Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with tacrolimus
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Cavaillé-Coll M and Mielach FA | Choice of cyclophosphamide dose in baboon-to-human liver transplantation. | 1993 | Lancet | pmid:7679768 |
Kobayashi M et al. | HLA-DR matching effect in orthotopic liver transplantation under FK 506. | 1993 | Transplant. Proc. | pmid:7679812 |
Watanabe K et al. | Fate of long-surviving allografts in tolerant recipients induced by fractionated lymphoid irradiation, donor bone marrow cell infusion, and FK 506 after retransplantation in dogs. | 1993 | Transplant. Proc. | pmid:7679813 |
Valdivia LA et al. | Hamster-to-rat liver xenografts protect extrahepatic organs from rejection. | 1993 | Transplant. Proc. | pmid:7679816 |
Murase N et al. | Effect of FK 506 and antiproliferative agents for heart and liver xenotransplantation from hamster to rat. | 1993 | Transplant. Proc. | pmid:7679817 |
Schreier MH et al. | Inhibition of T-cell signaling pathways by immunophilin drug complexes: are side effects inherent to immunosuppressive properties? | 1993 | Transplant. Proc. | pmid:7679818 |
Kahan BD | Cyclosporine: the base for immunosuppressive therapy--present and future. | 1993 | Transplant. Proc. | pmid:7679819 |
Starzl TE | FK 506 versus cyclosporine. | 1993 | Transplant. Proc. | pmid:7679820 |
Stephens J et al. | Effects of orthotopic liver transplantation and immunosuppression on inflammatory bowel disease in primary sclerosing cholangitis patients. | 1993 | Transplant. Proc. | pmid:7680144 |
Bonet H et al. | Survival of patients transplanted with alcoholic hepatitis plus cirrhosis as compared with those with cirrhosis alone. | 1993 | Transplant. Proc. | pmid:7680145 |
Fung J et al. | Randomized trial in primary liver transplantation under immunosuppression with FK 506 or cyclosporine. | 1993 | Transplant. Proc. | pmid:7680146 |
Shibata T et al. | Does FK 506 accelerate the development of coronary artery disease in the transplanted heart as well as the native heart? | 1993 | Transplant. Proc. | pmid:7680147 |
Todo S et al. | Intestinal transplantation in humans under FK 506. | 1993 | Transplant. Proc. | pmid:7680148 |
Reyes J et al. | Nutritional management of intestinal transplant recipients. | 1993 | Transplant. Proc. | pmid:7680149 |
Abu-Elmagd KM et al. | Monitoring and treatment of intestinal allograft rejection in humans. | 1993 | Transplant. Proc. | pmid:7680150 |
McCauley J et al. | FK 506 in the management of nephrotic syndrome after renal transplantation. | 1993 | Transplant. Proc. | pmid:7680154 |
Krentz AJ et al. | Metabolic effects of cyclosporin A and FK 506 in liver transplant recipients. | 1993 | Diabetes | pmid:7694879 |
Yem AW et al. | An active FK506-binding domain of 17,000 daltons is isolated following limited proteolysis of chicken thymus hsp56. | 1993 | Biochemistry | pmid:7504525 |
Manev H et al. | Macrolide antibiotics protect neurons in culture against the N-methyl-D-aspartate (NMDA) receptor-mediated toxicity of glutamate. | 1993 | Brain Res. | pmid:7504570 |
Takahara S et al. | [Blood level monitoring of FK506 on kidney transplant recipients]. | 1993 | Nippon Hinyokika Gakkai Zasshi | pmid:7504758 |
Lieberman I et al. | Synergy between tetrandrine and FK506 in prevention of diabetes in BB rats. | 1993 | Life Sci. | pmid:7504774 |
Xu RX et al. | 1H, 13C, and 15N assignments and secondary structure of the FK506 binding protein when bound to ascomycin. | 1993 | Biopolymers | pmid:7682113 |
Müller MK et al. | [Pathophysiologic concepts and protective possibilities in experimental pancreatic lesions]. | 1993 | Z Gastroenterol | pmid:7504856 |
Tanaka N et al. | Regulation of liver regeneration by interleukin-2 and its inhibitors: cyclosporine A and FK 506. | 1993 | Int. J. Immunopharmacol. | pmid:7682200 |
Panis Y and Valleur P | [Small intestine transplantation. Experimental and clinical results]. | 1993 | Ann Chir | pmid:7504899 |
Bruserud O and Pawelec G | Cyclosporine A and FK506 show similar immunosuppressive effects on long-term in vitro T-cell proliferation. | 1993 | Int. J. Immunopharmacol. | pmid:7682202 |
