| MeSH term | MeSH ID | Detail |
|---|---|---|
| Edema | D004487 | 152 associated lipids |
| Precancerous Conditions | D011230 | 48 associated lipids |
| Postoperative Complications | D011183 | 5 associated lipids |
| Arthritis | D001168 | 41 associated lipids |
| Arthritis, Experimental | D001169 | 24 associated lipids |
| Surgical Wound Infection | D013530 | 7 associated lipids |
| Neoplasm Recurrence, Local | D009364 | 5 associated lipids |
| Osteonecrosis | D010020 | 5 associated lipids |
| Hypotension | D007022 | 41 associated lipids |
| Acute Kidney Injury | D058186 | 34 associated lipids |
tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Boughton O et al. | A published pharmacogenetic algorithm was poorly predictive of tacrolimus clearance in an independent cohort of renal transplant recipients. | 2013 | Br J Clin Pharmacol | pmid:23305195 |
| Li Q et al. | Development and validation of a sensitive LC-MS/MS method for determination of tacrolimus on dried blood spots. | 2013 | Biomed. Chromatogr. | pmid:22893355 |
| Tsapepas D et al. | Sublingual tacrolimus: a pharmacokinetic evaluation pilot study. | 2013 | Pharmacotherapy | pmid:23307542 |
| Wimmer CD et al. | Impact of cyclosporine versus tacrolimus on the incidence of de novo malignancy following liver transplantation: a single center experience with 609 patients. | 2013 | Transpl. Int. | pmid:23952102 |
| Ladizinski B et al. | Frontal fibrosing alopecia: a retrospective review of 19 patients seen at Duke University. | 2013 | J. Am. Acad. Dermatol. | pmid:23375454 |
| Naora Y et al. | Expression analysis of XPhyH-like during development and tail regeneration in Xenopus tadpoles: possible role of XPhyH-like expressing immune cells in impaired tail regenerative ability. | 2013 | Biochem. Biophys. Res. Commun. | pmid:23313512 |
| Dumortier J et al. | Conversion from twice daily tacrolimus to once daily tacrolimus in long-term stable liver transplant recipients: a single-center experience with 394 patients. | 2013 | Liver Transpl. | pmid:23483701 |
| Chen G et al. | Characterization of a novel CRAC inhibitor that potently blocks human T cell activation and effector functions. | 2013 | Mol. Immunol. | pmid:23357789 |
| Hautz T et al. | Targeting the Kv1.3 potassium channel for immunosuppression in vascularized composite allotransplantation - a pilot study. | 2013 | Transpl. Int. | pmid:23489391 |
| Becker S et al. | Evaluation of a novel commercial assay for the determination of cyclosporine A, tacrolimus, sirolimus, and everolimus by liquid chromatography-tandem mass spectrometric assay. | 2013 | Ther Drug Monit | pmid:23188181 |
| Narayanan M et al. | Outcomes in African American kidney transplant patients receiving tacrolimus and mycophenolic acid immunosuppression. | 2013 | Transplantation | pmid:23423268 |
| Afshar M et al. | The effect of pimecrolimus on innate immunity in subjects with atopic dermatitis: a double-blind, randomized, vehicle-controlled study. | 2013 | Br. J. Dermatol. | pmid:22577776 |
| Levitsky J et al. | Systemic immunoregulatory and proteogenomic effects of tacrolimus to sirolimus conversion in liver transplant recipients. | 2013 | Hepatology | pmid:22234876 |
| Giannelli V et al. | Conversion from twice-daily to once-daily Tacrolimus administration in liver transplant patient: results of long term follow-up. | 2013 | Eur Rev Med Pharmacol Sci | pmid:24174352 |
| Doesch AO et al. | Increased adherence eight months after switch from twice daily calcineurin inhibitor based treatment to once daily modified released tacrolimus in heart transplantation. | 2013 | Drug Des Devel Ther | pmid:24174870 |
| Johannesson L et al. | Preclinical report on allogeneic uterus transplantation in non-human primates. | 2013 | Hum. Reprod. | pmid:23108346 |
