| MeSH term | MeSH ID | Detail |
|---|---|---|
| Edema | D004487 | 152 associated lipids |
| Precancerous Conditions | D011230 | 48 associated lipids |
| Postoperative Complications | D011183 | 5 associated lipids |
| Arthritis | D001168 | 41 associated lipids |
| Arthritis, Experimental | D001169 | 24 associated lipids |
| Surgical Wound Infection | D013530 | 7 associated lipids |
| Neoplasm Recurrence, Local | D009364 | 5 associated lipids |
| Osteonecrosis | D010020 | 5 associated lipids |
| Hypotension | D007022 | 41 associated lipids |
| Acute Kidney Injury | D058186 | 34 associated lipids |
tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Tanaka K et al. | Significant association between CYP3A5 polymorphism and blood concentration of tacrolimus in patients with connective tissue diseases. | 2014 | J. Hum. Genet. | pmid:24352002 |
| Gołębiewska J et al. | Tako-tsubo cardiomyopathy on the first day after renal transplantation - case report and literature review. | 2014 | Transplant. Proc. | pmid:25380951 |
| Ünlüsoy Aksu A et al. | Immune thrombocytopenic purpura in a liver transplant patient. | 2014 | Exp Clin Transplant | pmid:24635822 |
| Bakkour W et al. | Successful use of dapsone for the management of circinate balanitis. | 2014 | Clin. Exp. Dermatol. | pmid:24635073 |
| Kapoor K et al. | Lip hypertrophy due to cyclosporine therapy. | 2014 | Clin. Exp. Nephrol. | pmid:23615783 |
| Xu H et al. | The allo- and viral-specific immunosuppressive effect of belatacept, but not tacrolimus, attenuates with progressive T cell maturation. | 2014 | Am. J. Transplant. | pmid:24472192 |
| Lankarani KB et al. | Response to: Comment on: New-onset diabetes and impaired fasting glucose after liver transplant: risk analysis and the impact of tacrolimus dose. | 2014 | Exp Clin Transplant | pmid:24471728 |
| Kuypers DR et al. | Combined effects of CYP3A5*1, POR*28, and CYP3A4*22 single nucleotide polymorphisms on early concentration-controlled tacrolimus exposure in de-novo renal recipients. | 2014 | Pharmacogenet. Genomics | pmid:25322286 |
| Grillo E et al. | Necrobiosis lipoidica. | 2014 | Aust Fam Physician | pmid:24600675 |
| Kimura Y et al. | Evaluation of the Multi-ImmunoTox Assay composed of 3 human cytokine reporter cells by examining immunological effects of drugs. | 2014 | Toxicol In Vitro | pmid:24603311 |
| Demmers MW et al. | Limited efficacy of immunosuppressive drugs on CD8+ T cell-mediated and natural killer cell-mediated lysis of human renal tubular epithelial cells. | 2014 | Transplantation | pmid:24704664 |
| Størset E et al. | Importance of hematocrit for a tacrolimus target concentration strategy. | 2014 | Eur. J. Clin. Pharmacol. | pmid:24071959 |
| Sun Z et al. | Co-administration of Wuzhi capsules and tacrolimus in patients with idiopathic membranous nephropathy: clinical efficacy and pharmacoeconomics. | 2014 | Int Urol Nephrol | pmid:25145781 |
| Dannhorn E et al. | De novo use of generic tacrolimus in liver transplantation - a single center experience with one-yr follow-up. | 2014 | Clin Transplant | pmid:25142496 |
| Feliu J et al. | Transplant-acquired food allergy (TAFA) following cord blood stem cell transplantation in two adult patients with haematological malignancies. | 2014 | Br. J. Haematol. | pmid:24962133 |
| Grossman J et al. | Nonmyeloablative allogeneic hematopoietic stem cell transplantation for GATA2 deficiency. | 2014 | Biol. Blood Marrow Transplant. | pmid:25111582 |
| Kaieda S et al. | Successful treatment of rectal ulcers in a patient with systemic lupus erythematosus using corticosteroids and tacrolimus. | 2014 | Mod Rheumatol | pmid:24593214 |
| Little JA et al. | The safety and efficacy of noncorticosteroid triple immunosuppressive therapy in the treatment of refractory chronic noninfectious uveitis in childhood. | 2014 | J. Rheumatol. | pmid:24085549 |
