tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Burke GW et al. | Use of FK 506 in simultaneous pancreas/kidney transplantation: lack of impairment of glycemic or lipid metabolism. | 1995 | Transplant. Proc. | pmid:8539872 |
| Watanabe K et al. | Fate of long-surviving allografts in tolerant recipients induced by fractionated lymphoid irradiation, donor bone marrow cell infusion, and FK 506 after retransplantation in dogs. | 1993 | Transplant. Proc. | pmid:7679813 |
| Burke GW et al. | The use of FK506 in simultaneous pancreas/kidney transplantation: rescue, induction, and maintenance immunosuppression. | 1995 | Transplant. Proc. | pmid:8539874 |
| Ueki M et al. | Peritoneal-omental pouch as a site for islet allotransplantation. | 1994 | Transplant. Proc. | pmid:7513462 |
| Miura S et al. | Long-term results of spousal renal donor transplants with donor-specific blood transfusions. | 2001 Nov-Dec | Transplant. Proc. | pmid:11750463 |
| Valdivia LA et al. | Hamster-to-rat liver xenografts protect extrahepatic organs from rejection. | 1993 | Transplant. Proc. | pmid:7679816 |
| Meier-Kriesche HU and Kaplan B | Cyclosporine microemulsion and tacrolimus are associated with decreased chronic allograft failure and improved long-term graft survival as compared to Sandimmune. | 2001 Nov-Dec | Transplant. Proc. | pmid:11750465 |
| Ryu S and Yasunami Y | Prevention of immune rejection in rat islet allografts by continuous SC administration of FK 506 using a mini-osmotic pump. | 1991 | Transplant. Proc. | pmid:1703710 |
| Alejandro R et al. | Combined liver-islet allotransplantation in man under FK 506. | 1991 | Transplant. Proc. | pmid:1703712 |
| Sato S et al. | Specificity of therapeutic drug monitoring of tacrolimus in kidney transplant patients. | 1998 | Transplant. Proc. | pmid:9636517 |
| Uchida K et al. | Decreasing pancreatic toxicity of tacrolimus by dosage reduction. | 1998 | Transplant. Proc. | pmid:9636518 |
| Gołębiewska J et al. | Tako-tsubo cardiomyopathy on the first day after renal transplantation - case report and literature review. | 2014 | Transplant. Proc. | pmid:25380951 |
| Kanter J et al. | Cytomegalovirus infection renal transplant recipients: risk factors and outcome. | 2009 Jul-Aug | Transplant. Proc. | pmid:19715860 |
| Bilbao I et al. | Indications and management of everolimus after liver transplantation. | 2009 Jul-Aug | Transplant. Proc. | pmid:19715864 |
| TuÄŸcu M et al. | Tacrolimus-Induced Diabetic Ketoacidosis and Effect of Switching to Everolimus: A Case Report. | 2015 | Transplant. Proc. | pmid:26093759 |
| Facundo C et al. | Results of a triple induction regime with tacrolimus, mycophenolate mofetil, and prednisone in renal transplantation. | 2002 | Transplant. Proc. | pmid:11959203 |
| GarcÃa-Meseguer C et al. | Efficacy and safety of basiliximab in pediatric renal transplantation. | 2002 | Transplant. Proc. | pmid:11959206 |
| Rafael-Valdivia L et al. | How long should initiation of calcineurin inhibitors be delayed to protect renal function in liver transplantation? | 2011 | Transplant. Proc. | pmid:21486577 |
| Charco R et al. | A prospective, multicenter study of once-daily extended-release tacrolimus in de novo liver transplant recipients. | 2011 | Transplant. Proc. | pmid:21486582 |
| Monden M et al. | A potent immunosuppressive effect of FK 506 in orthotopic liver transplantation in primates. | 1990 | Transplant. Proc. | pmid:1689904 |
| Ericzon BG et al. | Pancreaticoduodenal allotransplantation with FK 506 in the cynomolgus monkey. | 1990 | Transplant. Proc. | pmid:1689905 |
| Santos T et al. | New Recipes With Known Ingredients: Combined Therapy of Everolimus and Low-dose Tacrolimus in De Novo Renal Allograft Recipients. | 2015 | Transplant. Proc. | pmid:26036483 |
| Shibata T et al. | Does FK 506 accelerate the development of coronary artery disease in the transplanted heart as well as the native heart? | 1993 | Transplant. Proc. | pmid:7680147 |
| Wu YM et al. | Interaction between FK 506 and cyclosporine in dogs. | 1991 | Transplant. Proc. | pmid:1721281 |
| Horimoto H et al. | Hepatocyte xenotransplantation for Nagase's analbuminemic rats: the effect of FK506. | 1996 | Transplant. Proc. | pmid:8623421 |
| Klupp J et al. | Risk and benefit of antibody induction therapy in combination with tacrolimus immunosuppression after liver transplantation. | 1998 | Transplant. Proc. | pmid:9636585 |
