| MeSH term | MeSH ID | Detail |
|---|---|---|
| Diabetes Mellitus, Type 1 | D003922 | 56 associated lipids |
| Dermatitis, Contact | D003877 | 59 associated lipids |
| Pain | D010146 | 64 associated lipids |
| Reperfusion Injury | D015427 | 65 associated lipids |
| Cystic Fibrosis | D003550 | 65 associated lipids |
| Liver Cirrhosis | D008103 | 67 associated lipids |
| Colitis | D003092 | 69 associated lipids |
| Melanoma | D008545 | 69 associated lipids |
| Hyperlipidemias | D006949 | 73 associated lipids |
| Leukemia | D007938 | 74 associated lipids |
tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Baran DA et al. | A novel tacrolimus dosing strategy in cardiac transplantation: drug levels, renal function, and biopsy results. | 2002 | Transplant. Proc. | pmid:12176595 |
| Undre NA and Stevenson PJ | Pharmacokinetics of tacrolimus in heart transplantation. | 2002 | Transplant. Proc. | pmid:12176596 |
| Pham SM et al. | Sirolimus and tacrolimus in clinical cardiac transplantation. | 2002 | Transplant. Proc. | pmid:12176597 |
| Uber PA et al. | Steroid weaning in heart transplantation is associated with decreased B-type natriuretic peptide: surrogate evidence for cardiac adaptation. | 2002 | Transplant. Proc. | pmid:12176598 |
| Baran DA et al. | Tacrolimus and cardiac transplantation: a comparison of monotherapy and steroid-dependent patients. | 2002 | Transplant. Proc. | pmid:12176599 |
| Chan MC et al. | Conversion of cyclosporine to tacrolimus for refractory or persistent myocardial rejection. | 2002 | Transplant. Proc. | pmid:12176601 |
| van Riemsdijk IC et al. | Improvement of cardiovascular risk factors in heart transplant recipients after conversion from cyclosporine to tacrolimus: a role of the TGF-beta system. | 2002 | Transplant. Proc. | pmid:12176606 |
| Baran DA et al. | Predictors of early renal insufficiency in cardiac transplant recipients initiated on tacrolimus. | 2002 | Transplant. Proc. | pmid:12176609 |
| Fieguth HG et al. | Tacrolimus for treatment of bronchiolitis obliterans syndrome after unilateral and bilateral lung transplantation. | 2002 | Transplant. Proc. | pmid:12176613 |
| Khwaja K et al. | Pancreas transplantation in cross-match-positive recipients using cyclosporine- or tacrolimus-based immunosuppression. | 2002 | Transplant. Proc. | pmid:12176621 |
| Rigotti P et al. | Antilymphocyte induction is no longer necessary in simultaneous pancreas and kidney transplantation. | 2002 | Transplant. Proc. | pmid:12176623 |
| Dette K et al. | Daclizumab and ATG versus ATG in combination with tacrolimus, mycophenolate mofetil, and steroids in simultaneous [correction of simultaneus] pancreas-kidney transplantation: analysis of early outcome. | 2002 | Transplant. Proc. | pmid:12176624 |
| Land W et al. | Tacrolimus versus cyclosporine in primary simultaneous pancreas-kidney transplantation: preliminary results at 1 year of a large multicenter trial. | 2002 | Transplant. Proc. | pmid:12176625 |
| Burke GW et al. | Steroid-resistant acute rejection following SPK: importance of maintaining therapeutic dosing in a triple-drug regimen. | 2002 | Transplant. Proc. | pmid:12176628 |
| Woeste G et al. | Tacrolimus/mycophenolate mofetil vs cyclosporine A/Azathioprine after simultaneous pancreas and kidney transplantation: five-year results of a randomized study. | 2002 | Transplant. Proc. | pmid:12176629 |
| Filler G et al. | One-year glomerular filtration rate predicts graft survival in pediatric renal recipients: a randomized trial of tacrolimus vs cyclosporine microemulsion. | 2002 | Transplant. Proc. | pmid:12176634 |
| Hasegawa A et al. | Optimal use of tacrolimus in living donor renal transplantation in children. | 2002 | Transplant. Proc. | pmid:12176635 |
| El-Sabrout R et al. | Rejection-free protocol using sirolimus-tacrolimus combination for pediatric renal transplant recipients. | 2002 | Transplant. Proc. | pmid:12176636 |
| Ciancio G et al. | Effect of daclizumab, tacrolimus, and mycophenolate mofetil in pediatric first renal transplant recipients. | 2002 | Transplant. Proc. | pmid:12176637 |
| El-Sabrout R et al. | Improved lipid profile and blood sugar control in pediatric renal transplant recipients using sirolimus-tacrolimus combination. | 2002 | Transplant. Proc. | pmid:12176638 |
| Webb NJ et al. | Pharmacokinetics of tacrolimus in paediatric renal transplant recipients. | 2002 | Transplant. Proc. | pmid:12176639 |
