pharmacokinetics and Cytochrome P450 3A5 and Multidrug Resistance Protein 1 Exon 21 Polymorphisms. | Transplant. Proc. | pmid:28736028 | |
| Alessiani M et al. | Infections with FK 506 immunosuppression: preliminary results with primary therapy. | 1990 | Transplant. Proc. | pmid:1689895 |
| Gregory CR et al. | Effects of treatment with cyclosporine, FK 506, rapamycin, mycophenolic acid, or deoxyspergualin on vascular muscle proliferation in vitro and in vivo. | 1993 | Transplant. Proc. | pmid:7679842 |
| McMichael J et al. | Evaluation of a novel "intelligent" dosing system for optimizing FK 506 therapy. | 1991 | Transplant. Proc. | pmid:1721275 |
| Valdivia LA et al. | Prolonged survival of hearts obtained from chimeric donors in a mouse to rat xenotransplant model. | 1996 | Transplant. Proc. | pmid:8623371 |
| Rudich SM et al. | Immunosuppression using tacrolimus, mycophenolate, and prednisone following orthotopic liver transplantation: a single-center experience. | 1998 | Transplant. Proc. | pmid:9636574 |
| Chueh SC et al. | Drug fever caused by mycophenolate mofetil in a renal transplant recipient--a case report. | 2000 | Transplant. Proc. | pmid:11120003 |
| Pratschke J et al. | Treatment of cyclosporine-related adverse effects by conversion to tacrolimus after liver transplantation: long-term results. | 1998 | Transplant. Proc. | pmid:9636575 |
| Ueno T et al. | Renal dysfunction following adult intestinal transplant under tacrolimus-based immunosuppression. | 2006 Jul-Aug | Transplant. Proc. | pmid:16908274 |
| Oltean M et al. | Transplantation of preconditioned intestinal grafts is associated with lower inflammatory activation and remote organ injury in rats. | 2006 Jul-Aug | Transplant. Proc. | pmid:16908278 |
| Bora F et al. | Drug interaction between tacrolimus and ertapenem in renal transplantation recipients. | 2012 | Transplant. Proc. | pmid:23195020 |
| Crespo-Leiro MG | Calcineurin inhibitors in heart transplantation. | 2005 | Transplant. Proc. | pmid:16386614 |
| Tan HP et al. | Steroid-free tacrolimus monotherapy after pretransplantation thymoglobulin or Campath and laparoscopy in living donor renal transplantation. | 2005 | Transplant. Proc. | pmid:16387087 |
| Thomas FT et al. | Comparative efficacy of immunosuppressive drugs in xenografting. | 1990 | Transplant. Proc. | pmid:1693452 |
| Jain AB et al. | One thousand consecutive primary orthotopic liver transplants under FK 506: survival and adverse events. | 1995 | Transplant. Proc. | pmid:7533353 |
| Zeevi A et al. | In vitro assessment of FK 506 immunosuppressive activity in transplant patients. | 1991 | Transplant. Proc. | pmid:1721307 |
| Lentine KL et al. | Variation in Comedication Use According to Kidney Transplant Immunosuppressive Regimens: Application of Integrated Registry and Pharmacy Claims Data. | Transplant. Proc. | pmid:26915843 | |
| Kita J et al. | Effects of tacrolimus on small and large bowel anastomoses in the rat. | 1999 | Transplant. Proc. | pmid:10578292 |
| Kato T et al. | Steroid-free induction and preemptive antiviral therapy for liver transplant recipients with hepatitis C: a preliminary report from a prospective randomized study. | 2005 | Transplant. Proc. | pmid:15848674 |
| Gavlik A et al. | Mycophenolate mofetil rescue therapy in liver transplant recipients: an extended follow-up. | 1997 | Transplant. Proc. | pmid:9365633 |
| Chen J et al. | Observation of efficacy and safety of converting the calcineurin inhibitor to sirolimus in renal transplant recipients with chronic allograft nephropathy. | 2008 | Transplant. Proc. | pmid:18589119 |
| Chen JW et al. | Ten-year results of a randomised prospective study of FK506 versus cyclosporine in management of primary orthotopic liver transplantation. | 2002 | Transplant. Proc. | pmid:12176460 |
