| MeSH term | MeSH ID | Detail |
|---|---|---|
| Edema | D004487 | 152 associated lipids |
| Precancerous Conditions | D011230 | 48 associated lipids |
| Postoperative Complications | D011183 | 5 associated lipids |
| Arthritis | D001168 | 41 associated lipids |
| Arthritis, Experimental | D001169 | 24 associated lipids |
| Surgical Wound Infection | D013530 | 7 associated lipids |
| Neoplasm Recurrence, Local | D009364 | 5 associated lipids |
| Osteonecrosis | D010020 | 5 associated lipids |
| Hypotension | D007022 | 41 associated lipids |
| Acute Kidney Injury | D058186 | 34 associated lipids |
tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Tanaka K et al. | Significant association between CYP3A5 polymorphism and blood concentration of tacrolimus in patients with connective tissue diseases. | 2014 | J. Hum. Genet. | pmid:24352002 |
| Kim EJ et al. | Costimulation blockade alters germinal center responses and prevents antibody-mediated rejection. | 2014 | Am. J. Transplant. | pmid:24354871 |
| Kamińska D et al. | Significant infections after hand transplantation in a Polish population. | 2014 | Transplant. Proc. | pmid:25380943 |
| Cho JH et al. | Development of novel fast-dissolving tacrolimus solid dispersion-loaded prolonged release tablet. | 2014 | Eur J Pharm Sci | pmid:24388864 |
| Smoter P et al. | Risk factors of acute renal failure after orthotopic liver transplantation: single-center experience. | 2014 | Transplant. Proc. | pmid:25380918 |
| Venkat VL et al. | Recurrence of primary sclerosing cholangitis in pediatric liver transplant recipients. | 2014 | Liver Transpl. | pmid:24634351 |
| Frassetto LA et al. | Best single time point correlations with AUC for cyclosporine and tacrolimus in HIV-infected kidney and liver transplant recipients. | 2014 | Transplantation | pmid:24389906 |
| Lerut JP et al. | Is minimal, [almost] steroid-free immunosuppression a safe approach in adult liver transplantation? Long-term outcome of a prospective, double blind, placebo-controlled, randomized, investigator-driven study. | 2014 | Ann. Surg. | pmid:25379858 |
| Levitsky J and Feng S | Sirolimus and mTOR inhibitors in liver transplantation: the wheel has come full circle. | 2014 | Am. J. Transplant. | pmid:24620373 |
| Muhetaer G et al. | Clinical significance of peripheral blood lymphocyte sensitivity to glucocorticoids for the differentiation of high-risk patients with decreased allograft function after glucocorticoid withdrawal in renal transplantation. | 2014 | Clin Ther | pmid:25037282 |
| Kabir A | Comment on: New-onset diabetes and impaired fasting glucose after a liver transplant: risk analysis and the effect of tacrolimus dosage. | 2014 | Exp Clin Transplant | pmid:24471727 |
| Backes AN et al. | Effects of tacrolimus and insulin in a liver regeneration model in growing animals with portal vein stenosis: immunohistochemical and molecular studies. | 2014 | Pediatr. Surg. Int. | pmid:24468714 |
| Kim H et al. | Safety of reduced dose of mycophenolate mofetil combined with tacrolimus in living-donor liver transplantation. | 2014 | Clin Mol Hepatol | pmid:25320733 |
| Tavira B et al. | [Pharmacogenetics of tacrolimus: from bench to bedside?]. | 2014 | Nefrologia | pmid:24463861 |
| Curtin BF et al. | Unusually late-onset mycophenolate mofetil-related colitis. | 2014 | Am J Health Syst Pharm | pmid:25320135 |
| Qin XL et al. | Effect of Tacrolimus on the pharmacokinetics of bioactive lignans of Wuzhi tablet (Schisandra sphenanthera extract) and the potential roles of CYP3A and P-gp. | 2014 | Phytomedicine | pmid:24462213 |
| Zheng X et al. | Patient with neuromyelitis optica spectrum disorder combined with Sjögren's syndrome relapse free following tacrolimus treatment. | 2014 | Intern. Med. | pmid:25318807 |
