tacrolimus

Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.

Cross Reference

Introduction

To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with tacrolimus?

tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with tacrolimus

MeSH term MeSH ID Detail
Edema D004487 152 associated lipids
Precancerous Conditions D011230 48 associated lipids
Postoperative Complications D011183 5 associated lipids
Arthritis D001168 41 associated lipids
Arthritis, Experimental D001169 24 associated lipids
Surgical Wound Infection D013530 7 associated lipids
Neoplasm Recurrence, Local D009364 5 associated lipids
Osteonecrosis D010020 5 associated lipids
Hypotension D007022 41 associated lipids
Acute Kidney Injury D058186 34 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with tacrolimus

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with tacrolimus?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with tacrolimus?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with tacrolimus?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with tacrolimus?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with tacrolimus?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with tacrolimus

Download all related citations
Per page 10 20 50 100 | Total 15051
Authors Title Published Journal PubMed Link
Zhu L et al. [Effect of CYP3A4*18B, CYP3A5*3 gene polymorphism on dosage and concentration of tacrolimus in renal transplant patients]. 2012 Yao Xue Xue Bao pmid:22993851
Wang M et al. Studies on the effects of the immunosuppressant FK-506 on the high-risk corneal graft rejection. 2002 Yan Ke Xue Bao pmid:15510746
Li S et al. Experiment study of retinal ultrastructure after intravitreal FK506. 2004 Yan Ke Xue Bao pmid:15124532
Xie H et al. Effect of topical FK506 used alone or combined with keratoplasty on patients with recurrent Mooren's corneal ulcer. 2006 Yan Ke Xue Bao pmid:17378150
Ma H et al. [The effect of FK506 on the proliferation of HRCECs]. 2006 Yan Ke Xue Bao pmid:17378157
Kagaya H et al. Quantification and 24-hour monitoring of mycophenolic acid by high-performance liquid chromatography in Japanese renal transplant recipients. 2006 Yakugaku Zasshi pmid:17139160
Tayama Y et al. [Influence of tacrolimus and ciprofloxacin on glucose metabolism]. 2007 Yakugaku Zasshi pmid:17978565
Naito T [Optimal immunosuppressive therapy based on pharmacokinetics and pharmacodynamics of antimetabolites in clinical practice]. 2010 Yakugaku Zasshi pmid:21139397
Yamaguchi K et al. [Case of encephalopathy seemingly caused by tacrolimus at blood concentration near the upper limit of therapeutic range]. 2012 Yakugaku Zasshi pmid:22790031
Nagao K et al. [Drug development from natural fermentation products: establishing a manufacturing process which maximizes the potential of microorganisms]. 2010 Yakugaku Zasshi pmid:21048405
Fukudo M [Individualized dosage regimen of immunosuppressive drugs based on pharmacokinetic and pharmacodynamic analysis]. 2007 Yakugaku Zasshi pmid:17603267
Sood S and Muthuraman A Activity of tacrolimus: an immunosuppressant, in pyloric ligation-induced peptic ulcer in the rat. 2009 Yakugaku Zasshi pmid:19952532
Tanaka H et al. [Discovery and development of a novel immunosuppressant, tacrolimus hydrate]. 1997 Yakugaku Zasshi pmid:9306728
Muraki Y [Factors affecting the pharmacokinetics after living donor liver transplant]. 2012 Yakugaku Zasshi pmid:23023417
Iwamoto T et al. [Successful treatment by tacrolimus in two patients with Osserman's grade III intractable myasthenia gravis and elderly IIb]. 2004 Yakugaku Zasshi pmid:15067188
Uchida K et al. Pharmacokinetics of orally administered tacrolimus in lupus nephritis patients. 2010 Yakugaku Zasshi pmid:20046074
Niwa T et al. Effect of cyclosporine and tacrolimus on cytochrome p450 activities in human liver microsomes. 2007 Yakugaku Zasshi pmid:17202802
Shimizu K Development of New Liposome Targeting Strategies for Application of Disease Therapies. 2017 Yakugaku Zasshi pmid:28049894
Tanaka Y et al. [Effect of tacrolimus on the pharmacokinetics and glucuronidation of SN-38, an active metabolite of irinotecan]. 2013 Yakugaku Zasshi pmid:23328499
Li J et al. [Regulatory effect of FK506 on the expression of CD152 and PD-1 in the liver allo-recipients]. 2008 Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi pmid:18177621