Tsai M et al. | Activation of MAP kinases, pp90rsk and pp70-S6 kinases in mouse mast cells by signaling through the c-kit receptor tyrosine kinase or Fc epsilon RI: rapamycin inhibits activation of pp70-S6 kinase and proliferation in mouse mast cells. | 1993 | Eur. J. Immunol. | pmid:7504992 |
Winkler M et al. | Anaemia associated with FK 506 immunosuppression. | 1993 | Lancet | pmid:7682273 |
Hendrickson BA et al. | Structural organization of the genes encoding human and murine FK506-binding protein (FKBP) 13 and comparison to FKBP1. | 1993 | Gene | pmid:7505249 |
Lundemose AG et al. | Chlamydia trachomatis Mip-like protein has peptidyl-prolyl cis/trans isomerase activity that is inhibited by FK506 and rapamycin and is implicated in initiation of chlamydial infection. | 1993 | Mol. Microbiol. | pmid:7682281 |
Wiesner RH et al. | Early cellular rejection treated with high-dose intravenous corticosteroid therapy is associated with a decrease in the incidence of steroid-resistant rejection and graft failure from rejection. | 1993 | Transplant. Proc. | pmid:7682352 |
Frank B et al. | Neurotoxicity of FK 506 in liver transplant recipients. | 1993 | Transplant. Proc. | pmid:7682355 |
Klintmalm GB et al. | Rejection: FK 506 for rescue or maintenance. | 1993 | Transplant. Proc. | pmid:7682356 |
Fernandes JB et al. | Comparative investigation of the effects of the immunosuppressants cyclosporine A, cyclosporine G, and FK-506 on platelet activation. | 1993 | Cell. Mol. Biol. Res. | pmid:7507391 |
Tabasco-Minguillan J et al. | Insulin requirements after liver transplantation and FK-506 immunosuppression. | 1993 | Transplantation | pmid:7692637 |
Wang SC et al. | A dual mechanism of immunosuppression by FK-506. Differential suppression of IL-4 and IL-10 levels in T helper 2 cells. | 1993 | Transplantation | pmid:7692640 |
McDiarmid SV et al. | FK506 conversion for intractable rejection of the liver allograft. | 1993 | Transpl. Int. | pmid:7507675 |
Akita K and Mandel TE | Effect of FK 506 and anti-CD4 monoclonal antibody treatment on xenografts of organ-cultured fetal pig pancreas and host lymphoid populations. | 1993 | Transplant. Proc. | pmid:7692650 |
Tokunaga Y et al. | Living related liver transplantation across ABO blood groups with FK506 and OKT3. | 1993 | Transpl. Int. | pmid:7507676 |
Liu J | FK506 and ciclosporin: molecular probes for studying intracellular signal transduction. | 1993 | Trends Pharmacol. Sci. | pmid:7692652 |
Winkler M et al. | Conversion from cyclosporin to FK 506 after liver transplantation. | 1993 | Transpl. Int. | pmid:7507677 |
David M et al. | [Changes in cervix cytology in women with liver transplants treated with immunosuppressive therapy]. | 1993 | Zentralbl Gynakol | pmid:7692689 |
Wallemacq PE and Reding R | FK506 (tacrolimus), a novel immunosuppressant in organ transplantation: clinical, biomedical, and analytical aspects. | 1993 | Clin. Chem. | pmid:7693372 |
Nakamura T et al. | Protein phosphatase type 2B (calcineurin)-mediated, FK506-sensitive regulation of intracellular ions in yeast is an important determinant for adaptation to high salt stress conditions. | 1993 | EMBO J. | pmid:7693452 |
Higa A et al. | Attenuation of epithelial injury in acute experimental colitis by immunomodulators. | 1993 | Eur. J. Pharmacol. | pmid:7693488 |
Yatscoff RW et al. | Comparison of the effect of rapamycin and FK506 on release of prostacyclin and endothelin in vitro. | 1993 | Clin. Biochem. | pmid:7507804 |
Lemster B et al. | FK 506 inhibits cytokine gene and adhesion molecule expression in psoriatic skin lesions. | 1993 | Ann. N. Y. Acad. Sci. | pmid:7509134 |
Tamura K et al. | Inhibitory effect of FK 506 on autoimmune thyroid disease in the PVG rat. | 1993 | Ann. N. Y. Acad. Sci. | pmid:7509135 |
Textor SC et al. | Systemic and renal hemodynamic differences between FK506 and cyclosporine in liver transplant recipients. | 1993 | Transplantation | pmid:7685934 |
Ochiai T et al. | Combination of immunosuppressive drugs for organ transplantation. | 1993 | Ann. N. Y. Acad. Sci. | pmid:7509136 |
Wiederrecht G et al. | The mechanism of action of FK-506 and cyclosporin A. | 1993 | Ann. N. Y. Acad. Sci. | pmid:7509138 |
