| MeSH term | MeSH ID | Detail |
|---|---|---|
| Edema | D004487 | 152 associated lipids |
| Precancerous Conditions | D011230 | 48 associated lipids |
| Postoperative Complications | D011183 | 5 associated lipids |
| Arthritis | D001168 | 41 associated lipids |
| Arthritis, Experimental | D001169 | 24 associated lipids |
| Surgical Wound Infection | D013530 | 7 associated lipids |
| Neoplasm Recurrence, Local | D009364 | 5 associated lipids |
| Osteonecrosis | D010020 | 5 associated lipids |
| Hypotension | D007022 | 41 associated lipids |
| Acute Kidney Injury | D058186 | 34 associated lipids |
tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Shi J et al. | Activity-dependent induction of tonic calcineurin activity mediates a rapid developmental downregulation of NMDA receptor currents. | 2000 | Neuron | pmid:11086987 |
| Jain A et al. | Long-term follow-up after liver transplantation for alcoholic liver disease under tacrolimus. | 2000 | Transplantation | pmid:11087149 |
| Jain S et al. | Tacrolimus has less fibrogenic potential than cyclosporin A in a model of renal ischaemia-reperfusion injury. | 2000 | Br J Surg | pmid:11091246 |
| Bicknell GR et al. | Differential effects of cyclosporin and tacrolimus on the expression of fibrosis-associated genes in isolated glomeruli from renal transplants. | 2000 | Br J Surg | pmid:11091247 |
| Toki K et al. | Arteriolopathy in non-episode biopsies of renal transplant allograft. | 2000 | Clin Transplant | pmid:11092348 |
| Watanabe S et al. | A peculiar vacuolization in the kidney transplant of a child treated with tacrolimus. | 2000 | Clin Transplant | pmid:11092350 |
| Ambach A et al. | The serine phosphatases PP1 and PP2A associate with and activate the actin-binding protein cofilin in human T lymphocytes. | 2000 | Eur. J. Immunol. | pmid:11093160 |
| Myers SA | Update on new immunomodulatory agents. | 2000 | Adv Dermatol | pmid:11094629 |
| Zabawski EJ et al. | Tacrolimus: pharmacology and therapeutic uses in dermatology. | 2000 | Int. J. Dermatol. | pmid:11095187 |
| Hortelano S et al. | Potentiation by nitric oxide of cyclosporin A and FK506-induced apoptosis in renal proximal tubule cells. | 2000 | J. Am. Soc. Nephrol. | pmid:11095654 |
| Almawi WY and Melemedjian OK | Clinical and mechanistic differences between FK506 (tacrolimus) and cyclosporin A. | 2000 | Nephrol. Dial. Transplant. | pmid:11096132 |
| Satchell S et al. | Pregnancy, tacrolimus, and renal transplantation: survival of a 358-g baby. | 2000 | Nephrol. Dial. Transplant. | pmid:11096162 |
| Lübbe J et al. | Eczema herpeticum during treatment of atopic dermatitis with 0.1% tacrolimus ointment. | 2000 | Dermatology (Basel) | pmid:11096198 |
| Vidal E et al. | Mycophenolate mofetil pharmacokinetics in transplant patients receiving cyclosporine or tacrolimus in combination therapy. | 2000 | Pharmacol. Toxicol. | pmid:11097273 |
| Furlong T et al. | Clinical outcome after conversion to FK 506 (tacrolimus) therapy for acute graft-versus-host disease resistant to cyclosporine or for cyclosporine-associated toxicities. | 2000 | Bone Marrow Transplant. | pmid:11100278 |
| Mori A et al. | Fatal cerebral hemorrhage associated with cyclosporin-A/FK506-related encephalopathy after allogeneic bone marrow transplantation. | 2000 | Ann. Hematol. | pmid:11100753 |
| Fong CW et al. | Specific induction of RGS16 (regulator of G-protein signalling 16) mRNA by protein kinase C in CEM leukaemia cells is mediated via tumour necrosis factor alpha in a calcium-sensitive manner. | 2000 | Biochem. J. | pmid:11104682 |
| Taniguchi T et al. | Phosphorylation of tau is regulated by PKN. | 2001 | J. Biol. Chem. | pmid:11104762 |
| Fatkin D et al. | An abnormal Ca(2+) response in mutant sarcomere protein-mediated familial hypertrophic cardiomyopathy. | 2000 | J. Clin. Invest. | pmid:11104788 |
| pmid:11111152 | ||||
| Jain S et al. | Sub-clinical acute rejection detected using protocol biopsies in patients with delayed graft function. | 2000 | Transpl. Int. | pmid:11111961 |
| Toki K et al. | Clinicopathological evaluation in non-episode biopsies of renal transplant allograft. | 2000 | Transpl. Int. | pmid:11111966 |
| Meyer D et al. | "Tolerogenic effect" of the liver for a small bowel allograft. | 2000 | Transpl. Int. | pmid:11111977 |