| Asrani SK et al. | De novo sirolimus and reduced-dose tacrolimus versus standard-dose tacrolimus after liver transplantation: the 2000-2003 phase II prospective randomized trial. | 2014 | Am. J. Transplant. | pmid:24456026 |
| Nevers W et al. | Safety of tacrolimus in pregnancy. | 2014 | Can Fam Physician | pmid:25316742 |
| Wang J et al. | Molecular mechanisms of FK506-induced hypertension in solid organ transplantation patients. | 2014 | Chin. Med. J. | pmid:25316243 |
| Shilbayeh S | The impact of genetic polymorphisms on time required to attain the target tacrolimus levels and subsequent pharmacodynamic outcomes in pediatric kidney transplant patients. | 2014 | Saudi J Kidney Dis Transpl | pmid:24625991 |
| Sagiroglu T et al. | Protective effect of everolimus on renal ischemia reperfusion injury in rats. | 2014 | Saudi J Kidney Dis Transpl | pmid:24625994 |
| Wang XZ et al. | Increased intracellular adenosine triphosphate level as an index to predict acute rejection in kidney transplant recipients. | 2014 | Transpl. Immunol. | pmid:24211610 |
| Shimizu M et al. | Successful multitarget therapy using mizoribine and tacrolimus for refractory Takayasu arteritis. | 2014 | Rheumatology (Oxford) | pmid:24609060 |
| Golubović B et al. | Total plasma protein effect on tacrolimus elimination in kidney transplant patients--population pharmacokinetic approach. | 2014 | Eur J Pharm Sci | pmid:24184751 |
| Hu YM et al. | Casein kinase II inhibition reverses pain hypersensitivity and potentiated spinal N-methyl-D-aspartate receptor activity caused by calcineurin inhibitor. | 2014 | J. Pharmacol. Exp. Ther. | pmid:24610957 |
| Bäckman L and Persson CA | An observational study evaluating tacrolimus dose, exposure, and medication adherence after conversion from twice- to once-daily tacrolimus in liver and kidney transplant recipients. | 2014 | Ann. Transplant. | pmid:24637379 |
| Ramachandran R et al. | Tacrolimus therapy in adult-onset steroid-resistant nephrotic syndrome due to a focal segmental glomerulosclerosis single-center experience. | 2014 | Nephrol. Dial. Transplant. | pmid:24771498 |
| Capone F et al. | Synergistic antitumor effect of Doxorubicin and tacrolimus (FK506) on hepatocellular carcinoma cell lines. | 2014 | ScientificWorldJournal | pmid:24701168 |
| Boran M et al. | Determining renal resistive and pulsatility indexes long-term after kidney transplantation in kidney transplant recipients on cyclosporine a-, tacrolimus-, or sirolimus-based regimens. | 2014 | Transplant. Proc. | pmid:24935296 |
| Tischer S and Fontana RJ | Drug-drug interactions with oral anti-HCV agents and idiosyncratic hepatotoxicity in the liver transplant setting. | 2014 | J. Hepatol. | pmid:24280292 |
| Motomura H et al. | Inhibitory effect of tacrolimus on progression of joint damage in patients with rheumatoid arthritis. | 2014 | Int J Rheum Dis | pmid:24251619 |
| Yasukochi Y et al. | Reduction of serum TARC levels in atopic dermatitis by topical anti-inflammatory treatments. | 2014 | Asian Pac. J. Allergy Immunol. | pmid:25268342 |
| Zhang L et al. | Ambrisentan improves the outcome of rats with liver transplantation partially through reducing nephrotoxicity. | 2014 | Eur Rev Med Pharmacol Sci | pmid:25268107 |
| Donnadieu B et al. | Central retinal vein occlusion-associated tacrolimus after liver transplantation. | 2014 | Transplantation | pmid:25955343 |
| Arduino PG et al. | Pimecrolimus vs. tacrolimus for the topical treatment of unresponsive oral erosive lichen planus: a 8 week randomized double-blind controlled study. | 2014 | J Eur Acad Dermatol Venereol | pmid:23451852 |
| Wasilewski G et al. | Inadequate blood pressure control in orthotopic heart transplant: is there a role of kidney function and immunosuppressive regimen? | 2014 | Transplant. Proc. | pmid:25380929 |
| Al-Harbi NO et al. | Protection against tacrolimus-induced cardiotoxicity in rats by olmesartan and aliskiren. | 2014 | Toxicol. Mech. Methods | pmid:25199528 |