He QH et al. [The role of superantigen SEB-induced immunotolerance in the immune privileged site]. 2003 Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi pmid:15132898
Bai YJ et al. [Regulatory function of tacrolimus and CsA on CD4/CD8 T lymphocyte subgroups and costimulators on them in allo-liver recipients]. 2008 Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi pmid:18845086
Pan ZX et al. [IL-18 expression in whole blood cell cultures from active lupus nephritis and the inhibitory effects of FK506, cyclosporin A and dexamethasone]. 2004 Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi pmid:15555450
Imamura R et al. ABO-incompatible kidney transplantation with anti-CD20 monoclonal antibodies, intravenous immunoglobulin and plasmapheresis without splenectomy: a case report. 2006 Xenotransplantation pmid:16623807
Song Z et al. Tacrolimus inhibits discordant islet xenograft rejection: a study in the pig-to-rat model. 2003 Xenotransplantation pmid:14617270
Balamurugan AN et al. Effect of various immunosuppressive monotherapies on survival and histopathology of monkey islet xenografts in rats. 2007 Xenotransplantation pmid:17669173
Miki T et al. Hamster-to-rat bone marrow xenotransplantation and humoral graft vs. host disease. 2001 Xenotransplantation pmid:11472629
Tachibana A et al. Repopulation of the immunosuppressed retrorsine-treated infant rat liver with human hepatocytes. 2013 Jul-Aug Xenotransplantation pmid:23683097
Zhou YN et al. Effect of amlodipine on the pharmacokinetics of tacrolimus in rats. 2013 Xenobiotica pmid:23312000
Picard N The pharmacokinetic interaction between mycophenolic acid and cyclosporine revisited: a commentary on "Mycophenolic acid glucuronide is transported by multidrug resistance-associated protein 2 and this transport is not inhibited by cyclosporine, tacrolimus or sirolimus". 2013 Xenobiotica pmid:23339626
Fujiyama N et al. Influence of carboxylesterase 2 genetic polymorphisms on mycophenolic acid pharmacokinetics in Japanese renal transplant recipients. 2009 Xenobiotica pmid:19274604
Tata PN et al. Species-dependent hepatic metabolism of immunosuppressive agent tacrolimus (FK-506). 2009 Xenobiotica pmid:19604035
Zhang S et al. Effect of voriconazole and other azole antifungal agents on CYP3A activity and metabolism of tacrolimus in human liver microsomes. 2012 Xenobiotica pmid:22106961
Ogawa K et al. A new approach to predicting human hepatic clearance of CYP3A4 substrates using monkey pharmacokinetic data. 2013 Xenobiotica pmid:23153054
Lu XF et al. Use of a semi-physiological pharmacokinetic model to investigate the influence of itraconazole on tacrolimus absorption, distribution and metabolism in mice. 2017 Xenobiotica pmid:27533047
Zhu L et al. Effects of CYP3A5 genotypes, ABCB1 C3435T and G2677T/A polymorphism on pharmacokinetics of Tacrolimus in Chinese adult liver transplant patients. 2015 Xenobiotica pmid:25869250
Lampen A et al. Catalytic activities, protein- and mRNA-expression of cytochrome P450 isoenzymes in intestinal cell lines. 1998 Xenobiotica pmid:9622846
Jeong H and Chiou WL Role of P-glycoprotein in the hepatic metabolism of tacrolimus. 2006 Xenobiotica pmid:16507509
Patel CG et al. Mycophenolic acid glucuronide is transported by multidrug resistance-associated protein 2 and this transport is not inhibited by cyclosporine, tacrolimus or sirolimus. 2013 Xenobiotica pmid:22934787
Chitnis SD et al. Concentration of tacrolimus and major metabolites in kidney transplant recipients as a function of diabetes mellitus and cytochrome P450 3A gene polymorphism. 2013 Xenobiotica pmid:23278282
Miura M et al. Comparison of enantioselective disposition of rabeprazole versus lansoprazole in renal-transplant recipients who are CYP2C19 extensive metabolizers. 2005 Xenobiotica pmid:16012079
Niioka T et al. Effects of CYP3A5 polymorphism and the tacrolimus 12 h concentration on tacrolimus-induced acute renal dysfunction in patients with lupus nephritis. 2015 Xenobiotica pmid:26189776
Gupta AS et al. Pyoderma Gangrenosum of the Scalp: A Rare Clinical Variant. 2018 Wounds pmid:29481333
Kiyama T et al. Tacrolimus enhances colon anastomotic healing in rats. 2002 Sep-Oct Wound Repair Regen pmid:12406167
Yang J et al. Zinc finger protein A20 protects rats against chronic liver allograft dysfunction. 2012 World J. Gastroenterol. pmid:22826618
Chen ZS et al. Early steroid withdrawal after liver transplantation for hepatocellular carcinoma. 2007 World J. Gastroenterol. pmid:17876900
