Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with tacrolimus
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Dumont FJ et al. | Up-regulation of gene expression by FK 506. | 1991 | Transplant. Proc. | pmid:1721300 |
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Uchida H et al. | Experimental intestinal transplantation using mouse fetal intestine in the rat: combination effect of FK 506 with cyclophosphamide. | 1999 | Transplant. Proc. | pmid:10578297 |
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Jin KB et al. | The production of reactive oxygen species in tacrolimus-treated glial cells. | 2008 | Transplant. Proc. | pmid:18929834 |
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Takara T et al. | Intraportal donor-specific transfusion given 24 hours before small bowel transplantation with cyclosporine and FK 506. | 1994 | Transplant. Proc. | pmid:7518150 |
Jain A et al. | Intravenous, oral pharmacokinetics, and oral dosing of FK 506 in small bowel transplant patients. | 1992 | Transplant. Proc. | pmid:1376518 |
Watanabe K et al. | Factors influencing long-term operational tolerance in dogs treated with fractionated lymphoid irradiation, donor bone marrow cell infusion and FK506. | 1995 | Transplant. Proc. | pmid:7533389 |
Borg AJ and Kumagai M | FK 506 and xenogeneic human anti-porcine cellular reactivity. | 1991 | Transplant. Proc. | pmid:1721332 |
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Fleck PR et al. | Tacrolimus use in kidney-pancreas recipients is associated with less acute renal dysfunction than cyclosporine. | 1998 | Transplant. Proc. | pmid:9865299 |
Krämer BK et al. | Cardiovascular risk estimates and risk factors in renal transplant recipients. | 2005 | Transplant. Proc. | pmid:15919488 |
Wlodarczyk Z et al. | Lipid metabolism in renal transplant patients receiving tacrolimus/sirolimus combination therapy. | 2005 | Transplant. Proc. | pmid:15919489 |
Regazzi MB et al. | Pharmacokinetics of FK506 and mycophenolic acid in experimental and clinical intestinal transplantation. | 1997 | Transplant. Proc. | pmid:9142302 |
Moro JA et al. | Randomized prospective study of the evolution of renal function depending on the anticalcineurin used. | 2008 | Transplant. Proc. | pmid:19010143 |
Fukuhara N et al. | Long-term outcome of tacrolimus in cadaveric kidney transplantation from non-heart-beating donors. | 2002 | Transplant. Proc. | pmid:12176492 |
Barrera-Pulido L et al. | Clinical relevance and prevalence of polymorphisms in CYP3A5 and MDR1 genes that encode tacrolimus biotransformation enzymes in liver transplant recipients. | 2008 | Transplant. Proc. | pmid:19010156 |
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Gruttadauria S et al. | Basiliximab in a triple-drug regimen with tacrolimus and steroids in liver transplantation. | 2005 Jul-Aug | Transplant. Proc. | pmid:16182762 |
Lemster B et al. | Cytokine gene expression in murine lymphocytes activated in the presence of FK 506, bredinin, mycophenolic acid, or brequinar sodium. | 1992 | Transplant. Proc. | pmid:1281576 |
Tze WJ et al. | FK 506: an effective immunosuppressant for islet xenotransplantation. | 1992 | Transplant. Proc. | pmid:1281577 |
Gojowy D et al. | High Frequency of Arterial Hypertension in Patients After Liver Transplantation. | 2016 | Transplant. Proc. | pmid:27496479 |
Jensen CW et al. | Pediatric renal transplantation under FK 506 immunosuppression. | 1991 | Transplant. Proc. | pmid:1721364 |
McCauley J et al. | The question of FK 506 nephrotoxicity after liver transplantation. | 1991 | Transplant. Proc. | pmid:1703344 |
Jordan ML et al. | FK 506 conversion of renal allografts failing cyclosporine immunosuppression. | 1991 | Transplant. Proc. | pmid:1721365 |
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Alessiani M et al. | Infections in adult liver transplant patients under FK 506 immunosuppression. | 1991 | Transplant. Proc. | pmid:1703345 |
Yamauchi M et al. | Effects of FK506 on rat thymic microenvironment in thymocyte maturation, proliferation, and mobilization. | 1998 | Transplant. Proc. | pmid:9838578 |
Mueller AR et al. | Is the use of marginal liver grafts justified? | 1999 Feb-Mar | Transplant. Proc. | pmid:10083160 |
