| MeSH term | MeSH ID | Detail |
|---|---|---|
| Intertrigo | D007402 | 1 associated lipids |
| Impetigo | D007169 | 3 associated lipids |
| Nocturnal Myoclonus Syndrome | D020189 | 1 associated lipids |
| Pterygium | D011625 | 3 associated lipids |
| Amyloid Neuropathies | D017772 | 1 associated lipids |
| Mucinoses | D017520 | 2 associated lipids |
| Carcinoma, Merkel Cell | D015266 | 2 associated lipids |
| Nocturia | D053158 | 1 associated lipids |
| Failed Back Surgery Syndrome | D055111 | 3 associated lipids |
| Malacoplakia | D008287 | 1 associated lipids |
tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Tesi RJ et al. | Conversion of pancreas transplants to FK 506 from CsA. | 1995 | Transplant. Proc. | pmid:8539828 |
| Kobayashi M et al. | HLA-DR matching effect in orthotopic liver transplantation under FK 506. | 1993 | Transplant. Proc. | pmid:7679812 |
| Burke GW et al. | Use of FK 506 in simultaneous pancreas/kidney transplantation: lack of impairment of glycemic or lipid metabolism. | 1995 | Transplant. Proc. | pmid:8539872 |
| Charpentier B | Induction versus non-induction protocols in anti-calcineurin-based immunosuppression. | 2001 Nov-Dec | Transplant. Proc. | pmid:11750425 |
| Watanabe K et al. | Fate of long-surviving allografts in tolerant recipients induced by fractionated lymphoid irradiation, donor bone marrow cell infusion, and FK 506 after retransplantation in dogs. | 1993 | Transplant. Proc. | pmid:7679813 |
| Ueki M et al. | Peritoneal-omental pouch as a site for islet allotransplantation. | 1994 | Transplant. Proc. | pmid:7513462 |
| Miura S et al. | Long-term results of spousal renal donor transplants with donor-specific blood transfusions. | 2001 Nov-Dec | Transplant. Proc. | pmid:11750463 |
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| Strasser S et al. | The effect of FK 506 on canine pancreatic islet cell function in beagle dogs. | 1991 | Transplant. Proc. | pmid:1703709 |
| Borro JM et al. | Conversion from cyclosporine to tacrolimus stabilizes the course of lung function in lung transplant recipients with bronchiolitis obliterans syndrome. | 2007 | Transplant. Proc. | pmid:17889206 |
| Ryu S and Yasunami Y | Prevention of immune rejection in rat islet allografts by continuous SC administration of FK 506 using a mini-osmotic pump. | 1991 | Transplant. Proc. | pmid:1703710 |
| Christiaans M et al. | Effect of breakfast on the oral bioavailability of tacrolimus and changes in pharmacokinetics at different times posttransplant in renal transplant recipients. | 1998 | Transplant. Proc. | pmid:9636516 |
| Sato S et al. | Specificity of therapeutic drug monitoring of tacrolimus in kidney transplant patients. | 1998 | Transplant. Proc. | pmid:9636517 |
| Crespo M et al. | De novo kidney transplant recipients need higher doses of Advagraf compared with Prograf to get therapeutic levels. | 2009 Jul-Aug | Transplant. Proc. | pmid:19715848 |
| Sancho Calabuig A et al. | Very low-grade proteinuria at 3 months posttransplantation is an earlier marker of graft survival. | 2009 Jul-Aug | Transplant. Proc. | pmid:19715850 |
| Pascual J et al. | One-center comparison between primary immunosuppression based on neoral cyclosporine and tacrolimus for renal transplantation. | 2002 | Transplant. Proc. | pmid:11959200 |
| Herrero JC et al. | Role of immunosuppressive treatments based on mycophenolate mofetil in posttransplantation renal surgical complications. | 2002 | Transplant. Proc. | pmid:11959201 |
| Fung JJ et al. | Conversion from cyclosporine to FK 506 in liver allograft recipients with cyclosporine-related complications. | 1990 | Transplant. Proc. | pmid:1689901 |
