| MeSH term | MeSH ID | Detail |
|---|---|---|
| Nervous System Autoimmune Disease, Experimental | D020721 | 3 associated lipids |
| Parkinsonian Disorders | D020734 | 20 associated lipids |
| Intracranial Thrombosis | D020767 | 2 associated lipids |
| Central Nervous System Viral Diseases | D020805 | 1 associated lipids |
| Hypoxia-Ischemia, Brain | D020925 | 22 associated lipids |
| Neuroaspergillosis | D020953 | 2 associated lipids |
| Brachial Plexus Neuritis | D020968 | 2 associated lipids |
| Lacerations | D022125 | 1 associated lipids |
| Coronary Stenosis | D023921 | 6 associated lipids |
| Polyomavirus Infections | D027601 | 1 associated lipids |
tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Lane BC et al. | Evaluation of calcineurin's role in the immunosuppressive activity of FK 506, related macrolactams, and cyclosporine. | 1993 | Transplant. Proc. | pmid:7679829 |
| Celli S et al. | Long-term survival of heart and liver xenografts with splenectomy and FK 506. | 1993 | Transplant. Proc. | pmid:7679830 |
| Japanese study of FK 506 on kidney transplantation: results of late phase II study. | 1993 | Transplant. Proc. | pmid:7679831 | |
| Kobayashi M et al. | Production of monoclonal antibody against recombinant human FKBP-12 and subcellular localization of FKBP-12 in human mononuclear and polymorphonuclear cells. | 1993 | Transplant. Proc. | pmid:7679832 |
| Kuroki H et al. | Effect of FK 506 and donor-specific blood transfusion on the rat composite tissue limb allograft and the mechanism of long-term graft survival. | 1993 | Transplant. Proc. | pmid:7679833 |
| Xu RX et al. | Heteronuclear 3D NMR studies of water bound to an FK506 binding protein/immunosuppressant complex. | 1993 | Biochemistry | pmid:7680570 |
| Egan DA et al. | Equilibrium denaturation of recombinant human FK binding protein in urea. | 1993 | Biochemistry | pmid:7680574 |
| Lionetti P et al. | Activation of mucosal V beta 3+ T cells and tissue damage in human small intestine by the bacterial superantigen, Staphylococcus aureus enterotoxin B. | 1993 | Eur. J. Immunol. | pmid:7680613 |
| Nelson PA et al. | Immunosuppressive activity of [MeBm2t]1-, D-diaminobutyryl-8-, and D-diaminopropyl-8-cyclosporin analogues correlates with inhibition of calcineurin phosphatase activity. | 1993 | J. Immunol. | pmid:7680683 |
| Piekoszewski W and Jusko WJ | Plasma protein binding of tacrolimus in humans. | 1993 | J Pharm Sci | pmid:7680714 |
| Kim YI et al. | Augmentation of hepatocyte proliferation by immunosuppressant pretherapy is associated with up-regulation of malondialdehyde production. | 1993 | Res Exp Med (Berl) | pmid:7506444 |
| Hytiroglou P et al. | FK506 versus cyclosporine as primary immunosuppressive agent for orthotopic liver allograft recipients. Histologic and immunopathologic observations. | 1993 | Transplantation | pmid:7506452 |
| Ishizuka J et al. | Effects of FK506 and cyclosporine on dynamic insulin secretion from isolated dog pancreatic islets. | 1993 | Transplantation | pmid:7506454 |
| Dhar DK et al. | Effective prevention of ischemic injury of the dearterialized canine liver by FK506 pretreatment. | 1993 | Transplantation | pmid:7506456 |
| Fabrega AJ et al. | Enhancement of allograft survival by single intraoperative donor-specific blood transfusion combined with FK506. | 1993 | Transplantation | pmid:7506458 |
| Wenzel-Seifert K and Seifert R | Partial inhibition of human neutrophil activation by FK-506 at supratherapeutic concentrations. | 1993 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:7690907 |
| Liu J | FK506 and cyclosporin, molecular probes for studying intracellular signal transduction. | 1993 | Immunol. Today | pmid:7691065 |
| Mori T et al. | FK-506: a new immunosuppressive agent, failed to reduce cerebral vasospasm after experimental subarachnoid hemorrhage. | 1993 | J. Vet. Med. Sci. | pmid:7691190 |
| Distant DA and Gonwa TA | The kidney in liver transplantation. | 1993 | J. Am. Soc. Nephrol. | pmid:7691205 |
| Yatscoff RW et al. | Comparison of the effect of rapamycin and FK506 on release of prostacyclin and endothelin in vitro. | 1993 | Clin. Biochem. | pmid:7507804 |
| Takada K et al. | Distribution characteristics of immunosuppressants FK506 and cyclosporin A in the blood compartment. | 1993 | Biopharm Drug Dispos | pmid:7508273 |
| Sperr WR et al. | [Effector cells in allergy: biological principles and new pharmacologic concepts]. | 1993 | Wien. Klin. Wochenschr. | pmid:7508662 |
