Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with tacrolimus
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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McDiarmid SV et al. | FK506 (tacrolimus) compared with cyclosporine for primary immunosuppression after pediatric liver transplantation. Results from the U.S. Multicenter Trial. | 1995 | Transplantation | pmid:7533345 |
Jain AB et al. | One thousand consecutive primary orthotopic liver transplants under FK 506: survival and adverse events. | 1995 | Transplant. Proc. | pmid:7533353 |
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Kuroki H and Ikuta Y | Nerve regeneration of vascularized rat limb allograft and functional recovery of long-term graft survivals treated by short course of FK 506 or cyclosporine. | 1995 | Transplant. Proc. | pmid:7533405 |
Ko S et al. | Significance of newly developed liposomal FK 506 in canine liver transplantation. | 1995 | Transplant. Proc. | pmid:7533406 |
Fukuzaki T et al. | Induction of unresponsiveness to islet allografts with donor spleen cell inoculation followed by a single injection of FK 506. | 1995 | Transplant. Proc. | pmid:7533407 |
Grochowicz PM et al. | Synergism of castanospermine and FK 506. | 1995 | Transplant. Proc. | pmid:7533408 |
Itoh S and Navia MA | Structure comparison of native and mutant human recombinant FKBP12 complexes with the immunosuppressant drug FK506 (tacrolimus). | 1995 | Protein Sci. | pmid:8563622 |
Tamura K et al. | Inhibition of insulin production by FK 506 is caused at the transcriptional level in pancreatic beta cell when FK BP-12 content is relatively high. | 1995 | Transplant. Proc. | pmid:7533409 |
Kawano K et al. | Protective effect of FK 506 on hepatic injury following cold ischemic preservation and transplantation: influence on hepatic microcirculation. | 1995 | Transplant. Proc. | pmid:7533410 |
Charters AR et al. | Developmental expression of FK506 binding proteins and calcineurin in rat brain. | 1995 | Biochem. Soc. Trans. | pmid:8566310 |
Tanabe M et al. | Therapeutic synergism between low-dose FK 506 and antimetabolites in rat allogeneic heart transplantation. | 1995 | Transplant. Proc. | pmid:7533411 |
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Swenson JM et al. | Immunosuppression switch in pediatric heart transplant recipients: cyclosporine to FK 506. | 1995 | J. Am. Coll. Cardiol. | pmid:7534779 |
Sen J et al. | Expression and induction of nuclear factor-kappa B-related proteins in thymocytes. | 1995 | J. Immunol. | pmid:7534792 |
Hodgkiss JP and Kelly JS | Only 'de novo' long-term depression (LTD) in the rat hippocampus in vitro is blocked by the same low concentration of FK506 that blocks LTD in the visual cortex. | 1995 | Brain Res. | pmid:8821755 |
Komori T | [The change of lymphocyte subset and effect of FK506 in experimental small bowel transplantation of rats]. | 1995 | Nihon Geka Gakkai Zasshi | pmid:7534867 |
Woo J et al. | Combined effects of FK506 (tacrolimus) and cyclophosphamide on atypical B220+ T cells, cytokine gene expression and disease activity in MRL/MpJ-lpr/lpr mice. | 1995 | Clin. Exp. Immunol. | pmid:7535208 |
Jusko WJ et al. | Pharmacokinetics of tacrolimus in liver transplant patients. | 1995 | Clin. Pharmacol. Ther. | pmid:7535213 |
Winkler M and Christians U | A risk-benefit assessment of tacrolimus in transplantation. | 1995 | Drug Saf | pmid:7545405 |
Nowaczyk M et al. | 2-Chlorodeoxyadenosine: lack of synergism with cyclosporine A and tacrolimus (FK 506). | 1995 | Arch. Immunol. Ther. Exp. (Warsz.) | pmid:8744655 |
Ellis D | Clinical use of tacrolimus (FK-506) in infants and children with renal transplants. | 1995 | Pediatr. Nephrol. | pmid:7577418 |
Furuke K et al. | Suppression of adult T cell leukemia-derived factor/human thioredoxin induction by FK506 and cyclosporin A: a new mechanism of immune modulation via redox control. | 1995 | Int. Immunol. | pmid:7577807 |
Ockenfels HM et al. | Cyclosporin A, FK506 and dithranol after tyrosine-specific protein phosphorylation in HaCaT keratinocytes. | 1995 | Arch. Dermatol. Res. | pmid:7541191 |
Victor RG et al. | Presynaptic modulation of cortical synaptic activity by calcineurin. | 1995 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7541535 |
Shapiro R et al. | FK506 in pediatric kidney transplantation--primary and rescue experience. | 1995 | Pediatr. Nephrol. | pmid:7492486 |
