tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Zahir H et al. | Validation of methods to study the distribution and protein binding of tacrolimus in human blood. | 2001 Jul-Aug | J Pharmacol Toxicol Methods | pmid:12164257 |
| van Gelder T | Drug interactions with tacrolimus. | 2002 | Drug Saf | pmid:12167066 |
| Zuber M and Donnerer J | Effect of FK506 on neurotransmitter content and expression of GAP-43 in neurotoxin-lesioned peripheral sensory and sympathetic neurons. | 2002 | Pharmacology | pmid:12169765 |
| Kapp A et al. | Long-term management of atopic dermatitis in infants with topical pimecrolimus, a nonsteroid anti-inflammatory drug. | 2002 | J. Allergy Clin. Immunol. | pmid:12170269 |
| Lyon CC et al. | Topical tacrolimus in the management of peristomal pyoderma gangrenosum. | 2001 | J Dermatolog Treat | pmid:12171681 |
| Goto M et al. | C3435T polymorphism in the MDR1 gene affects the enterocyte expression level of CYP3A4 rather than Pgp in recipients of living-donor liver transplantation. | 2002 | Pharmacogenetics | pmid:12172213 |
| Reinohs M et al. | Recurrent reversible cerebral edema after long term immunosuppression with tacrolimus. | 2002 | J. Neurol. | pmid:12173578 |
| Hardwick LL and Batiuk TD | Severe prolonged tacrolimus overdose with minimal consequences. | 2002 | Pharmacotherapy | pmid:12173792 |
| Walker SL et al. | The effect of topical tacrolimus on severe recalcitrant chronic discoid lupus erythematosus. | 2002 | Br. J. Dermatol. | pmid:12174136 |
| Marsella R and Nicklin CF | Investigation on the use of 0.3% tacrolimus lotion for canine atopic dermatitis: a pilot study. | 2002 | Vet. Dermatol. | pmid:12174182 |
| Ebbs A et al. | Tacrolimus treats ongoing allograft rejection by inhibiting interleukin-10 mediated functional cytotoxic cell infiltration. | 2002 | Transplant. Proc. | pmid:12176404 |
| Savikko J et al. | Tacrolimus inhibits platelet-derived growth factor ligand and receptor induction as well as rejection changes in rat renal allografts during long-term follow-up. | 2002 | Transplant. Proc. | pmid:12176405 |
| Erickson L et al. | Gene expression profiling of acute rejection and mixed lymphocyte reaction with tacrolimus immunosuppression. | 2002 | Transplant. Proc. | pmid:12176407 |
| Wynn C et al. | High level of TGF-beta in organ transplantation might be due to rejection rather than calcineurin inhibitor medication. | 2002 | Transplant. Proc. | pmid:12176408 |
| Schumacher G et al. | Sirolimus inhibits growth of human hepatoma cells in contrast to tacrolimus which promotes cell growth. | 2002 | Transplant. Proc. | pmid:12176410 |
| Tanabe K et al. | Synergistic effect of high-dose mizoribine and low-dose tacrolimus on renal allograft survival in nonhuman primates. | 2002 | Transplant. Proc. | pmid:12176425 |
| Ito Y et al. | Inhibition of epithelial replacement by nonspecific immunosuppressants accelerates rat orthotopic tracheal allograft rejection. | 2002 | Transplant. Proc. | pmid:12176430 |
| Shibutani S et al. | FK 506 abrogates induction of regulatory cells after intratracheal delivery of alloantigen. | 2002 | Transplant. Proc. | pmid:12176432 |
| Stockmann M et al. | Influence of immunosuppressive drugs on intestinal epithelial transport function. | 2002 | Transplant. Proc. | pmid:12176434 |
| Waller JR et al. | Effect of rapamycin in combination with calcineurin inhibitors, FK506 and cyclosporin, following arterial injury. | 2002 | Transplant. Proc. | pmid:12176449 |
| Mayer AD | Chronic rejection and graft half-life: five-year follow-up of the European Tacrolimus Multicenter Renal Study. | 2002 | Transplant. Proc. | pmid:12176452 |