| Zeevi A et al. | Bioassay of plasma specimens from liver transplant patients on FK 506 immunosuppression. | 1990 | Transplant. Proc. | pmid:1689902 |
| Bonet H et al. | Survival of patients transplanted with alcoholic hepatitis plus cirrhosis as compared with those with cirrhosis alone. | 1993 | Transplant. Proc. | pmid:7680145 |
| Melo MJ et al. | Impact of conversion from Advagraf to twice-daily generic tacrolimus in kidney transplant recipients: a single-center study. | 2015 | Transplant. Proc. | pmid:26036484 |
| Santos T et al. | New Recipes With Known Ingredients: Combined Therapy of Everolimus and Low-dose Tacrolimus in De Novo Renal Allograft Recipients. | 2015 | Transplant. Proc. | pmid:26036483 |
| Pichard L et al. | Effect of FK 506 on human hepatic cytochromes P-450: interaction with CyA. | 1991 | Transplant. Proc. | pmid:1721279 |
| Takeda M et al. | Methotrexate in rescue therapy for xenotransplanted lungs in primates. | 1996 | Transplant. Proc. | pmid:8623402 |
| Langrehr JM et al. | Comparison of quadruple induction including ATG or IL-2R antibody with FK506-based therapy after liver transplantation. | 1998 | Transplant. Proc. | pmid:9636583 |
| Nakao A et al. | Combined effect of donor-specific bone marrow transplantation via portal vein and FK506 on small bowel transplantation in the rat. | 2000 | Transplant. Proc. | pmid:11120044 |
| Viganó J et al. | Incidence of graft rejection in small bowel transplanted pigs after immunosuppression withdrawal. | 2006 Jul-Aug | Transplant. Proc. | pmid:16908291 |
| Undre NA et al. | Pharmacokinetics of tacrolimus: clinically relevant aspects. | 1999 | Transplant. Proc. | pmid:10576037 |
| Higuchi K et al. | FK506 induces the atrophy of enteric ganglia in small bowel transplantation, which can be prevented by the neuropeptide bombesin. | 2006 Jul-Aug | Transplant. Proc. | pmid:16908293 |
| Kaplinsky E et al. | Renal function improvement after conversion to proliferation signal inhibitors during long-term follow-up in heart transplant recipients. | 2012 | Transplant. Proc. | pmid:23146455 |
| Yilmaz A et al. | Severe angioedema caused by banana allergy under tacrolimus immunosuppression. | 2005 | Transplant. Proc. | pmid:16387091 |
| Lai WJ et al. | Is sirolimus a safe alternative to reduce or eliminate calcineurin inhibitors in chronic allograft nephropathy in kidney transplantation? | 2004 | Transplant. Proc. | pmid:15518744 |
| Barten MJ et al. | Pharmacodynamic monitoring of the conversion of cyclosporine to tacrolimus in heart and lung transplant recipients. | 2005 | Transplant. Proc. | pmid:16387162 |
| Chueh SC et al. | Pharmacokinetic variability of sirolimus in Taiwanese renal transplant recipients. | 2004 | Transplant. Proc. | pmid:15518745 |
| Colak H et al. | Relationship of Interleukin-10 and Transforming Growth Factor-β Levels With Short-Term Graft Function After Kidney Transplantation. | 2015 | Transplant. Proc. | pmid:25964218 |
| Nishimori H et al. | Combination therapy with FK 506 and splenectomy may induce tolerance in cardiac xenografts. | 1994 | Transplant. Proc. | pmid:7518102 |
| Kawauchi M et al. | Cardiac xenotransplantation from pig to Japanese monkey with splenectomy, tacrolims, filtration plasmapheresis, and nafamstat mesilate. | 1994 | Transplant. Proc. | pmid:7518105 |
| Yasuhara M et al. | Pharmacokinetics and pharmacodynamics of FK 506 in pediatric patients receiving living-related donor liver transplantations. | 1995 | Transplant. Proc. | pmid:7533356 |