| Wilusz M et al. | Effect of immunosuppressive therapy on the serum fatty acids of phospholipids fraction in patients after heart transplantation. | 2014 | Transplant. Proc. | pmid:25380928 |
| Notaro E et al. | Dose conversion factor between cyclosporine and tacrolimus in pediatric heart transplant recipients. | 2014 | J. Heart Lung Transplant. | pmid:24854566 |
| Lan CC et al. | Tacrolimus abrogates TGF-β1-induced type I collagen production in normal human fibroblasts through suppressing p38MAPK signalling pathway: implications on treatment of chronic atopic dermatitis lesions. | 2014 | J Eur Acad Dermatol Venereol | pmid:23301526 |
| Noceti OM et al. | Tacrolimus pharmacodynamics and pharmacogenetics along the calcineurin pathway in human lymphocytes. | 2014 | Clin. Chem. | pmid:25142246 |
| Guy-Viterbo V et al. | Influence of donor-recipient CYP3A4/5 genotypes, age and fluconazole on tacrolimus pharmacokinetics in pediatric liver transplantation: a population approach. | 2014 | Pharmacogenomics | pmid:25141896 |
| Cavalli RC et al. | Analysis of the histology of the scar bladder and biochemical parameters of rats with a solitary kidney undergoing immunosuppression with tacrolimus. | 2014 | Acta Cir Bras | pmid:25140592 |
| Zhao WY et al. | Single kidneys transplanted from small pediatric donors less than 15 kilograms into pediatric recipients. | 2014 | Transplantation | pmid:25955345 |
| Elens L et al. | Impact of POR*28 on the pharmacokinetics of tacrolimus and cyclosporine A in renal transplant patients. | 2014 | Ther Drug Monit | pmid:24061445 |
| Imataki O et al. | Reversible cerebral vasoconstriction syndrome resulted in cerebral infarction after allogeneic stem cell transplantation: a case report. | 2014 | Ann. Hematol. | pmid:24061786 |
| Hagihara Y et al. | Infliximab and/or immunomodulators inhibit immune responses to trivalent influenza vaccination in adults with inflammatory bowel disease. | 2014 | J Crohns Colitis | pmid:24011513 |
| Kilinc S et al. | The effects of preoperative immunosuppressive therapy on ischemia and reperfusion (I/R) injury in healthy rats. | 2014 | Int Urol Nephrol | pmid:24014133 |
| Feliu J et al. | Transplant-acquired food allergy (TAFA) following cord blood stem cell transplantation in two adult patients with haematological malignancies. | 2014 | Br. J. Haematol. | pmid:24962133 |
| Grossman J et al. | Nonmyeloablative allogeneic hematopoietic stem cell transplantation for GATA2 deficiency. | 2014 | Biol. Blood Marrow Transplant. | pmid:25111582 |
| Grafals M et al. | Immunophenotyping and efficacy of low dose ATG in non-sensitized kidney recipients undergoing early steroid withdrawal: a randomized pilot study. | 2014 | PLoS ONE | pmid:25111080 |
| Freire-Cobo C et al. | The calcineurin inhibitor Ascomicin interferes with the early stage of the epileptogenic process induced by Latrunculin A microperfusion in rat hippocampus. | 2014 | J Neuroimmune Pharmacol | pmid:25104570 |
| Shen T et al. | A modified protocol with rituximab and intravenous immunoglobulin in emergent ABO-incompatible liver transplantation for acute liver failure. | 2014 | HBPD INT | pmid:25100124 |
| Bica L et al. | Neuroprotective copper bis(thiosemicarbazonato) complexes promote neurite elongation. | 2014 | PLoS ONE | pmid:24587210 |
| Verghese PS et al. | Calcineurin inhibitors in HLA-identical living related donor kidney transplantation. | 2014 | Nephrol. Dial. Transplant. | pmid:24414376 |
| Bergmann TK et al. | Population pharmacokinetics of tacrolimus in adult kidney transplant patients: impact of CYP3A5 genotype on starting dose. | 2014 | Ther Drug Monit | pmid:24089074 |
| Da-Long S et al. | Tacrolimus on Kimura's disease: a case report. | 2014 | Oral Surg Oral Med Oral Pathol Oral Radiol | pmid:22939325 |