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Zipperle S et al. | Impaired T-cell IL-10 secretion and CD4 helper function in liver transplant patients treated with tacrolimus. | 1997 Feb-Mar | Transplant. Proc. | pmid:9123208 |
Chien YS et al. | Incidence and risk factors of new-onset diabetes mellitus after renal transplantation. | 2008 | Transplant. Proc. | pmid:18790250 |
Moons P et al. | Steroids may compromise quality of life of renal transplant recipients on a tacrolimus-based regimen. | 2002 | Transplant. Proc. | pmid:12176538 |
Sato K et al. | Pancreaticoduodenal allotransplantation with cyclosporine and FK506. | 1989 | Transplant. Proc. | pmid:2468212 |
Freise CE et al. | Similar clinical presentation of neurotoxicity following FK 506 and cyclosporine in a liver transplant recipient. | 1991 | Transplant. Proc. | pmid:1721397 |
Gu B et al. | Exploration of Fecal Microbiota Transplantation in the Treatment of Refractory Diarrhea After Renal Transplantation. | 2018 | Transplant. Proc. | pmid:29880353 |
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Nakao A et al. | Changes of allo-intestinal graft survival and intragraft cytokine expression by bone marrow augmentation with tacrolimus treatment in rats. | 2001 Feb-Mar | Transplant. Proc. | pmid:11266851 |
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Jiang H et al. | Inhibition of IL-10 by FK 506 may be responsible for overcoming ongoing allograft rejection in the rat. | 1999 Feb-Mar | Transplant. Proc. | pmid:10083538 |
Alessiani M et al. | Correlations between functional changes and different grades of acute rejection in swine small bowel allografts. | 2000 | Transplant. Proc. | pmid:10995933 |
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Chang HR et al. | Sirolimus addition is beneficial for renal allograft dysfunction due to simultaneous acute rejection episode and calcineurin inhibitor nephrotoxicity. | 2004 | Transplant. Proc. | pmid:15621119 |
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Fukuzawa M et al. | Effect of donor-specific transfusion and FK 506 on small intestine allotransplantation. | 1991 | Transplant. Proc. | pmid:1721427 |
Park KM et al. | Bone loss after orthotopic liver transplantation: FK 506 versus cyclosporine. | 1996 | Transplant. Proc. | pmid:8658863 |
Venkataramanan R et al. | Biopharmaceutical aspects of FK-506. | 1987 | Transplant. Proc. | pmid:2445070 |
Chakrabarti P et al. | Outcome after steroid withdrawal in adult renal transplant patients receiving tacrolimus-based immunosuppression. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267274 |
Fukuoka N et al. | Micafungin does not influence the concentration of tacrolimus in patients after allogeneic hematopoietic stem cell transplantation. | 2010 | Transplant. Proc. | pmid:20832577 |
Xu M et al. | FTY720 compares with FK 506 as rescue therapy in rat heterotopic cardiac transplantation. | 1998 | Transplant. Proc. | pmid:9723447 |
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Ito Y et al. | Complete replacement of tracheal epithelia by the host promotes spontaneous acceptance of orthotopic tracheal allografts in rats. | 2004 | Transplant. Proc. | pmid:15561264 |
Kiji T et al. | Relationship between immunological rejection and matrix GLA protein in cryopreserved vascular allografts. | 2004 | Transplant. Proc. | pmid:15561265 |
Fung JJ and Starzl TE | FK 506 in solid organ transplantation. | 1994 | Transplant. Proc. | pmid:7524226 |
McCauley J et al. | FK 506 in the management of transplant-related nephrotic syndrome and steroid-resistant nephrotic syndrome. | 1991 | Transplant. Proc. | pmid:1721459 |
Carrieri G et al. | Effect of FK 506 in the prophylaxis of autoimmune glomerulonephritis in NZB/WF1 mice. | 1991 | Transplant. Proc. | pmid:1721460 |
Griffin AD et al. | FK 506 in canine renal transplantation. | 1992 | Transplant. Proc. | pmid:1384209 |
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Ben-Ari Z et al. | Conversion of liver allograft recipients from cyclosporine A to FK 506 immunosuppressive therapy. | 2000 | Transplant. Proc. | pmid:10856553 |
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Ericzon BG et al. | Effect of FK 506 on glucose metabolism in the cynomolgus monkey: studies in pancreatic transplant recipients and nontransplanted animals. | 1991 | Transplant. Proc. | pmid:1703695 |