| Matin M et al. | The effectiveness of excimer laser on vitiligo treatment in comparison with a combination therapy of Excimer laser and tacrolimus in an Iranian population. | 2014 | J Cosmet Laser Ther | pmid:25046236 |
| de la Fuente V et al. | Calcineurin phosphatase as a negative regulator of fear memory in hippocampus: control on nuclear factor-κB signaling in consolidation and reconsolidation. | 2014 | Hippocampus | pmid:25043904 |
| Qi H et al. | Enhancement of ascomycin production in Streptomyces hygroscopicus var. ascomyceticus by combining resin HP20 addition and metabolic profiling analysis. | 2014 | J. Ind. Microbiol. Biotechnol. | pmid:24965502 |
| Jannot M et al. | Early conversion from twice-daily tacrolimus to once-daily extended formulation in renal transplant patients before hospital discharge. | 2014 | Ann. Transplant. | pmid:24999809 |
| Wannhoff A et al. | Increased levels of rivaroxaban in patients after liver transplantation treated with cyclosporine A. | 2014 | Transplantation | pmid:25022236 |
| Nafar M et al. | Prevalence and risk factors of recurrent cytomegalovirus infection in kidney transplant recipients. | 2014 | Iran J Kidney Dis | pmid:24878947 |
| van Gelder T | Within-patient variability in immunosuppressive drug exposure as a predictor for poor outcome after transplantation. | 2014 | Kidney Int. | pmid:24875549 |
| Maeda H et al. | Disappearance of GFP-positive hepatocytes transplanted into the liver of syngeneic wild-type rats pretreated with retrorsine. | 2014 | PLoS ONE | pmid:24796859 |
| Du W et al. | Improved FK506 production by the precursors and product-tolerant mutant of Streptomyces tsukubaensis based on genome shuffling and dynamic fed-batch strategies. | 2014 | J. Ind. Microbiol. Biotechnol. | pmid:24788378 |
| Nkongolo S et al. | Cyclosporin A inhibits hepatitis B and hepatitis D virus entry by cyclophilin-independent interference with the NTCP receptor. | 2014 | J. Hepatol. | pmid:24295872 |
| Gillard P et al. | Early alteration of kidney function in nonuremic type 1 diabetic islet transplant recipients under tacrolimus-mycophenolate therapy. | 2014 | Transplantation | pmid:24770614 |
| Pandey S et al. | Metabotropic glutamate receptor 1 recycles to the cell surface in protein phosphatase 2A-dependent manner in non-neuronal and neuronal cell lines. | 2014 | J. Neurochem. | pmid:25113668 |
| Madian AG et al. | Case report: Inability to achieve a therapeutic dose of tacrolimus in a pediatric allogeneic stem cell transplant patient after generic substitution. | 2014 | BMC Pharmacol Toxicol | pmid:25472557 |
| Heilman RL et al. | Delayed allograft inflammation following alemtuzumab induction for kidney transplantation. | 2013 Sep-Oct | Clin Transplant | pmid:23924146 |
| Benoit S and Hamm H | Psoriasis from a prosthesis: unusual Koebner phenomenon in a girl with autoamputation of the leg. | 2013 Sep-Oct | Pediatr Dermatol | pmid:23360396 |
| Zahdi MR et al. | Erosive pustular dermatosis of the scalp successfully treated with oral prednisone and topical tacrolimus. | 2013 Sep-Oct | An Bras Dermatol | pmid:24173187 |
| Riva N et al. | [Pharmacovigilance of calcineurin inhibitor in peidatric kidney and liver transplantation]. | 2013 Nov-Dec | Farm Hosp | pmid:24256007 |
| Brodrick B et al. | Influence of treatments on prognosis for vulvar lichen sclerosus: facts and controversies. | 2013 Nov-Dec | Clin. Dermatol. | pmid:24160287 |
| Bloom RD et al. | A randomized, crossover pharmacokinetic study comparing generic tacrolimus vs. the reference formulation in subpopulations of kidney transplant patients. | 2013 Nov-Dec | Clin Transplant | pmid:24118450 |
| Labirua-Iturburu A et al. | Calcineurin inhibitors in a cohort of patients with antisynthetase-associated interstitial lung disease. | 2013 May-Jun | Clin. Exp. Rheumatol. | pmid:23465087 |
| Chen SY et al. | Individualization of tacrolimus dosage basing on cytochrome P450 3A5 polymorphism--a prospective, randomized, controlled study. | 2013 May-Jun | Clin Transplant | pmid:23432535 |
