Kuo CJ et al. |
Rapamycin selectively inhibits interleukin-2 activation of p70 S6 kinase. |
1992 |
Nature |
pmid:1614535
|
Thomson AW et al. |
FK 506, cardiac transplantation, and graft-vessel disease. |
1992 |
Lancet |
pmid:1370563
|
First MR |
Transplantation in the nineties. |
1992 |
Transplantation |
pmid:1370734
|
Naito M et al. |
Reversal of multidrug resistance by an immunosuppressive agent FK-506. |
1992 |
Cancer Chemother. Pharmacol. |
pmid:1370765
|
Yem AW et al. |
The Hsp56 component of steroid receptor complexes binds to immobilized FK506 and shows homology to FKBP-12 and FKBP-13. |
1992 |
J. Biol. Chem. |
pmid:1371107
|
Park ST et al. |
PPIase catalysis by human FK506-binding protein proceeds through a conformational twist mechanism. |
1992 |
J. Biol. Chem. |
pmid:1371117
|
Moutabarrik A et al. |
In vitro FK506 kidney tubular cell toxicity. |
1992 |
Transpl. Int. |
pmid:14621743
|
Moutabarrik A et al. |
FK506 mechanism of nephrotoxicity: stimulatory effect on endothelin secretion by cultured kidney cells. |
1992 |
Transpl. Int. |
pmid:14621744
|
Stangl MJ et al. |
The use of FK506 and RS61443 for reversal of small-bowel rejection. |
1992 |
Transpl. Int. |
pmid:14621800
|
Wijnen RM et al. |
Toxicology of FK506 in the cynomolgus monkey: a clinical, biochemical, and histopathological study. |
1992 |
Transpl. Int. |
pmid:14621844
|
Johnson MC et al. |
QT prolongation and Torsades de Pointes after administration of FK506. |
1992 |
Transplantation |
pmid:1373538
|
Kim YI et al. |
Stimulation of liver regeneration by pretreatment with azathioprine as well as cyclosporine and FK506. |
1992 |
Transplantation |
pmid:1373539
|
Carobbi A et al. |
Synergism of splenectomy and immunosuppressive drugs in prolongation of cardiac xenograft survival. |
1992 |
Transplant. Proc. |
pmid:1373543
|
Ueno M et al. |
Immunosuppressive effect in combination therapy of cyclosporine A, FK 506, and 15-deoxyspergualin on pancreatic islet xenotransplantation. |
1992 |
Transplant. Proc. |
pmid:1373546
|
Matsuzaki T et al. |
Liver transplantation for diethylnitrosamine-induced hepatocellular carcinoma in rats. |
1992 |
Transplant. Proc. |
pmid:1373547
|
Vincent SH et al. |
In vitro metabolism of FK-506 in rat, rabbit, and human liver microsomes: identification of a major metabolite and of cytochrome P450 3A as the major enzymes responsible for its metabolism. |
1992 |
Arch. Biochem. Biophys. |
pmid:1373595
|
Hirai T et al. |
The immunosuppressive effect of FK 506 on canine lung transplantation. |
1992 |
J. Thorac. Cardiovasc. Surg. |
pmid:1375967
|
Tai PK et al. |
Association of a 59-kilodalton immunophilin with the glucocorticoid receptor complex. |
1992 |
Science |
pmid:1376003
|
Jegasothy BV et al. |
Tacrolimus (FK 506)--a new therapeutic agent for severe recalcitrant psoriasis. |
1992 |
Arch Dermatol |
pmid:1376102
|
Wiederrecht G et al. |
Isolation of a human cDNA encoding a 25 kDa FK-506 and rapamycin binding protein. |
1992 |
Biochem. Biophys. Res. Commun. |
pmid:1376117
|
Bernstein L and Daviss SR |
Organic anxiety disorder with symptoms of akathisia in a patient treated with the immunosuppressant FK506. |
1992 |
Gen Hosp Psychiatry |
pmid:1376291
|
Hatfield SM et al. |
Rapamycin and FK506 differentially inhibit mast cell cytokine production and cytokine-induced proliferation and act as reciprocal antagonists. |
