| MeSH term | MeSH ID | Detail |
|---|---|---|
| Edema | D004487 | 152 associated lipids |
| Precancerous Conditions | D011230 | 48 associated lipids |
| Postoperative Complications | D011183 | 5 associated lipids |
| Arthritis | D001168 | 41 associated lipids |
| Arthritis, Experimental | D001169 | 24 associated lipids |
| Surgical Wound Infection | D013530 | 7 associated lipids |
| Neoplasm Recurrence, Local | D009364 | 5 associated lipids |
| Osteonecrosis | D010020 | 5 associated lipids |
| Hypotension | D007022 | 41 associated lipids |
| Acute Kidney Injury | D058186 | 34 associated lipids |
tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Kim EJ et al. | Costimulation blockade alters germinal center responses and prevents antibody-mediated rejection. | 2014 | Am. J. Transplant. | pmid:24354871 |
| Ciancio G et al. | The use of daclizumab, tacrolimus and mycophenolate mofetil in african-american and Hispanic first renal transplant recipients. | 2003 | Am. J. Transplant. | pmid:12859538 |
| Boudjema K et al. | Reduced-dose tacrolimus with mycophenolate mofetil vs. standard-dose tacrolimus in liver transplantation: a randomized study. | 2011 | Am. J. Transplant. | pmid:21466650 |
| Knechtle SJ | Guidance for liver transplant immunosuppression. | 2011 | Am. J. Transplant. | pmid:21466652 |
| Grimm M et al. | Superior prevention of acute rejection by tacrolimus vs. cyclosporine in heart transplant recipients--a large European trial. | 2006 | Am. J. Transplant. | pmid:16686762 |
| Sis B et al. | Reproducibility studies on arteriolar hyaline thickening scoring in calcineurin inhibitor-treated renal allograft recipients. | 2006 | Am. J. Transplant. | pmid:16686769 |
| Ferguson R et al. | Immunosuppression with belatacept-based, corticosteroid-avoiding regimens in de novo kidney transplant recipients. | 2011 | Am. J. Transplant. | pmid:21114656 |
| Shemesh E et al. | The Medication Level Variability Index (MLVI) Predicts Poor Liver Transplant Outcomes: A Prospective Multi-Site Study. | 2017 | Am. J. Transplant. | pmid:28321975 |
| Diaz-Siso JR et al. | Initial experience of dual maintenance immunosuppression with steroid withdrawal in vascular composite tissue allotransplantation. | 2015 | Am. J. Transplant. | pmid:25777324 |
| Rodriguez-Rodriguez AE et al. | The higher diabetogenic risk of tacrolimus depends on pre-existing insulin resistance. A study in obese and lean Zucker rats. | 2013 | Am. J. Transplant. | pmid:23651473 |
| TruneÄŒka P et al. | Renal Function in De Novo Liver Transplant Recipients Receiving Different Prolonged-Release Tacrolimus Regimens-The DIAMOND Study. | 2015 | Am. J. Transplant. | pmid:25707487 |
| Adam R et al. | Improved survival in liver transplant recipients receiving prolonged-release tacrolimus in the European Liver Transplant Registry. | 2015 | Am. J. Transplant. | pmid:25703527 |
| Carenco C et al. | Tacrolimus and the risk of solid cancers after liver transplant: a dose effect relationship. | 2015 | Am. J. Transplant. | pmid:25648361 |
| Heller T et al. | Plasma concentrations of mycophenolic acid acyl glucuronide are not associated with diarrhea in renal transplant recipients. | 2007 | Am. J. Transplant. | pmid:17532750 |
| Grenda R et al. | A randomized trial to assess the impact of early steroid withdrawal on growth in pediatric renal transplantation: the TWIST study. | 2010 | Am. J. Transplant. | pmid:20420639 |
| Toso C et al. | Sequential kidney/islet transplantation: efficacy and safety assessment of a steroid-free immunosuppression protocol. | 2006 | Am. J. Transplant. | pmid:16611343 |
| Lacaille F et al. | Severe dysimmune cytopenia in children treated with tacrolimus after organ transplantation. | 2006 | Am. J. Transplant. | pmid:16611346 |
| Arango C et al. | A 29-year-old renal transplant recipient with acute respiratory failure. | 2012 | Am. J. Trop. Med. Hyg. | pmid:22665592 |
| Kyles AE et al. | Comparison of the in vitro antiproliferative effects of five immunosuppressive drugs on lymphocytes in whole blood from cats. | 2000 | Am. J. Vet. Res. | pmid:10951980 |