| Ramirez CB et al. | Completely steroid-free immunosuppression in liver transplantation: a randomized study. | 2013 May-Jun | Clin Transplant | pmid:23621629 |
| Krishna N et al. | Tacrolimus-induced paranoid delusions and fugue-like state. | 2013 May-Jun | Gen Hosp Psychiatry | pmid:22959421 |
| He L et al. | Treatment of idiopathic membranous nephropathy with combination of low-dose tacrolimus and corticosteroids. | 2013 May-Jun | J. Nephrol. | pmid:22956434 |
| Kanzelmeyer NK et al. | Correlations with six-month protocol biopsy findings in pediatric transplant recipients on low- and regular-dose CNI regimens. | 2013 Mar-Apr | Clin Transplant | pmid:23414365 |
| Tiwari R et al. | Enhancements in healthcare information technology systems: customizing vendor-supplied clinical decision support for a high-risk patient population. | 2013 Mar-Apr | J Am Med Inform Assoc | pmid:22813760 |
| Albekairy A et al. | Cytochrome P450 3A4FNx011B as pharmacogenomic predictor of tacrolimus pharmacokinetics and clinical outcome in the liver transplant recipients. | 2013 Mar-Apr | Saudi J Gastroenterol | pmid:23481136 |
| LaMattina JC et al. | Native kidney function following liver transplantation using calcineurin inhibitors: single-center analysis with 20 years of follow-up. | 2013 Mar-Apr | Clin Transplant | pmid:23294013 |
| Alfson ED et al. | Lysis of catatonic withdrawal by propofol in a bone-marrow transplant recipient with adenovirus limbic encephalitis. | 2013 Mar-Apr | Psychosomatics | pmid:22705183 |
| Yoshida EM et al. | Canadian national retrospective chart review comparing the long term effect of cyclosporine vs. tacrolimus on clinical outcomes in patients with post-liver transplantation hepatitis C virus infection. | 2013 Mar-Apr | Ann Hepatol | pmid:23396740 |
| Castillo G et al. | [Acute cellular rejection in a liver transplantation patient due to changing the brand of a generic immunosuppressant]. | 2013 Jul-Sep | Rev Gastroenterol Mex | pmid:23866966 |
| Bechstein WO et al. | A comparative, randomized trial of concentration-controlled sirolimus combined with reduced-dose tacrolimus or standard-dose tacrolimus in renal allograft recipients. | 2013 Jul-Aug | Transplant. Proc. | pmid:23953523 |
| Zhao YJ et al. | Late, severe, noninfectious diarrhea after renal transplantation: high-risk factors, therapy, and prognosis. | 2013 Jul-Aug | Transplant. Proc. | pmid:23953533 |
| Weiler N et al. | Tacrolimus effects and side effects after liver transplantation: is there a difference between immediate and extended release? | 2013 Jul-Aug | Transplant. Proc. | pmid:23953543 |
| Stringa P et al. | Ischemic preconditioning and tacrolimus pretreatment as strategies to attenuate intestinal ischemia-reperfusion injury in mice. | 2013 Jul-Aug | Transplant. Proc. | pmid:23953566 |
| Tachibana A et al. | Repopulation of the immunosuppressed retrorsine-treated infant rat liver with human hepatocytes. | 2013 Jul-Aug | Xenotransplantation | pmid:23683097 |
| Favi E et al. | Tacrolimus plus mycophenolate mofetil vs. cyclosporine plus everolimus in deceased donor kidney transplant recipients: three-yr results of a single-center prospective clinical trial. | 2013 Jul-Aug | Clin Transplant | pmid:23710603 |
| Eberlin M et al. | Increased medication compliance of liver transplant patients switched from a twice-daily to a once-daily tacrolimus-based immunosuppressive regimen. | 2013 Jul-Aug | Transplant. Proc. | pmid:23726723 |
| Satyanarayan HS et al. | Efficacy and tolerability of combined treatment with NB-UVB and topical tacrolimus versus NB-UVB alone in patients with vitiligo vulgaris: a randomized intra-individual open comparative trial. | 2013 Jul-Aug | Indian J Dermatol Venereol Leprol | pmid:23760325 |
| Babalola O and Strober BE | Treatment of atopic dermatitis in pregnancy. | 2013 Jul-Aug | Dermatol Ther | pmid:23914886 |
