tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Propper DJ et al. | Effects of the immunosuppressive macrolides rapamycin and FK 506 in high responder rats presensitized to major histocompatibility complex antigens. | 1993 | Transplant. Proc. | pmid:7679837 |
| Shapiro R et al. | Randomized trial of FK 506/prednisone vs FK 506/azathioprine/prednisone after renal transplantation: preliminary report. | 1993 | Transplant. Proc. | pmid:7679836 |
| Porayko MK et al. | Nephrotoxicity of FK 506 and cyclosporine when used as primary immunosuppression in liver transplant recipients. | 1993 | Transplant. Proc. | pmid:7679835 |
| Azhderian EM et al. | Nucleus associated FK 506 binding proteins with potential relevance to FK 506 immunosuppression. | 1993 | Transplant. Proc. | pmid:7679834 |
| Kuroki H et al. | Effect of FK 506 and donor-specific blood transfusion on the rat composite tissue limb allograft and the mechanism of long-term graft survival. | 1993 | Transplant. Proc. | pmid:7679833 |
| Kobayashi M et al. | Production of monoclonal antibody against recombinant human FKBP-12 and subcellular localization of FKBP-12 in human mononuclear and polymorphonuclear cells. | 1993 | Transplant. Proc. | pmid:7679832 |
| Japanese study of FK 506 on kidney transplantation: results of late phase II study. | 1993 | Transplant. Proc. | pmid:7679831 | |
| Celli S et al. | Long-term survival of heart and liver xenografts with splenectomy and FK 506. | 1993 | Transplant. Proc. | pmid:7679830 |
| Lane BC et al. | Evaluation of calcineurin's role in the immunosuppressive activity of FK 506, related macrolactams, and cyclosporine. | 1993 | Transplant. Proc. | pmid:7679829 |
| Klintmalm GB et al. | Prognostic factors for successful conversion from cyclosporine to FK 506-based immunosuppressive therapy for refractory rejection after liver transplantation. US Multicenter FK 506 Liver Study Group. | 1993 | Transplant. Proc. | pmid:7679828 |
| Jordan ML et al. | FK 506 salvage of renal allografts with ongoing rejection failing cyclosporine immunosuppression. | 1993 | Transplant. Proc. | pmid:7679827 |
| Klintmalm GB et al. | Use of FK 506 for the prevention of recurrent allograft rejection after successful conversion from cyclosporine for refractory rejection. US Multicenter FK 506 Liver Study Group. | 1993 | Transplant. Proc. | pmid:7679826 |
| Alessiani M et al. | Adverse effects of FK 506 overdosage after liver transplantation. | 1993 | Transplant. Proc. | pmid:7679825 |
| Morphological characteristics of renal allografts showing renal dysfunction under FK 506 therapy: is graft biopsy available to reveal the morphological findings corresponding with FK 506 nephropathy? Japanese FK 506 Study Group. | 1993 | Transplant. Proc. | pmid:7679824 | |
| Gibbs JF et al. | Outcome analysis of FK 506 therapy for acute and chronic rejection. | 1993 | Transplant. Proc. | pmid:7679823 |
| Tzakis AG et al. | Two-year experience with FK 506 in pediatric patients. | 1993 | Transplant. Proc. | pmid:7679822 |
| Nakajima K et al. | Effects of triple therapy of cyclosporine, FK 506, and RS-61443 on allogeneic small bowel transplantation in dogs. | 1993 | Transplant. Proc. | pmid:7679821 |
| Starzl TE | FK 506 versus cyclosporine. | 1993 | Transplant. Proc. | pmid:7679820 |
| Kahan BD | Cyclosporine: the base for immunosuppressive therapy--present and future. | 1993 | Transplant. Proc. | pmid:7679819 |
| Schreier MH et al. | Inhibition of T-cell signaling pathways by immunophilin drug complexes: are side effects inherent to immunosuppressive properties? | 1993 | Transplant. Proc. | pmid:7679818 |
| Murase N et al. | Effect of FK 506 and antiproliferative agents for heart and liver xenotransplantation from hamster to rat. | 1993 | Transplant. Proc. | pmid:7679817 |
| Valdivia LA et al. | Hamster-to-rat liver xenografts protect extrahepatic organs from rejection. | 1993 | Transplant. Proc. | pmid:7679816 |
| Watanabe K et al. | Fate of long-surviving allografts in tolerant recipients induced by fractionated lymphoid irradiation, donor bone marrow cell infusion, and FK 506 after retransplantation in dogs. | 1993 | Transplant. Proc. | pmid:7679813 |