1992 |
J. Pharmacol. Exp. Ther. |
pmid:1376361
|
Ericzon BG et al. |
The effect of FK506 treatment on pancreaticoduodenal allotransplantation in the primate. |
1992 |
Transplantation |
pmid:1376501
|
Tze WJ et al. |
FK 506--an effective immunosuppressant in achieving long-term functional islet allograft survival in diabetic rats. |
1992 |
Transplant. Proc. |
pmid:1376509
|
Benigni A et al. |
The acute effect of FK506 and cyclosporine on endothelial cell function and renal vascular resistance. |
1992 |
Transplantation |
pmid:1279848
|
Mor E et al. |
Late-onset acute rejection in orthotopic liver transplantation--associated risk factors and outcome. |
1992 |
Transplantation |
pmid:1279849
|
Hirano Y et al. |
The effects of FK506 and cyclosporine on the exocrine function of the rat pancreas. |
1992 |
Transplantation |
pmid:1279850
|
Takaya S et al. |
Liver transplantation in positive cytotoxic crossmatch cases using FK506, high-dose steroids, and prostaglandin E1. |
1992 |
Transplantation |
pmid:1279851
|
Partaledis JA et al. |
Saccharomyces cerevisiae contains a homolog of human FKBP-13, a membrane-associated FK506/rapamycin binding protein. |
1992 |
Yeast |
pmid:1279908
|
Ozawa K et al. |
An appraisal of pediatric liver transplantation from living relatives. Initial clinical experiences in 20 pediatric liver transplantations from living relatives as donors. |
1992 |
Ann. Surg. |
pmid:1280074
|
Akutsu I et al. |
[Inhibitory effects of cyclosporin A and FK-506 on eosinophil chemotactic factor activity in culture supernatants of mononuclear cells from asthmatics]. |
1992 |
Arerugi |
pmid:1280086
|
Bergstrand H and Lundquist B |
Human basophil histamine release is differently affected by inhibitors of calmodulin, diacylglycerol kinase and peptidyl prolyl cis-trans isomerase in a secretagogue specific manner. |
1992 |
Allergy |
pmid:1280915
|
Natazuka T |
FK506 reverses adriamycin resistance in a multidrug-resistant human leukemia cell line. |
1992 |
Kobe J Med Sci |
pmid:1284834
|
Tocci MJ and Sigal NH |
Recent advances in the mechanism of action of cyclosporine and FK506. |
1992 |
Curr. Opin. Nephrol. Hypertens. |
pmid:1285380
|
Bavandi A et al. |
Diet-induced dermatitis response of hairless rats to systemic treatment with cyclosporin A (Sandimmun), cyclosporin H and FK506. |
1992 |
Exp. Dermatol. |
pmid:1285411
|
High KP and Handschumacher RE |
Immunity, microbial pathogenesis, and immunophilins: finding the keys, now where are the locks? |
1992 |
Infect Agents Dis |
pmid:1285413
|
Akutsu I et al. |
[Inhibitory effect of inhaled FK-506 on increased bronchial responsiveness and eosinophil infiltration in the airway mucosa]. |
1992 |
Arerugi |
pmid:1377905
|
Takaori K et al. |
A comparative study on immunosuppressive effects of cyclosporin A and FK 506 on peripheral blood lymphocytes in dogs. |
1992 |
Biotherapy |
pmid:1377926
|
Murthy JN et al. |
Radioreceptor assay for quantifying FK-506 immunosuppressant in whole blood. |
1992 |
Clin. Chem. |
pmid:1377995
|
Leiva MC and Lyttle CR |
Leukocyte chemotactic activity of FKBP and inhibition by FK506. |
1992 |
Biochem. Biophys. Res. Commun. |
pmid:1379802
|
Iwasaki K et al. |
Effect of repeated oral doses of a novel immunosuppressive macrolide lactone on hepatic mixed-function oxidase system in the rat. Comparative study with ciclosporin. |