| Platz KP et al. | Liver transplantation for alcoholic cirrhosis. | 2000 | Transpl. Int. | pmid:11111978 |
| Ciancio G et al. | Use of tacrolimus and mycophenolate mofetil as induction and maintenance in simultaneous pancreas-kidney transplantation. | 2000 | Transpl. Int. | pmid:11111994 |
| Steurer W et al. | Incidence of intraabdominal infection in a consecutive series of 40 enteric-drained pancreas transplants with FK506 and MMF immunosuppression. | 2000 | Transpl. Int. | pmid:11111995 |
| Mohamed MA et al. | Active TGF-beta1 expression in kidney transplantation: a comparative study of cyclosporin-A (CyA) and tacrolimus (FK506). | 2000 | Transpl. Int. | pmid:11112017 |
| Kainz A et al. | Analysis of 100 pregnancy outcomes in women treated systemically with tacrolimus. | 2000 | Transpl. Int. | pmid:11112018 |
| Segoloni G et al. | Tacrolimus is highly effective in both dual and triple therapy regimens following renal transplantation. Spanish and Italian Tacrolimus Study Group. | 2000 | Transpl. Int. | pmid:11112027 |
| Spada M et al. | Rejection and tacrolimus conversion therapy in paediatric liver transplantation. | 2000 | Transpl. Int. | pmid:11112028 |
| Kohnle M et al. | Conversion from cyclosporine A to tacrolimus after kidney transplantation due to hyperlipidemia. | 2000 | Transpl. Int. | pmid:11112029 |
| Timmermann W et al. | Long-term small bowel allograft function induced by short-term FK 506 application is associated with split tolerance. | 2000 | Transpl. Int. | pmid:11112067 |
| von Steinbüchel N et al. | Assessment of health-related quality-of-life in patients after heart transplantation under therapy with tacrolimus or cyclosporine. | 2000 | Transpl. Int. | pmid:11112084 |
| Bousvaros A et al. | Oral tacrolimus treatment of severe colitis in children. | 2000 | J. Pediatr. | pmid:11113835 |
| Petty EM et al. | Successful bone marrow transplantation in a patient with Schimke immuno-osseous dysplasia. | 2000 | J. Pediatr. | pmid:11113849 |
| Uchida K et al. | Preventive effect of FK 506 (tacrolimus hydrate) on experimentally induced acute liver injury in rats. | 2000 | Dig. Dis. Sci. | pmid:11117573 |
| Braun F et al. | Primary tacrolimus immunosuppression in kidney recipients considered "higher immunological risk". | 2000 | Transplant. Proc. | pmid:11119893 |
| Hu RH et al. | Clinical influencing factors for daily dose, trough level, and relative clearance of tacrolimus in renal transplant recipients. | 2000 | Transplant. Proc. | pmid:11119894 |
| Yashima J et al. | Successful conversion from tacrolimus to cyclosporine after kidney transplantation. | 2000 | Transplant. Proc. | pmid:11119895 |
| Yuan QS et al. | Rescue therapy with tacrolimus in renal graft patients with cyclosporine A-induced hepatotoxicity: a preliminary study. | 2000 | Transplant. Proc. | pmid:11119896 |
| Tanabe K et al. | Japanese single-center experience of kidney transplantation under tacrolimus immunosuppression. | 2000 | Transplant. Proc. | pmid:11119897 |
| Lye WC | Primary tacrolimus-based immunosuppression in renal allograft recipients: a single center experience. | 2000 | Transplant. Proc. | pmid:11119898 |
| Wang XH et al. | Tacrolimus vs CyA Neoral in combination with MMF and steroids after cadaveric renal transplantation. | 2000 | Transplant. Proc. | pmid:11119899 |
| Youhua Z et al. | Clinical study of FK 506 in renal transplant recipients. | 2000 | Transplant. Proc. | pmid:11119900 |
| Park K et al. | Efficacy of tacrolimus in primary kidney transplant patients: multicenter, open-label prospective study. | 2000 | Transplant. Proc. | pmid:11119901 |
| Yu L et al. | Clinical experience with Prograf (tacrolimus, FK 506) in Chinese patients after renal transplantation. | 2000 | Transplant. Proc. | pmid:11119902 |
| Tanabe K et al. | ABO-incompatible living donor kidney transplantation under tacrolimus immunosuppression. | 2000 | Transplant. Proc. | pmid:11119903 |
| Jang HJ et al. | Conversion from cyclosporine to tacrolimus in renal allograft recipients with delayed graft function from severe acute tubular necrosis. | 2000 | Transplant. Proc. | pmid:11119904 |
| Okamoto M et al. | Beneficial effect of multiple drug therapy including tacrolimus in clinical renal transplantation. | 2000 | Transplant. Proc. | pmid:11119905 |