| White M et al. | Cardiac signaling molecules and plasma biomarkers after cardiac transplantation: impact of tacrolimus versus cyclosporine. | 2013 | J. Heart Lung Transplant. | pmid:24263023 |
| López E et al. | Immunophilins are involved in the altered platelet aggregation observed in patients with type 2 diabetes mellitus. | 2013 | Curr. Med. Chem. | pmid:23432586 |
| Chung BY et al. | The proactive treatment of atopic dermatitis with tacrolimus ointment in Korean patients: a comparative study between once-weekly and thrice-weekly applications. | 2013 | Br. J. Dermatol. | pmid:23110605 |
| Khanmoradi K et al. | Evaluating safety and efficacy of rabbit antithymocyte globulin induction in elderly kidney transplant recipients. | 2013 | Exp Clin Transplant | pmid:23432665 |
| Aoun B et al. | Protocol biopsies in pediatric renal transplant recipients on cyclosporine versus tacrolimus-based immunosuppression. | 2013 | Pediatr. Nephrol. | pmid:23111894 |
| Suszynski TM et al. | Prospective randomized trial of maintenance immunosuppression with rapid discontinuation of prednisone in adult kidney transplantation. | 2013 | Am. J. Transplant. | pmid:23432755 |
| Arora RB et al. | FK506 attenuates intracerebroventricular streptozotocin-induced neurotoxicity in rats. | 2013 | Behav Pharmacol | pmid:26057771 |
| Takahashi Y et al. | Immunomodulatory therapy versus surgery for Rasmussen syndrome in early childhood. | 2013 | Brain Dev. | pmid:23433490 |
| Chen D et al. | FK506 maturation involves a cytochrome p450 protein-catalyzed four-electron C-9 oxidation in parallel with a C-31 O-methylation. | 2013 | J. Bacteriol. | pmid:23435975 |
| TruneÄka P | [Immunosuppression after liver transplant, now and in future]. | 2013 | Vnitr Lek | pmid:24007221 |
| De Simone C et al. | Tacrolimus 0.1% ointment in nail psoriasis: a randomized controlled open-label study. | 2013 | J Eur Acad Dermatol Venereol | pmid:22788697 |
| Dong QE et al. | [Inhibitory effects of tacrolimus on effector T cells from patients with severe aplastic anemia]. | 2013 | Zhonghua Yi Xue Za Zhi | pmid:24028719 |
| Bayer J et al. | Effect of inhaled tacrolimus on ischemia reperfusion injury in rat lung transplant model. | 2013 | J. Thorac. Cardiovasc. Surg. | pmid:24029291 |
| Bourdeaux C et al. | Prope tolerance after pediatric liver transplantation. | 2013 | Pediatr Transplant | pmid:23171043 |
| Liu YY et al. | The effect of ABCB1 C3435T polymorphism on pharmacokinetics of tacrolimus in liver transplantation: a meta-analysis. | 2013 | Gene | pmid:24042126 |
| Eurich D et al. | YKL-40-gene polymorphism affects acute cellular rejection and fibrosis progression after transplantation for hepatitis C virus-induced liver disease. | 2013 | J. Gastroenterol. Hepatol. | pmid:22989351 |
| Miwa Y et al. | Depression is improved when low-dose tacrolimus is given to rheumatoid arthritis patients showing an inadequate response to biologic agents. | 2013 | Mod Rheumatol | pmid:22990336 |
| Li Y et al. | Low-concentration topical tacrolimus for the treatment of anogenital lichen sclerosus in childhood: maintenance treatment to reduce recurrence. | 2013 | J Pediatr Adolesc Gynecol | pmid:24049806 |
| Sayegh J et al. | A case of severe osteomalacia secondary to phosphate diabetes in a renal transplant recipient. | 2013 | Int Urol Nephrol | pmid:22990413 |
| Annesley TM et al. | Standardization of LC-MS for therapeutic drug monitoring of tacrolimus. | 2013 | Clin. Chem. | pmid:23902823 |
| Chaabane A et al. | Limited sampling strategy of mycophenolic acid in adult kidney transplant recipients: influence of the post-transplant period and the pharmacokinetic profile. | 2013 | J Clin Pharmacol | pmid:23813362 |
| Ma MK et al. | Significant reduction of Tacrolimus trough level after conversion from twice daily Prograf to once daily Advagraf in Chinese renal transplant recipients with or without concomitant diltiazem treatment. | 2013 | Ren Fail | pmid:23815459 |
