| MeSH term | MeSH ID | Detail |
|---|---|---|
| Poxviridae Infections | D011213 | 1 associated lipids |
| Seminoma | D018239 | 2 associated lipids |
| Hepatic Insufficiency | D048550 | 1 associated lipids |
| Myoclonic Cerebellar Dyssynergia | D002527 | 1 associated lipids |
| Brachial Plexus Neuritis | D020968 | 2 associated lipids |
| Lymphomatoid Granulomatosis | D008230 | 2 associated lipids |
| Dysuria | D053159 | 1 associated lipids |
| Mediastinal Diseases | D008477 | 1 associated lipids |
| Hernia, Ventral | D006555 | 1 associated lipids |
| Paraneoplastic Syndromes, Nervous System | D020361 | 1 associated lipids |
tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Meng QH et al. | Falsely elevated tacrolimus concentrations on the Dimension Xpand. | 2015 | Clin. Biochem. | pmid:26160209 |
| Fischer L et al. | Three-year Outcomes in De Novo Liver Transplant Patients Receiving Everolimus With Reduced Tacrolimus: Follow-Up Results From a Randomized, Multicenter Study. | 2015 | Transplantation | pmid:26151607 |
| Spolidorio LC et al. | The long-term administration of calcineurin inhibitors decreases antioxidant enzyme activity in the rat parotid and submandibular salivary glands. | 2015 | Life Sci. | pmid:26006038 |
| Ali H et al. | Mycophenolate mofetil-based salvage as acute GVHD prophylaxis after early discontinuation of tacrolimus and/or sirolimus. | 2015 | Bone Marrow Transplant. | pmid:25365064 |
| Lee SC et al. | Calcineurin orchestrates dimorphic transitions, antifungal drug responses and host-pathogen interactions of the pathogenic mucoralean fungus Mucor circinelloides. | 2015 | Mol. Microbiol. | pmid:26010100 |
| Sato K et al. | Late onset of progressive speech impairment due to tacrolimus-associated leukoencephalopathy after kidney transplantation. | 2015 | Int Urol Nephrol | pmid:26071870 |
| Pulk RA et al. | Multigene predictors of tacrolimus exposure in kidney transplant recipients. | 2015 | Pharmacogenomics | pmid:26067485 |
| Pardi C and Oltean M | An unusual case of red blood cell immunisation following liver transplantation. | 2015 | Blood Transfus | pmid:26057497 |
| Chen YB et al. | Phase II Trial of Tandem High-Dose Chemotherapy with Autologous Stem Cell Transplantation Followed by Reduced-Intensity Allogeneic Stem Cell Transplantation for Patients with High-Risk Lymphoma. | 2015 | Biol. Blood Marrow Transplant. | pmid:26009261 |
| Ribero S et al. | Efficacy of topical tacrolimus for oral lichen planus: real-life experience in a retrospective cohort of patients with a review of the literature. | 2015 | J Eur Acad Dermatol Venereol | pmid:25308924 |
| Revollo J | Update on the clinical utility of once-daily tacrolimus in the management of transplantation. | 2015 | Drug Des Devel Ther | pmid:26005334 |
| Qasim W et al. | Immunotherapy of HCC metastases with autologous T cell receptor redirected T cells, targeting HBsAg in a liver transplant patient. | 2015 | J. Hepatol. | pmid:25308176 |
| Chan TM | Treatment of severe lupus nephritis: the new horizon. | 2015 | Nat Rev Nephrol | pmid:25421826 |
| Andreu F et al. | Development of a population PK model of tacrolimus for adaptive dosage control in stable kidney transplant patients. | 2015 | Ther Drug Monit | pmid:25254416 |
| Fussner LA et al. | Cardiovascular disease after liver transplantation: When, What, and Who Is at Risk. | 2015 | Liver Transpl. | pmid:25880971 |
| Abuabara K et al. | Atopic dermatitis disease control and age: A cohort study. | 2015 | J. Allergy Clin. Immunol. | pmid:25935107 |
| Clark SL et al. | Making every drop count for pediatric kidney transplant patients. | 2015 | Hosp Pediatr | pmid:25934814 |
| de Sandes-Freitas TV et al. | Subclinical Lesions and Donor-Specific Antibodies in Kidney Transplant Recipients Receiving Tacrolimus-Based Immunosuppressive Regimen Followed by Early Conversion to Sirolimus. | 2015 | Transplantation | pmid:25929604 |