| Kyles AE et al. | Pharmacokinetics of tacrolimus after multidose oral administration and efficacy in the prevention of allograft rejection in cats with renal transplants. | 2003 | Am. J. Vet. Res. | pmid:12856780 |
| Holmgren G et al. | Successful pregnancies and fatherhood in familial amyloidotic polyneuropathy (FAP Val30Met) patients with liver transplantation. | 2004 | Amyloid | pmid:15478469 |
| Fix OK et al. | Liver transplant alone without kidney transplant for fibrinogen Aα-chain (AFib) renal amyloidosis. | 2016 | Amyloid | pmid:26972447 |
| Zahdi MR et al. | Erosive pustular dermatosis of the scalp successfully treated with oral prednisone and topical tacrolimus. | 2013 Sep-Oct | An Bras Dermatol | pmid:24173187 |
| Delgado L et al. | Zoon's plasma cell balanitis: a report of two cases treated with pimecrolimus. | 2011 Jul-Aug | An Bras Dermatol | pmid:22068766 |
| Viana Fde O et al. | Acral lichen sclerosus et atrophicus--case report. | 2011 Jul-Aug | An Bras Dermatol | pmid:22068779 |
| Cakici O et al. | Periorbital discoid lupus: a rare localization in a patient with systemic lupus erythematosus. | An Bras Dermatol | pmid:28300917 | |
| Lima RS et al. | Granuloma faciale: a good therapeutic response with the use of topical tacrolimus. | An Bras Dermatol | pmid:26560220 | |
| Sisti A et al. | Effectiveness and safety of topical tacrolimus monotherapy for repigmentation in vitiligo: a comprehensive literature review. | 2016 | An Bras Dermatol | pmid:27192518 |
| Tamler C et al. | Tacrolimus 0,1% ointment in the treatment of vitiligo: a series of cases. | 2011 Jan-Feb | An Bras Dermatol | pmid:21437550 |
| Navas López VM et al. | [Safety and efficacy of oral tacrolimus in the treatment of paediatric inflammatory bowel disease]. | 2009 | An Pediatr (Barc) | pmid:19427822 |
| Tomás ML | [Immunosuppressive agents: side effects]. | 1997 | An R Acad Nac Med (Madr) | pmid:9616947 |
| den Burger JC et al. | Analysis of cyclosporin A, tacrolimus, sirolimus, and everolimus in dried blood spot samples using liquid chromatography tandem mass spectrometry. | 2012 | Anal Bioanal Chem | pmid:22899246 |
| Neu V et al. | On-line solid-phase extraction high-performance liquid chromatography-tandem mass spectrometry for the quantitative analysis of tacrolimus in whole blood hemolyzate. | 2012 | Anal Bioanal Chem | pmid:22797715 |
| Takahashi T et al. | Isolating the whole complex of target proteins of FK506 using affinity resins from novel solid phases. | 2006 | Anal Bioanal Chem | pmid:16601955 |
| Nozaki K et al. | Elimination technique for alkali metal ion adducts from an electrospray ionization process using an on-line ion suppressor. | 2010 | Anal Sci | pmid:20543506 |
| Murakami Y et al. | On-chip micro-flow polystyrene bead-based immunoassay for quantitative detection of tacrolimus (FK506). | 2004 | Anal. Biochem. | pmid:15464959 |
| Sellar KJ et al. | Spectrophotometric assay for calcineurin activity in leukocytes isolated from human blood. | 2006 | Anal. Biochem. | pmid:16979577 |
| Cañadas O et al. | Equilibrium studies of a fluorescent tacrolimus binding to surfactant protein A. | 2005 | Anal. Biochem. | pmid:15802130 |
| Carreras CW et al. | An FKBP12 binding assay based upon biotinylated FKBP12. | 2001 | Anal. Biochem. | pmid:11673895 |
| Ahn SC et al. | A tactic for screening inhibitors of interleukin-2 production. | 2002 | Anal. Biochem. | pmid:12018952 |
| Park JW et al. | Liquid chromatography-mass spectrometry characterization of FK506 biosynthetic intermediates in Streptomyces clavuligerus KCTC 10561BP. | 2009 | Anal. Biochem. | pmid:19539594 |
| Sonatore LM et al. | The utility of FK506-binding protein as a fusion partner in scintillation proximity assays: application to SH2 domains. | 1996 | Anal. Biochem. | pmid:8811923 |
| Blanchet B et al. | Determination of serine/threonine protein phosphatase type 2B PP2B in lymphocytes by HPLC. | 2003 | Anal. Biochem. | pmid:12479828 |
| Ohtsu Y et al. | Selective ligand purification using high-performance affinity beads. | 2005 | Anal. Biochem. | pmid:15745744 |
| Rupprecht KR et al. | Development of a dot-blot assay for screening monoclonal antibodies to low-molecular-mass drugs. | 2010 | Anal. Biochem. | pmid:20696124 |