| Tanabe K et al. | Malabsorption of tacrolimus in kidney transplant recipients: a Japanese single center experience. | 2000 | Transplant. Proc. | pmid:11119906 |
| Wong KM et al. | Tacrolimus versus cyclosporine as primary prophylactic therapy after cadaveric renal transplant: two-year survival study. | 2000 | Transplant. Proc. | pmid:11119907 |
| Goto Y et al. | Outcome of tacrolimus-treated renal transplantation from elderly donors. | 2000 | Transplant. Proc. | pmid:11119908 |
| Toda F et al. | Non-heart-beating donor kidney transplantation under tacrolimus immunosuppression. | 2000 | Transplant. Proc. | pmid:11119909 |
| Suzuki K et al. | Effect of tacrolimus in renal transplant recipients with immunoglobulin-A nephropathy. | 2000 | Transplant. Proc. | pmid:11119910 |
| Ichikura H et al. | Conversion of renal transplant immunosuppression from tacrolimus (FK 506) to cyclosporine: a single center experience. | 2000 | Transplant. Proc. | pmid:11119911 |
| Manu M et al. | Impact of tacrolimus on hyperlipidemia after renal transplantation: a Japanese single center experience. | 2000 | Transplant. Proc. | pmid:11119912 |
| Tsang WK et al. | Efficacy and safety of mycophenolate mofetil in different dosages in Asian renal allograft recipients. | 2000 | Transplant. Proc. | pmid:11119921 |
| Ichikawa Y et al. | Acute rejection and the therapeutic choice of drug. | 2000 | Transplant. Proc. | pmid:11119923 |
| Jang HJ et al. | Tacrolimus for rescue therapy in refractory renal allograft rejection. | 2000 | Transplant. Proc. | pmid:11119925 |
| Shimada H et al. | Existence of serum p53 antibodies in cyclosporine A-treated transplant patients: possible detection of p53 protein over-expression. | 2000 | Transplant. Proc. | pmid:11119931 |
| Kim HC and Park SB | Mycophenolate mofetil-induced ischemic colitis. | 2000 | Transplant. Proc. | pmid:11119990 |
| Shimizu T et al. | Risk factors of acute tacrolimus nephrotoxicity in renal allografts. | 2000 | Transplant. Proc. | pmid:11119998 |
| Chueh SC et al. | Drug fever caused by mycophenolate mofetil in a renal transplant recipient--a case report. | 2000 | Transplant. Proc. | pmid:11120003 |
| Vathsala A et al. | Inhibition of apoptosis in anti-CD3-treated peripheral blood lymphocytes by immunosuppressive drugs. | 2000 | Transplant. Proc. | pmid:11120034 |
| Braun F et al. | An ex vivo model to study the intestinal biotransformation of immunosuppressive drugs. | 2000 | Transplant. Proc. | pmid:11120037 |
| Nakao A et al. | Combined effect of donor-specific bone marrow transplantation via portal vein and FK506 on small bowel transplantation in the rat. | 2000 | Transplant. Proc. | pmid:11120044 |
| Luk JM et al. | Immunosuppressive effects of Tripterygium wilfordii polysaccharide on LPS-stimulated human monocytes. | 2000 | Transplant. Proc. | pmid:11120045 |
| Fujikawa K et al. | Effects of tacrolimus on rat thymic epithelial cells. | 2000 | Transplant. Proc. | pmid:11120046 |
| Hossain MA et al. | Effect of the immunosuppressants FK506 and D-allose on allogenic orthotopic liver transplantation in rats. | 2000 | Transplant. Proc. | pmid:11120048 |
| Sekido H et al. | Successful conversion from cyclosporine to tacrolimus for immunosuppression. | 2000 | Transplant. Proc. | pmid:11120096 |
| Koyamada N et al. | Strategy for chronic rejection in recipient of living-related liver transplantation. | 2000 | Transplant. Proc. | pmid:11120102 |
| Harihara Y et al. | Correlation between graft size and necessary tacrolimus dose after living-related liver transplantation. | 2000 | Transplant. Proc. | pmid:11120116 |
| Oishi M et al. | A case of hyperkalemic distal renal tubular acidosis secondary to tacrolimus in living donor liver transplantation. | 2000 | Transplant. Proc. | pmid:11120143 |
| Lo CM et al. | More effective immunosuppression with the use of FK506 after liver transplantation. | 2000 | Transplant. Proc. | pmid:11120161 |
| Moriuchi H et al. | Mechanisms of immunosuppressive effects of FK 506 in light of apoptosis of hepatocytes and infiltrating lymphocytes in rat allografted livers. | 2000 | Transplant. Proc. | pmid:11120182 |
