tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Guermonprez L et al. | The neuronal choline transporter CHT1 is regulated by immunosuppressor-sensitive pathways. | 2002 | J. Neurochem. | pmid:12358793 |
| Murotani Y et al. | Non-myeloablative haematopoietic stem cell transplantation for severe aplastic anaemia with various complications. | 2002 | Clin Lab Haematol | pmid:12358892 |
| Andany MA and Kasiske BL | Care of the kidney transplant recipient. Vigilant monitoring creates the best outcome. | 2002 | Postgrad Med | pmid:12360661 |
| Everson GT | Impact of immunosuppressive therapy on recurrence of hepatitis C. | 2002 | Liver Transpl. | pmid:12362294 |
| Czaja AJ | Treatment strategies in autoimmune hepatitis. | 2002 | Clin Liver Dis | pmid:12362582 |
| Vierling JM and Flores PA | Evolving new therapies of autoimmune hepatitis. | 2002 | Clin Liver Dis | pmid:12362583 |
| Roberts CA et al. | Asymmetric cardiac hypertrophy at autopsy in patients who received FK506 (tacrolimus) or cyclosporine A after liver transplant. | 2002 | Transplantation | pmid:12364862 |
| Elisaf M and Mikhailidis DP | Statins and renal function. | 2002 Sep-Oct | Angiology | pmid:12365855 |
| Brouard MC et al. | Erosive pustular dermatosis of the leg: report of three cases. | 2002 | Br. J. Dermatol. | pmid:12366427 |
| Edlind T et al. | Antifungal activity in Saccharomyces cerevisiae is modulated by calcium signalling. | 2002 | Mol. Microbiol. | pmid:12366848 |
| Maeda M et al. | A combined treatment with tacrolimus (FK506) and recombinant tissue plasminogen activator for thrombotic focal cerebral ischemia in rats: increased neuroprotective efficacy and extended therapeutic time window. | 2002 | J. Cereb. Blood Flow Metab. | pmid:12368659 |
| MartÃnez Castelao A et al. | [Effect of cyclosporin and tacrolimus on lipoprotein oxidation after renal transplantation]. | 2002 | Nefrologia | pmid:12369128 |
| Pérez-ValentÃn MA et al. | [Atypical cytomegalovirus in renal transplantation: a new form of presentation]. | 2002 | Nefrologia | pmid:12369131 |
| Hudnall SD | Cardiac hypertrophy postliver transplantation: a role for FK506 and cyclosporine A? | 2002 | Transplantation | pmid:12369583 |
| Hausberg M et al. | Sympathetic nerve activity in end-stage renal disease. | 2002 | Circulation | pmid:12370222 |
| Light JA et al. | Daclizumab induction/tacrolimus sparing: a randomized prospective trial in renal transplantation. | 2002 | Clin Transplant | pmid:12372041 |
| Trofe J et al. | Thymoglobulin for induction or rejection therapy in pancreas allograft recipients: a single centre experience. | 2002 | Clin Transplant | pmid:12372042 |
| OdabaÅŸ AR et al. | Severe alloimmune hemolytic anemia after renal transplantation. | 2002 | Nephron | pmid:12372972 |
| Olivier V et al. | Treatment of chronic erosive oral lichen planus with low concentrations of topical tacrolimus: an open prospective study. | 2002 | Arch Dermatol | pmid:12374539 |
| Ault BH et al. | Short-term outcomes of Thymoglobulin induction in pediatric renal transplant recipients. | 2002 | Pediatr. Nephrol. | pmid:12376809 |
| Couriel DR et al. | Chronic graft-versus-host disease manifesting as polymyositis: an uncommon presentation. | 2002 | Bone Marrow Transplant. | pmid:12379897 |
| Hanaoka M et al. | Effect of tacrolimus on endotoxin-induced lung injury in sheep. | 2002 | Respir Physiol Neurobiol | pmid:12380019 |
| Roy J et al. | The immunosuppressant rapamycin represses human immunodeficiency virus type 1 replication. | 2002 | Antimicrob. Agents Chemother. | pmid:12384349 |
| Taylor PA et al. | Combined effects of calcineurin inhibitors or sirolimus with anti-CD40L mAb on alloengraftment under nonmyeloablative conditions. | 2002 | Blood | pmid:12384443 |
| Scheffold C et al. | Visualization of effective tumor targeting by CD8+ natural killer T cells redirected with bispecific antibody F(ab')(2)HER2xCD3. | 2002 | Cancer Res. | pmid:12384539 |
| Presbitero P and Asioli M | [Drug-eluting stents do they make the difference? ]. | 2002 | Minerva Cardioangiol | pmid:12384625 |