Zhou J et al. Conversion to sirolimus immunosuppression in liver transplantation recipients with hepatocellular carcinoma: Report of an initial experience. 2006 World J. Gastroenterol. pmid:16718799
Song JL et al. Minimizing tacrolimus decreases the risk of new-onset diabetes mellitus after liver transplantation. 2016 World J. Gastroenterol. pmid:26877618
Li DW et al. Risk factors for new onset diabetes mellitus after liver transplantation: A meta-analysis. 2015 World J. Gastroenterol. pmid:26034369
Filipec Kanizaj T and Mijic M Inflammatory bowel disease in liver transplanted patients. 2017 World J. Gastroenterol. pmid:28566881
Provenzani A et al. Pharmacogenetic considerations for optimizing tacrolimus dosing in liver and kidney transplant patients. 2013 World J. Gastroenterol. pmid:24409044
Guo YW et al. Successful treatment of ileal ulcers caused by immunosuppressants in two organ transplant recipients. 2016 World J. Gastroenterol. pmid:27350740
Kang YZ et al. Autoimmune hepatitis-primary biliary cirrhosis concurrent with biliary stricture after liver transplantation. 2015 World J. Gastroenterol. pmid:25717264
Liu F et al. Tacrolimus dosage requirements in living donor liver transplant recipients with small-for-size grafts. 2009 World J. Gastroenterol. pmid:19701975
Schott E et al. Development of ulcerative colitis in a patient with multiple sclerosis following treatment with interferon beta 1a. 2007 World J. Gastroenterol. pmid:17659718
Schumacher G et al. Sirolimus inhibits growth of human hepatoma cells alone or combined with tacrolimus, while tacrolimus promotes cell growth. 2005 World J. Gastroenterol. pmid:15770715
Jia JJ et al. ''Minimizing tacrolimus'' strategy and long-term survival after liver transplantation. 2014 World J. Gastroenterol. pmid:25170223
Hao JC et al. Effect of low-dose tacrolimus with mycophenolate mofetil on renal function following liver transplantation. 2014 World J. Gastroenterol. pmid:25170222
Takeichi T et al. Effect of ONO-4057 and tacrolimus on ischemia-reperfusion injury of the liver. 2009 World J. Gastroenterol. pmid:19960569
Hilgard P et al. Cyclosporine versus tacrolimus in patients with HCV infection after liver transplantation: effects on virus replication and recurrent hepatitis. 2006 World J. Gastroenterol. pmid:16521181
Eshraghian A et al. Post-transplant lymphoproliferative disorder after liver transplantation: Incidence, long-term survival and impact of serum tacrolimus level. 2017 World J. Gastroenterol. pmid:28275302
Jiang JW et al. Optimal immunosuppressor induces stable gut microbiota after liver transplantation. 2018 World J. Gastroenterol. pmid:30228781
Wu SY et al. Comprehensive risk assessment for early neurologic complications after liver transplantation. 2016 World J. Gastroenterol. pmid:27350733
Liu C et al. Cyclosporine A, FK-506, 40-0-[2-hydroxyethyl]rapamycin and mycophenolate mofetil inhibit proliferation of human intrahepatic biliary epithelial cells in vitro. 2005 World J. Gastroenterol. pmid:16437685
Kawakami K et al. Effects of oral tacrolimus as a rapid induction therapy in ulcerative colitis. 2015 World J. Gastroenterol. pmid:25684955
Lan X et al. Efficacy of immunosuppression monotherapy after liver transplantation: a meta-analysis. 2014 World J. Gastroenterol. pmid:25232269
Del Bello A et al. High tacrolimus intra-patient variability is associated with graft rejection, and donor-specific antibodies occurrence after liver transplantation. 2018 World J. Gastroenterol. pmid:29713132
Meier J and Sturm A Current treatment of ulcerative colitis. 2011 World J. Gastroenterol. pmid:21912469
Okan G et al. Vanishing bile duct and Stevens-Johnson syndrome associated with ciprofloxacin treated with tacrolimus. 2008 World J. Gastroenterol. pmid:18698687
Akamatsu N et al. Late-onset acute rejection after living donor liver transplantation. 2006 World J. Gastroenterol. pmid:17075982
Larsen FS et al. Low-dose tacrolimus ameliorates liver inflammation and fibrosis in steroid refractory autoimmune hepatitis. 2007 World J. Gastroenterol. pmid:17589903
Wietzke-Braun P et al. Initial steroid-free immunosuppression after liver transplantation in recipients with hepatitis C virus related cirrhosis. 2004 World J. Gastroenterol. pmid:15259068
Higashi H et al. First successful perinatal management of pregnancy after ABO-incompatible liver transplantation. 2017 World J. Gastroenterol. pmid:28210092