| Aelvoet SA et al. | Noninvasive bioluminescence imaging of α-synuclein oligomerization in mouse brain using split firefly luciferase reporters. | 2014 | J. Neurosci. | pmid:25471588 |
| Klintmalm GB et al. | Belatacept-based immunosuppression in de novo liver transplant recipients: 1-year experience from a phase II randomized study. | 2014 | Am. J. Transplant. | pmid:25041339 |
| Ikeuchi H et al. | Efficacy and safety of multi-target therapy using a combination of tacrolimus, mycophenolate mofetil and a steroid in patients with active lupus nephritis. | 2014 | Mod Rheumatol | pmid:24252014 |
| Jaksch P et al. | Alemtuzumab in lung transplantation: an open-label, randomized, prospective single center study. | 2014 | Am. J. Transplant. | pmid:25039364 |
| Bax K et al. | Rapid resolution of tacrolimus intoxication-induced AKI with a corticosteroid and phenytoin. | 2014 | Ann Pharmacother | pmid:25104567 |
| Dessilly G et al. | ABCB1 1199G>A genetic polymorphism (Rs2229109) influences the intracellular accumulation of tacrolimus in HEK293 and K562 recombinant cell lines. | 2014 | PLoS ONE | pmid:24621983 |
| Zhao J et al. | FK506-loaded chitosan conduit promotes the regeneration of injured sciatic nerves in the rat through the upregulation of brain-derived neurotrophic factor and TrkB. | 2014 | J. Neurol. Sci. | pmid:24954089 |
| Wannhoff A et al. | Increased levels of rivaroxaban in patients after liver transplantation treated with cyclosporine A. | 2014 | Transplantation | pmid:25022236 |
| Sureshkumar KK and Chopra B | In search of an optimal induction agent in kidney transplantation. | 2014 | Transplantation | pmid:24978038 |
| Falconer SJ et al. | Conversion from twice-daily to once-daily tacrolimus in simultaneous pancreas-kidney transplant patients. | 2014 | Transplant. Proc. | pmid:24935313 |
| Welberry Smith MP and Baker RJ | The author's reply. | 2014 | Transplantation | pmid:24978039 |
| Hacker C et al. | Falsely elevated cyclosporin and tacrolimus concentrations over prolonged periods of time due to reversible adsorption to central venous catheters. | 2014 | Clin. Chim. Acta | pmid:24631133 |
| Terada Y et al. | Intestinal P-glycoprotein expression is multimodally regulated by intestinal ischemia-reperfusion. | 2014 | J Pharm Pharm Sci | pmid:24934555 |
| Singla AK et al. | Cerulomycin Caerulomycin [corrected] A: a potent novel immunosuppressive agent. | 2014 | Transplantation | pmid:24949498 |
| Goring SM et al. | A network meta-analysis of the efficacy of belatacept, cyclosporine and tacrolimus for immunosuppression therapy in adult renal transplant recipients. | 2014 | Curr Med Res Opin | pmid:24628478 |
| Urbanowicz T et al. | Comparison of conventional tacrolimus versus prolong release formula as initial therapy in heart transplantation. | 2014 | Ann. Transplant. | pmid:24949728 |
| Fuchs U et al. | Incidence of malignant neoplasia after heart transplantation--a comparison between cyclosporine a and tacrolimus. | 2014 | Ann. Transplant. | pmid:24953848 |
| Hallowell RW and Danoff SK | Interstitial lung disease associated with the idiopathic inflammatory myopathies and the antisynthetase syndrome: recent advances. | 2014 | Curr Opin Rheumatol | pmid:25203119 |
| Katayama M et al. | Preliminary study of interaction of clarithromycin with tacrolimus in cats. | 2014 | J. Vet. Med. Sci. | pmid:25099737 |
| Lalan S et al. | Effect of CYP3A5 genotype, steroids, and azoles on tacrolimus in a pediatric renal transplant population. | 2014 | Pediatr. Nephrol. | pmid:24875272 |
| Ricardo E et al. | In vivo and in vitro acquisition of resistance to voriconazole by Candida krusei. | 2014 | Antimicrob. Agents Chemother. | pmid:24867987 |
| Shihab F et al. | Focus on mTOR inhibitors and tacrolimus in renal transplantation: pharmacokinetics, exposure-response relationships, and clinical outcomes. | 2014 | Transpl. Immunol. | pmid:24861504 |