| Wada A et al. | Ribosome display and photo-cross-linking techniques for in vitro identification of target proteins of bioactive small molecules. | 2014 | Anal. Chem. | pmid:24380432 |
| Hopper JT and Oldham NJ | Alkali metal cation-induced destabilization of gas-phase protein-ligand complexes: consequences and prevention. | 2011 | Anal. Chem. | pmid:21863818 |
| Sage L | Fishing for MAGIC targets. | 2005 | Anal. Chem. | pmid:16285140 |
| Menotta M et al. | Label-free quantification of Tacrolimus in biological samples by atomic force microscopy. | 2015 | Anal. Chim. Acta | pmid:26073814 |
| Gómez-RÃos GA et al. | Rapid determination of immunosuppressive drug concentrations in whole blood by coated blade spray-tandem mass spectrometry (CBS-MS/MS). | 2018 | Anal. Chim. Acta | pmid:29254576 |
| Kim SK et al. | Inflammatory mimetic microfluidic chip by immobilization of cell adhesion molecules for T cell adhesion. | 2012 | Analyst | pmid:22822477 |
| Park JY et al. | Monitoring the status of T-cell activation in a microfluidic system. | 2011 | Analyst | pmid:21623432 |
| Brecht S et al. | FK506 protects against various immune responses and secondary degeneration following cerebral ischemia. | 2009 | Anat Rec (Hoboken) | pmid:19728359 |
| Georgiou GK et al. | Calcineurin inhibitors and male fertility after renal transplantation - a review. | 2016 | Andrologia | pmid:26341518 |
| Lang-Lazdunski L et al. | The effects of FK506 on neurologic and histopathologic outcome after transient spinal cord ischemia induced by aortic cross-clamping in rats. | 2001 | Anesth. Analg. | pmid:11323353 |
| Siniscalchi A et al. | Opioid-induced hyperalgesia and rapid opioid detoxification after tacrolimus administration. | 2008 | Anesth. Analg. | pmid:18227327 |
| Brooksbank RL et al. | Treatment of normal skeletal muscle with FK506 or rapamycin results in halothane-induced muscle contracture. | 1998 | Anesthesiology | pmid:9743407 |
| Chini EN and Walker H | FK506 (tacrolimus) increases halothane-induced Ca2+ release from skeletal muscle sarcoplasmic reticulum. | 2000 | Anesthesiology | pmid:10781282 |
| Brittain DE et al. | Total synthesis of antascomicin B. | 2005 | Angew. Chem. Int. Ed. Engl. | pmid:15806607 |
| Lee KB et al. | Direct monitoring of the inhibition of protein-protein interactions in cells by translocation of PKCδ fusion proteins. | 2011 | Angew. Chem. Int. Ed. Engl. | pmid:21290501 |
| McKenzie KM et al. | Simultaneous identification of multiple protein targets by using complementary-DNA phage display and a natural-product-mimetic probe. | 2004 | Angew. Chem. Int. Ed. Engl. | pmid:15300693 |
| Feng S et al. | A rapidly reversible chemical dimerizer system to study lipid signaling in living cells. | 2014 | Angew. Chem. Int. Ed. Engl. | pmid:24841150 |
| Althoff EA and Cornish VW | A bacterial small-molecule three-hybrid system. | 2002 | Angew. Chem. Int. Ed. Engl. | pmid:12203581 |
| Elisaf M and Mikhailidis DP | Statins and renal function. | 2002 Sep-Oct | Angiology | pmid:12365855 |
| Wüthrich B et al. | Atopic eczema: genetics or environment? | 2007 | Ann Agric Environ Med | pmid:18247450 |
| Sahu MK et al. | High blood tacrolimus and hyperkalemia in a heart transplant patient. | Ann Card Anaesth | pmid:28393798 | |
| Philippe F et al. | [Drug eluting stents: from evidence based medicine to clinical practice]. | 2005 | Ann Cardiol Angeiol (Paris) | pmid:16104621 |
| Panis Y and Valleur P | [Small intestine transplantation. Experimental and clinical results]. | 1993 | Ann Chir | pmid:7504899 |
| Busque S et al. | [Hypertrichosis and gingival hypertrophy regression in renal transplants following the substitution of cyclosporin by tacrolimus]. | 1999 | Ann Chir | pmid:10584376 |
| Martin D et al. | [First case in the world of autoreplantation of a limb associated with oral administration of an immunosupressant agent (FK 506-Tacrolimus)]. | 2005 | Ann Chir Plast Esthet | pmid:16087038 |
| Elloudi S et al. | [Frontal fibrosing alopecia: A prospective study of 20Â cases]. | Ann Dermatol Venereol | pmid:28258757 | |
