tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Abu-Elmagd K et al. | Hepatic and intestinal transplantation at the University of Pittsburgh. | 1998 | Clin Transpl | pmid:10503105 |
| Nakai T et al. | Immunologic changes in heterotopic and orthotopic small bowel transplantation in rats. | 1999 | Transplant. Proc. | pmid:10500761 |
| Toki K et al. | Histopathologic findings in routine biopsies of renal transplant allografts. | 1999 | Transplant. Proc. | pmid:10500759 |
| Ribas Y et al. | Lack of accommodation after long-term survival of hamster xenografts in rats. | 1999 | Transplant. Proc. | pmid:10500752 |
| EscartÃn A et al. | Orthotopic small bowel transplantation in pigs without steroids. | 1999 | Transplant. Proc. | pmid:10500720 |
| Chávez R et al. | Hepatotrophic effect of cyclosporine and FK 506 is not mimicked by rapamycin. | 1999 | Transplant. Proc. | pmid:10500655 |
| Bárcena R et al. | Immunosuppression in liver transplantation: a European survey. | 1999 | Transplant. Proc. | pmid:10500654 |
| González-Pinto I et al. | Usefulness of the switch to tacrolimus in liver transplantation. | 1999 | Transplant. Proc. | pmid:10500653 |
| González MG et al. | Comparison of post-liver transplantation electrocardiographic alterations between cyclosporine- and tacrolimus-treated patients. | 1999 | Transplant. Proc. | pmid:10500652 |
| GarcÃa González M et al. | Reversal of QT interval electrocardiographic alterations in cirrhotic patients undergoing liver transplantation. | 1999 | Transplant. Proc. | pmid:10500620 |
| Cofan F et al. | Oxidation of low-density lipoproteins in renal transplant recipients. | 1999 | Transplant. Proc. | pmid:10500604 |
| Cofan F et al. | Fatty acid composition in low-density lipoproteins from renal transplant recipients. | 1999 | Transplant. Proc. | pmid:10500603 |
| Torregrosa JV et al. | Combined liver-kidney transplantation: our experience. | 1999 | Transplant. Proc. | pmid:10500591 |
| GarcÃa Meseguer C et al. | The effect of different immunosuppression on the outcome of pediatric renal transplants. | 1999 | Transplant. Proc. | pmid:10500577 |
| Moreno M et al. | Clinical management of tacrolimus drug interactions in renal transplant patients. | 1999 | Transplant. Proc. | pmid:10500564 |
| Gómez G et al. | Acute tacrolimus nephrotoxicity in renal transplant patients treated with clarithromycin. | 1999 | Transplant. Proc. | pmid:10500563 |
| Morales E et al. | Conversion from cyclosporine to FK 506 as rescue therapy in renal transplantation with poorly steroid-responsive acute rejection. | 1999 | Transplant. Proc. | pmid:10500562 |
| Shapiro R | Tacrolimus in solid organ transplantation: an update. | 1999 | Transplant. Proc. | pmid:10500545 |
| Sengoku T et al. | Possible inhibitory mechanism of FK506 (tacrolimus hydrate) ointment for atopic dermatitis based on animal models. | 1999 | Eur. J. Pharmacol. | pmid:10497905 |
| Woo KT | Current therapeutic strategies in glomerulonephritis. | 1999 | Ann. Acad. Med. Singap. | pmid:10497681 |
| Jain A et al. | What have we learned about primary liver transplantation under tacrolimus immunosuppression? Long-term follow-up of the first 1000 patients. | 1999 | Ann. Surg. | pmid:10493490 |
| Yeh CN et al. | Acute overdoses of tacrolimus (FK 506). | 1999 | Dig. Dis. Sci. | pmid:10492148 |
| Sata M and Walsh K | Cyclosporine downregulates Fas ligand expression on vascular endothelial cells: implication for accelerated vasculopathy by immunosuppressive therapy. | 1999 | Biochem. Biophys. Res. Commun. | pmid:10491310 |
| Ahlers C et al. | Cyclosporin A inhibits Ca2+-mediated upregulation of the DNA repair enzyme DNA polymerase beta in human peripheral blood mononuclear cells. | 1999 | Eur. J. Biochem. | pmid:10491144 |
| Muthuswamy SK et al. | Controlled dimerization of ErbB receptors provides evidence for differential signaling by homo- and heterodimers. | 1999 | Mol. Cell. Biol. | pmid:10490623 |
| Pinna AD et al. | Unusual presentation of graft-versus-host disease in pediatric liver transplant recipients: evidence of late and recurrent disease. | 1999 | Pediatr Transplant | pmid:10487286 |