| Ikitimur B et al. | Long-Term Impact of Different Immunosuppressive Drugs on QT and PR Intervals in Renal Transplant Patients. | 2015 | Ann Noninvasive Electrocardiol | pmid:25367596 |
| Ganetsky A et al. | Lack of a significant pharmacokinetic interaction between maraviroc and tacrolimus in allogeneic HSCT recipients. | 2015 | J. Antimicrob. Chemother. | pmid:25881619 |
| Goldthorpe H et al. | Occlusive lung arterial lesions in endothelial-targeted, fas-induced apoptosis transgenic mice. | 2015 | Am. J. Respir. Cell Mol. Biol. | pmid:25879383 |
| Liang GB et al. | Impact of immunosuppressive agents on the expression of indoleamine 2,3-dioxygenase, heme oxygenase-1 and interleukin-7 in mesangial cells. | 2015 | Mol Med Rep | pmid:25936769 |
| Chapron B et al. | Reversible, time-dependent inhibition of CYP3A-mediated metabolism of midazolam and tacrolimus by telaprevir in human liver microsomes. | 2015 | J Pharm Pharm Sci | pmid:25877445 |
| Zijlstra LE et al. | [Heart transplantation in the 21st century in Netherlands: improved survival in the last decade]. | 2015 | Ned Tijdschr Geneeskd | pmid:26648576 |
| Söderlund C and Rådegran G | Immunosuppressive therapies after heart transplantation--The balance between under- and over-immunosuppression. | 2015 | Transplant Rev (Orlando) | pmid:25812489 |
| Zegarska J et al. | Mycophenolic Acid Metabolites Acyl-Glucuronide and Glucoside Affect the Occurrence of Infectious Complications and Bone Marrow Dysfunction in Liver Transplant Recipients. | 2015 | Ann. Transplant. | pmid:26313036 |
| Lee JR et al. | Gut microbiota and tacrolimus dosing in kidney transplantation. | 2015 | PLoS ONE | pmid:25815766 |
| Dave V et al. | Managing psychosis in a renal transplant recipient with bipolar affective disorder and allograft rejection. | 2015 | Nephrology (Carlton) | pmid:25807849 |
| Stevens RB et al. | A randomized 2×2 factorial trial, part 1: single-dose rabbit antithymocyte globulin induction may improve renal transplantation outcomes. | 2015 | Transplantation | pmid:25083614 |
| La Placa M et al. | Disfiguring papular sarcoidosis of the face: dramatic improvement with pimecrolimus. | 2015 | J Eur Acad Dermatol Venereol | pmid:25073484 |
| Ravaioli M et al. | Immunosuppression Modifications Based on an Immune Response Assay: Results of a Randomized, Controlled Trial. | 2015 | Transplantation | pmid:25757214 |
| Bis DM et al. | Characterization of the nocardiopsin biosynthetic gene cluster reveals similarities to and differences from the rapamycin and FK-506 pathways. | 2015 | Chembiochem | pmid:25755076 |
| Rahman Z et al. | Comparison of X-ray powder diffraction and solid-state nuclear magnetic resonance in estimating crystalline fraction of tacrolimus in sustained-release amorphous solid dispersion and development of discriminating dissolution method. | 2015 | J Pharm Sci | pmid:25753829 |
| Devine SM et al. | Phase II Study of Allogeneic Transplantation for Older Patients With Acute Myeloid Leukemia in First Complete Remission Using a Reduced-Intensity Conditioning Regimen: Results From Cancer and Leukemia Group B 100103 (Alliance for Clinical Trials in Oncology)/Blood and Marrow Transplant Clinical Trial Network 0502. | 2015 | J. Clin. Oncol. | pmid:26527780 |
| Qian G et al. | Successful treatment of recalcitrant granulomatous rosacea with oral thalidomide and topical pimecrolimus. | 2015 | J. Dermatol. | pmid:25753523 |
| Pennington CA et al. | Evaluation of a Weight-based Rabbit Anti-thymocyte Globulin Induction Dosing Regimen for Kidney Transplant Recipients. | 2015 | Pharmacotherapy | pmid:26234282 |
| Zhu L et al. | Adrenergic stimulation sensitizes TRPV1 through upregulation of cystathionine β-synthetase in a rat model of visceral hypersensitivity. | 2015 | Sci Rep | pmid:26527188 |