| Mirkamali A et al. | [Ulcerated necrobiosis lipoidica: successful treatment with topical tacrolimus and hydroxychloroquine]. | 2010 Aug-Sep | Ann Dermatol Venereol | pmid:20804904 |
| Parodi A et al. | Treatment of rosacea. | 2011 | Ann Dermatol Venereol | pmid:22183101 |
| Alquier-Bouffard A et al. | [Chronic actinic dermatitis: treatment with topical tacrolimus (two cases)]. | 2007 Jun-Jul | Ann Dermatol Venereol | pmid:17657183 |
| Schmutz JL | [No increased risk of cancer under pimecrolimus]. | 2016 | Ann Dermatol Venereol | pmid:26708204 |
| Parodi A et al. | [Treatment of rosacea]. | 2011 | Ann Dermatol Venereol | pmid:21907876 |
| Mahé E et al. | [Plane warts in areas of atopic dermatitis treated with tacrolimus ointment]. | 2006 Aug-Sep | Ann Dermatol Venereol | pmid:17053745 |
| Girault PY et al. | [Topical tacrolimus in chronic actinic dermatitis]. | 2008 | Ann Dermatol Venereol | pmid:18929923 |
| Rouxel AM et al. | [Tacrolimus mouthwash as second-line treatment for erosive oral lichen planus]. | 2010 | Ann Dermatol Venereol | pmid:20932447 |
| Schmutz JL et al. | [Contact allergy with tacrolimus then pimecrolimus]. | 2008 | Ann Dermatol Venereol | pmid:18342086 |
| Skowron F et al. | [Important systemic absorption of topical tacrolimus during treatment of severe pemphigus vulgaris]. | 2005 | Ann Dermatol Venereol | pmid:15924053 |
| Martel J et al. | [Subcutaneous mycosis due to Scopulariopsis brevicaulis in an immunocompromised patient]. | 2001 | Ann Dermatol Venereol | pmid:11275588 |
| Reynaert G et al. | [Streptococcal impetigo at topical tacrolimus application sites in a woman with atopic dermatitis]. | 2007 | Ann Dermatol Venereol | pmid:17389853 |
| Paul C | [Science, marketing and pharmacovigilance: the example of topical calcineurin inhibitors]. | 2007 | Ann Dermatol Venereol | pmid:18033059 |
| Al Gain M et al. | [Sirolimus-induced lymphedema in a kidney-transplant recipient: Partial recovery after changeover to tacrolimus]. | 2015 | Ann Dermatol Venereol | pmid:25683011 |
| Chiheb S et al. | [Behçet's disease]. | 2003 Jun-Jul | Ann Dermatol Venereol | pmid:13679709 |
| Baubion E et al. | [Oral lichen planus and treatment with topical tacrolimus rinse]. | 2009 | Ann Dermatol Venereol | pmid:19328313 |
| Schmutz JL et al. | [Kaposi's sarcoma in an AIDS patient after application of tacrolimus (Protopic)]. | 2006 | Ann Dermatol Venereol | pmid:16800194 |
| Henno A et al. | [Improvement of Netherton syndrome associated erythroderma in two adult sisters through use of topical pimecrolimus]. | 2006 | Ann Dermatol Venereol | pmid:16495860 |
| Michel JL and Gain P | [Topical tacrolimus treatment for ocular cicatricial pemphigoid]. | 2006 | Ann Dermatol Venereol | pmid:16508602 |
| Lacour JP | [Topical tacrolimus in dermatology: what can one expect?]. | 2001 | Ann Dermatol Venereol | pmid:11908129 |
| Macario-Barrel A et al. | [Mouth ulcers in patients receiving tacrolimus]. | 2001 | Ann Dermatol Venereol | pmid:11908135 |
| Firmin D et al. | [Tacrolimus ointment in the treatment of chronic cutaneous graft-versus-host disease]. | 2008 | Ann Dermatol Venereol | pmid:18374862 |
| Ferraro V et al. | [Efficacy of topical tacrolimus in Hailey-Hailey disease]. | 2006 | Ann Dermatol Venereol | pmid:16760841 |
| Fery-Blanco C et al. | [Disseminated molluscum contagiosum during topical treatment of atopic dermatitis with tacrolimus: efficacy of cidofovir]. | 2007 | Ann Dermatol Venereol | pmid:17507844 |
| Schmutz J et al. | [Gingival hypertrophy and tacrolimus]. | 2000 Jun-Jul | Ann Dermatol Venereol | pmid:10930868 |
| Lübbe J and Saurat JH | [A monograph on topical tacrolimus (Protopic]. | 2003 | Ann Dermatol Venereol | pmid:12700537 |
| de Prost Y | [The value of topical immunosuppressors in the treatment of atopic dermatitis in children]. | 2005 | Ann Dermatol Venereol | pmid:15984296 |
| Nicolie B | [What is the treatment for atopic dermatitis flares in children?]. | 2005 | Ann Dermatol Venereol | pmid:15984308 |
| de Prost Y | [Can the precautionary principle obstruct therapeutic progress?]. | 2005 Aug-Sep | Ann Dermatol Venereol | pmid:16230911 |