| Tsuji-Takayama K et al. | Interleukin-18 induces interferon-gamma production through NF-kappaB and NFAT activation in murine T helper type 1 cells. | 1999 | Cell. Immunol. | pmid:10486154 |
| Otsu S et al. | [T cell non-depleted bone marrow transplantation for primary refractory erythroleukemia using a partially HLA-mismatched related donor]. | 1999 | Rinsho Ketsueki | pmid:10483142 |
| Mookerjee B et al. | Salvage therapy for refractory chronic graft-versus-host disease with mycophenolate mofetil and tacrolimus. | 1999 | Bone Marrow Transplant. | pmid:10482936 |
| Fleischer AB | Treatment of atopic dermatitis: role of tacrolimus ointment as a topical noncorticosteroidal therapy. | 1999 | J. Allergy Clin. Immunol. | pmid:10482864 |
| Hodge S et al. | Postinoculation PMPA treatment, but not preinoculation immunomodulatory therapy, protects against development of acute disease induced by the unique simian immunodeficiency virus SIVsmmPBj. | 1999 | J. Virol. | pmid:10482616 |
| Hughes JR et al. | Blood levels of TGFbeta1 in liver transplant recipients receiving either tacrolimus or micro-emulsified cyclosporine. | 1999 | Transplantation | pmid:10480422 |
| Fredericks S and Holt DW | TGF-beta quantitation can be tricky. | 1999 | Transplantation | pmid:10480399 |
| Chan MA et al. | Triptolide is more effective in preventing T cell proliferation and interferon-gamma production than is FK506. | 1999 | Phytother Res | pmid:10479754 |
| Christner C et al. | Synthesis and cytotoxic evaluation of cycloheximide derivatives as potential inhibitors of FKBP12 with neuroregenerative properties. | 1999 | J. Med. Chem. | pmid:10479292 |
| Perry SS et al. | Direct effects of cyclosporin A on proliferation of hematopoietic stem and progenitor cells. | 1999 Jul-Aug | Cell Transplant | pmid:10478713 |
| Herrero JI et al. | Conversion of liver transplant recipients on cyclosporine with renal impairment to mycophenolate mofetil. | 1999 | Liver Transpl Surg | pmid:10477843 |
| Medina J et al. | Cytokine profile of human bronchoalveolar macrophages and bronchial epithelial cells in response to inhalation particles of the cyclosporine derivative IMM 125. | 1999 | Inhal Toxicol | pmid:10477442 |
| Hohl CM and Altschuld RA | FK506 alters sarcoplasmic reticulum calcium release in neonatal piglet cardiac myocytes. | 1999 | Pediatr. Res. | pmid:10473047 |
| MacFarlane GD et al. | Analytical validation of the PRO-Trac II ELISA for the determination of tacrolimus (FK506) in whole blood. | 1999 | Clin. Chem. | pmid:10471647 |
| Holtbäck U and Eklöf AC | Mechanism of FK 506/520 action on rat renal proximal tubular Na+, K+-ATPase activity. | 1999 | Kidney Int. | pmid:10469369 |
| Grassberger M et al. | A novel anti-inflammatory drug, SDZ ASM 981, for the treatment of skin diseases: in vitro pharmacology. | 1999 | Br. J. Dermatol. | pmid:10468798 |
| Yokogawa K et al. | P-glycoprotein-dependent disposition kinetics of tacrolimus: studies in mdr1a knockout mice. | 1999 | Pharm. Res. | pmid:10468022 |
| Ogino Y et al. | Comparison of cyclosporin A and tacrolimus concentrations in whole blood between jejunal and ileal transplanted rats. | 1999 | J. Pharm. Pharmacol. | pmid:10467956 |
| Johnson CE and Truong NM | Stability and compatibility of tacrolimus and fluconazole in 0.9% sodium chloride. | 1999 Jul-Aug | J Am Pharm Assoc (Wash) | pmid:10467814 |
| Ivery MT | A proposed molecular model for the interaction of calcineurin with the cyclosporin A-cyclophilin A complex. | 1999 | Bioorg. Med. Chem. | pmid:10465413 |
| Shuto H et al. | Inhibition of GABA system involved in cyclosporine-induced convulsions. | 1999 | Life Sci. | pmid:10465348 |
| Alexanian AR and Bamburg JR | Neuronal survival activity of s100betabeta is enhanced by calcineurin inhibitors and requires activation of NF-kappaB. | 1999 | FASEB J. | pmid:10463953 |
| Wandel C et al. | P-glycoprotein and cytochrome P-450 3A inhibition: dissociation of inhibitory potencies. | 1999 | Cancer Res. | pmid:10463589 |
| Arndt C et al. | Secretion of FK506/FK520 and rapamycin by Streptomyces inhibits the growth of competing Saccharomyces cerevisiae and Cryptococcus neoformans. | 1999 | Microbiology (Reading, Engl.) | pmid:10463165 |