| Kobayashi M et al. | HLA-DR matching effect in orthotopic liver transplantation under FK 506. | 1993 | Transplant. Proc. | pmid:7679812 |
| Hirasé Y et al. | Transplantation of long-term cryopreserved allocutaneous tissue by skin graft or microsurgical anastomosis: experimental studies in the rat. | 1993 | Plast. Reconstr. Surg. | pmid:7679796 |
| Cavaillé-Coll M and Mielach FA | Choice of cyclophosphamide dose in baboon-to-human liver transplantation. | 1993 | Lancet | pmid:7679768 |
| Doi R et al. | Biochemical characterization of the effects of FK506 on signal transduction in exocytotic function of rat pancreatic acini. | 1993 | J. Pharmacol. Exp. Ther. | pmid:7679738 |
| Talento A et al. | A single administration of LFA-1 antibody confers prolonged allograft survival. | 1993 | Transplantation | pmid:7679531 |
| Uemoto S et al. | Experience with FK506 in living-related liver transplantation. | 1993 | Transplantation | pmid:7679528 |
| Langrehr JM et al. | Clinical course, morphology, and treatment of chronically rejecting small bowel allografts. | 1993 | Transplantation | pmid:7679526 |
| Ito K and Komatsu Y | [Drug induced hemolytic uremic syndrome]. | 1993 | Nippon Rinsho | pmid:7679450 |
| Armitage JM et al. | Pediatric lung transplantation. The years 1985 to 1992 and the clinical trial of FK 506. | 1993 | J. Thorac. Cardiovasc. Surg. | pmid:7679172 |
| McCaffrey PG et al. | NF-ATp, a T lymphocyte DNA-binding protein that is a target for calcineurin and immunosuppressive drugs. | 1993 | J. Biol. Chem. | pmid:7679116 |
| Fingar DC et al. | Dissociation of pp70 ribosomal protein S6 kinase from insulin-stimulated glucose transport in 3T3-L1 adipocytes. | 1993 | J. Biol. Chem. | pmid:7679106 |
| Barthelmess IB and Tropschug M | FK506-binding protein of Neurospora crassa (NcFKBP) mediates sensitivity to the immunosuppressant FK506; resistant mutants identify two loci. | 1993 | Curr. Genet. | pmid:7679056 |
| Naito M et al. | Enhancement of cellular accumulation of cyclosporine by anti-P-glycoprotein monoclonal antibody MRK-16 and synergistic modulation of multidrug resistance. | 1993 | J. Natl. Cancer Inst. | pmid:7678867 |
| Jiang H et al. | Anti-tumor-promoting action of FK506, a potent immunosuppressive agent. | 1993 | Carcinogenesis | pmid:7678785 |
| Meadows RP et al. | Three-dimensional structure of the FK506 binding protein/ascomycin complex in solution by heteronuclear three- and four-dimensional NMR. | 1993 | Biochemistry | pmid:7678499 |
| Van Duyne GD et al. | Atomic structures of the human immunophilin FKBP-12 complexes with FK506 and rapamycin. | 1993 | J. Mol. Biol. | pmid:7678431 |
| Kawai M et al. | Structure-activity profiles of macrolactam immunosuppressant FK-506 analogues. | 1993 | FEBS Lett. | pmid:7678400 |
| Holman MJ et al. | FK506-associated thrombotic thrombocytopenic purpura. | 1993 | Transplantation | pmid:7678357 |
| Herold KC et al. | Inhibition of glucose-stimulated insulin release from beta TC3 cells and rodent islets by an analog of FK506. | 1993 | Transplantation | pmid:7678356 |
| Murase N et al. | Graft-versus-host disease after brown Norway-to-Lewis and Lewis-to-Brown Norway rat intestinal transplantation under FK506. | 1993 | Transplantation | pmid:7678353 |
| Ibarra F et al. | Bidirectional regulation of Na+,K(+)-ATPase activity by dopamine and an alpha-adrenergic agonist. | 1993 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7678337 |
| Hirai T et al. | Prolonged lung allograft survival with a short course of FK 506. | 1993 | J. Thorac. Cardiovasc. Surg. | pmid:7678313 |
| Foxwell BM et al. | Inhibition of activation-induced changes in the structure of the T cell interleukin-7 receptor by cyclosporin A and FK506. | 1993 | Eur. J. Immunol. | pmid:7678231 |
| Galvin F et al. | Effects of cyclosporin A, FK 506, and mycalamide A on the activation of murine CD4+ T cells by the murine B7 antigen. | 1993 | Eur. J. Immunol. | pmid:7678228 |
| Lee KK et al. | Successful treatment of ongoing intestinal allograft rejection permits recovery of graft structure and function. | 1993 | Am. J. Surg. | pmid:7678188 |
| Lam E et al. | A novel FK506 binding protein can mediate the immunosuppressive effects of FK506 and is associated with the cardiac ryanodine receptor. | 1995 | J. Biol. Chem. | pmid:7592869 |
