| MeSH term | MeSH ID | Detail |
|---|---|---|
| Cutis Laxa | D003483 | 1 associated lipids |
| Invasive Pulmonary Aspergillosis | D055744 | 1 associated lipids |
| Intestinal Volvulus | D045822 | 1 associated lipids |
| Hand Injuries | D006230 | 1 associated lipids |
| Beckwith-Wiedemann Syndrome | D001506 | 1 associated lipids |
| Eye Diseases, Hereditary | D015785 | 1 associated lipids |
| Hepatopulmonary Syndrome | D020065 | 1 associated lipids |
| Herpes Labialis | D006560 | 1 associated lipids |
| End Stage Liver Disease | D058625 | 1 associated lipids |
| Nocturnal Myoclonus Syndrome | D020189 | 1 associated lipids |
tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Platz KP et al. | Causes of death following liver transplantation in FK 506- and cyclosporine-treated patients. | 1994 | Transplant. Proc. | pmid:7527952 |
| Christe W | Neurological disorders in liver and kidney transplant recipients. | 1994 | Transplant. Proc. | pmid:7527953 |
| Meiser BM and Reichart B | New trends in clinical immunosuppression. | 1994 | Transplant. Proc. | pmid:7527954 |
| Hara Y et al. | Unresponsiveness to rat cardiac allografts induced by intrathymic injection of donor bone marrow cells and short course of immunosuppression. | 1994 | Transplant. Proc. | pmid:7527955 |
| Guy S et al. | Immunosuppression conversion for relief of side effects. | 1994 | Transplant. Proc. | pmid:7527956 |
| Knoop C et al. | FK 506 rescue therapy for irreversible airway rejection in heart-lung transplant recipients: report on five cases. | 1994 | Transplant. Proc. | pmid:7527957 |
| Candinas D et al. | Efficacy of leflunomide in combination with current immunosuppressive agents in rat cardiac allotransplantation. | 1994 | Transplant. Proc. | pmid:7527959 |
| Reduced incidence of acute, refractory acute, and chronic rejection after liver transplantation with FK506-based immunosuppression. European FK506 Multicentre Liver Study Group. | 1994 | Transplant. Proc. | pmid:7527960 | |
| Ueda H et al. | FR901228, a novel antitumor bicyclic depsipeptide produced by Chromobacterium violaceum No. 968. I. Taxonomy, fermentation, isolation, physico-chemical and biological properties, and antitumor activity. | 1994 | J. Antibiot. | pmid:7513682 |
| Tai J et al. | Effect of FK506 on rat Leydig cell function--in vivo and in vitro study. | 1994 | Metab. Clin. Exp. | pmid:7513780 |
| Egawa H et al. | FK506 conversion therapy in pediatric liver transplantation. | 1994 | Transplantation | pmid:7513911 |
| Cvetkovic M et al. | The deleterious effects of long-term cyclosporine A, cyclosporine G, and FK506 on bone mineral metabolism in vivo. | 1994 | Transplantation | pmid:7513912 |
| Arakawa H et al. | Molecular cloning and expression of a novel human gene that is highly homologous to human FK506-binding protein 12kDa (hFKBP-12) and characterization of two alternatively spliced transcripts. | 1994 | Biochem. Biophys. Res. Commun. | pmid:7513996 |
| Langrehr JM et al. | Mucosal recipient-type mononuclear repopulation and low-grade chronic rejection occur simultaneously in indefinitely surviving recipients of small bowel allografts. | 1994 | Transpl. Int. | pmid:7513999 |
| Leach KL et al. | A soluble binding assay for measuring 3H-FK506 binding to the hsp56 immunophilin. | 1994 | J Immunoassay | pmid:7530727 |
| Genestier L et al. | Cyclosporin A and FK506 inhibit activation-induced cell death in the murine WEHI-231 B cell line. | 1994 | Cell. Immunol. | pmid:7514101 |