| Daly I et al. | Mycophenolate mofetil for treatment of chronic rejection in liver allograft under tacrolimus. | 2002 | Transplant. Proc. | pmid:12176458 |
| Jonas S et al. | Cyclosporine-based quadruple induction therapy versus tacrolimus-based dual immunosuppression after liver transplantation: ten-year follow-up. | 2002 | Transplant. Proc. | pmid:12176459 |
| Chen JW et al. | Ten-year results of a randomised prospective study of FK506 versus cyclosporine in management of primary orthotopic liver transplantation. | 2002 | Transplant. Proc. | pmid:12176460 |
| Figueras J et al. | Steroid-free regimen with daclizumab, mycophenolate mofetil, and tacrolimus in liver transplant recipients. | 2002 | Transplant. Proc. | pmid:12176461 |
| Timmermann W et al. | A randomised trial comparing the efficacy and safety of tacrolimus with microemulsified cyclosporine after liver transplantation. | 2002 | Transplant. Proc. | pmid:12176463 |
| Hassoun Z et al. | The choice of calcineurin inhibitor does not influence centrilobular necrosis after orthotopic liver transplantation. | 2002 | Transplant. Proc. | pmid:12176464 |
| Oike F et al. | Complete withdrawal of immunosuppression in living donor liver transplantation. | 2002 | Transplant. Proc. | pmid:12176465 |
| Jain A et al. | Steroid withdrawal under tacrolimus for primary biliary cirrhosis, primary sclerosing cholangitis and autoimmune hepatitis after liver transplantation and long-term survival. | 2002 | Transplant. Proc. | pmid:12176467 |
| Lladó L et al. | Prospective study of a tacrolimus-based quadruple immunosuppressive regimen: evaluation of safety and efficacy. | 2002 | Transplant. Proc. | pmid:12176468 |
| Serrano J et al. | Tacrolimus is effective in both dual and triple regimens after liver transplantation. | 2002 | Transplant. Proc. | pmid:12176469 |
| Troisi R et al. | Are reduced tacrolimus dosages needed in the early postoperative period following living donor liver transplantation in adults? | 2002 | Transplant. Proc. | pmid:12176470 |
| Varo E et al. | Alternative immunosuppression for acute renal failure in liver transplantation: role of ultra-low dose tacrolimus and basiliximab. | 2002 | Transplant. Proc. | pmid:12176471 |
| Braun F et al. | Therapeutic drug monitoring of tacrolimus early after liver transplantation. | 2002 | Transplant. Proc. | pmid:12176473 |
| Jain AK et al. | Interaction between tacrolimus and antiretroviral agents in human immunodeficiency virus-positive liver and kidney transplantation patients. | 2002 | Transplant. Proc. | pmid:12176474 |
| Junge G et al. | Microchimerism in patients after orthotopic liver transplantation: a prognostic indicator? | 2002 | Transplant. Proc. | pmid:12176475 |
| Böttiger Y et al. | Effect of bile flow on the absorption of tacrolimus in liver allograft transplantation. | 2002 | Transplant. Proc. | pmid:12176476 |
| Hodge EE et al. | Use of mycophenolate mofetil in liver transplant recipients experiencing renal dysfunction on cyclosporine or tacrolimus-randomized, prospective, multicenter study results. | 2002 | Transplant. Proc. | pmid:12176477 |
| Charco R et al. | Changes in renal function in long-term survivors of liver transplantation: a comparison between cyclosporine microemulsion and tacrolimus therapy. | 2002 | Transplant. Proc. | pmid:12176478 |
| Aguirrezabalaga J et al. | Lipid profiles after liver transplantation in patients receiving tacrolimus or cyclosporin. | 2002 | Transplant. Proc. | pmid:12176480 |
| Varo E et al. | Cardiovascular risk factors in liver allograft recipients: relationship with immunosuppressive therapy. | 2002 | Transplant. Proc. | pmid:12176481 |