Mehta BA et al. | Two pathways of exocytosis of cytoplasmic granule contents and target cell killing by cytokine-induced CD3+ CD56+ killer cells. | 1995 | Blood | pmid:7579455 |
Kaufman DB et al. | The successful use of tacrolimus (FK506) in a pancreas/kidney transplant recipient with recurrent cyclosporine-associated hemolytic uremic syndrome. | 1995 | Transplantation | pmid:7541579 |
Ito A et al. | Induction of tolerance in rat cardiac allograft model by intrathymic injection of donor bone marrow cells. | 1995 | Transplant. Proc. | pmid:7536974 |
Coss MC et al. | Molecular cloning, DNA sequence analysis, and biochemical characterization of a novel 65-kDa FK506-binding protein (FKBP65). | 1995 | J. Biol. Chem. | pmid:7493967 |
Hemenway C | FK506 in bone marrow transplantation. | 1995 | Blood | pmid:7579473 |
Büttemeyer R et al. | Peripheral nerve allotransplant immunosuppressed with FK 506: preliminary results. | 1995 | Transplant. Proc. | pmid:7536979 |
Lee MJ et al. | Physicochemical, pharmacokinetic and pharmacodynamic evaluation of liposomal tacrolimus (FK 506) in rats. | 1995 | Pharm. Res. | pmid:7494802 |
Yamamoto M et al. | Cyclosporin A and FK506 reverse anthracycline resistance by altering the cell cycle. | 1995 | Anticancer Drugs | pmid:7579561 |
Venkataramanan R et al. | Clinical pharmacokinetics of tacrolimus. | 1995 | Clin Pharmacokinet | pmid:8787947 |
Arita S et al. | Effect of FK 506 in experimental pancreas transplantation. | 1995 | Transplant. Proc. | pmid:7536980 |
Zhao Y and Iwata M | Cross-linking of the TCR-CD3 complex with CD4, CD8 or LFA-1 induces an anti-apoptotic signal in thymocytes: the signal is canceled by FK506. | 1995 | Int. Immunol. | pmid:7495746 |
O'Gorman MA et al. | Proximal renal tubular acidosis secondary to FK506 in pediatric liver transplant patients. | 1995 | Clin Transplant | pmid:7579739 |
Aono T et al. | Minimal threshold of FK 506 for enhancing liver regeneration in thymectomized rats. | 1995 | Transplant. Proc. | pmid:7536981 |
Saito T et al. | In situ dephosphorylation of tau by protein phosphatase 2A and 2B in fetal rat primary cultured neurons. | 1995 | FEBS Lett. | pmid:7498550 |
Kanamaru A et al. | FK506 treatment of graft-versus-host disease developing or exacerbating during prophylaxis and therapy with cyclosporin and/or other immunosuppressants. Japanese FK506 BMT Study Group. | 1995 | Bone Marrow Transplant. | pmid:7581086 |
Iwabuchi T et al. | Effects of immunosuppressive peptidyl-prolyl cis-trans isomerase (PPIase) inhibitors, cyclosporin A, FK506, ascomycin and rapamycin, on hair growth initiation in mouse: immunosuppression is not required for new hair growth. | 1995 | J. Dermatol. Sci. | pmid:7537082 |
Antoni FA et al. | Calcineurin feedback inhibition of agonist-evoked cAMP formation. | 1995 | J. Biol. Chem. | pmid:7499291 |
Koehler MT et al. | FK506 (tacrolimus) in the treatment of steroid-resistant acute graft-versus-host disease in children undergoing bone marrow transplantation. | 1995 | Bone Marrow Transplant. | pmid:7581088 |
Arnold JC and Theilmann L | [Comparison between tacrolimus (FK 506) and cyclosporin in immunosuppressive therapy after liver transplantation]. | 1995 | Z Gastroenterol | pmid:7502559 |
Osman A et al. | Schistosoma mansoni: characterization of p50, an immunophilin. | 1995 | Exp. Parasitol. | pmid:7537219 |
Tanida I et al. | Cooperation of calcineurin and vacuolar H(+)-ATPase in intracellular Ca2+ homeostasis of yeast cells. | 1995 | J. Biol. Chem. | pmid:7537264 |
Koch K et al. | The C-32 triacetyl-L-rhamnose derivative of ascomycin: a potent, orally active macrolactone immunosuppressant. | 1995 | J. Med. Chem. | pmid:7537331 |
Corey HE et al. | Renal allograft rejection in children and young adults: the Banff classification. | 1995 | Pediatr. Nephrol. | pmid:7543274 |
Griffith JP et al. | X-ray structure of calcineurin inhibited by the immunophilin-immunosuppressant FKBP12-FK506 complex. | 1995 | Cell | pmid:7543369 |
Prud'homme GJ et al. | Effects of cyclosporin A, rapamycin, and FK520 on peripheral T-cell deletion and anergy. | 1995 | Cell. Immunol. | pmid:7543371 |
Migita K et al. | FK506 augments activation-induced programmed cell death of T lymphocytes in vivo. | 1995 | J. Clin. Invest. | pmid:7543492 |
Rodriguez Rilo HL et al. | Rapid hair regrowth in refractory alopecia universalis associated with autoimmune disease following liver transplantation and tacrolimus (FK506) therapy. | 1995 | Transplantation | pmid:7539169 |