| Rao US and Scarborough GA | Direct demonstration of high affinity interactions of immunosuppressant drugs with the drug binding site of the human P-glycoprotein. | 1994 | Mol. Pharmacol. | pmid:7514263 |
| Mulkey RM et al. | Involvement of a calcineurin/inhibitor-1 phosphatase cascade in hippocampal long-term depression. | 1994 | Nature | pmid:7515479 |
| Douglas CM et al. | The Saccharomyces cerevisiae FKS1 (ETG1) gene encodes an integral membrane protein which is a subunit of 1,3-beta-D-glucan synthase. | 1994 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7528927 |
| Breuder T et al. | Calcineurin is essential in cyclosporin A- and FK506-sensitive yeast strains. | 1994 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7515500 |
| Lhoëst G et al. | Isolation and identification of a FK-506 C36-C37 dihydrodiol from erythromycin-induced rabbit liver microsomes. | 1994 | J Pharm Biomed Anal | pmid:7516189 |
| Kraus-Friedmann N and Feng L | Reduction of ryanodine binding and cytosolic Ca2+ levels in liver by the immunosuppressant FK506. | 1994 | Biochem. Pharmacol. | pmid:7529023 |
| Ohtsuka S et al. | Experimental rat pancreas transplant: surgical technique and immunological considerations. | 1994 | Surg. Today | pmid:7516209 |
| Cardenas ME et al. | Immunophilins interact with calcineurin in the absence of exogenous immunosuppressive ligands. | 1994 | EMBO J. | pmid:7529175 |
| Hisatomi K et al. | Limited effectiveness of FK506 administration for ongoing rejection in heterotopic rat heart transplantation. | 1994 | Surg. Today | pmid:7516210 |
| Burkhalter EL et al. | Severe neurological complications following orthotopic liver transplantation in patients receiving FK 506 and prednisone. | 1994 | J. Hepatol. | pmid:7529272 |
| Kawano K et al. | Evidence that FK506 alleviates ischemia/reperfusion injury to the rat liver: in vivo demonstration for suppression of TNF-a production in response to endotoxemia. | 1994 | Eur Surg Res | pmid:7516291 |
| Morozumi K and Takeda A | [Kidney disorders induced by immunosuppressive agents]. | 1994 | Nippon Naika Gakkai Zasshi | pmid:7529294 |
| Hashimoto T et al. | Treatment with FK506 prevents rejection of rat colon allografts. | 1994 | Transplantation | pmid:7516586 |
| Krentz AJ et al. | Postoperative glucose metabolism in liver transplant recipients. A two-year prospective randomized study of cyclosporine versus FK506. | 1994 | Transplantation | pmid:7516590 |
| Dawson VL et al. | Expression of inducible nitric oxide synthase causes delayed neurotoxicity in primary mixed neuronal-glial cortical cultures. | 1994 | Neuropharmacology | pmid:7532825 |
| Morikawa K et al. | Immunomodulatory effects of three macrolides, midecamycin acetate, josamycin, and clarithromycin, on human T-lymphocyte function in vitro. | 1994 | Antimicrob. Agents Chemother. | pmid:7532933 |
| Raymond M et al. | Functional expression of P-glycoprotein in Saccharomyces cerevisiae confers cellular resistance to the immunosuppressive and antifungal agent FK520. | 1994 | Mol. Cell. Biol. | pmid:7505392 |
| Valdivia LA et al. | Complement and target cells belong to the same species after liver xenografting: protection from hyperacute rejection. | 1994 | Transplant. Proc. | pmid:7518123 |
| Hayashi S et al. | Synergistic effect of donor pretreatment using FK 506 in hamster-to-rat cardiac xenotransplantation. | 1994 | Transplant. Proc. | pmid:7518126 |
| Ohtsuka S et al. | Mechanism of antibody production in guinea pig to rat discordant xenotransplant: establishment of a simple model by intravenous injection of discordant splenocytes. | 1994 | Transplant. Proc. | pmid:7518130 |