| Almeida-Paulo GN et al. | Limited sampling strategies for tacrolimus exposure (AUC0-24) prediction after Prograf(®) and Advagraf(®) administration in children and adolescents with liver or kidney transplants. | 2014 | Transpl. Int. | pmid:24861353 |
| Chamienia A et al. | Open prospective study to evaluate cardiovascular risk factors and renal function in 2 dosage regimens of tacrolimus combined with mycophenolate mofetil and steroids in renal transplant patients: 5-year results. | 2014 | Transplant. Proc. | pmid:25380901 |
| Agrawal YP et al. | Transplant patient classification and tacrolimus assays: more evidence of the need for assay standardization. | 2014 | Ther Drug Monit | pmid:24784024 |
| Sageshima J et al. | Everolimus with low-dose tacrolimus in simultaneous pancreas and kidney transplantation. | 2014 | Clin Transplant | pmid:24779669 |
| Lee CM et al. | Monotherapy with tacrolimus for heart and liver transplant: a case report. | 2014 | Transplant. Proc. | pmid:24767396 |
| Abe T et al. | Risk factors for development of new-onset diabetes mellitus and progressive impairment of glucose metabolism after living-donor liver transplantation. | 2014 | Transplant. Proc. | pmid:24767367 |
| Mita A et al. | Optimal initial dose of orally administered once-daily extended-release tacrolimus following intravenous tacrolimus therapy after liver transplantation. | 2014 | Transplant. Proc. | pmid:24767351 |
| Jin L et al. | Dipeptidyl peptidase IV inhibitor MK-0626 attenuates pancreatic islet injury in tacrolimus-induced diabetic rats. | 2014 | PLoS ONE | pmid:24959755 |
| Mitsides N et al. | Dapsone-induced methemoglobinemia in renal transplant recipients: more prevalent than previously thought. | 2014 | Transpl Infect Dis | pmid:24215452 |
| Wan XC and Dimov V | Pharmacokinetic evaluation of topical calcineurin inhibitors for treatment of allergic conjunctivitis. | 2014 | Expert Opin Drug Metab Toxicol | pmid:24490943 |
| Madian AG et al. | Case report: Inability to achieve a therapeutic dose of tacrolimus in a pediatric allogeneic stem cell transplant patient after generic substitution. | 2014 | BMC Pharmacol Toxicol | pmid:25472557 |
| Huang W et al. | Tacrolimus (FK506) suppresses TREM-1 expression at an early but not at a late stage in a murine model of fungal keratitis. | 2014 | PLoS ONE | pmid:25464008 |
| Philipone E et al. | Oral ulcerations as a sequela of tacrolimus and mycophenolate mofetil therapy. | 2014 | Oral Surg Oral Med Oral Pathol Oral Radiol | pmid:25457894 |
| Nair S and Waters B | Telaprevir in treatment of recurrent hepatitis C infection in liver transplant recipients. | 2014 | Exp Clin Transplant | pmid:24702143 |
| Chen C et al. | Rapid construction of a Bacterial Artificial Chromosomal (BAC) expression vector using designer DNA fragments. | 2014 | Plasmid | pmid:25454071 |
| Olson KA et al. | Toxic tacrolimus levels after application of topical tacrolimus and use of occlusive dressings in two bone marrow transplant recipients with cutaneous graft-versus-host disease. | 2014 | Pharmacotherapy | pmid:24700567 |
| Momohara S et al. | Recent trends in orthopedic surgery aiming to improve quality of life for those with rheumatoid arthritis: data from a large observational cohort. | 2014 | J. Rheumatol. | pmid:24692532 |
| Lin Q et al. | Pharmacological mobilization of endogenous stem cells significantly promotes skin regeneration after full-thickness excision: the synergistic activity of AMD3100 and tacrolimus. | 2014 | J. Invest. Dermatol. | pmid:24682043 |
| Navas-López VM et al. | Successful treatment for ulcerative proctitis with rectal tacrolimus in an 8-year-old girl with intolerance to mesalamine. | 2014 | Clin J Gastroenterol | pmid:26185880 |
| Lee CH et al. | Raised tacrolimus level and acute renal injury associated with acute gastroenteritis in a child receiving local rectal tacrolimus. | 2014 | Clin J Gastroenterol | pmid:26183743 |