| Asano K et al. | Generation of effector T cells in Hymenolepis nana-infected, FK-506-treated BALB/c mice. | 1995 | Immunol. Lett. | pmid:7590919 |
| Stemmer PM et al. | Factors responsible for the Ca(2+)-dependent inactivation of calcineurin in brain. | 1995 | FEBS Lett. | pmid:7589543 |
| Farcasanu IC et al. | Protein phosphatase 2B of Saccharomyces cerevisiae is required for tolerance to manganese, in blocking the entry of ions into the cells. | 1995 | Eur. J. Biochem. | pmid:7588708 |
| Stoller G et al. | A ribosome-associated peptidyl-prolyl cis/trans isomerase identified as the trigger factor. | 1995 | EMBO J. | pmid:7588623 |
| Wera S et al. | Cyclosporin A, rapamycin and FK506 decrease prolactin release from rat pituitary cells in primary culture. | 1995 | Endocr. Res. | pmid:7588431 |
| Lauerma AI | Immunomodulation of contact dermatitis. | 1995 | Curr. Probl. Dermatol. | pmid:7587333 |
| Tsuchida M et al. | The effects of FK506 and dexamethasone on rat thymocyte differentiation. | 1994 | Ther Immunol | pmid:7584489 |
| Kahan BD | New immunosuppressive drugs--pharmacologic approaches to alter immunoregulation. | 1994 | Ther Immunol | pmid:7584478 |
| Jung-Testas I et al. | Cyclosporin A promotes nuclear transfer of a cytoplasmic progesterone receptor mutant. | 1995 | C. R. Acad. Sci. III, Sci. Vie | pmid:7583777 |
| Koehler MT et al. | FK506 (tacrolimus) in the treatment of steroid-resistant acute graft-versus-host disease in children undergoing bone marrow transplantation. | 1995 | Bone Marrow Transplant. | pmid:7581088 |
| Kanamaru A et al. | FK506 treatment of graft-versus-host disease developing or exacerbating during prophylaxis and therapy with cyclosporin and/or other immunosuppressants. Japanese FK506 BMT Study Group. | 1995 | Bone Marrow Transplant. | pmid:7581086 |
| O'Gorman MA et al. | Proximal renal tubular acidosis secondary to FK506 in pediatric liver transplant patients. | 1995 | Clin Transplant | pmid:7579739 |
| Yamamoto M et al. | Cyclosporin A and FK506 reverse anthracycline resistance by altering the cell cycle. | 1995 | Anticancer Drugs | pmid:7579561 |
| Hemenway C | FK506 in bone marrow transplantation. | 1995 | Blood | pmid:7579473 |
| Mehta BA et al. | Two pathways of exocytosis of cytoplasmic granule contents and target cell killing by cytokine-induced CD3+ CD56+ killer cells. | 1995 | Blood | pmid:7579455 |
| Kawahara K et al. | Effects of deoxyspergualin on bronchial anastomosis healing in canine pulmonary allografts. | 1995 Jul-Aug | J. Heart Lung Transplant. | pmid:7578196 |
| Furuke K et al. | Suppression of adult T cell leukemia-derived factor/human thioredoxin induction by FK506 and cyclosporin A: a new mechanism of immune modulation via redox control. | 1995 | Int. Immunol. | pmid:7577807 |
| Ellis D | Clinical use of tacrolimus (FK-506) in infants and children with renal transplants. | 1995 | Pediatr. Nephrol. | pmid:7577418 |
| Cunningham EB | The human erythrocyte membrane contains a novel 12-kDa inositolphosphate-binding protein that is an immunophilin. | 1995 | Biochem. Biophys. Res. Commun. | pmid:7575593 |
| Paterson JM et al. | Control of a novel adenylyl cyclase by calcineurin. | 1995 | Biochem. Biophys. Res. Commun. | pmid:7575502 |
| Thomson AW and Bonham CA | Inhibition of T lymphocyte activation and apoptotic cell death by cyclosporin A and tacrolimus (FK506). Its relevance to therapy of HIV infection. | 1995 | Adv. Exp. Med. Biol. | pmid:7572394 |
| Petrides AS | [Do immunosuppressive agents really impair glucose tolerance in liver transplant patients?]. | 1995 | Z Gastroenterol | pmid:7571761 |
| Shackleton CR et al. | Lack of correlation between the magnitude of preservation injury and the incidence of acute rejection, need for OKT3, and conversion to FK506 in cyclosporine-treated primary liver allograft recipients. | 1995 | Transplantation | pmid:7570950 |
| DÃaz M et al. | [Tacrolimus (FK 506): an immunosuppression alternative in solid organ transplantation. (Part 2)]. | 1995 Apr-Jun | Rev Med Univ Navarra | pmid:7569553 |
| Holsinger LJ et al. | Signal transduction in T lymphocytes using a conditional allele of Sos. | 1995 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7568223 |