| Schafer DF and Sorrell MF | Optimising immunosuppression. | 2002 | Lancet | pmid:12387953 |
| O'Grady JG et al. | Tacrolimus versus microemulsified ciclosporin in liver transplantation: the TMC randomised controlled trial. | 2002 | Lancet | pmid:12387959 |
| Herman M et al. | DNA repair in mononuclear cells: role of serine/threonine phosphatases. | 2002 | J. Lab. Clin. Med. | pmid:12389024 |
| Sharma AK et al. | Repulsive body odour due to cyclosporin A. | 2002 | Transpl. Int. | pmid:12389087 |
| Waller JR et al. | Effects of the combination of rapamycin with tacrolimus or cyclosporin on experimental intimal hyperplasia. | 2002 | Br J Surg | pmid:12390379 |
| Dharnidharka VR et al. | Mycophenolate, tacrolimus and post-transplant lymphoproliferative disorder: a report of the North American Pediatric Renal Transplant Cooperative Study. | 2002 | Pediatr Transplant | pmid:12390426 |
| Filler G et al. | Universal approach to pharmacokinetic monitoring of immunosuppressive agents in children. | 2002 | Pediatr Transplant | pmid:12390429 |
| Malat GE et al. | Tacrolimus-induced pain syndrome in a pediatric orthotopic liver transplant patient. | 2002 | Pediatr Transplant | pmid:12390434 |
| Miller LW | Cardiovascular toxicities of immunosuppressive agents. | 2002 | Am. J. Transplant. | pmid:12392286 |
| Holt DW | Therapeutic drug monitoring of immunosuppressive drugs in kidney transplantation. | 2002 | Curr. Opin. Nephrol. Hypertens. | pmid:12394613 |
| Allen BR and Luger TA | Risk: benefit ratio is important in treating atopic dermatitis. | 2002 | BMJ | pmid:12399360 |
| Yang CW et al. | Cyclosporine or FK506 decrease mature epidermal growth factor protein expression and renal tubular regeneration in rat kidneys with ischemia/reperfusion injury. | 2002 | Nephron | pmid:12399639 |
| Meurer M et al. | Pimecrolimus cream in the long-term management of atopic dermatitis in adults: a six-month study. | 2002 | Dermatology (Basel) | pmid:12399676 |
| Smith DA et al. | Repigmentation of vitiligo with topical tacrolimus. | 2002 | Dermatology (Basel) | pmid:12399684 |
| Grimes PE et al. | Topical tacrolimus for repigmentation of vitiligo. | 2002 | J. Am. Acad. Dermatol. | pmid:12399778 |
| Rabeni EJ and Cunningham NM | Effective treatment of Hailey-Hailey disease with topical tacrolimus. | 2002 | J. Am. Acad. Dermatol. | pmid:12399782 |
| Cho CS et al. | Modulation of the electrophoretic mobility of the linker for activation of T cells (LAT) by the calcineurin inhibitors CsA and FK506: LAT is a potential substrate for PKC and calcineurin signaling pathways. | 2003 | Cell. Signal. | pmid:12401523 |
| Crutchfield CE | Pimecrolimus: a new treatment for seborrheic dermatitis. | 2002 | Cutis | pmid:12403310 |
| Piérard GE et al. | [Drug of month. Topical tacrolimus (Protopic)]. | 2002 | Rev Med Liege | pmid:12405029 |
| Kiyama T et al. | Tacrolimus enhances colon anastomotic healing in rats. | 2002 Sep-Oct | Wound Repair Regen | pmid:12406167 |
| Rappersberger K et al. | Pimecrolimus identifies a common genomic anti-inflammatory profile, is clinically highly effective in psoriasis and is well tolerated. | 2002 | J. Invest. Dermatol. | pmid:12406334 |
| Sho M et al. | New insights into the interactions between T-cell costimulatory blockade and conventional immunosuppressive drugs. | 2002 | Ann. Surg. | pmid:12409674 |
| Feldmann KA et al. | Is topical tacrolimus effective in alopecia areata universalis? | 2002 | Br. J. Dermatol. | pmid:12410729 |
| Morales JM | Influence of the new immunosuppressive combinations on arterial hypertension after renal transplantation. | 2002 | Kidney Int. Suppl. | pmid:12410861 |
| Zamos DT and Tabin G | Tacrolimus (FK506) for high-risk corneal and limbal grafts. | 2002 | Ophthalmology | pmid:12414395 |
| Mathis AS et al. | Interaction of chloramphenicol and the calcineurin inhibitors in renal transplant recipients. | 2002 | Transpl Infect Dis | pmid:12421465 |
| Haasch D et al. | T cell activation induces a noncoding RNA transcript sensitive to inhibition by immunosuppressant drugs and encoded by the proto-oncogene, BIC. | 2002 May-Jun | Cell. Immunol. | pmid:12426003 |