| Platz KP et al. | OKT3 vs FK 506 rescue management of acute steroid-resistant and chronic rejection. | 1995 | Transplant. Proc. | pmid:7533357 |
| Su MS and Semerjian A | Activation of transcription factor NF kappa B in Jurkat cells is inhibited selectively by FK 506 in a signal-dependent manner. | 1991 | Transplant. Proc. | pmid:1721310 |
| Andersson J et al. | The effects of FK 506 on cytokine production are dependent on the mode of cell activation. | 1991 | Transplant. Proc. | pmid:1721311 |
| Li D et al. | Tacrolimus dosing in Chinese renal transplant patients is related to MDR1 gene C3435T polymorphisms. | 2006 | Transplant. Proc. | pmid:17112846 |
| Antoniou EA et al. | Effect of donor-specific transfusion in combination with FK 506 in rat cardiac allotransplantation. | 1999 | Transplant. Proc. | pmid:10578296 |
| Abecassis MM et al. | Patient outcomes and economics of once-daily tacrolimus in renal transplant patients: results of a modeling analysis. | 2008 | Transplant. Proc. | pmid:18589126 |
| Hassoun Z et al. | The choice of calcineurin inhibitor does not influence centrilobular necrosis after orthotopic liver transplantation. | 2002 | Transplant. Proc. | pmid:12176464 |
| Kawano K et al. | Protective effect of FK 506 on hepatic injury following cold ischemic preservation and transplantation: influence on hepatic microcirculation. | 1995 | Transplant. Proc. | pmid:7533410 |
| Opelz G | Evaluation of immunosuppressive induction regimens in renal transplantation. Collaborative Transplant Study. | 1998 | Transplant. Proc. | pmid:9865286 |
| Rintala JM et al. | The effect of FK778 on acute rat renal allograft rejection and expression of platelet-derived growth factor and transforming growth factor-beta. | 2006 | Transplant. Proc. | pmid:17098049 |
| Tzakis AG et al. | FK 506 versus cyclosporine in pediatric liver transplantation. | 1991 | Transplant. Proc. | pmid:1721343 |
| Moffatt SD et al. | Comparative efficacy of liposomal FK506 with FK506. | 1998 | Transplant. Proc. | pmid:9865297 |
| Mieles LA et al. | Liver transplantation of American veterans under FK 506 immunosuppression: a preliminary report. | 1991 | Transplant. Proc. | pmid:1721344 |
| Zhou W et al. | Calcineurin inhibitors block B-1 cell differentiation: the relevance to immunosuppressive treatment in ABO-incompatible transplantation. | 2005 | Transplant. Proc. | pmid:15919474 |
| Marin M et al. | Factors influencing the onset of diabetes mellitus after kidney transplantation: a single French center experience. | 2005 | Transplant. Proc. | pmid:15919484 |
| Jacques F et al. | Comparison of cyclosporine and tacrolimus in combination with rabbit antithymocyte immunoglobulins as induction therapy in cardiac transplantation. | 2009 | Transplant. Proc. | pmid:19857745 |
| Cardinal H et al. | The evolution of kidney function after lung transplantation: a retrospective cohort study. | 2009 | Transplant. Proc. | pmid:19857746 |
| Spada M et al. | Tacrolimus and mycophenolate mofetil in pig small bowel transplantation: different protocols and their outcome. | 1997 | Transplant. Proc. | pmid:9142286 |
| Ronchetti F et al. | Intestinal damage evaluation in swine allograft small bowel through hyaluronic acid quantification. | 1997 | Transplant. Proc. | pmid:9142293 |
| Rabkin JM et al. | Tacrolimus is associated with a lower incidence of cardiovascular complications in liver transplant recipients. | 2002 | Transplant. Proc. | pmid:12176483 |
| Langrehr JM et al. | First results from a prospective randomized trial comparing steroid-free induction therapy with tacrolimus and MMF versus tacrolimus and steroids in patients after liver transplantation for HCV. | 2002 | Transplant. Proc. | pmid:12176487 |