| Figueras J et al. | Steroid-free regimen with daclizumab, mycophenolate mofetil, and tacrolimus in liver transplant recipients. | 2002 | Transplant. Proc. | pmid:12176461 |
| Takaori K et al. | Basic study on immunologic effects of cyclosporine and FK 506 for application to pancreatic transplantation. | 1992 | Transplant. Proc. | pmid:1376531 |
| Kuroki H and Ikuta Y | Nerve regeneration of vascularized rat limb allograft and functional recovery of long-term graft survivals treated by short course of FK 506 or cyclosporine. | 1995 | Transplant. Proc. | pmid:7533405 |
| Ohtsuka S et al. | The effect of short-term FK 506 therapy on pancreas transplantation using the cuff technique in rats. | 1992 | Transplant. Proc. | pmid:1376532 |
| Shaw BW et al. | FK 506 for rescue treatment of acute and chronic rejection in liver allograft recipients. | 1991 | Transplant. Proc. | pmid:1721338 |
| McDiarmid SV et al. | FK 506 rescue therapy in liver transplantation: outcome and complications. | 1991 | Transplant. Proc. | pmid:1721339 |
| Mortensen DM et al. | Calcineurin activity in tacrolimus-treated renal transplant patients early after and 5 years after transplantation. | 2006 | Transplant. Proc. | pmid:17098028 |
| Bäckman L et al. | Steroid-free immunosuppression in kidney transplant recipients and prograf monotherapy: an interim analysis of a prospective multicenter trial. | 2006 | Transplant. Proc. | pmid:17098029 |
| Loucaidou M et al. | Late steroid withdrawal for renal transplant recipients on tacrolimus and MMF is safe. | 2005 | Transplant. Proc. | pmid:15919469 |
| Malyszko J et al. | A possible role of hepcidin in the pathogenesis of anemia among kidney allograft recipients. | 2009 | Transplant. Proc. | pmid:19857675 |
| Takahashi K et al. | Successful results after 5 years of tacrolimus therapy in ABO-incompatible kidney transplantation in Japan. | 2005 | Transplant. Proc. | pmid:15919471 |
| Foroncewicz B et al. | Safety and efficacy of steroid-free immunosuppression with tacrolimus and daclizumab in liver transplant recipients: 6-year follow-up in a single center. | 2009 | Transplant. Proc. | pmid:19857686 |
| Tsuchida Y et al. | Vascularized bone marrow allotransplantation in rats prolongs a simultaneous skin allograft. | 1997 | Transplant. Proc. | pmid:9142252 |
| Lin YH et al. | The 4-week serum creatinine level predicts long-term renal dysfunction after adult living donor liver transplantation. | 2012 | Transplant. Proc. | pmid:22483492 |
| Yoshimura R et al. | Study of the effect of immunosuppressive agents on renal cytochrome P-450 system in the rat. | 1994 | Transplant. Proc. | pmid:7520610 |
| Wijnen RM et al. | Toxicity of FK 506 in the cynomolgus monkey: noncorrelation with FK 506 serum levels. | 1991 | Transplant. Proc. | pmid:1721371 |
| Venkataramanan R et al. | Pharmacokinetics of FK 506 following oral administration: a comparison of FK 506 and cyclosporine. | 1991 | Transplant. Proc. | pmid:1703355 |
| Cheng HM et al. | Primary prophylaxis with tacrolimus in kidney transplants in China. | 1998 | Transplant. Proc. | pmid:9838573 |
| Undre NA et al. | Low systemic exposure to tacrolimus correlates with acute rejection. | 1999 Feb-Mar | Transplant. Proc. | pmid:10083114 |
| Peraira JR et al. | High incidence of severe infections in heart transplant recipients receiving tacrolimus. | 2003 | Transplant. Proc. | pmid:12962875 |
| Pisitkun T et al. | The roles of C4 and AUC0-4 in monitoring of tacrolimus in stable kidney transplant patients. | 2002 | Transplant. Proc. | pmid:12493410 |
| Khanna A et al. | Cardiac changes at autopsy in adult liver transplant recipients under tacrolimus. | 1997 Feb-Mar | Transplant. Proc. | pmid:9123118 |
| Alper G and Small SL | Cerebrospinal fluid after organ transplantation. | 1996 | Transplant. Proc. | pmid:8908142 |