Lhoëst G et al. | The in vitro immunosuppressive activity of the C15-demethylated metabolite of FK-506 is governed by ring- and open-chain tautomerism effects. | 1995 | J. Pharmacol. Exp. Ther. | pmid:7543569 |
Schleibner S et al. | FK 506 versus cyclosporin in the prevention of renal allograft rejection--European pilot study: six-week results. | 1995 | Transpl. Int. | pmid:7539270 |
Textor SC et al. | Urinary endothelin and renal vasoconstriction with cyclosporine or FK506 after liver transplantation. | 1995 | Kidney Int. | pmid:7543625 |
Ko S et al. | The enhanced immunosuppressive efficacy of newly developed liposomal FK506 in canine liver transplantation. | 1995 | Transplantation | pmid:7539553 |
Dollinger MM et al. | Tacrolimus and cardiotoxicity in adult liver transplant recipients. | 1995 | Lancet | pmid:7543645 |
Fealy MJ et al. | Association of down-regulation of cytokine activity with rat hind limb allograft survival. | 1995 | Transplantation | pmid:7539555 |
Romero DF et al. | Rapamycin: a bone sparing immunosuppressant? | 1995 | J. Bone Miner. Res. | pmid:7543725 |
Hisatomi K et al. | Changes in the mononuclear cell subpopulations of rat cardiac transplant recipients administered FK506 for the treatment of ongoing rejection. | 1995 | Surg. Today | pmid:7539647 |
Kinoshita I et al. | Myoblast allotransplantation in primates. | 1995 | Muscle Nerve | pmid:7544871 |
Monsour HP et al. | Renal insufficiency and hypertension as long-term complications in liver transplantation. | 1995 | Semin. Liver Dis. | pmid:7544917 |
Varela E | [Small bowel transplantation]. | 1995 | Acta Gastroenterol. Latinoam. | pmid:7544939 |
Taler SJ et al. | Loss of nocturnal blood pressure fall after liver transplantation during immunosuppressive therapy. | 1995 | Am. J. Hypertens. | pmid:7544983 |
Morris RE and Brown BW | Tacrolimus for prevention of liver allograft rejection: clinical trials and tribulations. | 1995 | Lancet | pmid:7475764 |
Starzl TE et al. | Randomised trialomania? The multicentre liver transplant trials of tacrolimus. | 1995 | Lancet | pmid:7475777 |
Teague S | Lessons from molecular matchmakers. | 1995 | Nat. Struct. Biol. | pmid:7545076 |
Milad M et al. | Interaction of the progesterone receptor with binding proteins for FK506 and cyclosporin A. | 1995 | Mol. Endocrinol. | pmid:7476967 |
Ito T et al. | Immunosuppressive agents induce the reduction of local pancreatic blood flow. | 1995 | Pancreas | pmid:7545292 |
Zhang J and Steiner JP | Nitric oxide synthase, immunophilins and poly(ADP-ribose) synthetase: novel targets for the development of neuroprotective drugs. | 1995 | Neurol. Res. | pmid:7477744 |
Han CW et al. | Differential effects of the immunosuppressants cyclosporin A, FK506 and KM2210 on cytokine gene expression. | 1995 | Bone Marrow Transplant. | pmid:7545487 |
Jindal RM and Popescu I | Renal dysfunction associated with liver transplantation. | 1995 | Postgrad Med J | pmid:7479462 |
Yeh WC et al. | Identification and characterization of an immunophilin expressed during the clonal expansion phase of adipocyte differentiation. | 1995 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7479941 |
Yeh WC et al. | Rapamycin inhibits clonal expansion and adipogenic differentiation of 3T3-L1 cells. | 1995 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7479942 |
Shaw KT et al. | Immunosuppressive drugs prevent a rapid dephosphorylation of transcription factor NFAT1 in stimulated immune cells. | 1995 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7479966 |
Holsinger LJ et al. | Signal transduction in T lymphocytes using a conditional allele of Sos. | 1995 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7568223 |
Faerman CH and Karplus PA | Consensus preferred hydration sites in six FKBP12-drug complexes. | 1995 | Proteins | pmid:8539241 |
Groth CG | Immunosuppressive regimens of tomorrow. | 1995 | Transplant. Proc. | pmid:8539797 |
Hariharan S et al. | Conversion from cyclosporine to tacrolimus after pancreas transplantation. | 1995 | Transplant. Proc. | pmid:8539799 |
Henley SE et al. | Lipids following pancreas transplantation in recipients receiving FK 506. | 1995 | Transplant. Proc. | pmid:8539809 |
Stratta RJ et al. | Preliminary experience with FK 506 in pancreas transplant recipients. | 1995 | Transplant. Proc. | pmid:8539823 |