| MeSH term | MeSH ID | Detail |
|---|---|---|
| Psoriasis | D011565 | 47 associated lipids |
| Fatty Liver | D005234 | 48 associated lipids |
| Precancerous Conditions | D011230 | 48 associated lipids |
| Thrombosis | D013927 | 49 associated lipids |
| Osteosarcoma | D012516 | 50 associated lipids |
| Kidney Failure, Chronic | D007676 | 51 associated lipids |
| Leukemia, Myeloid | D007951 | 52 associated lipids |
| Parkinson Disease | D010300 | 53 associated lipids |
| Nerve Degeneration | D009410 | 53 associated lipids |
| Weight Loss | D015431 | 56 associated lipids |
tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Muraki Y et al. | Impact of CYP3A5 genotype of recipients as well as donors on the tacrolimus pharmacokinetics and infectious complications after living-donor liver transplantation for Japanese adult recipients. | 2011 Oct-Dec | Ann. Transplant. | pmid:22210422 |
| Boratyńska M et al. | Conversion from cyclosporine-based immunosuppression to tacrolimus/mycophenolate mofetil in patients with refractory and ongoing acute renal allograft rejection. | 2006 | Ann. Transplant. | pmid:17494290 |
| Foroncewicz B et al. | A comparison between two tacrolimus-based immunosuppression regimens in renal transplant recipients: 7-year follow-up. | 2013 | Ann. Transplant. | pmid:23896824 |
| Grochowiecki T et al. | A retrospective study of steroid elimination in simultaneous pancreas and preemptive kidney transplant (Sppre-Ktx) recipients. | 2006 | Ann. Transplant. | pmid:17494291 |
| Rhu J et al. | Clinical Implication of Mycophenolic Acid Trough Concentration Monitoring in Kidney Transplant Patients on a Tacrolimus Triple Maintenance Regimen: A Single-Center Experience. | 2017 | Ann. Transplant. | pmid:29180612 |
| Fox BD et al. | Tacrolimus Levels Are Not Associated with Risk of Malignancy in Lung Transplant Recipients. | 2017 | Ann. Transplant. | pmid:29133776 |
| Rehman S et al. | Effect of different tacrolimus levels on early outcomes after kidney transplantation. | 2014 | Ann. Transplant. | pmid:24509826 |
| Legris T et al. | Humoral immunity after kidney transplantation: impact of two randomized immunosuppressive protocols. | 2013 | Ann. Transplant. | pmid:24231646 |
| Hakeam HA et al. | Sirolimus induced dyslipidemia in tacrolimus based vs. tacrolimus free immunosuppressive regimens in renal transplant recipients. | 2008 | Ann. Transplant. | pmid:18566560 |
| Bäckman L and Persson CA | An observational study evaluating tacrolimus dose, exposure, and medication adherence after conversion from twice- to once-daily tacrolimus in liver and kidney transplant recipients. | 2014 | Ann. Transplant. | pmid:24637379 |
| Gijsen VM et al. | Tacrolimus-induced nephrotoxicity and genetic variability: a review. | 2012 Apr-Jun | Ann. Transplant. | pmid:22743729 |
| Urbanowicz T et al. | Induction therapy, tacrolimus plasma concentration, and duration if intensive care unit stay are risk factors for peripheral leucopenia following heart transplantation. | 2014 | Ann. Transplant. | pmid:25274118 |
| Baron PW et al. | Post-Transplant Diabetes Mellitus After Kidney Transplant in Hispanics and Caucasians Treated with Tacrolimus-Based Immunosuppression. | 2017 | Ann. Transplant. | pmid:28533501 |
| Furmańczyk A et al. | Atypical calcineurin inhibitor-induced haemolytic uremic syndrome after liver transplantation. | 2009 Oct-Dec | Ann. Transplant. | pmid:20009155 |
