tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| McAlister VC et al. | A clinical pharmacokinetic study of tacrolimus and sirolimus combination immunosuppression comparing simultaneous to separated administration. | 2002 | Ther Drug Monit | pmid:12021624 |
| Bilmen JG et al. | The inhibition of the sarcoplasmic/endoplasmic reticulum Ca2+-ATPase by macrocyclic lactones and cyclosporin A. | 2002 | Biochem. J. | pmid:12022919 |
| Nashan B et al. | Clinical validation studies of Neoral C(2) monitoring: a review. | 2002 | Transplantation | pmid:12023607 |
| Ibarra FR et al. | Intracellular sodium modulates the state of protein kinase C phosphorylation of rat proximal tubule Na+,K+-ATPase. | 2002 | Acta Physiol. Scand. | pmid:12028137 |
| Ishani A et al. | Predictors of renal function following lung or heart-lung transplantation. | 2002 | Kidney Int. | pmid:12028464 |
| Streit F et al. | Rapid liquid chromatography-tandem mass spectrometry routine method for simultaneous determination of sirolimus, everolimus, tacrolimus, and cyclosporin A in whole blood. | 2002 | Clin. Chem. | pmid:12029019 |
| Van Vlem B et al. | In vitro evaluation of motilin agonism by macrolide immunosuppressive drugs. | 2002 | Nephrol. Dial. Transplant. | pmid:12032184 |
| Tzakis AG et al. | Campath-1H in intestinal and multivisceral transplantation: preliminary data. | 2002 | Transplant. Proc. | pmid:12034248 |
| Allers C et al. | Tacrolimus, daclizumab, sirolimus, and budesonide after small bowel transplantation in order to reduce nephrotoxicity. | 2002 | Transplant. Proc. | pmid:12034251 |
| Ishikawa T et al. | Intestinal function and morphology after ex vivo irradiated small bowel transplantation. | 2002 | Transplant. Proc. | pmid:12034274 |
| Sano N et al. | Oral FK 506 blood levels are elevated in pig short bowel model: further investigations with co-administration of an intestinal CYP3A4 inhibitor. | 2002 | Transplant. Proc. | pmid:12034301 |
| Rabkin JM et al. | Immunosuppression impact on long-term cardiovascular complications after liver transplantation. | 2002 | Am. J. Surg. | pmid:12034401 |
| Dissemond J et al. | [Pimecrolimus (SDZ ASM 981). Current state of research]. | 2002 | Dtsch. Med. Wochenschr. | pmid:12035117 |
| Jones TE and Morris RG | Pharmacokinetic interaction between tacrolimus and diltiazem: dose-response relationship in kidney and liver transplant recipients. | 2002 | Clin Pharmacokinet | pmid:12036394 |
| Czaja AJ | Autoimmune hepatitis after liver transplantation and other lessons of self-intolerance. | 2002 | Liver Transpl. | pmid:12037780 |
| Luan FL et al. | Rapamycin blocks tumor progression: unlinking immunosuppression from antitumor efficacy. | 2002 | Transplantation | pmid:12042641 |
| Smets F et al. | Ratio between Epstein-Barr viral load and anti-Epstein-Barr virus specific T-cell response as a predictive marker of posttransplant lymphoproliferative disease. | 2002 | Transplantation | pmid:12042647 |
| van Rijen MM et al. | CD154 is expressed during treatment with calcineurin inhibitors after organ transplantation. | 2002 | Transplantation | pmid:12042657 |
| Bouret S et al. | Galanin modulates the activity of proopiomelanocortin neurons in the isolated mediobasal hypothalamus of the male rat. | 2002 | Neuroscience | pmid:12044465 |
| Saito S et al. | Cyclosporin A inhibits angiotensin II-induced c-Jun NH(2)-terminal kinase activation but not protein synthesis in vascular smooth muscle cells. | 2002 | Eur. J. Pharmacol. | pmid:12044791 |
| Myckatyn TM et al. | The effects of rapamycin in murine peripheral nerve isografts and allografts. | 2002 | Plast. Reconstr. Surg. | pmid:12045568 |
| Topical pimecrolimus (Elidel) for treatment of atopic dermatitis. | 2002 | Med Lett Drugs Ther | pmid:12045753 | |
| Gupta AK et al. | Tacrolimus: a review of its use for the management of dermatoses. | 2002 | J Eur Acad Dermatol Venereol | pmid:12046809 |
| Blackmore M et al. | The effects of haloalkene cysteine conjugates on cytosolic free calcium levels in LLC-PK(1) cells--studies utilising digital imaging fluorescence microscopy. | 2002 | Toxicology | pmid:12049843 |
| Kimble RM et al. | Successful topical tacrolimus (FK506) therapy in a child with pyoderma gangrenosum. | 2002 | J. Pediatr. Gastroenterol. Nutr. | pmid:12050584 |