| Vanhove T et al. | Response to 'Tacrolimus pharmacokinetics after kidney transplantation--Influence of changes in haematocrit and steroid dose'. | 2015 | Br J Clin Pharmacol | pmid:26235051 |
| Hanifin JM | A Reassuring Rejoinder Against Malignant Influences of Topical Calcineurin Use in Children. | 2015 | JAMA Dermatol | pmid:25692944 |
| Margolis DJ et al. | Association Between Malignancy and Topical Use of Pimecrolimus. | 2015 | JAMA Dermatol | pmid:25692459 |
| Shuker N et al. | Intra-patient variability in tacrolimus exposure: causes, consequences for clinical management. | 2015 | Transplant Rev (Orlando) | pmid:25687818 |
| Fan DM et al. | Successful ABO-incompatible living-related intestinal transplantation: a 2-year follow-up. | 2015 | Am. J. Transplant. | pmid:25808777 |
| Matsushima M et al. | [A case of anti-PL7 antibody positive myositis and a clinical and pathological review of the anti-synthetase syndrome]. | 2015 | Rinsho Shinkeigaku | pmid:26458569 |
| Almeida-Corrêa S et al. | Calcineurin inhibition blocks within-, but not between-session fear extinction in mice. | 2015 | Learn. Mem. | pmid:25691516 |
| Leneghan D and Bell A | Immunophilin-protein interactions in Plasmodium falciparum. | 2015 | Parasitology | pmid:26156578 |
| Luo X et al. | Evaluation of 6β-Hydroxycortisol and 6β-Hydroxycortisone as Biomarkers for Cytochrome P450 3A Activity: Insight into Their Predictive Value for Estimating Oral Immunosuppressant Metabolism. | 2015 | J Pharm Sci | pmid:26150050 |
| Chen QJ et al. | Tacrolimus decreases insulin sensitivity without reducing fasting insulin concentration: a 2-year follow-up study in kidney transplant recipients. | 2015 | Ren Fail | pmid:25644968 |
| Herbst S et al. | Phagocytosis-dependent activation of a TLR9-BTK-calcineurin-NFAT pathway co-ordinates innate immunity to Aspergillus fumigatus. | 2015 | EMBO Mol Med | pmid:25637383 |
| Joneja U and Uppal G | Pseudo-Pelger-Huët anomaly in a patient on tacrolimus. | 2015 | Blood | pmid:26371350 |
| Ustundag UV et al. | The effects of tacrolimus on the activity and expression of tissue factor in the rat ovary with ischemia-reperfusion induced injury. | 2015 | Reprod Biol | pmid:26370456 |
| Kawahara T et al. | Cyclosporine A and tacrolimus inhibit bladder cancer growth through down-regulation of NFATc1. | 2015 | Oncotarget | pmid:25638160 |
| Dagher M et al. | Overweight, central obesity, and cardiometabolic risk factors in pediatric liver transplantation. | 2015 | Pediatr Transplant | pmid:25581506 |
| Kita A et al. | Imp2, the PSTPIP homolog in fission yeast, affects sensitivity to the immunosuppressant FK506 and membrane trafficking in fission yeast. | 2015 | Biochem. Biophys. Res. Commun. | pmid:25580011 |
| Cortina G et al. | De novo tacrolimus-induced thrombotic microangiopathy in the early stage after renal transplantation successfully treated with conversion to everolimus. | 2015 | Pediatr. Nephrol. | pmid:25577332 |
| Annunziato RA et al. | Can transition to adult care for transplant recipients be improved by intensified services while patients are still in pediatrics? | 2015 | Prog Transplant | pmid:26308783 |
| Pape E et al. | Management of Tacrolimus-Telaprevir Drug-Drug Interaction in a Liver Transplant Patient With Hepatitis C Virus: Practical Considerations. | 2015 | Transplantation | pmid:26308424 |
| Ruiz J et al. | Impact of Single Nucleotide Polymorphisms (SNPs) on Immunosuppressive Therapy in Lung Transplantation. | 2015 | Int J Mol Sci | pmid:26307985 |
| Kurita T et al. | The efficacy of tacrolimus in patients with interstitial lung diseases complicated with polymyositis or dermatomyositis. | 2015 | Rheumatology (Oxford) | pmid:24764266 |
| Cavalié M et al. | Maintenance therapy of adult vitiligo with 0.1% tacrolimus ointment: a randomized, double blind, placebo-controlled study. | 2015 | J. Invest. Dermatol. | pmid:25521460 |