| Spencer DM et al. | A general strategy for producing conditional alleles of Src-like tyrosine kinases. | 1995 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7568222 |
| Mazur P et al. | Differential expression and function of two homologous subunits of yeast 1,3-beta-D-glucan synthase. | 1995 | Mol. Cell. Biol. | pmid:7565718 |
| Hadad SJ et al. | FK 506: effects on glomerular hemodynamics and on mesangial cells in culture. | 1995 | Kidney Int. | pmid:7564092 |
| Dix SP et al. | Re: Severe interaction between methotrexate and a macrolide-like antibiotic. | 1995 | J. Natl. Cancer Inst. | pmid:7563209 |
| [Experimental and clinical studies on the effectiveness of new immunosuppressive agents used in heart transplantation and transplantation-related complications]. | 1995 | Nihon Kyobu Geka Gakkai Zasshi | pmid:7561285 | |
| Zhu D et al. | Myristoylation of calcineurin B is not required for function or interaction with immunophilin-immunosuppressant complexes in the yeast Saccharomyces cerevisiae. | 1995 | J. Biol. Chem. | pmid:7559604 |
| David M et al. | [Occurrence of suspicious changes in cervix cytology in women after liver transplantation]. | 1995 | Geburtshilfe Frauenheilkd | pmid:7557217 |
| Adachi M et al. | IL-2-induced gene expression of protein-tyrosine phosphatase LC-PTP requires acidic and serine-rich regions within IL-2 receptor beta chain. | 1995 | FEBS Lett. | pmid:7556630 |
| Kobayashi I et al. | Combination therapy with tacrolimus and betamethasone for a patient with X-linked auto-immune enteropathy. | 1995 | Eur. J. Pediatr. | pmid:7556338 |
| Elitsur Y et al. | FK-506 and cyclosporine A (CsA) immunomodulation of the human gut mucosal immune system. | 1995 | Dig. Dis. Sci. | pmid:7555446 |
| Holmes JA and Twentyman PR | The activity of deoxyspergualin in multidrug-resistant cells. | 1995 | Cancer Chemother. Pharmacol. | pmid:7554042 |
| MacDonald AS and Sketris IS | Tacrolimus in transplantation. | 1995 | Am J Health Syst Pharm | pmid:7552906 |
| Kelly PA et al. | Tacrolimus: a new immunosuppressive agent. | 1995 | Am J Health Syst Pharm | pmid:7552894 |
| Woo J et al. | Effects of FK 506 on chimerism and the induction of donor-specific unresponsiveness following fully allogeneic bone marrow transplantation in mice. | 1995 | Transpl. Immunol. | pmid:7551985 |
| Reisman L et al. | Modulation of interleukin-1 secretion by immunosuppressive drugs, alone and in combination. | 1995 | Transpl. Immunol. | pmid:7551978 |
| Nagai H et al. | Effect of some immunosuppressors on allergic bronchial inflammation and airway hyperresponsiveness in mice. | 1995 | Int. Arch. Allergy Immunol. | pmid:7549508 |
| Mueller AR et al. | The optimal immunosuppressant after liver transplantation according to diagnosis: cyclosporine A or FK506? | 1995 | Clin Transplant | pmid:7549057 |
| Platz KP et al. | Toxicity versus rejection--or why conversions between cyclosporine A and FK506 were performed after liver transplantation. | 1995 | Clin Transplant | pmid:7549052 |
| Shapiro R et al. | Renal transplantation at the University of Pittsburgh: the impact of FK506. | 1994 | Clin Transpl | pmid:7547544 |
| Abu-Elmagd K et al. | Hepatic transplantation at the University of Pittsburgh: new horizons and paradigms after 30 years of experience. | 1994 | Clin Transpl | pmid:7547533 |
| Pham SM et al. | Cardiac transplantation at the University of Pittsburgh: 1994 update. | 1994 | Clin Transpl | pmid:7547531 |
| Okamoto M et al. | In situ proliferating status of mononuclear cells in rat small bowel grafts. | 1995 | Int J Exp Pathol | pmid:7547442 |
| Keenan RJ et al. | Clinical trial of tacrolimus versus cyclosporine in lung transplantation. | 1995 | Ann. Thorac. Surg. | pmid:7545889 |
| Bolman RM | Advantage--FK 506: reduced chronic rejection for lung transplant recipients. | 1995 | Ann. Thorac. Surg. | pmid:7545888 |
| Jain AB et al. | Capillary blood versus arterial or venous blood for tacrolimus monitoring in liver transplantation. | 1995 | Transplantation | pmid:7545836 |
| Matsuo S and Okamoto K | Enhancement of FK-506 activities by ganglioside (GM3) in vivo. | 1995 | Life Sci. | pmid:7545772 |