| Tashiro H et al. | Donor bone marrow perioperatively administered via portal vein induced prolongation of skin allograft survival and microchimerism in liver-transplanted rats. | 2000 | Transplant. Proc. | pmid:11120201 |
| Imamura M et al. | FK 506 inhibits severe graft-versus-host disease without mediating cytokine balance and/or cytotoxic molecules. | 2000 | Transplant. Proc. | pmid:11120238 |
| Jang HJ et al. | Comparison of pancreas transplantation outcome between the cyclosporine and tacrolimus eras. | 2000 | Transplant. Proc. | pmid:11120249 |
| Yamaguchi M et al. | FK 506 significantly improves transferred insulin gene expression in total pancreatectomized dogs. | 2000 | Transplant. Proc. | pmid:11120255 |
| Yoshida S et al. | Combination therapy with FK 506 and RS61443 for rejection following allogeneic small bowel transplantation in rats. | 2000 | Transplant. Proc. | pmid:11120262 |
| Braun F et al. | Primary tacrolimus immunosuppression in kidney recipients considered "higher immunologic risk". | 2000 | Transplant. Proc. | pmid:11120281 |
| Braun F et al. | An ex vivo model to study the intestinal biotransformation of immunosuppressives. | 2000 | Transplant. Proc. | pmid:11120282 |
| Ringe B et al. | Replacement of corticosteroids by mycophenolate mofetil in liver graft recipients on initial tacrolimus immunosuppression. | 2000 | Transplant. Proc. | pmid:11120285 |
| Watanabe K et al. | Donor bone marrow cell infusion is effective in inducing tolerance in dogs treated with fractionated lymphoid irradiation and FK506. | 2000 | Transplant. Proc. | pmid:11120286 |
| Frey N and Olson EN | Making matters worse for a broken heart. | 2000 | J. Clin. Invest. | pmid:11120749 |
| Goto Y et al. | Suppressive effects of cyclosporin A and FK-506 on superoxide generation in human polymorphonuclear leukocytes primed by tumor necrosis factor alpha. | 2000 | J. Invest. Dermatol. | pmid:11121130 |
| England K et al. | Signalling pathways regulating the dephosphorylation of Ser729 in the hydrophobic domain of protein kinase Cepsilon upon cell passage. | 2001 | J. Biol. Chem. | pmid:11121415 |
| Arai S and Vogelsang GB | Management of graft-versus-host disease. | 2000 | Blood Rev. | pmid:11124107 |
| Salm P et al. | Evaluation of microparticle enzyme immunoassay against HPLC-mass spectrometry for the determination of whole-blood tacrolimus in heart- and lung-transplant recipients. | 2000 | Clin. Biochem. | pmid:11124341 |
| Revell MP et al. | Conservation of small-airway function by tacrolimus/cyclosporine conversion in the management of bronchiolitis obliterans following lung transplantation. | 2000 | J. Heart Lung Transplant. | pmid:11124493 |
| Nowak JL | [Adverse effects of drug interactions of cyclosporin A and tacrolimus therapy]. | 2000 | Pol. Merkur. Lekarski | pmid:11126995 |
| Becker DB et al. | Effects of FKBP-12 ligands following tibial nerve injury in rats. | 2000 | J Reconstr Microsurg | pmid:11127284 |
| Carnevale-Schianca F et al. | Changing from cyclosporine to tacrolimus as salvage therapy for chronic graft-versus-host disease. | 2000 | Biol. Blood Marrow Transplant. | pmid:11128811 |
| Jongen VH et al. | Vaginal delivery after lung transplantation. | 2000 | Acta Obstet Gynecol Scand | pmid:11130101 |
| Morisaki T et al. | A combination of cyclosporin-A (CsA) and interferon-gamma (INF-gamma) induces apoptosis in human gastric carcinoma cells. | 2000 Sep- Oct | Anticancer Res. | pmid:11131636 |
| Tanaka K et al. | Immunophilin ligands prevent H2O2-induced apoptotic cell death by increasing glutathione levels in neuro 2A neuroblastoma cells. | 2000 | Acta Med. Okayama | pmid:11132921 |
| Martins L et al. | Conversion to tacrolimus in case-problem kidney transplant recipients under cyclosporine-based immunosuppression. | 2000 | Transplant. Proc. | pmid:11134735 |
| Nardo B et al. | Evidence of microchimerism after pretransplant blood transfusion and FK 506 in liver xenograft. | 2000 | Transplant. Proc. | pmid:11134771 |
| Khoury N et al. | Posttransplant diabetes mellitus in kidney transplant recipients under tacrolimus immunosuppression. | 2000 | Transplant. Proc. | pmid:11134791 |
| Tur MD et al. | Apolipoprotein CIII is upregulated by anticalcineurins and rapamycin: implications in transplantation-induced dyslipidemia. | 2000 | Transplant. Proc. | pmid:11134804 |