| Reddy YN et al. | Is there a genetic predisposition to new-onset diabetes after kidney transplantation? | 2015 | Saudi J Kidney Dis Transpl | pmid:26586047 |
| Yu Y et al. | Investigation into the interchangeability of generic formulations using immunosuppressants and a broad selection of medicines. | 2015 | Eur. J. Clin. Pharmacol. | pmid:26062932 |
| Millner L et al. | A clinical approach to solving discrepancies in therapeutic drug monitoring results for patients on sirolimus or tacrolimus: Towards personalized medicine, immunosuppression and pharmacogenomics. | 2015 | Clin. Chim. Acta | pmid:26232156 |
| Li JL et al. | Interactive effects of CYP3A4, CYP3A5, MDR1 and NR1I2 polymorphisms on tracrolimus trough concentrations in early postrenal transplant recipients. | 2015 | Pharmacogenomics | pmid:26228923 |
| Li YX and Dijkers PF | Specific calcineurin isoforms are involved in Drosophila toll immune signaling. | 2015 | J. Immunol. | pmid:25429067 |
| Allison SJ | Lupus nephritis: Multitarget induction therapy for LN. | 2015 | Nat Rev Nephrol | pmid:25421833 |
| Tan ES et al. | Effective treatment of scrotal lichen simplex chronicus with 0.1% tacrolimus ointment: an observational study. | 2015 | J Eur Acad Dermatol Venereol | pmid:24666218 |
| Takeuchi S et al. | Pruritus of patients with atopic dermatitis in daily life and their experience of therapeutic effects: results of a web-based questionnaire survey. | 2015 | Br. J. Dermatol. | pmid:25421804 |
| Kabrine M and Laraba-Djebari F | Immunomodulatory and protective properties of tacrolimus in experimental scorpion envenomation. | 2014 Jan-Mar | Int J Immunopathol Pharmacol | pmid:24674680 |
| Wang C and Lin A | Efficacy of topical calcineurin inhibitors in psoriasis. | 2014 Jan-Feb | J Cutan Med Surg | pmid:24377467 |
| Feito-RodrÃguez M et al. | Bacterial vaginosis in the context of lichen sclerosus in a prepubertal girl. | 2014 Jan-Feb | Pediatr Dermatol | pmid:24125016 |
| Veisa G et al. | The importance of renal biopsy in the management of renal transplantation. | 2014 Apr-Jun | Rev Med Chir Soc Med Nat Iasi | pmid:25076703 |
| Singh K et al. | Superiority of rapamycin over tacrolimus in preserving nonhuman primate Treg half-life and phenotype after adoptive transfer. | 2014 | Am. J. Transplant. | pmid:25359003 |
| Silva HT et al. | Long-term follow-up of a phase III clinical trial comparing tacrolimus extended-release/MMF, tacrolimus/MMF, and cyclosporine/MMF in de novo kidney transplant recipients. | 2014 | Transplantation | pmid:24521771 |
| Kiiski V et al. | Long-term safety of topical pimecrolimus and topical tacrolimus in atopic blepharoconjunctivitis. | 2014 | JAMA Dermatol | pmid:24500107 |
| Højfeldt JW et al. | Bifunctional ligands allow deliberate extrinsic reprogramming of the glucocorticoid receptor. | 2014 | Mol. Endocrinol. | pmid:24422633 |
| Mekaj AY et al. | Application of topical pharmacological agents at the site of peripheral nerve injury and methods used for evaluating the success of the regenerative process. | 2014 | J Orthop Surg Res | pmid:25303779 |
| Satoh S et al. | Pharmacokinetic and CYP3A5 pharmacogenetic differences between once- and twice-daily tacrolimus from the first dosing day to 1 year after renal transplantation. | 2014 | Pharmacogenomics | pmid:25303300 |
| Souto-RodrÃguez R et al. | Differences in the incidence and clinical evolution of early neurotoxicity after liver transplantation based on tacrolimus formulation used in the immunosuppressive induction protocol. | 2014 | Transplant. Proc. | pmid:25420839 |
| de la Fuente S et al. | Long-term survivors after pediatric liver transplatation are at increased risk for development of cardiovascular disease events: analysis of 30 cases. | 2014 | Transplant. Proc. | pmid:25420837 |