| Conti R et al. | Jessner-Kanof disease: two effective and sure therapeutic options. | 2013 Jul-Aug | Dermatol Ther | pmid:23914897 |
| Chakkera HA et al. | Genetic differences in Native Americans and tacrolimus dosing after kidney transplantation. | 2013 Jan-Feb | Transplant. Proc. | pmid:23375287 |
| Tian Ch et al. | B- and T-lymphocyte attenuator/herpes virus entry mediator as early indicators for acute rejection following kidney transplantation. | 2013 Jan-Feb | Transplant. Proc. | pmid:23375291 |
| Yao B et al. | The incidence of posttransplantation diabetes mellitus during follow-up in kidney transplant recipients and relationship to Fok1 vitamin D receptor polymorphism. | 2013 Jan-Feb | Transplant. Proc. | pmid:23375298 |
| Miyazaki T et al. | Two case reports of successful withdrawal of mycofenolate mofetil after living donor lobar lung transplantation. | 2013 Jan-Feb | Transplant. Proc. | pmid:23375323 |
| Chang HY et al. | Long-term follow-up of arrhythmia characteristics and clinical outcomes in heart transplant patients. | 2013 Jan-Feb | Transplant. Proc. | pmid:23375324 |
| Al Nahdi N et al. | First successful treatment of post-liver transplant hepatitis C fibrosing cholestatic hepatitis with boceprevir, peginterferon and ribavirin in a pre-transplant null responder. | 2013 Jan-Feb | Ann Hepatol | pmid:23293209 |
| Seco-Melantuche R et al. | [Incidence of drug-induced thrombocytopenia in hospitalized patients]. | 2013 Jan-Feb | Farm Hosp | pmid:23461497 |
| Rao V et al. | A non-induction renal sparing approach after liver transplantation: high dose mycophenolate mofetil with delayed, low-dose tacrolimus. | 2013 Jan-Feb | Transplant. Proc. | pmid:23267806 |
| Langone A et al. | Does reduction in mycophenolic acid dose compromise efficacy regardless of tacrolimus exposure level? An analysis of prospective data from the Mycophenolic Renal Transplant (MORE) Registry. | 2013 Jan-Feb | Clin Transplant | pmid:22861144 |
| Shiba H et al. | Switching from tacrolimus to cyclosporine A to prevent primary biliary cirrhosis recurrence after living-donor liver transplantation. | 2013 Apr-Jun | Int Surg | pmid:23701152 |
| Adamu B et al. | New-onset diabetes after renal transplantation: a case series as seen in a Nigerian kidney transplant population. | 2013 Apr-Jun | Niger J Clin Pract | pmid:23563475 |
| Cangemi G et al. | Comparison of antibody-conjugated magnetic immunoassay and liquid chromatography-tandem mass spectrometry for the measurement of cyclosporine and tacrolimus in whole blood. | 2013 Apr-Jun | Int J Immunopathol Pharmacol | pmid:23755756 |
| Uslu Gokceoglu A et al. | Hyperuricemia in pediatric renal transplant recipients. | 2013 | Exp Clin Transplant | pmid:24344940 |
| Peddi VR et al. | Review of combination therapy with mTOR inhibitors and tacrolimus minimization after transplantation. | 2013 | Transplant Rev (Orlando) | pmid:23932018 |
| Ormaechea-Pérez N et al. | Superficial granulomatous pyoderma. Report of 2 cases treated with topical tacrolimus. | 2013 | Actas Dermosifiliogr | pmid:23933249 |
| Bock ME et al. | Treatment of childhood nephrotic syndrome with long-term, low-dose tacrolimus. | 2013 | Clin. Nephrol. | pmid:23380387 |
| Andrades KM et al. | Modulation of Candida albicans virulence by antirejection immunosuppressant drugs. | 2013 | Transplantation | pmid:23380869 |
| Ali MN et al. | Case series: hemolytic uremic syndrome--another cause of transplant dysfunction. | 2013 | Transplant. Proc. | pmid:24182801 |
| Chen YL et al. | Posaconazole exhibits in vitro and in vivo synergistic antifungal activity with caspofungin or FK506 against Candida albicans. | 2013 | PLoS ONE | pmid:23472097 |
| Tsukamoto H et al. | Infliximab salvage therapy for patients with ulcerative colitis who failed to respond to tacrolimus. | 2013 | Eur J Gastroenterol Hepatol | pmid:23411870 |
| Zhang J et al. | Helminth protein vaccine induced follicular T helper cell for enhancement of humoral immunity against Schistosoma japonicum. | 2013 | Biomed Res Int | pmid:24308005 |