| Charco R et al. | Low incidence of hypercholesterolemia among liver transplant patients under tacrolimus monotherapy immunosuppression. | 2002 | Transplant. Proc. | pmid:12176482 |
| Rabkin JM et al. | Tacrolimus is associated with a lower incidence of cardiovascular complications in liver transplant recipients. | 2002 | Transplant. Proc. | pmid:12176483 |
| Langrehr JM et al. | First results from a prospective randomized trial comparing steroid-free induction therapy with tacrolimus and MMF versus tacrolimus and steroids in patients after liver transplantation for HCV. | 2002 | Transplant. Proc. | pmid:12176487 |
| Varo E et al. | Incidence of cytomegalovirus infection and disease in orthotopic liver transplant patients immunosuppressed with cyclosporin versus tacrolimus. | 2002 | Transplant. Proc. | pmid:12176488 |
| Fukuhara N et al. | Long-term outcome of tacrolimus in cadaveric kidney transplantation from non-heart-beating donors. | 2002 | Transplant. Proc. | pmid:12176492 |
| Tanabe K et al. | Outcome of kidney transplantation from non-heart-beating donors followed by tacrolimus immunosuppression in japan. | 2002 | Transplant. Proc. | pmid:12176493 |
| Squifflet JP et al. | Safe withdrawal of corticosteroids or mycophenolate mofetil: results of a large, prospective, multicenter, randomized study. | 2002 | Transplant. Proc. | pmid:12176495 |
| Waller JR et al. | Primary immunosuppression with tacrolimus is associated with a reduction in renal allograft fibrosis compared with neoral therapy. | 2002 | Transplant. Proc. | pmid:12176496 |
| Miyagi M et al. | Comparison of the therapeutic effects between CsA and FK506 on chronic renal allograft injury and TGF-beta expression. | 2002 | Transplant. Proc. | pmid:12176497 |
| van Hooff JP et al. | Benelux experience with a combination of tacrolimus and mycophenolate mofetil: 4-year results. | 2002 | Transplant. Proc. | pmid:12176498 |
| Budde K et al. | Five year outcome of tacrolimus rescue therapy in late rejection after renal transplantation. | 2002 | Transplant. Proc. | pmid:12176499 |
| Takahara S et al. | Excellent results following 3 years of tacrolimus immunosuppression in kidney transplantation recipients in Japan: overall analysis of more than 1000 patients. | 2002 | Transplant. Proc. | pmid:12176500 |
| Yoshimura N et al. | Safety analysis following tacrolimus immunosuppression in renal transplant recipients in Japan: 3-year results in over 1000 patients. | 2002 | Transplant. Proc. | pmid:12176501 |
| Takahashi K et al. | Successful results after 3 years' tacrolimus immunosuppression in ABO-incompatible kidney transplantation recipients in Japan. | 2002 | Transplant. Proc. | pmid:12176502 |
| Uchida K et al. | Excellent 3-year results following living-donor kidney transplantation and tacrolimus immunosuppression in Japan. | 2002 | Transplant. Proc. | pmid:12176503 |
| Burke GW et al. | Randomized trial of three different immunosuppressive regimens to prevent chronic renal allograft rejection. | 2002 | Transplant. Proc. | pmid:12176505 |
| Coupes BM et al. | Tacrolimus monotherapy in renal transplantation: four-year data. | 2002 | Transplant. Proc. | pmid:12176506 |
| Sonnenday CJ et al. | Preemptive therapy with plasmapheresis/intravenous immunoglobulin allows successful live donor renal transplantation in patients with a positive cross-match. | 2002 | Transplant. Proc. | pmid:12176507 |
| Ciancio G et al. | Effect of daclizumab, tacrolimus and mycophenolate mofetil in racial minority first renal transplant recipients. | 2002 | Transplant. Proc. | pmid:12176508 |