| Khanna A et al. | Expression of TGF-beta and fibrogenic genes in transplant recipients with tacrolimus and cyclosporine nephrotoxicity. | 2002 | Kidney Int. | pmid:12427154 |
| Kaihara S et al. | Effect of FK506 on osteoinduction by recombinant human bone morphogenetic protein-2. | 2002 | Life Sci. | pmid:12427484 |
| Nottingham S et al. | FK506 treatment inhibits caspase-3 activation and promotes oligodendroglial survival following traumatic spinal cord injury. | 2002 | Exp. Neurol. | pmid:12429226 |
| Park SW et al. | Topical tacrolimus (FK506): treatment failure in four cases of alopecia universalis. | 2002 | Acta Derm. Venereol. | pmid:12430746 |
| Fujii H and Hirano T | Calcineurin regulates induction of late phase of cerebellar long-term depression in rat cultured Purkinje neurons. | 2002 | Eur. J. Neurosci. | pmid:12431231 |
| Garcia CD et al. | Pediatric renal transplantation under tacrolimus or cyclosporine immunosuppression and basiliximab induction. | 2002 | Transplant. Proc. | pmid:12431513 |
| Iwata H et al. | Prolongation of xenograft survival by combining donor-specific intravenous presensitization with FK 506. | 2002 | Transplant. Proc. | pmid:12431592 |
| Itagaki F et al. | Drug interaction of tacrolimus and proton pump inhibitors in renal transplant recipients with CYP2C19 gene mutation. | 2002 | Transplant. Proc. | pmid:12431607 |
| Nichelle L et al. | Arterial hypertension in renal transplant recipients treated with tacrolimus or cyclosporine-Neoral. | 2002 | Transplant. Proc. | pmid:12431623 |
| Barten MJ et al. | Assessment of immunosuppression by lymphocyte functions in human blood. | 2002 | Transplant. Proc. | pmid:12431640 |
| Bahra M et al. | Significance of mycophenolate mofetil treatment in patients with HCV reinfection after liver transplantation: impact on clinical course and histologic damage. | 2002 | Transplant. Proc. | pmid:12431663 |
| Hesse CJ et al. | Evaluation of the new EMIT enzyme immunoassay for the determination of whole-blood tacrolimus concentrations in kidney, heart, and liver transplant recipients. | 2002 | Transplant. Proc. | pmid:12431679 |
| Kohno M et al. | A new cardioprotective agent, JTV519, improves defective channel gating of ryanodine receptor in heart failure. | 2003 | Am. J. Physiol. Heart Circ. Physiol. | pmid:12433661 |
| Mallet VO et al. | Conditional cell ablation by tight control of caspase-3 dimerization in transgenic mice. | 2002 | Nat. Biotechnol. | pmid:12434157 |
| Topical [symbol: see text] tacrolimus--a role in atopic dermatitis? | 2002 | Drug Ther Bull | pmid:12434738 | |
| Assmann T and Ruzicka T | New immunosuppressive drugs in dermatology (mycophenolate mofetil, tacrolimus): unapproved uses, dosages, or indications. | 2002 Sep-Oct | Clin. Dermatol. | pmid:12435521 |
| Tan M et al. | Reduced dose Thymoglobulin, tacrolimus, and mofetil mycophenolate results in excellent solitary pancreas transplantation outcomes. | 2002 | Clin Transplant | pmid:12437620 |
| Krook H et al. | Immunosuppressive drugs in islet xenotransplantation: a tool for gaining further insights in the mechanisms of the rejection process. | 2002 | Transplantation | pmid:12438951 |
| Baran DA et al. | Tacrolimus in cardiac transplantation: efficacy and safety of a novel dosing protocol. | 2002 | Transplantation | pmid:12438960 |
| Kasahara M et al. | Role of HLA compatibility in pediatric living-related liver transplantation. | 2002 | Transplantation | pmid:12438966 |
| Ochiai N et al. | Successful non-T cell-depleted HLA haplo-identical three-loci mismatched hematopoietic stem cell transplantation from mother to son based on the feto-maternal microchimerism in chronic myelogenous leukemia. | 2002 | Bone Marrow Transplant. | pmid:12439703 |
| Bernstein CN | Treatment of the extraintestinal manifestations of inflammatory bowel disease. | 2002 | Curr Gastroenterol Rep | pmid:12441042 |
| Phillis JW et al. | Effects of immunosuppressants, calcineurin inhibition, and blockade of endoplasmic reticulum calcium channels on free fatty acid efflux from the ischemic/reperfused rat cerebral cortex. | 2002 | Brain Res. | pmid:12443975 |