Morikawa K et al. | Immunosuppressive activity of fosfomycin on human T-lymphocyte function in vitro. | 1993 | Antimicrob. Agents Chemother. | pmid:7509146 |
Schwaninger M et al. | The immunosuppressive drugs cyclosporin A and FK506 inhibit calcineurin phosphatase activity and gene transcription mediated through the cAMP-responsive element in a nonimmune cell line. | 1993 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:7509460 |
Natazuka T et al. | FK506 and cyclosporin a regulate proliferation and proto-oncogene expression in HTLV-1-associated myelopathy/tropical-spastic-paraparesis-derived T cells. | 1993 | Int. J. Cancer | pmid:7683633 |
Mukai H et al. | FKBP12-FK506 complex inhibits phosphatase activity of two mammalian isoforms of calcineurin irrespective of their substrates or activation mechanisms. | 1993 | J. Biochem. | pmid:7683641 |
Jachez B et al. | Reversion of the P-glycoprotein-mediated multidrug resistance of cancer cells by FK-506 derivatives. | 1993 | Anticancer Drugs | pmid:7683935 |
Shapiro R et al. | FK 506 interaction with danazol. | 1993 | Lancet | pmid:7684106 |
Becker JW et al. | FK-506-binding protein: three-dimensional structure of the complex with the antagonist L-685,818. | 1993 | J. Biol. Chem. | pmid:7684380 |
Dickey JB et al. | Periocular FK-506 delays allograft rejection in rat penetrating keratoplasty. | 1993 | Cornea | pmid:7684663 |
Francavilla A et al. | Hepatic regeneration and growth factors. | 1993 | J Surg Oncol Suppl | pmid:7684910 |
Connelly PR et al. | Probing hydration contributions to the thermodynamics of ligand binding by proteins. Enthalpy and heat capacity changes of tacrolimus and rapamycin binding to FK506 binding protein in D2O and H2O. | 1993 | Biochemistry | pmid:7684925 |
Hibbins M et al. | Inhibition of PHA induced mononuclear cell proliferation by FK506 in combination with cyclosporine, methylprednisolone, 6-mercaptopurine and mycophenolic acid. | 1993 | Transpl. Immunol. | pmid:7521736 |
Thomson AW et al. | Effects of combined administration of FK 506 and the purine biosynthesis inhibitors mizoribine or mycophenolic acid on lymphocyte DNA synthesis and T cell activation molecule expression in human mixed lymphocyte cultures. | 1993 | Transpl. Immunol. | pmid:7521738 |
Matsuura T et al. | Organ-specific unresponsiveness induced by intrathymic injection of donor bone marrow cells and a short course of immunosuppression in the rat heart transplantation model. | 1993 | Transpl. Immunol. | pmid:7521742 |
Calne RY et al. | Intestinal transplant for recurring mesenteric desmoid tumour. | 1993 | Lancet | pmid:7686241 |
Langer A et al. | Humoral and cellular immunopathology of hepatic and cardiac hamster-into-rat xenograft rejection. Marked stimulation of IgM++bright/IgD+dull splenic B cells. | 1993 | Am. J. Pathol. | pmid:7686346 |
Fujisawa T et al. | Dose study of the immunosuppression of FK 506 in canine lung allo-transplantation. | 1993 | Surg. Today | pmid:7686416 |
Ueno M et al. | [Immunosuppressive effect in combination therapy of cyclosporine A, FK506 and 15-deoxyspergualin on a pancreatic islet xenotransplantation]. | 1993 | Nihon Geka Gakkai Zasshi | pmid:7686615 |
Thomson AW et al. | FK 506: a novel immunosuppressant for treatment of autoimmune disease. Rationale and preliminary clinical experience at the University of Pittsburgh. | 1993 | Springer Semin. Immunopathol. | pmid:7686690 |
Koga T et al. | Pulmonary infiltrates recovered by FK506 in a patient with Behçet's disease. | 1993 | Chest | pmid:7686837 |
Nishi M et al. | Effects of the immunosuppressant FK506 on a penetrating keratoplasty rejection model in the rat. | 1993 | Invest. Ophthalmol. Vis. Sci. | pmid:7686893 |
Shaefer MS et al. | Falsely elevated FK-506 levels caused by sampling through central venous catheters. | 1993 | Transplantation | pmid:7689264 |
Valdivia LA et al. | Dendritic cell replacement in long-surviving liver and cardiac xenografts. | 1993 | Transplantation | pmid:7689265 |
Odocha O et al. | Posttransplant diabetes mellitus in African Americans after renal transplantation under FK 506 immunosuppression. | 1993 | Transplant. Proc. | pmid:7689268 |
Odocha O et al. | Serum cholesterol levels in African Americans after renal transplantation under FK 506 immunosuppression. | 1993 | Transplant. Proc. | pmid:7689269 |