| Gerlach UA et al. | Aspergillus spondylodiscitis after multivisceral transplantation. | 2009 Oct-Dec | Ann. Transplant. | pmid:20009156 |
| Malinowski M et al. | Effect of tacrolimus dosing on glucose metabolism in an experimental rat model. | 2010 Jul-Sep | Ann. Transplant. | pmid:20877268 |
| Roan JN et al. | Dose-normalization for exposure to mycophenolic acid and the early clinical outcome in patients taking tacrolimus after heart transplantation. | 2013 | Ann. Transplant. | pmid:23792500 |
| Tanaka T et al. | Evaluation of immune function under conversion from Prograf to Advagraf in living donor liver transplantation. | 2013 | Ann. Transplant. | pmid:23792533 |
| El-Agroudy AE et al. | Long-term graft outcome in patients with chronic allograft dysfunction after immunosuppression modifications. | 2008 | Ann. Transplant. | pmid:19034223 |
| Miyata Y et al. | Pharmacokinetics of a Once-Daily Dose of Tacrolimus Early After Liver Transplantation: With Special Reference to CYP3A5 and ABCB1 Single Nucleotide Polymorphisms. | 2016 | Ann. Transplant. | pmid:27503662 |
| Herden U et al. | Early Initiation of Everolimus After Liver Transplantation: A Single-Center Experience. | 2016 | Ann. Transplant. | pmid:26842532 |
| Grenda R et al. | Evaluation of the genetic background of standard-immunosuppressant-related toxicity in a cohort of 200 paediatric renal allograft recipients--a retrospective study. | 2009 Jul-Sep | Ann. Transplant. | pmid:19644155 |
| Figurski MJ et al. | Pharmacokinetic monitoring of mycophenolic acid in heart transplant patients: correlation the side-effects and rejections with pharmacokinetic parameters. | 2012 Jan-Mar | Ann. Transplant. | pmid:22466911 |
| Acott P and Babel N | BK virus replication following kidney transplant: does the choice of immunosuppressive regimen influence outcomes? | 2012 Jan-Mar | Ann. Transplant. | pmid:22466913 |
| Bułanowski M et al. | Influence of conversion from cyclosporine A to tacrolimus on insulin sensitivity assessed by euglicaemic hyperinsulinemic clamp technique in patients after kidney transplantation. | 2012 Jul-Sep | Ann. Transplant. | pmid:23018257 |
| Baran DA and Galin ID | "One size fits all": immunosuppression in cardiac transplantation. | 2003 | Ann. Transplant. | pmid:12848376 |
| Ogura Y et al. | Early Conversion From Twice-Daily Tacrolimus to Prolonged-Release Tacrolimus in Liver Transplantation: A Single-Center Experience. | 2016 | Ann. Transplant. | pmid:27432248 |
| Dedinská I et al. | Waist circumference as an independent risk factor for NODAT. | 2015 | Ann. Transplant. | pmid:25791039 |
| Eguchi S et al. | Intentional conversion from tacrolimus to cyclosporine for HCV-positive patients on preemptive interferon therapy after living donor liver transplantation. | 2007 | Ann. Transplant. | pmid:18344932 |
| Zahn A et al. | Mycophenolate mofetil combination therapy improves survival after liver transplantation. A single-center retrospective analysis. | 2013 | Ann. Transplant. | pmid:24088725 |
| WÅ‚odarczyk Z et al. | Freedom from rejection and stable kidney function are excellent criteria for steroid withdrawal in tacrolimus-treated kidney transplant recipients. | 2002 | Ann. Transplant. | pmid:12465429 |
| Park S et al. | Reduced Tacrolimus Trough Level Is Reflected by Estimated Glomerular Filtration Rate (eGFR) Changes in Stable Renal Transplantation Recipients: Results of the OPTIMUM Phase 3 Randomized Controlled Study. | 2018 | Ann. Transplant. | pmid:29891834 |