| Arnold R et al. | Association between calcineurin inhibitor treatment and peripheral nerve dysfunction in renal transplant recipients. | 2013 | Am. J. Transplant. | pmid:23841745 |
| Klintmalm G and O'Farrelly C | Taking the rap: multiple effects of blocking mammalian target of rapamycin. | 2013 | Hepatology | pmid:22767219 |
| Carmona A et al. | Distinct deleterious effects of cyclosporine and tacrolimus and combined tacrolimus-sirolimus on endothelial cells: protective effect of defibrotide. | 2013 | Biol. Blood Marrow Transplant. | pmid:23845694 |
| Min SI et al. | Therapeutic equivalence and pharmacokinetics of generic tacrolimus formulation in de novo kidney transplant patients. | 2013 | Nephrol. Dial. Transplant. | pmid:24084327 |
| Niu YJ et al. | Establishment of tacrolimus-induced diabetes in rat model and assessment of clinical treatments for post-transplant diabetes mellitus in liver transplant recipients. | 2013 | Clin. Lab. | pmid:24133918 |
| Azevedo LS et al. | Seroconversion of 2009 pandemic influenza A (H1N1) vaccination in kidney transplant patients and the influence of different risk factors. | 2013 | Transpl Infect Dis | pmid:24134688 |
| van Boekel GA et al. | Treatment satisfaction in renal transplant patients taking tacrolimus once daily. | 2013 | Clin Ther | pmid:24135441 |
| Sun W et al. | [Association factors analysis of diarrhea in patients receiving kidney transplantation]. | 2013 | Beijing Da Xue Xue Bao | pmid:24136278 |
| Wei H et al. | Effects of traditional chinese medicine Wuzhi capsule on pharmacokinetics of tacrolimus in rats. | 2013 | Drug Metab. Dispos. | pmid:23628674 |
| Maguire O et al. | Nuclear translocation of nuclear factor of activated T cells (NFAT) as a quantitative pharmacodynamic parameter for tacrolimus. | 2013 | Cytometry A | pmid:24136923 |
| Rickels MR et al. | Improvement in β-cell secretory capacity after human islet transplantation according to the CIT07 protocol. | 2013 | Diabetes | pmid:23630300 |
| Nishimura R et al. | Tacrolimus inhibits the revascularization of isolated pancreatic islets. | 2013 | PLoS ONE | pmid:23613708 |
| Namkoong S et al. | Topical tacrolimus does not negatively impact acute skin wound healing. | 2013 | Exp. Dermatol. | pmid:23614749 |
| Thin LW et al. | Oral tacrolimus for the treatment of refractory inflammatory bowel disease in the biologic era. | 2013 | Inflamm. Bowel Dis. | pmid:23615528 |
| Chapin RW et al. | Case report: imaging features in a renal transplant patient with calcineurin inhibitor-induced pain syndrome (CIPS). | 2013 | Skeletal Radiol. | pmid:23615775 |
| Pan F et al. | Tacolimus postconditioning alleviates apoptotic cell death in rats after spinal cord ischemia-reperfusion injury via up-regulating protein-serine-threonine kinases phosphorylation. | 2013 | J. Huazhong Univ. Sci. Technol. Med. Sci. | pmid:24337847 |
| Harikishore A et al. | Adamantyl derivative as a potent inhibitor of Plasmodium FK506 binding protein 35. | 2013 | ACS Med Chem Lett | pmid:24900611 |
| Tszyrsznic W et al. | Two rapid ultra performance liquid chromatography/tandem mass spectrometry (UPLC/MS/MS) methods with common sample pretreatment for therapeutic drug monitoring of immunosuppressants compared to immunoassay. | 2013 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:23584041 |
| Santoro AB et al. | CYP3A5 genotype, but not CYP3A4*1b, CYP3A4*22, or hematocrit, predicts tacrolimus dose requirements in Brazilian renal transplant patients. | 2013 | Clin. Pharmacol. Ther. | pmid:23588314 |
| Poi MJ et al. | Standard pentostatin dose reductions in renal insufficiency are not adequate: selected patients with steroid-refractory acute graft-versus-host disease. | 2013 | Clin Pharmacokinet | pmid:23588536 |