McCauley J et al. | Renal transplantation under FK 506 in African-Americans: early experience. | 1993 | Transplant. Proc. | pmid:7689270 |
Groth CG et al. | New immunosuppressive drugs in transplantation. | 1993 | Transplant. Proc. | pmid:7689274 |
McMaster P and Buist L | FK 506 in transplantation. | 1993 | Transplant. Proc. | pmid:7689275 |
Cetinkale O et al. | The use of FK506 and skin allografting for the treatment of severe burns in an animal model. | 1993 | Br J Plast Surg | pmid:7690295 |
Hacker J and Fischer G | Immunophilins: structure-function relationship and possible role in microbial pathogenicity. | 1993 | Mol. Microbiol. | pmid:7526121 |
Hom JT and Estridge T | FK506 and rapamycin modulate the functional activities of human peripheral blood eosinophils. | 1993 | Clin. Immunol. Immunopathol. | pmid:7690315 |
Olivera DL et al. | Divergent effects of rapamycin on mouse and rat cells following mitogenic stimulation. | 1993 | Clin. Immunol. Immunopathol. | pmid:7690317 |
Whitington PF et al. | Orthotopic auxiliary liver transplantation for Crigler-Najjar syndrome type 1. | 1993 | Lancet | pmid:7690444 |
Takahashi H and Iizuka H | Neither cyclosporin A nor FK506 affects adenylate cyclase responses of fetal rat keratinizing epidermal cells (FRSK cells) at concentrations that inhibit thymidine incorporation. | 1993 | J. Dermatol. Sci. | pmid:7511000 |
Zuany-Amorim C et al. | Characterization and pharmacological modulation of antigen-induced peritonitis in actively sensitized mice. | 1993 | Br. J. Pharmacol. | pmid:7694762 |
Hirasé Y et al. | Transplantation of long-term cryopreserved allocutaneous tissue by skin graft or microsurgical anastomosis: experimental studies in the rat. | 1993 | Plast. Reconstr. Surg. | pmid:7679796 |
Piekoszewski W et al. | Disposition of tacrolimus (FK 506) in rabbits. Role of red blood cell binding in hepatic clearance. | 1993 Jul-Aug | Drug Metab. Dispos. | pmid:7690698 |
Kobayashi J et al. | A new rat infection-heart transplant model: effect of infection on graft survival studies. | 1993 Jul-Aug | J. Heart Lung Transplant. | pmid:7690253 |
Schreier MH | Immunophilins and immunosuppression. | 1993 Mar-Apr | Clin. Exp. Rheumatol. | pmid:7686830 |
Iwasaki K et al. | Isolation, identification, and biological activities of oxidative metabolites of FK506, a potent immunosuppressive macrolide lactone. | 1993 Nov-Dec | Drug Metab. Dispos. | pmid:7507815 |
Fukuse T et al. | Combined therapy with FK-506 and cyclosporine for canine lung allotransplantation: immunosuppressive effects and blood trough levels. | 1993 Nov-Dec | J. Heart Lung Transplant. | pmid:7508750 |
Morris RE | New small molecule immunosuppressants for transplantation: review of essential concepts. | 1993 Nov-Dec | J. Heart Lung Transplant. | pmid:7508752 |
Lhoëst G et al. | Isolation and identification of a novel isomerized epoxide metabolite of FK-506 from erythromycin-induced rabbit liver microsomes. | 1993 Sep-Oct | Drug Metab. Dispos. | pmid:7694828 |
Breuder T et al. | Calcineurin is essential in cyclosporin A- and FK506-sensitive yeast strains. | 1994 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7515500 |
Prasad TN et al. | FK 506 (Tacrolimus) metabolism by rat liver microsomes and its inhibition by other drugs. | 1994 | Res. Commun. Chem. Pathol. Pharmacol. | pmid:7518966 |
Kitamura Y et al. | Suppressive effect of FK-506, a novel immunosuppressant, against MPTP-induced dopamine depletion in the striatum of young C57BL/6 mice. | 1994 | J. Neuroimmunol. | pmid:7509816 |
Oishi M et al. | Successful swine small bowel transplantation using FK506: effect on endotoxin translocation. | 1994 | Transplant. Proc. | pmid:7520629 |
Holländer GA et al. | Molecular and biological actions of cyclosporin A and FK506 on T cell development and function. | 1994 | Transfus Sci | pmid:10155542 |
Ayres RC et al. | Peripheral neurotoxicity with tacrolimus. | 1994 | Lancet | pmid:7511197 |
Ishii T et al. | Immunodepressants ameliorate normothermic ischemia injury to the rat liver by down-regulating tumor necrosis factor, not by alleviation of lipid peroxidative injury. | 1994 | Transpl. Int. | pmid:11271294 |