| Tavira B et al. | Mitochondrial DNA haplogroups and risk of new-onset diabetes among tacrolimus-treated renal transplanted patients. | 2014 | Gene | pmid:24445060 |
| Barreiro C and MartÃnez-Castro M | Trends in the biosynthesis and production of the immunosuppressant tacrolimus (FK506). | 2014 | Appl. Microbiol. Biotechnol. | pmid:24272367 |
| Salehi-Najafabadi Z et al. | The gamma-butyrolactone receptors BulR1 and BulR2 of Streptomyces tsukubaensis: tacrolimus (FK506) and butyrolactone synthetases production control. | 2014 | Appl. Microbiol. Biotechnol. | pmid:24562179 |
| Gomez-Moyano E et al. | Periorbital granuloma annulare successfully treated with tacrolimus 0.1% ointment. | 2014 | Int. J. Dermatol. | pmid:23432464 |
| Nasu R et al. | Favorable outcomes of tacrolimus compared with cyclosporine A for GVHD prophylaxis in HSCT for standard-risk hematological diseases. | 2014 | Ann. Hematol. | pmid:24590535 |
| Rahman Z et al. | Determination of tacrolimus crystalline fraction in the commercial immediate release amorphous solid dispersion products by a standardized X-ray powder diffraction method with chemometrics. | 2014 | Int J Pharm | pmid:25173870 |
| Aulagnon F et al. | Diarrhea after kidney transplantation: a new look at a frequent symptom. | 2014 | Transplantation | pmid:25073040 |
| Piao SG et al. | Combined treatment of tacrolimus and everolimus increases oxidative stress by pharmacological interactions. | 2014 | Transplantation | pmid:24825522 |
| Navas-López VM et al. | Oral tacrolimus for pediatric steroid-resistant ulcerative colitis. | 2014 | J Crohns Colitis | pmid:23582736 |
| van Gelder T et al. | Pharmacogenetics and immunosuppressive drugs in solid organ transplantation. | 2014 | Nat Rev Nephrol | pmid:25247332 |
| Tapirdamaz Ö et al. | Genetic variance in ABCB1 and CYP3A5 does not contribute toward the development of chronic kidney disease after liver transplantation. | 2014 | Pharmacogenet. Genomics | pmid:25014506 |
| Helmschrott M et al. | Superior rejection profile during the first 24 months after heart transplantation under tacrolimus as baseline immunosuppressive regimen. | 2014 | Drug Des Devel Ther | pmid:25246772 |
| Picchianti-Diamanti A et al. | P-glycoprotein and drug resistance in systemic autoimmune diseases. | 2014 | Int J Mol Sci | pmid:24658440 |
| Wolfram D et al. | Insights from computational modeling in inflammation and acute rejection in limb transplantation. | 2014 | PLoS ONE | pmid:24926998 |
| Zhao X et al. | [A retrospective cohort study regarding the effect of sirolimus-based immunosuppression protocol on the long-term survival of hepatocellular carcinoma patients after liver transplantation]. | 2014 | Zhonghua Wai Ke Za Zhi | pmid:24924566 |
| Saito E et al. | Efficacy of salvage therapy and its effect on operative outcomes in patients with ulcerative colitis. | 2014 | Digestion | pmid:24458114 |
| Wang YB et al. | In vitro and in vivo performance of dry powder inhalation formulations: comparison of particles prepared by thin film freezing and micronization. | 2014 | AAPS PharmSciTech | pmid:24824172 |
| Taube D et al. | Generic tacrolimus in solid organ transplantation. | 2014 | Clin Transplant | pmid:24750309 |
| Cvetkovic TP et al. | Gender differences in oxidative and nitrosative stress parameters in kidney transplant patients on tacrolimus-based immunosuppression. | 2014 | Int Urol Nephrol | pmid:24101297 |
| Hässig A et al. | Association of BK viremia with human leukocyte antigen mismatches and acute rejection, but not with type of calcineurin inhibitor. | 2014 | Transpl Infect Dis | pmid:24134704 |
| Manousou P et al. | Reduced fibrosis in recurrent HCV with tacrolimus, azathioprine and steroids versus tacrolimus: randomised trial long term outcomes. | 2014 | Gut | pmid:24131637 |