| Fujikawa K et al. | Effects of tacrolimus on rat thymic epithelial cells. | 2000 | Transplant. Proc. | pmid:11120046 |
| Higuchi K et al. | FK506 induces the atrophy of enteric ganglia in small bowel transplantation, which can be prevented by the neuropeptide bombesin. | 2006 Jul-Aug | Transplant. Proc. | pmid:16908293 |
| Jordan ML et al. | Tacrolimus-based immunosuppression in pediatric renal transplantation. | 1999 | Transplant. Proc. | pmid:10576039 |
| Kaplinsky E et al. | Renal function improvement after conversion to proliferation signal inhibitors during long-term follow-up in heart transplant recipients. | 2012 | Transplant. Proc. | pmid:23146455 |
| MartÃn-Mateos RM et al. | Initial immunosuppression with or without basiliximab: a comparative study. | 2012 | Transplant. Proc. | pmid:23146457 |
| Barten MJ et al. | Pharmacodynamic monitoring of the conversion of cyclosporine to tacrolimus in heart and lung transplant recipients. | 2005 | Transplant. Proc. | pmid:16387162 |
| Chueh SC et al. | Pharmacokinetic variability of sirolimus in Taiwanese renal transplant recipients. | 2004 | Transplant. Proc. | pmid:15518745 |
| Nakamuta M et al. | Cyclosporine suppresses cell growth and collagen production in hepatic stellate cells. | 2005 | Transplant. Proc. | pmid:16387179 |
| Kim HC et al. | Primary immunosuppression with tacrolimus in kidney transplantation: three-year follow-up in a single center. | 2004 | Transplant. Proc. | pmid:15518753 |
| Ohtsuka S et al. | Effect of splenectomy on hamster-to-rat pancreas xenotransplantation. | 1994 | Transplant. Proc. | pmid:7518109 |
| Yasutomi M et al. | Mechanism of antibody production in hamster-to-rat concordant xenotransplantation: establishment of a simple model using intravenous injection of concordant splenocytes. | 1994 | Transplant. Proc. | pmid:7518110 |
| Porayko MK et al. | Comparing nephrotoxicity of FK 506 and cyclosporine regimens after liver transplantation: preliminary results from US Multicenter trial. U.S. Multicenter Liver Study Group. | 1995 | Transplant. Proc. | pmid:7533358 |
| Mueller AR et al. | The superior immunosuppressant according to diagnosis: FK 506 or cyclosporine A. | 1995 | Transplant. Proc. | pmid:7533359 |
| Wang SC et al. | FK 506, rapamycin, and cyclosporine: effects on IL-4 and IL-10 mRNA levels in a T-helper 2 cell line. | 1991 | Transplant. Proc. | pmid:1721312 |
| Woo J et al. | Kinetics of early T-cell repopulation in the mouse following syngeneic bone marrow transplantation: FK 506 causes a maturational defect of CD4+ CD8- T cells. | 1991 | Transplant. Proc. | pmid:1721313 |
| Lischke R et al. | Initial single-center experience with sirolimus after lung transplantation. | 2006 | Transplant. Proc. | pmid:17112886 |
| Moreno Gonzales M et al. | Sublingual Tacrolimus in Liver Transplantation: A Valid Option? | Transplant. Proc. | pmid:27569953 | |
| Wang SS et al. | Heart transplantation under cyclosporine or tacrolimus combined with mycophenolate mofetil or everolimus. | 2008 | Transplant. Proc. | pmid:18929814 |
| Ennaifer R et al. | Nodular hyperplasia of the gastrointestinal tract after liver transplantation: role of immunosuppressive therapy? A case report. | 2015 | Transplant. Proc. | pmid:25891739 |
| Yang YJ et al. | Sirolimus-based immunosuppressive therapy in liver transplant recipient with tacrolimus-related chronic renal insufficiency. | 2008 | Transplant. Proc. | pmid:18589147 |
| Oike F et al. | Complete withdrawal of immunosuppression in living donor liver transplantation. | 2002 | Transplant. Proc. | pmid:12176465 |
| Akita K and Mandel TE | Effect of FK 506 and anti-CD4 monoclonal antibody treatment on xenografts of organ-cultured fetal pig pancreas and host lymphoid populations. | 1993 | Transplant. Proc. | pmid:7692650 |
| Masri MA | Comparative study of toxicity and efficacy of cyclosporine, cyclosporine G (OG37), FK 506, and rapamycin in BALB/c mice with fitted skin grafts. | 1995 | Transplant. Proc. | pmid:7533412 |
| Moffatt SD et al. | Comparative efficacy of liposomal FK506 with FK506. | 1998 | Transplant. Proc. | pmid:9865297 |
| Mieles LA et al. | Liver transplantation of American veterans under FK 506 immunosuppression: a preliminary report. | 1991 | Transplant. Proc. | pmid:1721344 |