| Kawauchi M et al. | Prolonged survival of orthotopically transplanted heart xenograft in infant baboons. | 1993 | J. Thorac. Cardiovasc. Surg. | pmid:7693999 |
| Shutter LA et al. | Cortical blindness and white matter lesions in a patient receiving FK506 after liver transplantation. | 1993 | Neurology | pmid:7694189 |
| Dawson TM et al. | Immunosuppressant FK506 enhances phosphorylation of nitric oxide synthase and protects against glutamate neurotoxicity. | 1993 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7694293 |
| Spencer DM et al. | Controlling signal transduction with synthetic ligands. | 1993 | Science | pmid:7694365 |
| Travis J | Making molecular matches in the cell. | 1993 | Science | pmid:7694368 |
| Textor SC et al. | Systemic and renal hemodynamic differences between FK506 and cyclosporine in liver transplant recipients. | 1993 | Transplantation | pmid:7685934 |
| Sewell KL | Immunotherapy and other novel therapies, including biologic response modifiers, apheresis, and dietary modifications. | 1993 | Curr Opin Rheumatol | pmid:7685614 |
| Wagner JA et al. | Failure of FK 506 to suppress the T cell-mediated immunity of mice to Listeria monocytogenes. | 1993 | Clin. Exp. Immunol. | pmid:7685672 |
| Pilot-Matias TJ et al. | High-level synthesis of the 12-kDa human FK506-binding protein in Escherichia coli using translational coupling. | 1993 | Gene | pmid:7685727 |
| Akamine S et al. | [Effect of FK-506 on bronchial healing of canine lung allografts]. | 1993 | Nihon Kyobu Geka Gakkai Zasshi | pmid:7685803 |
| Partaledis JA and Berlin V | The FKB2 gene of Saccharomyces cerevisiae, encoding the immunosuppressant-binding protein FKBP-13, is regulated in response to accumulation of unfolded proteins in the endoplasmic reticulum. | 1993 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7685904 |
| Henke W and Jung K | Comparison of the effects of the immunosuppressive agents FK 506 and cyclosporin A on rat kidney mitochondria. | 1993 | Biochem. Pharmacol. | pmid:7690566 |
| Murase N et al. | Hamster-to-rat heart and liver xenotransplantation with FK506 plus antiproliferative drugs. | 1993 | Transplantation | pmid:7682735 |
| Bram RJ et al. | Identification of the immunophilins capable of mediating inhibition of signal transduction by cyclosporin A and FK506: roles of calcineurin binding and cellular location. | 1993 | Mol. Cell. Biol. | pmid:7687744 |
| Heitman J et al. | The immunosuppressant FK506 inhibits amino acid import in Saccharomyces cerevisiae. | 1993 | Mol. Cell. Biol. | pmid:7687745 |
| Hirakawa K et al. | [The effect of perioperative portal venous inoculation with donor lymphocytes in combination with immunosuppressive agents on rat cardiac allograft survivals]. | 1993 | Nihon Geka Gakkai Zasshi | pmid:7688065 |
| Entani C et al. | Effect of a novel immunosuppressant, FK506, on spontaneous lupus nephritis in MRL/MpJ-lpr/lpr mice. | 1993 | Nephron | pmid:7688103 |
| Ueki M et al. | Diabetogenic effects of FK506 on renal subcapsular islet isografts in rat. | 1993 | Diabetes Res. Clin. Pract. | pmid:7688276 |
| Kondo T et al. | [Antitumor sensitivity test, subrenal capsule assay using FK-506: preliminary report]. | 1993 | Nihon Geka Gakkai Zasshi | pmid:7689693 |
| Abu-Elmagd K et al. | Resolution of severe pyoderma gangrenosum in a patient with streaking leukocyte factor disease after treatment with tacrolimus (FK 506). | 1993 | Ann. Intern. Med. | pmid:7689802 |
| Christensen BG | FK-506: its role in immunosuppression. | 1993 | Ann. N. Y. Acad. Sci. | pmid:7689803 |
| Kino T and Goto T | Discovery of FK-506 and update. | 1993 | Ann. N. Y. Acad. Sci. | pmid:7689804 |
| Parsons WH et al. | FK-506--a novel immunosuppressant. | 1993 | Ann. N. Y. Acad. Sci. | pmid:7689805 |
| Holman MJ et al. | FK506-associated thrombotic thrombocytopenic purpura. | 1993 | Transplantation | pmid:7678357 |
| Kawai M et al. | Structure-activity profiles of macrolactam immunosuppressant FK-506 analogues. | 1993 | FEBS Lett. | pmid:7678400 |
| Van Duyne GD et al. | Atomic structures of the human immunophilin FKBP-12 complexes with FK506 and rapamycin. | 1993 | J. Mol. Biol. | pmid:7678431 |
| Meadows RP et al. | Three-dimensional structure of the FK506 binding protein/ascomycin complex in solution by heteronuclear three- and four-dimensional NMR. | 1993 | Biochemistry | pmid:7678499 |
| Jiang H et al. | Anti-tumor-promoting action of FK506, a potent immunosuppressive agent. | 1993 | Carcinogenesis | pmid:7678785 |