| Kakegawa T et al. | Rapamycin induces binding activity to the terminal oligopyrimidine tract of ribosomal protein mRNA in rats. | 2002 | Arch. Biochem. Biophys. | pmid:12051685 |
| Deters M et al. | Sirolimus/cyclosporine/tacrolimus interactions on bile flow and biliary excretion of immunosuppressants in a subchronic bile fistula rat model. | 2002 | Br. J. Pharmacol. | pmid:12055139 |
| Peherstorfer E et al. | Effects of microinjection of synthetic Bcl-2 domain peptides on apoptosis of renal tubular epithelial cells. | 2002 | Am. J. Physiol. Renal Physiol. | pmid:12060601 |
| Ishchenko AV and Shakhnovich EI | SMall Molecule Growth 2001 (SMoG2001): an improved knowledge-based scoring function for protein-ligand interactions. | 2002 | J. Med. Chem. | pmid:12061879 |
| Yamamoto K et al. | Myocardial stiffness is determined by ventricular fibrosis, but not by compensatory or excessive hypertrophy in hypertensive heart. | 2002 | Cardiovasc. Res. | pmid:12062710 |
| Oz HS et al. | Effects of immunomodulators on acute Trypanosoma Cruzi infection in mice. | 2002 | Med. Sci. Monit. | pmid:12070425 |
| Erdogan M et al. | Liposomal tacrolimus lotion as a novel topical agent for treatment of immune-mediated skin disorders: experimental studies in a murine model. | 2002 | Br. J. Dermatol. | pmid:12072063 |
| Kilinç M et al. | FK 506-induced fulminant leukoencephalopathy after kidney transplantation: case report. | 2002 | Transplant. Proc. | pmid:12072309 |
| Fahlke J et al. | Staggered immunosuppression with the interleukin-2 receptor antagonist daclizumab combined with tacrolimus, prednisolone, and mycophenolate mofetil after orthotopic liver transplantation: a pilot efficacy and safety study. | 2002 | Transplant. Proc. | pmid:12072328 |
| Teebken OE et al. | Primary immunosuppression with tacrolimus and mycophenolate mofetil versus cyclosporine and azathioprine in heart transplant recipients. | 2002 | Transplant. Proc. | pmid:12072335 |
| Miyazawa H et al. | Graft immunomodulation by donor irradiation and recipient-specific bone marrow cells in rat small bowel transplantation. | 2002 | Transplant. Proc. | pmid:12072357 |
| McPherson M et al. | Drug receptor identification from multiple tissues using cellular-derived mRNA display libraries. | 2002 | Chem. Biol. | pmid:12079780 |
| Sobie EA et al. | Termination of cardiac Ca(2+) sparks: an investigative mathematical model of calcium-induced calcium release. | 2002 | Biophys. J. | pmid:12080100 |
| Ferro CJ et al. | Central aortic pressure augmentation in stable renal transplant recipients. | 2002 | Kidney Int. | pmid:12081575 |
| Kelly D | Transplantation--new beginnings and new horizons. | 2002 May-Jun | J. Pediatr. Gastroenterol. Nutr. | pmid:12082389 |
| Fuchs M et al. | Tacrolimus enhances irritation in a 5-day human irritancy in vivo model. | 2002 | Contact Derm. | pmid:12084083 |
| Jiang H et al. | Tacrolimus and cyclosporine differ in their capacity to overcome ongoing allograft rejection as a result of their differential abilities to inhibit interleukin-10 production. | 2002 | Transplantation | pmid:12085006 |
| Grudé P et al. | MDR1 gene expression in peripheral blood mononuclear cells after liver transplantation. | 2002 | Transplantation | pmid:12085008 |
| Xu X et al. | FKBP12 is the only FK506 binding protein mediating T-cell inhibition by the immunosuppressant FK506. | 2002 | Transplantation | pmid:12085010 |
| Nomura T et al. | Enhancement by cyclosporin A of taxol-induced apoptosis of human urinary bladder cancer cells. | 2002 | Urol. Res. | pmid:12086014 |
| van Duijnhoven EM et al. | A late episode of post-transplant diabetes mellitus during active hepatitis C infection in a renal allograft recipient using tacrolimus. | 2002 | Am. J. Kidney Dis. | pmid:12087579 |
| Soldevila G et al. | Analysis of the individual role of the TCRzeta chain in transgenic mice after conditional activation with chemical inducers of dimerization. | 2001 | Cell. Immunol. | pmid:12088411 |
| Williams H | New treatments for atopic dermatitis. | 2002 | BMJ | pmid:12089073 |
| Bornhövd EC et al. | Immunomodulatory macrolactams for topical treatment of inflammatory skin diseases. | 2002 | Curr Opin Investig Drugs | pmid:12090543 |