| Cho WH et al. | Basiliximab does not reduce the early rejection incidence in high-risk kidney recipients under tacrolimus-based immunosuppression. | 2008 | Transplant. Proc. | pmid:18790201 |
| Okamoto M et al. | Tacrolimus-based immunosuppression in renal transplantation: 78 experiences in a single Japanese center. | 2002 | Transplant. Proc. | pmid:12176527 |
| Chen WY et al. | Betel Nut Chewing Is Associated With Reduced Tacrolimus Concentration in Taiwanese Liver Transplant Recipients. | 2017 | Transplant. Proc. | pmid:28219593 |
| Kato H et al. | Long-Term Influence of CYP3A5 Gene Polymorphism on Pharmacokinetics of Tacrolimus and Patient Outcome After Living Donor Liver Transplantation. | 2016 | Transplant. Proc. | pmid:27320564 |
| Arita S et al. | Effect of FK 506 in experimental pancreas transplantation. | 1995 | Transplant. Proc. | pmid:7536980 |
| Aono T et al. | Minimal threshold of FK 506 for enhancing liver regeneration in thymectomized rats. | 1995 | Transplant. Proc. | pmid:7536981 |
| Viebahn R et al. | Hypoxic and reoxygenation injury in human and rat hepatocytes--influence of FK 506 and cyclosporine. | 1991 | Transplant. Proc. | pmid:1721401 |
| Sato K et al. | Effectiveness of triple drug immunosuppression for pancreaticoduodenal allotransplantation in dogs. | 1992 | Transplant. Proc. | pmid:1379753 |
| Masaki Y et al. | Microchimerism and rat small bowel transplantation combined with donor-type bone marrow cells. | 1996 | Transplant. Proc. | pmid:8769154 |
| Morrisett JD et al. | Effect of FK 506 and cyclosporine on plasma cholesterol levels in rabbits. | 1991 | Transplant. Proc. | pmid:1721402 |
| Kobayashi N et al. | Abdominal organ cluster transplantation in pigs receiving FK 506. | 1992 | Transplant. Proc. | pmid:1379754 |
| Murphy MP and Morris RE | Brequinar sodium effectively and potently suppresses allograft rejection in a heterotopic mouse heart transplant model. | 1993 | Transplant. Proc. | pmid:7685955 |
| Jordan ML et al. | Tacrolimus rescue therapy for renal transplant rejection. | 1996 | Transplant. Proc. | pmid:8769174 |
| Weinbroum AA et al. | Lack of cumulative effect of tacrolimus and low flow on a rat isolated liver. | 2001 | Transplant. Proc. | pmid:11543812 |
| Kobayashi C et al. | Suppression of corneal graft rejection in rabbits by a new immunosuppressive agent, FK-506. | 1989 | Transplant. Proc. | pmid:2468254 |
| Zuckermann A et al. | Benefit of mycophenolate mofetil in patients with cyclosporine A-induced nephropathy after lung transplantation. | 1999 Feb-Mar | Transplant. Proc. | pmid:10083518 |
| Kuroki H et al. | Experimental studies of vascularized allogeneic limb transplantation in the rat using a new immunosuppressive agent, FK-506: morphological and immunological analysis. | 1989 | Transplant. Proc. | pmid:2468255 |
| Zanker B et al. | Comparison of MPA trough levels in patients with severe diabetes mellitus and from non-diabetics after transplantation. | 1999 Feb-Mar | Transplant. Proc. | pmid:10083521 |
| Matsumiya G et al. | Serum interleukin-6 level after cardiac xenotransplantation in primates. | 1997 Feb-Mar | Transplant. Proc. | pmid:9123586 |
| Nagashima N et al. | Immunocompetence assay for net effect of combined immunosuppression. | 2001 | Transplant. Proc. | pmid:11377556 |
| Baran DA et al. | Tacrolimus and cardiac transplantation: a comparison of monotherapy and steroid-dependent patients. | 2002 | Transplant. Proc. | pmid:12176599 |
| Wu M et al. | Cyclosporine and tacrolimus alter renin-angiotesin system in mouse medullary-thick ascending limb cultured cells. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267198 |
| Wu GD et al. | FK 506 inhibits the development of transplant arteriosclerosis. | 1991 | Transplant. Proc. | pmid:1721433 |
| Todo S et al. | Canine kidney transplantation with FK-506 alone or in combination with cyclosporine and steroids. | 1987 | Transplant. Proc. | pmid:2445076 |