| Todo S et al. | Intestinal transplantation at the University of Pittsburgh. | 1994 | Transplant. Proc. | pmid:7518136 |
| Reyes J et al. | Lymphoproliferative disease after intestinal transplantation under primary FK 506 immunosuppression. | 1994 | Transplant. Proc. | pmid:7518137 |
| Murase N et al. | Small bowel transplantation in sensitized recipients: comparison with heart, kidney, and liver grafts. | 1994 | Transplant. Proc. | pmid:7518139 |
| Fujisaki S et al. | Effects of preformed antibodies induced by whole blood transfusion on small bowel transplantation. | 1994 | Transplant. Proc. | pmid:7518140 |
| Pruschy MN et al. | Mechanistic studies of a signaling pathway activated by the organic dimerizer FK1012. | 1994 | Chem. Biol. | pmid:9383386 |
| Fujimura A and Ebihara A | Administration time-dependent toxicity of a new immunosuppressive agent, tacrolimus (FK 506). | 1994 | Life Sci. | pmid:7518886 |
| Gottschalk AR et al. | Identification of immunosuppressant-induced apoptosis in a murine B-cell line and its prevention by bcl-x but not bcl-2. | 1994 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7518929 |
| Prasad TN et al. | FK 506 (Tacrolimus) metabolism by rat liver microsomes and its inhibition by other drugs. | 1994 | Res. Commun. Chem. Pathol. Pharmacol. | pmid:7518966 |
| Dumont FJ et al. | Quantitative and temporal analysis of the cellular interaction of FK-506 and rapamycin in T-lymphocytes. | 1994 | J. Pharmacol. Exp. Ther. | pmid:7507994 |
| Mueller AR et al. | Neurotoxicity after orthotopic liver transplantation. A comparison between cyclosporine and FK506. | 1994 | Transplantation | pmid:7518974 |
| Platz KP et al. | Nephrotoxicity following orthotopic liver transplantation. A comparison between cyclosporine and FK506. | 1994 | Transplantation | pmid:7518975 |
| Cakaloglu Y et al. | Importance of cytochrome P-450IIIA activity in determining dosage and blood levels of FK 506 and cyclosporine in liver transplant recipients. | 1994 | Hepatology | pmid:7519161 |
| Luan S et al. | Light-regulated, tissue-specific immunophilins in a higher plant. | 1994 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7508125 |
| Blazar BR et al. | FK506 inhibits graft-versus-host disease and bone marrow graft rejection in murine recipients of MHC disparate donor grafts by interfering with mature peripheral T cell expansion post-transplantation. | 1994 | J. Immunol. | pmid:7519216 |
| Laifer SA et al. | Pregnancy after cardiac transplantation. | 1994 | Am J Perinatol | pmid:7519426 |
| Dawson TM et al. | Nitric oxide: cellular regulation and neuronal injury. | 1994 | Prog. Brain Res. | pmid:7533914 |
| Bäckman L et al. | FK506 trough levels in whole blood and plasma in liver transplant recipients. Correlation with clinical events and side effects. | 1994 | Transplantation | pmid:7509516 |
| Kitamura Y et al. | Suppressive effect of FK-506, a novel immunosuppressant, against MPTP-induced dopamine depletion in the striatum of young C57BL/6 mice. | 1994 | J. Neuroimmunol. | pmid:7509816 |
| Sato K et al. | Effectiveness of triple regimen immunosuppression in canine pancreatic allotransplantation. | 1994 | Transplant. Proc. | pmid:7520628 |
| Tze WJ et al. | Successful islet allotransplantation in diabetic rats immunosuppressed with FK506: a functional and immunological study. | 1994 | Metab. Clin. Exp. | pmid:7510012 |