1992 |
Arzneimittelforschung |
pmid:1379812
|
Takada K et al. |
Distribution kinetics of FK-506, a novel immunosuppressant, after intravenous administration to rats in comparison with cyclosporin A. |
1992 |
Biopharm Drug Dispos |
pmid:1379839
|
Kahan BD |
Cyclosporin A, FK506, rapamycin: the use of a quantitative analytic tool to discriminate immunosuppressive drug interactions. |
1992 |
J. Am. Soc. Nephrol. |
pmid:1379841
|
Lauerma AI et al. |
Inhibition of contact allergy reactions by topical FK506. |
1992 |
Lancet |
pmid:1380111
|
Steiner JP et al. |
High brain densities of the immunophilin FKBP colocalized with calcineurin. |
1992 |
Nature |
pmid:1380130
|
Aperia A et al. |
Calcineurin mediates alpha-adrenergic stimulation of Na+,K(+)-ATPase activity in renal tubule cells. |
1992 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:1380157
|
Thomson AW and Starzl TE |
FK 506 and autoimmune disease: perspective and prospects. |
1992 |
Autoimmunity |
pmid:1382646
|
Christians U et al. |
Specific and sensitive measurement of FK506 and its metabolites in blood and urine of liver-graft recipients. |
1992 |
Clin. Chem. |
pmid:1382896
|
Fruman DA et al. |
Correlation of calcineurin phosphatase activity and programmed cell death in murine T cell hybridomas. |
1992 |
Eur. J. Immunol. |
pmid:1382988
|
Mittrücker HW and Fleischer B |
Functional localization of an exocytosis-triggering G-protein in human cytotoxic T lymphocytes. |
1992 |
Immunology |
pmid:1383135
|
Yasutomi D et al. |
Inhibition of programmed cell death by cyclosporin A; preferential blocking of cell death induced by signals via TCR/CD3 complex and its mode of action. |
1992 |
Immunology |
pmid:1383138
|
Ruff VA et al. |
Tissue distribution and cellular localization of hsp56, an FK506-binding protein. Characterization using a highly specific polyclonal antibody. |
1992 |
J. Biol. Chem. |
pmid:1383222
|
Wiederrecht G et al. |
Characterization of high molecular weight FK-506 binding activities reveals a novel FK-506-binding protein as well as a protein complex. |
1992 |
J. Biol. Chem. |
pmid:1383226
|
Morris RE |
Immunopharmacology of new xenobiotic immunosuppressive molecules. |
1992 |
Semin. Nephrol. |
pmid:1384096
|
Strom TB |
Molecular immunology and immunopharmacology of allograft rejection. |
1992 |
Kidney Int. Suppl. |
pmid:1383599
|
Wang SC et al. |
FK-506 inhibits proliferation and IL-4 messenger RNA production by a T-helper 2 cell line. |
1992 |
J. Surg. Res. |
pmid:1383612
|
Mizuno K et al. |
Modulation of multidrug resistance by immunosuppressive agents: cyclosporin analogues, FK506 and mizoribine. |
1992 Jan-Feb |
Anticancer Res. |
pmid:1373592
|
Arai S et al. |
The impact of FK506 on graft coronary disease of rat cardiac allograft--a comparison with cyclosporine. |
1992 Jul-Aug |
J. Heart Lung Transplant. |
pmid:1379829
|
Fagiuoli S et al. |
FK 506: a new immunosuppressive agent for organ transplantation. Pharmacology, mechanism of action and clinical applications. |
1992 Jul-Aug |
Ital J Gastroenterol |
pmid:1381245
|
Tong J et al. |
Effect of FK-506 and cyclosporin A on in vitro CFU-GM growth in severe aplastic anemia patients. |
1992 Jul-Aug |
Haematologica |
pmid:1385279
|
Nazer H et al. |
FK 506 associated disorders in liver transplantation. |
1992 May-Jun |
J. Gastroenterol. Hepatol. |