Shao ZY et al. Prophylaxis of chronic kidney disease after liver transplantation--experience from west China. 2012 World J. Gastroenterol. pmid:22408361
Indriolo A and Ravelli P Clinical management of inflammatory bowel disease in the organ recipient. 2014 World J. Gastroenterol. pmid:24707135
Buchholz BM et al. Role of colectomy in preventing recurrent primary sclerosing cholangitis in liver transplant recipients. 2018 World J. Gastroenterol. pmid:30065563
Shen T et al. Reversible sinusoidal obstruction syndrome associated with tacrolimus following liver transplantation. 2015 World J. Gastroenterol. pmid:26034381
Jordan ML et al. The use of tacrolimus in renal transplantation. 1996 World J Urol pmid:8873438
Schlosser K et al. Surgical treatment of tertiary hyperparathyroidism: the choice of procedure matters! 2007 World J Surg pmid:17665243
Platz KP et al. Management of acute steroid-resistant rejection after liver transplantation. 1996 World J Surg pmid:8798364
Sutherland DE et al. Pancreas transplantation for treatment of diabetes mellitus. 2001 World J Surg pmid:11344403
Kato T et al. Intestinal and multivisceral transplantation. 2002 World J Surg pmid:11865353
Motoyama K et al. Pretransplant intrathymic inoculation of donor antigen combined with FK506 treatment: prolongation of survival of cardiac, but not renal, allografts in rats. 1995 Mar-Apr World J Surg pmid:7538717
Ramakant P and Agarwal G Surgical treatment of tertiary hyperparathyroidism: the choice of procedure matters: surgical management of tertiary hyperparathyroidism: an enigma. 2008 World J Surg pmid:18404286
Montenegro F et al. Surgical treatment of tertiary hyperparathyroidism: the choice of procedure matters! 2008 World J Surg pmid:18204944
Zong YP et al. Effects of CYP3A5 polymorphisms on tacrolimus pharmacokinetics in pediatric kidney transplantation: a systematic review and meta-analysis of observational studies. 2017 World J Pediatr pmid:28540692
Yang EM et al. Tacrolimus for children with refractory nephrotic syndrome: a one-year prospective, multicenter, and open-label study of Tacrobell®, a generic formula. 2016 World J Pediatr pmid:26684309
Kallash M and Aviles D Efficacy of tacrolimus in the treatment of children with focal segmental glomerulosclerosis. 2014 World J Pediatr pmid:24801235
Schwarz C et al. Rescue therapy with tacrolimus and mycophenolate mofetil does not prevent deterioration of graft function in C4d-positive chronic allograft nephropathy. 2006 Wien. Klin. Wochenschr. pmid:16865644
Sperr WR et al. [Effector cells in allergy: biological principles and new pharmacologic concepts]. 1993 Wien. Klin. Wochenschr. pmid:7508662
Haas M et al. Hypothyroidism as a cause of tacrolimus intoxication and acute renal failure: a case report. 2000 Wien. Klin. Wochenschr. pmid:11144010
Bakardzhiev I et al. Unilateral unique Lupus tumidus: pathogenetic mystery and diagnostic problem. 2016 Wien Med Wochenschr pmid:26762262
Durrant-Finn U et al. [Pruritus and dryness of the skin in chronic kidney insufficiency and dialysis patients - a review]. 2009 Wien Med Wochenschr pmid:19652938
Trunečka P [Immunosuppression after liver transplant, now and in future]. 2013 Vnitr Lek pmid:24007221
Kass L et al. Inhibition of the calcineurin-like protein phosphatase activity in Limulus ventral eye photoreceptor cells alters the characteristics of the spontaneous quantal bumps and the light-mediated inward currents, and enhances arrestin phosphorylation. 1998 Nov-Dec Vis. Neurosci. pmid:9839968
Carbajo-Lozoya J et al. Human coronavirus NL63 replication is cyclophilin A-dependent and inhibited by non-immunosuppressive cyclosporine A-derivatives including Alisporivir. 2014 Virus Res. pmid:24566223
Carbajo-Lozoya J et al. Replication of human coronaviruses SARS-CoV, HCoV-NL63 and HCoV-229E is inhibited by the drug FK506. 2012 Virus Res. pmid:22349148
Juvvadi PR et al. Calcineurin in fungal virulence and drug resistance: Prospects for harnessing targeted inhibition of calcineurin for an antifungal therapeutic approach. 2017 Virulence pmid:27325145
Mahalingam R et al. Simian varicella virus reactivation in cynomolgus monkeys. 2007 Virology pmid:17651776
Goldfeld AE et al. Cyclosporin A and FK506 block induction of the Epstein-Barr virus lytic cycle by anti-immunoglobulin. 1995 Virology pmid:7538254