| De Simone P et al. | Everolimus with reduced tacrolimus in liver transplantation. | 2013 | Am. J. Transplant. | pmid:23601137 |
| Guy-Viterbo V et al. | Population pharmacokinetic analysis of tacrolimus in the first year after pediatric liver transplantation. | 2013 | Eur. J. Clin. Pharmacol. | pmid:23588560 |
| Kumar AJ et al. | Pilot study of prophylactic ex vivo costimulated donor leukocyte infusion after reduced-intensity conditioned allogeneic stem cell transplantation. | 2013 | Biol. Blood Marrow Transplant. | pmid:23635453 |
| Ogata H | Response to Roblin and Del Tedesco. | 2013 | Inflamm. Bowel Dis. | pmid:23538853 |
| Ucak H et al. | Efficacy of topical tacrolimus for the treatment of persistent pruritus ani in patients with atopic dermatitis. | 2013 | J Dermatolog Treat | pmid:23638997 |
| Ma L et al. | Comparison of release and penetration of tacrolimus ointment reference and trial formulation after dermal application to pigs by liquid chromatography-electrospray ionization tandem mass spectrometry. | 2013 | Biomed. Chromatogr. | pmid:23657920 |
| MartÃn-Cano FE et al. | mTOR pathway and Ca²⺠stores mobilization in aged smooth muscle cells. | 2013 | Aging (Albany NY) | pmid:23661091 |
| Sanz-Marco E et al. | Treatment of refractory dry eye associated with graft versus host disease with 0.03% tacrolimus eyedrops. | 2013 | J Ocul Pharmacol Ther | pmid:23947579 |
| van Maarseveen EM et al. | Pretransplantation pharmacokinetic curves of tacrolimus in HIV-infected patients on ritonavir-containing cART: a pilot study. | 2013 | Transplantation | pmid:23250333 |
| Hou Q et al. | Pharmacokinetic interaction between tacrolimus and berberine in a child with idiopathic nephrotic syndrome. | 2013 | Eur. J. Clin. Pharmacol. | pmid:23765408 |
| Viana RA et al. | Negative functional interaction between cell integrity MAPK pathway and Rho1 GTPase in fission yeast. | 2013 | Genetics | pmid:23934882 |
| Shivaswamy V et al. | Metformin improves immunosuppressant induced hyperglycemia and exocrine apoptosis in rats. | 2013 | Transplantation | pmid:23250335 |
| Eun SC et al. | Prolongation of the rat composite tissue allograft survival by the combination of tolerogenic immature dendritic cells and short-term treatment with FK506. | 2013 | Transplant. Proc. | pmid:23769045 |
| Xu H et al. | Simultaneous bone marrow and composite tissue transplantation in rats treated with nonmyeloablative conditioning promotes tolerance. | 2013 | Transplantation | pmid:23250336 |
| Li Y et al. | Long-term comparison of rat model of chronic allograft rejection of orthotopic small bowel transplantation induced by cyclosporine versus tacrolimus. | 2013 | Transplant. Proc. | pmid:23769050 |
| Szabó L et al. | Effects of tacrolimus on action potential configuration and transmembrane ion currents in canine ventricular cells. | 2013 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:23250339 |
| Ueno T et al. | Conversion to prolonged-release tacrolimus for pediatric living related donor liver transplant recipients. | 2013 | Transplant. Proc. | pmid:23769087 |
| Oteo I et al. | Tacrolimus pharmacokinetics in the early post-liver transplantation period and clinical applicability via Bayesian prediction. | 2013 | Eur. J. Clin. Pharmacol. | pmid:22660442 |
| Kimelman M and Brandacher G | Trends in immunosuppression after pancreas transplantation: what is in the pipeline? | 2013 | Curr Opin Organ Transplant | pmid:23254700 |
| Fuchs U et al. | Clinical outcome in cardiac transplant recipients receiving tacrolimus retard. | 2013 | Transplant. Proc. | pmid:23769094 |
| Sarkar S et al. | Tacrolimus induced diabetic ketoacidosis in nephrotic syndrome. | 2013 | Indian J Pediatr | pmid:22660906 |
| Gauthier AS et al. | [Galenic and analytic development of tacrolimus 0.06% eye drops]. | 2013 | J Fr Ophtalmol | pmid:23218600 |