| Oishi M et al. | Successful swine small bowel transplantation using FK506: effect on endotoxin translocation. | 1994 | Transplant. Proc. | pmid:7520629 |
| Yamauchi T | [Multiple abdominal organ transplantation in swine using FK-506]. | 1994 | Nihon Geka Gakkai Zasshi | pmid:7510015 |
| Jiang H et al. | FK 506 and deoxyspergualin: additive immunosuppressive effect on rat cardiac allograft rejection in vivo and mitogen-stimulated human lymphocyte responses in vitro. | 1994 | Transplant. Proc. | pmid:7520631 |
| Hara Y et al. | Heterotopic rat heart transplantation to the iliac vessels. | 1994 | Transplant. Proc. | pmid:7520632 |
| Nozaki S et al. | Effect of brequinar sodium on accelerated cardiac allograft rejection in presensitized recipients. | 1994 | Transplant. Proc. | pmid:7520633 |
| Masaoka T | Problems of bone marrow transplantation in Japan. | 1994 | Transplant. Proc. | pmid:7520634 |
| Okano K et al. | Ameliorative effect of FK 506 on cold ischemia reperfusion injury of the rat liver. | 1994 | Transplant. Proc. | pmid:7520635 |
| Surdacka E et al. | [New immunosuppressive drugs in transplantation]. | 1994 | Prz. Lek. | pmid:7532870 |
| Kim YI et al. | FK 506 prevents critical warm ischemia damage to the pig liver and improves hepatic microcirculation. | 1994 | Transplant. Proc. | pmid:7520636 |
| Bierer BE | Biology of cyclosporin A and FK506. | 1994 | Prog. Clin. Biol. Res. | pmid:7536944 |
| Krentz AJ et al. | Serum lipids and apolipoproteins in liver transplant recipients: a comparative study of cyclosporin A and FK 506. | 1994 | J. Lab. Clin. Med. | pmid:7521895 |
| Jensen C et al. | Interaction between tacrolimus and erythromycin. | 1994 | Lancet | pmid:7521928 |
| Winkler M et al. | Comparison of different assays for the quantitation of FK 506 levels in blood or plasma. | 1994 | Ther Drug Monit | pmid:7521978 |
| D'Ambrosio R et al. | Multicenter comparison of tacrolimus (FK 506) whole blood concentrations as measured by the Abbott IMX analyzer and enzyme immunoassay with methylene chloride extraction. | 1994 | Ther Drug Monit | pmid:7521979 |
| Metcalfe S et al. | FK506 and cyclosporin A each inhibit antigen-specific signaling in the T cell line 171 in the absence of a calcium signal. | 1994 | Cell. Immunol. | pmid:7522130 |
| Nichols RA et al. | Calcineurin-mediated protein dephosphorylation in brain nerve terminals regulates the release of glutamate. | 1994 | J. Biol. Chem. | pmid:7522234 |
| Ueda K et al. | Human P-glycoprotein as a multi-drug transporter analyzed by using transepithelial transport system. | 1994 | Jpn. J. Physiol. | pmid:7538609 |
| Schmidt A et al. | Two FK506 resistance-conferring genes in Saccharomyces cerevisiae, TAT1 and TAT2, encode amino acid permeases mediating tyrosine and tryptophan uptake. | 1994 | Mol. Cell. Biol. | pmid:7523855 |
| A comparison of tacrolimus (FK 506) and cyclosporine for immunosuppression in liver transplantation. The U.S. Multicenter FK506 Liver Study Group. | 1994 | N. Engl. J. Med. | pmid:7523946 | |
| Calne RY | Immunosuppression in liver transplantation. | 1994 | N. Engl. J. Med. | pmid:7523947 |
| Schleuning M et al. | Inhibition of cyclosporin A/FK506 resistant, lymphokine-induced T-cell activation by phenothiazine derivatives. | 1994 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:7523957 |
| Perotti BY et al. | HPLC assay for FK 506 and two metabolites in isolated rat hepatocytes and rat liver microsomes. | 1994 | Pharm. Res. | pmid:7524055 |
| FDA approved new drug bulletin: aprotinin injection (trasylol), tacrolimus (prograf). | 1994 | RN | pmid:7524131 | |