| Liu Y et al. | Delayed Initiation of Tacrolimus Is Safe and Effective in Renal Transplant Recipients With Delayed and Slow Graft Function. | 2018 | Transplant. Proc. | pmid:30316359 |
| Morphopathological findings of renal allografts under FK 506 therapy. Japanese FK 506 Study Group. | 1994 | Transplant. Proc. | pmid:7520614 | |
| Goh BL and Tan SY | FK506 "rescue" therapy complicated by renal tubular acidosis in renal allograft recipients. | 1998 | Transplant. Proc. | pmid:9838575 |
| Morris SM et al. | Disruption of renal function and gene expression by FK 506 and cyclosporine. | 1991 | Transplant. Proc. | pmid:1721375 |
| Tacrolimus in renal transplantation: a comparison of induction vs noninduction therapy (triple therapy): three-month results. | 1999 Feb-Mar | Transplant. Proc. | pmid:10083131 | |
| Takayama K et al. | Hepatocyte growth factor and vascular endothelial growth factor expression in pig-to-primate xenotransplanted hearts. | 2000 | Transplant. Proc. | pmid:10936314 |
| Mieles L et al. | Glycemia and insulin need following FK 506 rescue therapy in liver transplant recipients. | 1991 | Transplant. Proc. | pmid:1703362 |
| Izbicki G et al. | Improved survival after lung transplantation in patients treated with tacrolimus/mycophenolate mofetil as compared with cyclosporine/azathioprine. | 2002 | Transplant. Proc. | pmid:12493439 |
| Warty V et al. | Distribution of FK 506 in plasma lipoproteins in transplant patients. | 1991 | Transplant. Proc. | pmid:1703363 |
| Meiser BM et al. | Tacrolimus (FK506) proves superior to OKT3 for treating episodes of persistent rejection following intrathoracic transplantation. | 1997 Feb-Mar | Transplant. Proc. | pmid:9123150 |
| Shimizu T et al. | Clinical and histological analysis of chronic tacrolimus nephrotoxicity in renal allografts. | 2008 | Transplant. Proc. | pmid:18790237 |
| Ushigome H et al. | Immunosuppression in cadaveric renal transplant recipients from non-heart-beating donors in a single center. | 2002 | Transplant. Proc. | pmid:12176533 |
| Adams CK and Famili P | A study of the effects of the drug FK 506 on gingival tissues. | 1991 | Transplant. Proc. | pmid:1721405 |
| Mohamed MA et al. | The effect of cyclosporin A and tacrolimus on cultured human epithelial cells: the role of TGF-beta. | 1999 Feb-Mar | Transplant. Proc. | pmid:10083523 |
| Furtado A et al. | Local immunosuppression in clinical small bowel transplantation (report of two cases). | 2000 | Transplant. Proc. | pmid:10995910 |
| Pirsch JD et al. | Pulmonary infiltrates and eosinophilia in an FK 506 liver transplant recipient. | 1991 | Transplant. Proc. | pmid:1721406 |
| Wada H et al. | Combination use of suboptimal doses of FK 506 and cyclosporine in canine lung transplantation. | 1992 | Transplant. Proc. | pmid:1379758 |
| Yamashita K et al. | Effect of a novel immunosuppressant, FTY720, on heart and liver transplantations in rats. | 1999 Feb-Mar | Transplant. Proc. | pmid:10083526 |
| Alessiani M et al. | Pharmacokinetic study of intraarterial local intestinal infusion of tacrolimus. | 2000 | Transplant. Proc. | pmid:10995915 |
| Shinozuka H et al. | Effect of FK 506 on experimental liver carcinogenesis. | 1991 | Transplant. Proc. | pmid:1721407 |
| Cai X et al. | Low-dose of FK 506 and associated blood levels in allotransplantation of rat liver, heart, and skin. | 1992 | Transplant. Proc. | pmid:1379759 |
| Beck Y and Akiyama N | Effect of FK-506 and cyclosporine on human lymphocyte responses in vitro. | 1989 | Transplant. Proc. | pmid:2472695 |