| Kikuchi K and Tagami H | Comparison of the effects of daily applications between topical corticosteroid and tacrolimus ointments on normal skin: evaluation with noninvasive methods. | 2002 | Dermatology (Basel) | pmid:12444335 |
| Castanedo-Cazares JP et al. | Lichen amyloidosis improved by 0.1% topical tacrolimus. | 2002 | Dermatology (Basel) | pmid:12444346 |
| Fujii Y et al. | Effects of FK506 (tacrolimus hydrate) on chronic oxazolone-induced dermatitis in rats. | 2002 | Eur. J. Pharmacol. | pmid:12450577 |
| Shimada T et al. | Lowered blood concentration of tacrolimus and its recovery with changes in expression of CYP3A and P-glycoprotein after high-dose steroid therapy. | 2002 | Transplantation | pmid:12451243 |
| Uetsu N et al. | Treatment of chronic actinic dermatitis with tacrolimus ointment. | 2002 | J. Am. Acad. Dermatol. | pmid:12451373 |
| Ibrahim RB et al. | Tacrolimus-clarithromycin interaction in a patient receiving bone marrow transplantation. | 2002 | Ann Pharmacother | pmid:12452763 |
| Abe R et al. | Severe refractory chronic actinic dermatitis successfully treated with tacrolimus ointment. | 2002 | Br. J. Dermatol. | pmid:12452891 |
| McKaig SJ et al. | Investigation of the effect of FK506 (tacrolimus) and cyclosporin on gingival overgrowth following paediatric liver transplantation. | 2002 | Int J Paediatr Dent | pmid:12452980 |
| Reding R | Tacrolimus in pediatric liver transplantation. | 2002 | Pediatr Transplant | pmid:12453195 |
| Kelly DA | Optimal immunosuppression in teenagers. | 2002 | Pediatr Transplant | pmid:12453200 |
| Baksh S et al. | NFATc2-mediated repression of cyclin-dependent kinase 4 expression. | 2002 | Mol. Cell | pmid:12453415 |
| Lazzaro C et al. | Tacrolimus versus cyclosporin in renal transplantation in Italy: cost-minimisation and cost-effectiveness analyses. | 2002 Sep-Oct | J. Nephrol. | pmid:12455727 |
| Whalley D et al. | The benefit of pimecrolimus (Elidel, SDZ ASM 981) on parents' quality of life in the treatment of pediatric atopic dermatitis. | 2002 | Pediatrics | pmid:12456910 |
| Hernández G et al. | Rapid progression from oral leukoplakia to carcinoma in an immunosuppressed liver transplant recipient. | 2003 | Oral Oncol. | pmid:12457727 |
| Romero TarÃn E et al. | [Cardiac hypertrophy in kidney transplanted female patient treated with tacrolimus]. | 2002 | Med Clin (Barc) | pmid:12459112 |
| Marsland AM and Griffiths CE | The macrolide immunosuppressants in dermatology: mechanisms of action. | 2002 Nov-Dec | Eur J Dermatol | pmid:12459545 |
| Orii T et al. | Decreasing the Epstein-Barr virus load by adjusting the FK506 blood level. | 2002 | Transpl. Int. | pmid:12461655 |
| Toki K et al. | Analysis of allograft biopsy specimens from long-term surviving patients with stable renal function: predictive value of long-term graft prognosis. | 2002 | Clin Transplant | pmid:12464128 |
| Kyo M et al. | Differential diagnosis of kidney transplant rejection and cyclosporin/tacrolimus nephropathy using urine cytology. | 2002 | Clin Transplant | pmid:12464131 |
| Nakagawa Y et al. | The clinical significance of antibody to vascular endothelial cells after renal transplantation. | 2002 | Clin Transplant | pmid:12464133 |
| Reynolds NJ and Al-Daraji WI | Calcineurin inhibitors and sirolimus: mechanisms of action and applications in dermatology. | 2002 | Clin. Exp. Dermatol. | pmid:12464150 |
| WÅ‚odarczyk Z et al. | Freedom from rejection and stable kidney function are excellent criteria for steroid withdrawal in tacrolimus-treated kidney transplant recipients. | 2002 | Ann. Transplant. | pmid:12465429 |
| Hirshberg B et al. | Histopathological study of intrahepatic islets transplanted in the nonhuman primate model using edmonton protocol immunosuppression. | 2002 | J. Clin. Endocrinol. Metab. | pmid:12466330 |
| Nakatani T et al. | Renin mRNA expression and renal dysfunction in tacrolimus-induced acute nephrotoxicity. | 2003 | Int. J. Mol. Med. | pmid:12469222 |