pmid:1377038
|
Bowman H and Lennard TW |
Immunosuppressive drugs. |
1992 Nov 4-17 |
Br J Hosp Med |
pmid:1282440
|
Sattler M et al. |
Cytochrome P-450 3A enzymes are responsible for biotransformation of FK506 and rapamycin in man and rat. |
1992 Sep-Oct |
Drug Metab. Dispos. |
pmid:1385058
|
Jordan ML et al. |
FK 506 salvage of renal allografts with ongoing rejection failing cyclosporine immunosuppression. |
1993 |
Transplant. Proc. |
pmid:7679827
|
Klintmalm GB et al. |
Prognostic factors for successful conversion from cyclosporine to FK 506-based immunosuppressive therapy for refractory rejection after liver transplantation. US Multicenter FK 506 Liver Study Group. |
1993 |
Transplant. Proc. |
pmid:7679828
|
Lane BC et al. |
Evaluation of calcineurin's role in the immunosuppressive activity of FK 506, related macrolactams, and cyclosporine. |
1993 |
Transplant. Proc. |
pmid:7679829
|
Tamura K et al. |
Suppression of autoimmune thyroid disease by FK 506: influence on thyroid-infiltrating cells, adhesion molecule expression and anti-thyroglobulin antibody production. |
1993 |
Clin. Exp. Immunol. |
pmid:7680293
|
Armitage JM et al. |
A decade (1982 to 1992) of pediatric cardiac transplantation and the impact of FK 506 immunosuppression. |
1993 |
J. Thorac. Cardiovasc. Surg. |
pmid:7680396
|
Randhawa PS et al. |
The histopathological changes associated with allograft rejection and drug toxicity in renal transplant recipients maintained on FK506. Clinical significance and comparison with cyclosporine. |
1993 |
Am. J. Surg. Pathol. |
pmid:7680544
|
Xu RX et al. |
Heteronuclear 3D NMR studies of water bound to an FK506 binding protein/immunosuppressant complex. |
1993 |
Biochemistry |
pmid:7680570
|
López-Gil JA and GarcÃa Sáiz M |
[FK506: an immunosuppressor for the '90's?]. |
1993 |
Med Clin (Barc) |
pmid:7505871
|
Kagayama A et al. |
Oral absorption of FK506 in rats. |
1993 |
Pharm. Res. |
pmid:7505939
|
Kim YI et al. |
Augmentation of hepatocyte proliferation by immunosuppressant pretherapy is associated with up-regulation of malondialdehyde production. |
1993 |
Res Exp Med (Berl) |
pmid:7506444
|
Hutchison KA et al. |
FK506 binding to the 56-kilodalton immunophilin (Hsp56) in the glucocorticoid receptor heterocomplex has no effect on receptor folding or function. |
1993 |
Biochemistry |
pmid:7682438
|
Shorrock C and Neuberger J |
The changing face of liver transplantation. |
1993 |
Gut |
pmid:7682532
|
Nakajima J |
[The immunosuppressive effects of FK506 on single lung allotransplantation in Japanese monkey (Macaca fuscata)]. |
1993 |
Nihon Kyobu Geka Gakkai Zasshi |
pmid:7690829
|
Takada K et al. |
Distribution characteristics of immunosuppressants FK506 and cyclosporin A in the blood compartment. |
1993 |
Biopharm Drug Dispos |
pmid:7508273
|
Thomson AW et al. |
Comparative effects of rapamycin, FK 506 and cyclosporine on antibody production, lymphocyte populations and immunoglobulin isotype switching in the rat. |
1993 |
Immunopharmacol Immunotoxicol |
pmid:7693791
|
Tzakis AG et al. |
Intestinal transplantation in children under FK 506 immunosuppression. |
1993 |
J. Pediatr. Surg. |
pmid:7693907
|
Kawauchi M et al. |
Prolonged survival of orthotopically transplanted heart xenograft in infant baboons. |
1993 |
J. Thorac. Cardiovasc. Surg. |
pmid:7693999
|
Shutter LA et al. |