| Yamada MF et al. | Myeloablative cord blood transplantation for adults with hematological malignancies using tacrolimus and short-term methotrexate for graft-versus-host disease prophylaxis: single-institution analysis. | 2008 | Transplant. Proc. | pmid:19100456 |
| Molinaro M et al. | Pharmacokinetics of tacrolimus during the early phase after heart transplantation. | 2001 | Transplant. Proc. | pmid:11377570 |
| Yamanaka K et al. | Induction Immunosuppressive Therapy With Everolimus and Low-Dose Tacrolimus Extended-Release Preserves Good Renal Function at 1Â Year After Kidney Transplantation. | 2016 | Transplant. Proc. | pmid:27234735 |
| van Riemsdijk IC et al. | Improvement of cardiovascular risk factors in heart transplant recipients after conversion from cyclosporine to tacrolimus: a role of the TGF-beta system. | 2002 | Transplant. Proc. | pmid:12176606 |
| Franke GH et al. | Switching from cyclosporine to tacrolimus leads to improved disease-specific quality of life in patients after kidney transplantation. | 2006 | Transplant. Proc. | pmid:16797285 |
| Evans NJ et al. | The expression of endothelin and inducible nitric oxide synthase in human renal allografts and their role in chronic renal allograft nephropathy. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267247 |
| DeValeria PA et al. | FK 506 fails to reverse moderate cardiac allograft rejection in a canine heterotopic model. | 1991 | Transplant. Proc. | pmid:1721438 |
| Dikow R et al. | Blood pressure profile and treatment quality in liver allograft recipients-benefit of tacrolimus versus cyclosporine. | 2004 | Transplant. Proc. | pmid:15251373 |
| Chu Z et al. | Influence of immunosuppressive drugs on the development of CD4(+)CD25(high) Foxp3(+) T cells in liver transplant recipients. | 2010 | Transplant. Proc. | pmid:20832552 |
| Jonas S et al. | Five-year follow-up of tacrolimus as primary immunosuppressant after liver transplantation. | 1998 | Transplant. Proc. | pmid:9723433 |
| Dutta S et al. | Liposomal tacrolimus and intestinal drug concentration. | 1998 | Transplant. Proc. | pmid:9745533 |
| Ochiai T et al. | Histopathologic studies in renal transplant recipient dogs receiving treatment with FK-506. | 1987 | Transplant. Proc. | pmid:2445085 |
| Morales J et al. | Alemtuzumab induction in kidney transplantation: clinical results and impact on T-regulatory cells. | 2008 | Transplant. Proc. | pmid:19010240 |
| Wang CH et al. | Efficacy and safety of tacrolimus versus cyclosporine microemulsion in primary cardiac transplant recipients: 6-month results in Taiwan. | 2004 | Transplant. Proc. | pmid:15561256 |
| Wang CH et al. | Therapeutic drug monitoring of tacrolimus in cardiac transplant recipients: a comparison with cyclosporine neoral. | 2004 | Transplant. Proc. | pmid:15561257 |
| Kahl A et al. | Long-term prednisolone withdrawal after pancreas and kidney transplantation in patients treated with ATG, tacrolimus, and mycophenolate mofetil. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267473 |
| Rieber J et al. | Effects of tacrolimus and cyclosporine on the coronary microcirculation after heart transplantation: a prospective study with serial intracoronary flow measurements. | 1998 | Transplant. Proc. | pmid:9636446 |
| Nielsen FT et al. | Nephrotoxity of FK 506: a preliminary study on comparative aspects of FK 506 and cyclosporine nephrotoxicity. | 1994 | Transplant. Proc. | pmid:7527946 |
| Fisher A et al. | Gastrointestinal toxicity associated with FK 506 in liver transplant recipients. | 1994 | Transplant. Proc. | pmid:7527947 |