| Knops N et al. | From gut to kidney: transporting and metabolizing calcineurin-inhibitors in solid organ transplantation. | 2013 | Int J Pharm | pmid:23711732 |
| Miyauchi T et al. | Therapeutic targeting of the axonal and microvascular change associated with repetitive mild traumatic brain injury. | 2013 | J. Neurotrauma | pmid:23796228 |
| Mourer JS et al. | Impact of late calcineurin inhibitor withdrawal on ambulatory blood pressure and carotid intima media thickness in renal transplant recipients. | 2013 | Transplantation | pmid:23715049 |
| Nagaraja P et al. | Role of insulin resistance indices in predicting new-onset diabetes after kidney transplantation. | 2013 | Transpl. Int. | pmid:23230898 |
| Gaber AO et al. | Conversion from twice-daily tacrolimus capsules to once-daily extended-release tacrolimus (LCPT): a phase 2 trial of stable renal transplant recipients. | 2013 | Transplantation | pmid:23715050 |
| Musso CG et al. | Furosemide test in stage III-chronic kidney disease and kidney transplant patients on tacrolimus. | 2013 | Int Urol Nephrol | pmid:23233031 |
| Goldust M et al. | Treatment of seborrheic dermatitis: comparison of sertaconazole 2 % cream versus pimecrolimus 1 % cream. | 2013 | Ir J Med Sci | pmid:23715821 |
| Im BH et al. | The effects of 8-arm-PEG-catechol/heparin shielding system and immunosuppressive drug, FK506 on the survival of intraportally allotransplanted islets. | 2013 | Biomaterials | pmid:23261215 |
| Nakane S et al. | Successful treatment of stiff person syndrome with sequential use of tacrolimus. | 2013 | J. Neurol. Neurosurg. Psychiatr. | pmid:23715915 |
| Swartz DJ et al. | P-glycoprotein is fully active after multiple tryptophan substitutions. | 2013 | Biochim. Biophys. Acta | pmid:23261390 |
| Yang CH et al. | Effect of tacrolimus on myocardial infarction is associated with inflammation, ROS, MAP kinase and Akt pathways in mini-pigs. | 2013 | J. Atheroscler. Thromb. | pmid:22972310 |
| Peng Y et al. | Donor-derived mesenchymal stem cells combined with low-dose tacrolimus prevent acute rejection after renal transplantation: a clinical pilot study. | 2013 | Transplantation | pmid:23263506 |
| Lee KY et al. | Endothelin-1 enhances the proliferation of normal human melanocytes in a paradoxical manner from the TNF-α-inhibited condition, but tacrolimus promotes exclusively the cellular migration without proliferation: a proposed action mechanism for combination therapy of phototherapy and topical tacrolimus in vitiligo treatment. | 2013 | J Eur Acad Dermatol Venereol | pmid:22404745 |
| Sommers CD et al. | Analyses of marketplace tacrolimus drug product quality: bioactivity, NMR and LC-MS. | 2013 | J Pharm Biomed Anal | pmid:23917038 |
| Noll BD et al. | Validation of an LC-MS/MS method to measure tacrolimus in rat kidney and liver tissue and its application to human kidney biopsies. | 2013 | Ther Drug Monit | pmid:23921430 |
| Snell GI et al. | Evolution to twice daily bolus intravenous tacrolimus: optimizing efficacy and safety of calcineurin inhibitor delivery early post lung transplant. | 2013 | Ann. Transplant. | pmid:23921892 |
| Barbarino JM et al. | PharmGKB summary: cyclosporine and tacrolimus pathways. | 2013 | Pharmacogenet. Genomics | pmid:23922006 |
| Gül FC et al. | The comparison of the impact of ghrelin and tacrolimus on vitreous cytokine levels in an experimental uveitis model. | 2013 | Graefes Arch. Clin. Exp. Ophthalmol. | pmid:23334350 |
| Wojtusciszyn A et al. | Continuous glucose monitoring after kidney transplantation in non-diabetic patients: early hyperglycaemia is frequent and may herald post-transplantation diabetes mellitus and graft failure. | 2013 | Diabetes Metab. | pmid:23999231 |
| Martina MR et al. | The precise chemical-physical nature of the pharmacore in FK506 binding protein inhibition: ElteX, a New class of nanomolar FKBP12 ligands. | 2013 | J. Med. Chem. | pmid:23301792 |