Cortical blindness and white matter lesions in a patient receiving FK506 after liver transplantation. |
1993 |
Neurology |
pmid:7694189
|
Textor SC et al. |
Systemic and renal hemodynamic differences between FK506 and cyclosporine in liver transplant recipients. |
1993 |
Transplantation |
pmid:7685934
|
Lemster B et al. |
Blood lymphocytes of autoimmune disease patients receiving FK506 exhibit normal ex vivo cytokine gene expression and proliferative responses. |
1993 |
Immunol. Lett. |
pmid:7510265
|
Parent SA et al. |
Calcineurin-dependent growth of an FK506- and CsA-hypersensitive mutant of Saccharomyces cerevisiae. |
1993 |
J. Gen. Microbiol. |
pmid:7510323
|
Metcalfe S et al. |
Prodigiosin 25C: effect in in vitro models for T cell activation and T cell cycling and in vivo for rat heart allografts. |
1993 |
Int. Arch. Allergy Immunol. |
pmid:7685216
|
Bumgardner GL and Roberts JP |
New immunosuppressive agents. |
1993 |
Gastroenterol. Clin. North Am. |
pmid:7685324
|
Ahmed SS et al. |
Adrenochrome reaction implicates oxygen radicals in metabolism of cyclosporine A and FK-506 in rat and human liver microsomes. |
1993 |
J. Pharmacol. Exp. Ther. |
pmid:7685382
|
Sewell KL |
Immunotherapy and other novel therapies, including biologic response modifiers, apheresis, and dietary modifications. |
1993 |
Curr Opin Rheumatol |
pmid:7685614
|
Henke W and Jung K |
Comparison of the effects of the immunosuppressive agents FK 506 and cyclosporin A on rat kidney mitochondria. |
1993 |
Biochem. Pharmacol. |
pmid:7690566
|
Altmeyer A and Dumont FJ |
Rapamycin inhibits IL-1-mediated interferon-gamma production in the YAC-1 T cell lymphoma. |
1993 |
Cytokine |
pmid:7687472
|
Przepiorka D et al. |
Bronchiolitis obliterans organizing pneumonia in a BMT patient receiving FK506. |
1993 |
Bone Marrow Transplant. |
pmid:7687503
|
Bram RJ et al. |
Identification of the immunophilins capable of mediating inhibition of signal transduction by cyclosporin A and FK506: roles of calcineurin binding and cellular location. |
1993 |
Mol. Cell. Biol. |
pmid:7687744
|
Fesik SW |
NMR structure-based drug design. |
1993 |
J. Biomol. NMR |
pmid:7689377
|
McManus BM et al. |
Direct myocardial injury by enterovirus: a central role in the evolution of murine myocarditis. |
1993 |
Clin. Immunol. Immunopathol. |
pmid:7689428
|
Namiki Y et al. |
Tautomeric phenomenon of a novel potent immunosuppressant (FK506) in solution. I. Isolation and structure determination of tautomeric compounds. |
1993 |
J. Antibiot. |
pmid:7689551
|
Kondo T et al. |
[Antitumor sensitivity test, subrenal capsule assay using FK-506: preliminary report]. |
1993 |
Nihon Geka Gakkai Zasshi |
pmid:7689693
|
Ibarra F et al. |
Bidirectional regulation of Na+,K(+)-ATPase activity by dopamine and an alpha-adrenergic agonist. |
1993 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:7678337
|
Murase N et al. |
Graft-versus-host disease after brown Norway-to-Lewis and Lewis-to-Brown Norway rat intestinal transplantation under FK506. |
1993 |
Transplantation |
pmid:7678353
|
Herold KC et al. |
Inhibition of glucose-stimulated insulin release from beta TC3 cells and rodent islets by an analog of FK506. |
1993 |
Transplantation |
pmid:7678356
|
Holman MJ et al. |
FK506-associated thrombotic thrombocytopenic purpura. |
1993 |
Transplantation |
pmid:7678357
|