| Gordon S et al. | Success using tacrolimus in patients with proliferative and membranous lupus nephritis and refractory proteinuria. | 2013 | Hawaii J Med Public Health | pmid:24052913 |
| Bouamar R et al. | Tacrolimus predose concentrations do not predict the risk of acute rejection after renal transplantation: a pooled analysis from three randomized-controlled clinical trials(†). | 2013 | Am. J. Transplant. | pmid:23480233 |
| Kanzaki T et al. | Long-term therapeutic effects and safety of tacrolimus added to methotrexate in patients with rheumatoid arthritis. | 2013 | Rheumatol. Int. | pmid:22806421 |
| Watanabe M et al. | Efficacy of DHMEQ, a NF-κB inhibitor, in islet transplantation: II. Induction DHMEQ treatment ameliorates subsequent alloimmune responses and permits long-term islet allograft acceptance. | 2013 | Transplantation | pmid:23860082 |
| Kim YC et al. | Tacrolimus decreases albuminuria in patients with IgA nephropathy and normal blood pressure: a double-blind randomized controlled trial of efficacy of tacrolimus on IgA nephropathy. | 2013 | PLoS ONE | pmid:23977072 |
| Bumbacea RS and Ghiordanescu I | Atopic dermatitis induced by systemic immunosupression with tacrolimus--case report. | 2013 | Eur Ann Allergy Clin Immunol | pmid:23862401 |
| Zhang JJ et al. | Effect of the P450 oxidoreductase 28 polymorphism on the pharmacokinetics of tacrolimus in Chinese healthy male volunteers. | 2013 | Eur. J. Clin. Pharmacol. | pmid:23097010 |
| Wang NK et al. | Origin of fundus hyperautofluorescent spots and their role in retinal degeneration in a mouse model of Goldmann-Favre syndrome. | 2013 | Dis Model Mech | pmid:23828046 |
| Li X et al. | Tacrolimus as rescue therapy for adult-onset refractory minimal change nephrotic syndrome with reversible acute renal failure. | 2013 | Nephrol. Dial. Transplant. | pmid:23787554 |
| Zahn A et al. | Mycophenolate mofetil combination therapy improves survival after liver transplantation. A single-center retrospective analysis. | 2013 | Ann. Transplant. | pmid:24088725 |
| Rodriguez-Rodriguez AE et al. | The higher diabetogenic risk of tacrolimus depends on pre-existing insulin resistance. A study in obese and lean Zucker rats. | 2013 | Am. J. Transplant. | pmid:23651473 |
| Yuan H et al. | Effect of prolonged tacrolimus treatment in idiopathic membranous nephropathy with nephrotic syndrome. | 2013 | Pharmacology | pmid:23652322 |
| Tirado-Sánchez A and Ponce-Olivera RM | Tacrolimus in confluent and reticulated papillomatosis of Gougerot Carteaud. | 2013 | Int. J. Dermatol. | pmid:22512695 |
| Rerknimitr P et al. | Topical tacrolimus significantly promotes repigmentation in idiopathic guttate hypomelanosis: a double-blind, randomized, placebo-controlled study. | 2013 | J Eur Acad Dermatol Venereol | pmid:22324720 |
| Barequet IS et al. | Topical tacrolimus for the management of acute allergic conjunctivitis in a mouse model. | 2013 | Graefes Arch. Clin. Exp. Ophthalmol. | pmid:23553288 |
| Moore LW | Food, food components, and botanicals affecting drug metabolism in transplantation. | 2013 | J Ren Nutr | pmid:23611558 |
| Ramos E et al. | Post-transplant lymphoproliferative disorders and other malignancies after pediatric intestinal transplantation: incidence, clinical features and outcome. | 2013 | Pediatr Transplant | pmid:23730927 |
| Zhao W et al. | Limited sampling strategy using Bayesian estimation for estimating individual exposure of the once-daily prolonged-release formulation of tacrolimus in kidney transplant children. | 2013 | Eur. J. Clin. Pharmacol. | pmid:23208323 |
| Tavira B et al. | A search for new CYP3A4 variants as determinants of tacrolimus dose requirements in renal-transplanted patients. | 2013 | Pharmacogenet. Genomics | pmid:23778326 |
| Lieber SR and Volk ML | Non-adherence and graft failure in adult liver transplant recipients. | 2013 | Dig. Dis. Sci. | pmid:23053889 |