| Charpentier B | A three arm study comparing immediate tacrolimus therapy with ATG induction therapy followed by either tacrolimus or cyclosporine in adult renal transplant recipients. | 2002 | Transplant. Proc. | pmid:12176511 |
| Montagnino G et al. | Efficacy and safety of tacrolimus compared with cyclosporine microemulsion in kidney transplantation: twelve-month follow-up. | 2002 | Transplant. Proc. | pmid:12176515 |
| Garcia I | Efficacy and safety of dual versus triple tacrolimus-based therapy in kidney transplantation: two-year follow-up. | 2002 | Transplant. Proc. | pmid:12176516 |
| Craig AM et al. | A cost-effectiveness analysis of tacrolimus versus cyclosporine microemulsion following kidney transplantation. | 2002 | Transplant. Proc. | pmid:12176519 |
| Rashid I et al. | Medium-term outcome using sirolimus-tacrolimus combination in adult renal transplant recipients. | 2002 | Transplant. Proc. | pmid:12176520 |
| Shapiro R et al. | A pilot trial of tacrolimus, sirolimus, and steroids in renal transplant recipients. | 2002 | Transplant. Proc. | pmid:12176521 |
| Youseff N and Small S | A retrospective analysis of a sirolimus/prograf regimen for the prevention of acute rejection in recipients of primary mismatched renal allografts. | 2002 | Transplant. Proc. | pmid:12176522 |
| Campos HH and Abbud Filho M | One-year follow-up of a Brazilian randomized multicenter study comparing tacrolimus versus cyclosporine in kidney transplantation. | 2002 | Transplant. Proc. | pmid:12176523 |
| Dietl KH | Oral dosing of tacrolimus and cyclosporine microemulsion--results from a large multicenter study in renal transplantation. | 2002 | Transplant. Proc. | pmid:12176524 |
| Gurkan A et al. | Comparison of tacrolimus and neoral-based immunosuppressive regimens in renal transplantation patients: singles-center experience. | 2002 | Transplant. Proc. | pmid:12176525 |
| Wayman MR et al. | Two-year outcome in renal allograft recipients comparing neoral-led with tacrolimus-led therapy. | 2002 | Transplant. Proc. | pmid:12176526 |
| Okamoto M et al. | Tacrolimus-based immunosuppression in renal transplantation: 78 experiences in a single Japanese center. | 2002 | Transplant. Proc. | pmid:12176527 |
| Tanabe K et al. | Improved outcome of minor-mismatched living renal allografts under tacrolimus immunosuppression. | 2002 | Transplant. Proc. | pmid:12176528 |
| Scolari MP et al. | Acute rejection after renal transplantation with tacrolimus-based therapy in conditions of normal clinical practice. | 2002 | Transplant. Proc. | pmid:12176529 |
| Ushigome H et al. | Immunosuppression in cadaveric renal transplant recipients from non-heart-beating donors in a single center. | 2002 | Transplant. Proc. | pmid:12176533 |
| Citterio F et al. | Conversion to tacrolimus immunosuppression in renal transplant recipients: 12-month follow-up. | 2002 | Transplant. Proc. | pmid:12176535 |
| Sola E et al. | Low-dose and rapid steroid withdrawal in renal transplant patients treated with tacrolimus and mycophenolate mofetil. | 2002 | Transplant. Proc. | pmid:12176537 |
| Moons P et al. | Steroids may compromise quality of life of renal transplant recipients on a tacrolimus-based regimen. | 2002 | Transplant. Proc. | pmid:12176538 |
| Beaunoyer M et al. | Low-dose tacrolimus, trough-monitored mycophenolate mofetil, and planned steroid withdrawal for cadaveric kidney transplantation: a single center experience. | 2002 | Transplant. Proc. | pmid:12176540 |
| Boots JM et al. | Risk of adrenal insufficiency with steroid maintenance therapy in renal transplantation. | 2002 | Transplant. Proc. | pmid:12176541 |