| Rostaing L et al. | The pharmacokinetics of everolimus in de novo kidney transplant patients receiving tacrolimus: an analysis from the randomized ASSET study. | 2014 | Ann. Transplant. | pmid:25017487 |
| Jannot M et al. | Early conversion from twice-daily tacrolimus to once-daily extended formulation in renal transplant patients before hospital discharge. | 2014 | Ann. Transplant. | pmid:24999809 |
| Provenzani A et al. | The effect of CYP3A5 and ABCB1 single nucleotide polymorphisms on tacrolimus dose requirements in Caucasian liver transplant patients. | 2009 Jan-Mar | Ann. Transplant. | pmid:19289993 |
| Urbanowicz T et al. | Comparison of conventional tacrolimus versus prolong release formula as initial therapy in heart transplantation. | 2014 | Ann. Transplant. | pmid:24949728 |
| Fuchs U et al. | Incidence of malignant neoplasia after heart transplantation--a comparison between cyclosporine a and tacrolimus. | 2014 | Ann. Transplant. | pmid:24953848 |
| Hošková L et al. | Comparison of Cystatin C and NGAL in Early Diagnosis of Acute Kidney Injury After Heart Transplantation. | 2016 | Ann. Transplant. | pmid:27226081 |
| Bösmüller C et al. | Tacrolimus monotherapy following alemtuzumab induction in combined kidney-pancreas transplantation: results of a prospective randomized trial. | 2012 | Ann. Transplant. | pmid:23274323 |
| Olczak-Kowalczyk D et al. | The status of dental and jaw bones in children and adolescents after kidney and liver transplantation. | 2012 | Ann. Transplant. | pmid:23274327 |
| Schnitzbauer AA et al. | Delayed bottom-up and amended simple method of dosing with once-daily tacrolimus application to achieve stable trough levels in liver transplantation. | 2015 | Ann. Transplant. | pmid:25553853 |
| Ruangkanchanasetr P et al. | Beta Cell Function and Insulin Resistance After Conversion from Tacrolimus Twice-Daily to Extended-Release Tacrolimus Once-Daily in Stable Renal Transplant Recipients. | 2016 | Ann. Transplant. | pmid:27980321 |
| Van Laecke S et al. | Effect of Magnesium Supplements on Insulin Secretion After Kidney Transplantation: A Randomized Controlled Trial. | 2017 | Ann. Transplant. | pmid:28848225 |
| Kitazawa F et al. | Pharmacokinetic Interaction Between Tacrolimus and Fentanyl in Patients Receiving Allogeneic Hematopoietic Stem Cell Transplantation. | 2017 | Ann. Transplant. | pmid:28947731 |
| Hirano Y et al. | Prolonged Administration of Twice-Daily Bolus Intravenous Tacrolimus in the Early Phase After Lung Transplantation. | 2017 | Ann. Transplant. | pmid:28798289 |
| Illsinger S et al. | Effect of tacrolimus on energy metabolism in human umbilical endothelial cells. | 2011 Apr-Jun | Ann. Transplant. | pmid:21716189 |
| Duvoux C et al. | Sustained virological response to antiviral therapy in a randomized trial of cyclosporine versus tacrolimus in liver transplant patients with recurrent hepatitis C infection. | 2015 | Ann. Transplant. | pmid:25588713 |
| Mijal J et al. | Formation of synapses between dendritic cells and lymphocytes in skin lymph in an allogeneic reaction. | 2002 | Ann. Transplant. | pmid:12854345 |
| Albano L et al. | Dosing of Enteric-Coated Mycophenolate Sodium Under Routine Conditions: An Observational, Multicenter Study in Kidney Transplantation. | 2016 | Ann. Transplant. | pmid:27122116 |
| Thölking G et al. | Tacrolimus Concentration/Dose Ratio is Associated with Renal Function After Liver Transplantation. | 2016 | Ann. Transplant. | pmid:27003330 |