| Ghio L et al. | Conversion from tacrolimus to cyclosporine for a non-dose-dependent tacrolimus-induced toxicity, a pediatric kidney transplant recipient case report. | 2004 | Transplant. Proc. | pmid:15251325 |
| Ersoy A et al. | Diabetic ketoacidosis following development of de novo diabetes in renal transplant recipient associated with tacrolimus. | 2004 | Transplant. Proc. | pmid:15251345 |
| Halloran PF et al. | Calcineurin and the biological effect of cyclosporine and tacrolimus. | 1998 | Transplant. Proc. | pmid:9723430 |
| Renner FC et al. | The risk of polyomavirus-associated graft nephropathy is increased by a combined suppression of CD8 and CD4 cell-dependent immune effects. | 2013 | Transplant. Proc. | pmid:23726630 |
| Walgenbach KJ et al. | Upregulation of basic fibroblast growth factor during chronic rejection of rat intestinal allografts and its downregulation by FK 506. | 1998 | Transplant. Proc. | pmid:9745501 |
| Eberlin M et al. | Increased medication compliance of liver transplant patients switched from a twice-daily to a once-daily tacrolimus-based immunosuppressive regimen. | 2013 Jul-Aug | Transplant. Proc. | pmid:23726723 |
| Gatti S et al. | Graft-versus-host reaction and graft rejection after liver, small bowel or small bowel allotransplantation in the pig. | 1998 | Transplant. Proc. | pmid:9745509 |
| Laftavi MR et al. | The role of antibiotic prophylaxis in the new era of immunosuppression. | 2011 | Transplant. Proc. | pmid:21440753 |
| Sigal NH et al. | Inhibition of human T-cell activation by FK 506, rapamycin, and cyclosporine A. | 1991 | Transplant. Proc. | pmid:1712132 |
| Fung JJ et al. | Current status of FK 506 in liver transplantation. | 1991 | Transplant. Proc. | pmid:1712133 |
| Lo A et al. | Outcome of simultaneous kidney-pancreas transplantation in African-American recipients: a case control study. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267465 |
| Tsujimura K et al. | Effect of Influenza Vaccine in Patients With Kidney Transplant. | 2018 | Transplant. Proc. | pmid:30316375 |
| Miki T et al. | Tacrolimus enhances the immunosuppressive effect of cyclophosphamide but not that of leflunomide or mycophenolate mofetil in a model of discordant liver xenotransplantation. | 1998 | Transplant. Proc. | pmid:9636444 |
| Shullo MA et al. | Elevated tacrolimus levels associated with intravenous azithromycin and ceftriaxone: a case report. | 2010 | Transplant. Proc. | pmid:20620540 |
| Suarez Benjumea A et al. | Hepatitis C Virus in Kidney Transplant Recipients: A Problem on the Path to Eradication. | 2016 | Transplant. Proc. | pmid:27932111 |
| Xie L et al. | Pretransplantation Risk Factors Associated With New-onset Diabetes After Living-donor Kidney Transplantation. | 2016 | Transplant. Proc. | pmid:27931572 |
| Rathi M et al. | Conversion from tacrolimus to cyclosporine in patients with new-onset diabetes after renal transplant: an open-label randomized prospective pilot study. | 2015 | Transplant. Proc. | pmid:26036543 |
| Mohsin N et al. | Pharmacokinetics of mycophenolate mofetil in Omani patients on cyclosporine or tacrolimus. | 2015 | Transplant. Proc. | pmid:26036534 |
| Groth CG | Immunosuppressive regimens of tomorrow. | 1995 | Transplant. Proc. | pmid:8539797 |
| Hariharan S et al. | Conversion from cyclosporine to tacrolimus after pancreas transplantation. | 1995 | Transplant. Proc. | pmid:8539799 |
| Jiang H et al. | Effect of FK 506 on heart allograft survival in highly sensitized recipient rats in comparison with cyclosporine. | 1991 | Transplant. Proc. | pmid:1703702 |
| Pridöhl O et al. | Low-dose immunosuppression with FK 506 and sirolimus after liver transplantation: 1-year results. | 2001 Nov-Dec | Transplant. Proc. | pmid:11750384 |