| Bouchta NB et al. | Conversion from tacrolimus to cyclosporin is associated with a significant improvement of glucose metabolism in patients with new-onset diabetes mellitus after renal transplantation. | 2005 | Transplant. Proc. | pmid:15919485 |
| Wasiak D et al. | Delayed, Uncommon Recurrence of Hepatocellular Carcinoma After Liver Transplantation: A Case Report. | 2016 | Transplant. Proc. | pmid:27496507 |
| Cardinal H et al. | The evolution of kidney function after lung transplantation: a retrospective cohort study. | 2009 | Transplant. Proc. | pmid:19857746 |
| Numakura K et al. | Incidence and risk factors of clinical characteristics, tacrolimus pharmacokinetics, and related genomic polymorphisms for posttransplant diabetes mellitus in the early stage of renal transplant recipients. | 2005 | Transplant. Proc. | pmid:15919487 |
| Ronchetti F et al. | Intestinal damage evaluation in swine allograft small bowel through hyaluronic acid quantification. | 1997 | Transplant. Proc. | pmid:9142293 |
| Velio P et al. | Combined orthotopic liver-small bowel transplantation or small bowel transplantation in pigs: relations between survival, rejection, and mucosal morphometry. | 1997 | Transplant. Proc. | pmid:9142295 |
| Langrehr JM et al. | First results from a prospective randomized trial comparing steroid-free induction therapy with tacrolimus and MMF versus tacrolimus and steroids in patients after liver transplantation for HCV. | 2002 | Transplant. Proc. | pmid:12176487 |
| Varo E et al. | Incidence of cytomegalovirus infection and disease in orthotopic liver transplant patients immunosuppressed with cyclosporin versus tacrolimus. | 2002 | Transplant. Proc. | pmid:12176488 |
| De Ruvo N et al. | Preliminary results of immunosuppression with thymoglobuline pretreatment and hepatitis C virus recurrence in liver transplantation. | 2005 Jul-Aug | Transplant. Proc. | pmid:16182760 |
| Matsuura T et al. | Organ-specific tolerance induced by intrathymic injection of donor bone marrow cells and FK 506 or antilymphocyte serum in rat heart transplantation. | 1994 | Transplant. Proc. | pmid:7520616 |
| Yura H et al. | Development of a macromolecular prodrug of FK506: I. Synthesis of FK506-dextran conjugate. | 1998 | Transplant. Proc. | pmid:9838577 |
| Ueda D et al. | Influence of FK 506 on renal blood flow. | 1991 | Transplant. Proc. | pmid:1721377 |
| Thomson AW et al. | The influence of FK 506 on the thymus: implications of drug-induced injury to thymic epithelial cells. | 1991 | Transplant. Proc. | pmid:1703361 |
| Kato T et al. | Mycophenolate mofetil rescue therapy in patients with chronic hepatic allograft rejection. | 1999 Feb-Mar | Transplant. Proc. | pmid:10083158 |
| Song Z et al. | Protective effect of FK-506 in pig-to-rat islet xenotransplantation is abrogated by prednisolone. | 2000 | Transplant. Proc. | pmid:10936332 |
| Morozumi K et al. | Electron-microscopic peritubular capillary lesion is a specific and useful diagnostic indicator for chronic rejection of renal allografts showing less specific morphologic lesions in the cyclosporine era. | 1997 Feb-Mar | Transplant. Proc. | pmid:9123167 |
| Nishioka T et al. | Arterial stiffness after successful renal transplantation. | 2008 | Transplant. Proc. | pmid:18790249 |
| Sola E et al. | Low-dose and rapid steroid withdrawal in renal transplant patients treated with tacrolimus and mycophenolate mofetil. | 2002 | Transplant. Proc. | pmid:12176537 |
| Utsugi R et al. | Tolerance across a two-haplotype, fully MHC-mismatched barrier induced in miniature swine renal allografts treated with a 12-day course of tacrolimus. | 2001 Feb-Mar | Transplant. Proc. | pmid:11266727 |
| Shinozuka H et al. | Effect of FK 506 on experimental liver carcinogenesis. | 1991 | Transplant. Proc. | pmid:1721407 |
| Cai X et al. | Low-dose of FK 506 and associated blood levels in allotransplantation of rat liver, heart, and skin. | 1992 | Transplant. Proc. | pmid:1379759 |
| Wu MS et al. | Cyclosporine, but not FK506 and rapamycin, enhances Na(+)-K(+)-CL- cotransport activity in cultured medullary thick ascending limb cells. | 1999 Feb-Mar | Transplant. Proc. | pmid:10083527 |
| Madariaga JR et al. | The long-term efficacy of multivisceral transplantation. | 2000 | Transplant. Proc. | pmid:10995918 |