| Apanay DC et al. | Cyclosporine increases the oxidizability of low-density lipoproteins in renal transplant recipients. | 1994 | Transplantation | pmid:7524202 |
| Kinoshita I et al. | Very efficient myoblast allotransplantation in mice under FK506 immunosuppression. | 1994 | Muscle Nerve | pmid:7526208 |
| Cullen BR and Heitman J | Human immunodeficiency virus. Chaperoning a pathogen. | 1994 | Nature | pmid:7526224 |
| Connolly JO et al. | Renal arteriopathy associated with FK 506 therapy following liver transplantation. | 1994 | Nephrol. Dial. Transplant. | pmid:7526278 |
| Pham SM et al. | Cardiac transplantation at the University of Pittsburgh: 1994 update. | 1994 | Clin Transpl | pmid:7547531 |
| Radanyi C et al. | The ability of the immunophilin FKBP59-HBI to interact with the 90-kDa heat shock protein is encoded by its tetratricopeptide repeat domain. | 1994 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7526392 |
| Abu-Elmagd K et al. | Hepatic transplantation at the University of Pittsburgh: new horizons and paradigms after 30 years of experience. | 1994 | Clin Transpl | pmid:7547533 |
| Ericzon B et al. | Glucose metabolism in liver transplant recipients treated with FK 506 or cyclosporin in the European multicentre study. | 1994 | Transpl. Int. | pmid:11271178 |
| Ko S et al. | The pharmacokinetic benefits of newly developed liposome-incorporated FK506. | 1994 | Transplantation | pmid:7526494 |
| Shapiro R et al. | Renal transplantation at the University of Pittsburgh: the impact of FK506. | 1994 | Clin Transpl | pmid:7547544 |
| Undre N and Möller A | Pharmacokinetic interpretation of FK 506 levels in blood and in plasma during a European randomised study in primary liver transplant patients. The FK 506 European Study Group. | 1994 | Transpl. Int. | pmid:11271189 |
| Holländer GA et al. | Disruption of T cell development and repertoire selection by calcineurin inhibition in vivo. | 1994 | Transplantation | pmid:7526495 |
| Yano K et al. | Effects of intrahepatic arterial and intraportal administration of FK 506 on liver allograft survival in rats. | 1994 | Transpl. Int. | pmid:11271200 |
| Devlin J et al. | Renal complications and development of hypertension in the European study of FK 506 and cyclosporin in primary liver transplant recipients. | 1994 | Transpl. Int. | pmid:11271207 |
| Todo S et al. | Small intestinal transplantation in humans with or without the colon. | 1994 | Transplantation | pmid:7512291 |
| Griffith BP et al. | A prospective randomized trial of FK506 versus cyclosporine after human pulmonary transplantation. | 1994 | Transplantation | pmid:7512292 |
| Jordan ML et al. | FK506 "rescue" for resistant rejection of renal allografts under primary cyclosporine immunosuppression. | 1994 | Transplantation | pmid:7512293 |
| Wijdicks EF et al. | FK506-induced neurotoxicity in liver transplantation. | 1994 | Ann. Neurol. | pmid:7512320 |
| Cheng JW et al. | 15N NMR relaxation studies of the FK506 binding protein: dynamic effects of ligand binding and implications for calcineurin recognition. | 1994 | Biochemistry | pmid:7512379 |
| Mori A et al. | Regulation of interleukin-5 production by peripheral blood mononuclear cells from atopic patients with FK506, cyclosporin A and glucocorticoid. | 1994 | Int. Arch. Allergy Immunol. | pmid:7512393 |
| Okubo Y et al. | Cytokine production in patients with mite-sensitive bronchial asthma. | 1994 | Int. Arch. Allergy Immunol. | pmid:7512395 |