| Schopf RE | Pimecrolimus. Novartis. | 2002 | Curr Opin Investig Drugs | pmid:12090545 |
| Cos J et al. | FK506 in the maturation of dendritic cells. | 2002 | Haematologica | pmid:12091117 |
| Agarwala S et al. | Evaluation of renal function in transplant patients on tacrolimus therapy. | 2002 | J Clin Pharmacol | pmid:12092747 |
| Wahn U et al. | Efficacy and safety of pimecrolimus cream in the long-term management of atopic dermatitis in children. | 2002 | Pediatrics | pmid:12093983 |
| Meier-Kriesche HU and Kaplan B | Cyclosporine microemulsion and tacrolimus are associated with decreased chronic allograft failure and improved long-term graft survival as compared with sandimmune. | 2002 | Am. J. Transplant. | pmid:12095048 |
| Walker SL et al. | Use of 0.1% tacrolimus ointment in patients with various forms of lupus erythematosus. | 2002 Jul-Aug | Eur J Dermatol | pmid:12095891 |
| Bernard LA et al. | Pimecrolimus 1% cream (Elidel) for atopic dermatitis. | 2002 | Skin Therapy Lett. | pmid:12097994 |
| Bultynck G et al. | Washing out of lipophilic compounds induces a transient increase in the passive Ca(2+) leak in permeabilized A7r5 cells. | 2002 | Cell Calcium | pmid:12098225 |
| Koefoed-Nielsen PB et al. | Blood tacrolimus levels and calcineurin phosphatase activity early after renal transplantation. | 2002 | Am. J. Transplant. | pmid:12099520 |
| Felipe CR et al. | The impact of ethnic miscegenation on tacrolimus clinical pharmacokinetics and therapeutic drug monitoring. | 2002 | Clin Transplant | pmid:12099982 |
| Kimball P et al. | Comparison of two drug regimens upon clinical outcome among renal transplant recipients with positive flow cytometric crossmatches. | 2002 | Clin Transplant | pmid:12099986 |
| Katoh N et al. | Cutaneous sarcoidosis successfully treated with topical tacrolimus. | 2002 | Br. J. Dermatol. | pmid:12100200 |
| Wilhelmi E et al. | Organotypic brain-slice cultures from adult rats: approaches for a prolonged culture time. | 2002 May-Jun | Altern Lab Anim | pmid:12106005 |
| Edinger RS et al. | Effect of immunosuppressive agents on glucocorticoid receptor function in A6 cells. | 2002 | Am. J. Physiol. Renal Physiol. | pmid:12110508 |
| Jin MB et al. | A novel leflunomide derivative, FK778, for immunosuppression after kidney transplantation in dogs. | 2002 | Surgery | pmid:12110798 |
| Okajima S et al. | Histological and electrophysiological analysis of the peripheral nerve allografts using an immunosuppressive agent. | 2002 | Microsc. Res. Tech. | pmid:12112423 |
| Reitamo S et al. | Topical noncorticosteroid immunomodulation in the treatment of atopic dermatitis. | 2002 | Am J Clin Dermatol | pmid:12113647 |
| Wellington K and Jarvis B | Spotlight on topical pimecrolimus in atopic dermatitis. | 2002 | Am J Clin Dermatol | pmid:12113651 |
| Kim MJ et al. | Calpain-dependent cleavage of cain/cabin1 activates calcineurin to mediate calcium-triggered cell death. | 2002 | Proc. Natl. Acad. Sci. U.S.A. | pmid:12114545 |
| Cho ML et al. | Cyclosporine inhibition of vascular endothelial growth factor production in rheumatoid synovial fibroblasts. | 2002 | Arthritis Rheum. | pmid:12115224 |
| Kahn K and Bruice TC | Parameterization of OPLS-AA force field for the conformational analysis of macrocyclic polyketides. | 2002 | J Comput Chem | pmid:12116403 |
| Nazzaro G and Cestari R | Topical tacrolimus ointment in ulcerative lichen planus: an alternative therapeutic approach. | 2002 Jul-Aug | Eur J Dermatol | pmid:12118424 |
| Montgomery SP et al. | Efficacy and toxicity of a protocol using sirolimus, tacrolimus and daclizumab in a nonhuman primate renal allotransplant model. | 2002 | Am. J. Transplant. | pmid:12118862 |
| Ahsan N et al. | Limited dose monoclonal IL-2R antibody induction protocol after primary kidney transplantation. | 2002 | Am. J. Transplant. | pmid:12118902 |
| [Corticosteroid-free therapy for the neurodermatitis patient. Rapid cessation for tormenting urticaria]. | 2002 | MMW Fortschr Med | pmid:12119889 | |
| Rico MJ and Lawrence I | Tacrolimus ointment for the treatment of atopic dermatitis: clinical and pharmacologic effects. | 2002 May-Jun | Allergy Asthma Proc | pmid:12125507 |