| Pelekanou V et al. | FK 506 and rapamycin do not affect platelet aggregation or mitochondrial function. | 1991 | Transplant. Proc. | pmid:1721408 |
| Taki J et al. | DNA analysis of peripheral blood mononuclear cells for early detection of hepatic graft rejection. | 1992 | Transplant. Proc. | pmid:1379760 |
| Schorlemmer HU et al. | Coadministration of malononitrilamides and tacrolimus induces tolerance in a rat skin allograft model. | 1999 Feb-Mar | Transplant. Proc. | pmid:10083529 |
| Fishbein T et al. | Isolated intestinal transplantation in adults with nonreconstructible GI tracts. | 2000 | Transplant. Proc. | pmid:10995925 |
| McCarter JF et al. | FK 506 protects brain tissue in animal models of stroke. | 2001 | Transplant. Proc. | pmid:11377571 |
| Wen J et al. | Tripterygium wilfordii hook f increase the blood concentration of tacrolimus. | 2008 | Transplant. Proc. | pmid:19100464 |
| van Gelder T et al. | ATP-binding cassette transporters and calcineurin inhibitors: potential clinical implications. | 2001 | Transplant. Proc. | pmid:11377580 |
| Fieguth HG et al. | Tacrolimus for treatment of bronchiolitis obliterans syndrome after unilateral and bilateral lung transplantation. | 2002 | Transplant. Proc. | pmid:12176613 |
| Lorenzini S et al. | Posttransplant lymphoproliferative disorders in liver transplanted patients: a report of four cases. | 2006 | Transplant. Proc. | pmid:16797338 |
| Quiroga I et al. | Differential homocysteine levels in renal transplant patients receiving neoral versus tacrolimus. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267261 |
| Sato K et al. | Comparative study of FK 506, cyclosporine, and triple regimen immunosuppression with FK 506, cyclosporine, and mizoribine. | 1991 | Transplant. Proc. | pmid:1721440 |
| Odocha O et al. | Posttransplant diabetes mellitus in African Americans after renal transplantation under FK 506 immunosuppression. | 1993 | Transplant. Proc. | pmid:7689268 |
| Chu Z et al. | Influence of immunosuppressive drugs on the development of CD4(+)CD25(high) Foxp3(+) T cells in liver transplant recipients. | 2010 | Transplant. Proc. | pmid:20832552 |
| Ochiai T et al. | Effects of FK-506 on xenotransplantation of the heart and skin in a mouse-rat combination. | 1987 | Transplant. Proc. | pmid:2445083 |
| Timmermann W et al. | Noninvasive videomicroscopic monitoring of rat small bowel rejection. | 1998 | Transplant. Proc. | pmid:9745537 |
| Yonan NA et al. | Tracheal allograft transplantation in rats: the role of immunosuppressive agents in development of obliterative airway disease. | 1998 | Transplant. Proc. | pmid:9723443 |
| Greenstein SM et al. | Nifedipine prevents tacrolimus-induced intestinal hemodynamic and functional impairments. | 1998 | Transplant. Proc. | pmid:9745540 |
| Morales J et al. | Alemtuzumab induction in kidney transplantation: clinical results and impact on T-regulatory cells. | 2008 | Transplant. Proc. | pmid:19010240 |
| Valenzuela M et al. | Early steroid withdrawal in pediatric renal transplantation at a single center: preliminary report. | 2008 | Transplant. Proc. | pmid:19010242 |
| Wang CH et al. | Therapeutic drug monitoring of tacrolimus in cardiac transplant recipients: a comparison with cyclosporine neoral. | 2004 | Transplant. Proc. | pmid:15561257 |
| Aidong W et al. | Therapeutic drug monitoring of tacrolimus in early stage after heart transplantation. | 2004 | Transplant. Proc. | pmid:15561258 |
| Lo A et al. | Limited benefits of induction with monoclonal antibody to interleukin-2 receptor in combination with tacrolimus, mycophenolate mofetil, and steroids in simultaneous kidney-pancreas transplantation. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267477 |
| Granot E et al. | Monitoring of Epstein-Barr virus serology in children after liver transplant: lack of clinical correlation. | 2000 | Transplant. Proc. | pmid:10856551 |
| Walker RE et al. | Clinical outcomes associated with conversion to tacrolimus-based immunosuppression in pediatric cardiac transplantation. | 1998 | Transplant. Proc. | pmid:9636452 |
| Soh KS et al. | Simultaneous liver and kidney transplantation from different living donors. | 2012 | Transplant. Proc. | pmid:22410057 |
| Fisher A et al. | Gastrointestinal toxicity associated with FK 506 in liver transplant recipients. | 1994 | Transplant. Proc. | pmid:7527947 |