| Boots JM et al. | Early steroid withdrawal in renal transplantation with tacrolimus dual therapy: a pilot study. | 2002 | Transplant. Proc. | pmid:12176542 |
| Citterio F et al. | Steroid withdrawal from tacrolimus-based therapy in renal transplant patients. | 2002 | Transplant. Proc. | pmid:12176545 |
| Baran DA et al. | Tacrolimus and new onset diabetes mellitus: the effect of steroid weaning. | 2002 | Transplant. Proc. | pmid:12176547 |
| Rodrigo E et al. | Histopathological findings according to Banff-97 classification system comparing tacrolimus versus cyclosporine. | 2002 | Transplant. Proc. | pmid:12176550 |
| Jørgensen KA et al. | Two-hour blood tacrolimus levels are not superior to trough levels as estimates of the area under the curve in tacrolimus-treated renal transplant patients. | 2002 | Transplant. Proc. | pmid:12176551 |
| van Duijnhoven EM et al. | Evidence that fasting does not significantly affect trough levels of tacrolimus in stable renal transplant recipients. | 2002 | Transplant. Proc. | pmid:12176552 |
| Saito K et al. | Study of pharmacokinetic parameters of tacrolimus by different oral administration periods in renal transplantation. | 2002 | Transplant. Proc. | pmid:12176553 |
| Sifontis NM et al. | Clinically significant drug interaction between basiliximab and tacrolimus in renal transplant recipients. | 2002 | Transplant. Proc. | pmid:12176554 |
| Toda F et al. | Tacrolimus trough level adjustment after administration of fluconazole to kidney recipients. | 2002 | Transplant. Proc. | pmid:12176555 |
| Uchida K et al. | Usefulness of monitoring of AUC(0-4h) during the induction period of immunosuppressive therapy with tacrolimus after renal transplantation. | 2002 | Transplant. Proc. | pmid:12176556 |
| Pozzetto U et al. | Effects of immunosuppressive regimens on plasma levels of transforming growth factor-beta 1 in renal transplant recipients. | 2002 | Transplant. Proc. | pmid:12176558 |
| Koefoed-Nielsen PB and Jørgensen KA | Alterations in calcineurin phosphatase activity in tacrolimus-treated renal transplant patients. | 2002 | Transplant. Proc. | pmid:12176559 |
| Baid S et al. | Tacrolimus-associated posttransplant diabetes mellitus in renal transplant recipients: role of hepatitis C infection. | 2002 | Transplant. Proc. | pmid:12176569 |
| Akioka K et al. | Diabetes in renal transplant recipients treated with tacrolimus. | 2002 | Transplant. Proc. | pmid:12176570 |
| Artz MA et al. | Randomized conversion from cyclosporine to tacrolimus in renal transplant patients: improved lipid profile and unchanged plasma homocysteine levels. | 2002 | Transplant. Proc. | pmid:12176579 |
| Boucher A et al. | Impact of immunosuppressive regimen on cardiovascular risk factors in kidney transplant recipients. | 2002 | Transplant. Proc. | pmid:12176582 |
| Suwelack B et al. | Replacement of calcineurin inhibitors by mycophenolate mofetil: effect on hemoglobine levels. | 2002 | Transplant. Proc. | pmid:12176585 |
| El Haggan W et al. | One year evolution of bone mineral density in kidney transplant recipients receiving tacrolimus versus cyclosporine. | 2002 | Transplant. Proc. | pmid:12176589 |
| Tanabe K et al. | Prospective analysis of thrombotic microangiopathy after renal transplantation: comparison between cyclosporine and tacrolimus immunosuppression. | 2002 | Transplant. Proc. | pmid:12176590 |
| Omoto K et al. | Adverse events in renal transplantation under tacrolimus/mycophnolate mofetil immunosuppression: a single-center experience. | 2002 | Transplant. Proc. | pmid:12176591 |