| Su M et al. | Acute tacrolimus overdose without significant toxicity. | 2002 | J. Toxicol. Clin. Toxicol. | pmid:12126198 |
| Egi H et al. | Downregulation of both interleukin-12 and interleukin-2 in heart allografts by pretransplant host treatment with granulocyte colony-stimulating factor and tacrolimus. | 2002 | Cytokine | pmid:12126653 |
| Hackstein H et al. | Rapamycin inhibits macropinocytosis and mannose receptor-mediated endocytosis by bone marrow-derived dendritic cells. | 2002 | Blood | pmid:12130531 |
| Bernard LA and Eichenfield LF | Topical immunomodulators for atopic dermatitis. | 2002 | Curr. Opin. Pediatr. | pmid:12130904 |
| Gloor JM et al. | Subclinical rejection in tacrolimus-treated renal transplant recipients. | 2002 | Transplantation | pmid:12131699 |
| Verleden GM et al. | Successful conversion from cyclosporine to tacrolimus for gastric motor dysfunction in a lung transplant recipient. | 2002 | Transplantation | pmid:12131703 |
| Siemionow M and Ozer K | Advances in composite tissue allograft transplantation as related to the hand and upper extremity. | 2002 | J Hand Surg Am | pmid:12132078 |
| Margreiter R et al. | A double-hand transplant can be worth the effort! | 2002 | Transplantation | pmid:12134104 |
| Tian L et al. | Association of the CD134/CD134L costimulatory pathway with acute rejection of small bowel allograft. | 2002 | Transplantation | pmid:12134113 |
| Perrino BA et al. | Substrate selectivity and sensitivity to inhibition by FK506 and cyclosporin A of calcineurin heterodimers composed of the alpha or beta catalytic subunit. | 2002 | Eur. J. Biochem. | pmid:12135494 |
| Walzel H et al. | Galectin-induced activation of the transcription factors NFAT and AP-1 in human Jurkat T-lymphocytes. | 2002 | Cell. Signal. | pmid:12135707 |
| Pustisek N et al. | Tacrolimus ointment: a new therapy for atopic dermatitis--review of the literature. | 2002 | Acta Dermatovenerol Croat | pmid:12137728 |
| Higashigawa M and Komada Y | Role of Ca2+ in the intracellular signaling pathway of anti-IgM-induced apoptosis in the human B-cell line, MBC-1, established from Burkitt lymphoma. | 2002 | Int. J. Hematol. | pmid:12138894 |
| Yango A et al. | Successful treatment of tacrolimus-associated thrombotic microangiopathy with sirolimus conversion and plasma exchange. | 2002 | Clin. Nephrol. | pmid:12141412 |
| Adachi S and Iwata M | Duration of calcineurin and Erk signals regulates CD4/CD8 lineage commitment of thymocytes. | 2002 | Cell. Immunol. | pmid:12142035 |
| Kuzuya T et al. | Interference of hematocrit in the tacrolimus II microparticle enzyme immunoassay. | 2002 | Ther Drug Monit | pmid:12142635 |
| Stolk LM et al. | Trough levels of tacrolimus. | 2002 | Ther Drug Monit | pmid:12142646 |
| Ducobu J | [Metabolic modifications related to immunosuppressive drugs]. | 2002 | Rev Med Brux | pmid:12143154 |
| Hämäläinen M et al. | Calcineurin inhibitors, cyclosporin A and tacrolimus inhibit expression of inducible nitric oxide synthase in colon epithelial and macrophage cell lines. | 2002 | Eur. J. Pharmacol. | pmid:12144947 |
| Jørgensen K et al. | C2 (2-h) levels are not superior to trough levels as estimates of the area under the curve in tacrolimus-treated renal-transplant patients. | 2002 | Nephrol. Dial. Transplant. | pmid:12147799 |
| Therapondos G et al. | Cardiac function after orthotopic liver transplantation and the effects of immunosuppression: a prospective randomized trial comparing cyclosporin (Neoral) and tacrolimus. | 2002 | Liver Transpl. | pmid:12149762 |
| Lee KH et al. | Delayed tacrolimus is safe with basiliximab induction therapy. | 2002 | Liver Transpl. | pmid:12149770 |
| Hricik DE et al. | Outcomes of African American kidney transplant recipients treated with sirolimus, tacrolimus, and corticosteroids. | 2002 | Transplantation | pmid:12151730 |
| Ogawa H et al. | Combination of tacrolimus, methotrexate, and methylprednisolone prevents acute but not chronic graft-versus-host disease in unrelated bone marrow transplantation. | 2002 | Transplantation | pmid:12151737 |
| Nagata K et al. | AT1 receptor blockade reduces cardiac calcineurin activity in hypertensive rats. | 2002 | Hypertension | pmid:12154108 |