| Sundberg AK et al. | Conversion from cyclosporine to tacrolimus is preferred by pediatric renal transplant recipients: a focus on opinions and outcomes. | 2002 | Transplant. Proc. | pmid:12176640 |
| Ojogho ON et al. | Mycophenolate mofetil without antibody induction in pediatric renal transplantation. | 2002 | Transplant. Proc. | pmid:12176641 |
| Sindhi R et al. | Pharmacodynamics of sirolimus in transplanted children receiving tacrolimus. | 2002 | Transplant. Proc. | pmid:12176644 |
| Petz W et al. | Experience with the use of basiliximab in liver transplantation--use in pediatric and adult recipients in combination with cyclosporine or tacrolimus. | 2002 | Transplant. Proc. | pmid:12176648 |
| Jain A et al. | Almost total absence of chronic rejection in primary pediatric liver transplantation under tacrolimus. | 2002 | Transplant. Proc. | pmid:12176649 |
| Asensio M et al. | Induction with basiliximab reduces acute rejection in pediatric liver transplant patients treated with tacrolimus and steroids. | 2002 | Transplant. Proc. | pmid:12176650 |
| Sindhi R et al. | Preliminary immunosuppression withdrawal strategies with sirolimus in children with liver transplants. | 2002 | Transplant. Proc. | pmid:12176651 |
| Zajicek A et al. | Thirteen years' experience in pediatric liver transplantation: differences between tacrolimus and cyclosporine. | 2002 | Transplant. Proc. | pmid:12176653 |
| Ma L et al. | Immunosuppressive effects of glucosamine. | 2002 | J. Biol. Chem. | pmid:12176986 |
| Cheng H et al. | Role of the Rab GTP-binding protein Ypt3 in the fission yeast exocytic pathway and its connection to calcineurin function. | 2002 | Mol. Biol. Cell | pmid:12181359 |
| Minder D et al. | Immunophilins and HIV-1 infection. | 2002 | Arch. Virol. | pmid:12181673 |
| Venkataramanan R et al. | Voriconazole inhibition of the metabolism of tacrolimus in a liver transplant recipient and in human liver microsomes. | 2002 | Antimicrob. Agents Chemother. | pmid:12183280 |
| Revill WP et al. | Genetically engineered analogs of ascomycin for nerve regeneration. | 2002 | J. Pharmacol. Exp. Ther. | pmid:12183690 |
| Ferraresso M et al. | Conversion from cyclosporine to tacrolimus in pediatric kidney transplant recipients. | 2002 | Pediatr. Nephrol. | pmid:12185478 |
| Manzanares C | Therapeutic drug monitoring of tacrolimus: a moving matter. | 2002 Mar-Apr | Therapie | pmid:12185961 |
| Homma M et al. | False positive blood tacrolimus concentration in microparticle enzyme immunoassay. | 2002 | Biol. Pharm. Bull. | pmid:12186423 |
| Fox SC et al. | Platelet aggregation and intracellular calcium mobilisation responses are enhanced by cyclosporin A but not by pimecrolimus (SDZ ASM 981). | 2002 | Platelets | pmid:12189022 |
| Christians U et al. | Mechanisms of clinically relevant drug interactions associated with tacrolimus. | 2002 | Clin Pharmacokinet | pmid:12190331 |
| Slowinski T et al. | Interaction of the endothelin system and calcineurin inhibitors after kidney transplantation. | 2002 | Clin. Sci. | pmid:12193131 |
| Pawinski T et al. | Limited sampling strategy for the estimation of mycophenolic acid area under the curve in adult renal transplant patients treated with concomitant tacrolimus. | 2002 | Clin. Chem. | pmid:12194926 |
| Guilbeau JM | Delayed wound healing with sirolimus after liver transplant. | 2002 | Ann Pharmacother | pmid:12196058 |
| Cho YM et al. | A case showing complete insulin independence after severe diabetic ketoacidosis associated with tacrolimus treatment. | 2002 | Diabetes Care | pmid:12196452 |
| Mettang T et al. | Uraemic pruritus--new perspectives and insights from recent trials. | 2002 | Nephrol. Dial. Transplant. | pmid:12198205 |
| Escribano O et al. | Pretreatment with FK506 up-regulates insulin receptors in regenerating rat liver. | 2002 | Hepatology | pmid:12198647 |
| Neff T et al. | Pharmacologically regulated in vivo selection in a large animal. | 2002 | Blood | pmid:12200362 |
| Jain AK et al. | The interaction between antiretroviral agents and tacrolimus in liver and kidney transplant patients. | 2002 | Liver Transpl. | pmid:12200788 |
| McAlister V | Predicting behavior of immunosuppressants in liver transplantation. | 2002 | Liver Transpl. | pmid:12200790 |
| Tsinalis D et al. | Acute renal failure in a renal allograft recipient treated with intravenous immunoglobulin. | 2002 | Am. J. Kidney Dis. | pmid:12200824 |
| Pradhan M et al. | Decline in renal function following thoracic organ transplantation in children. | 2002 | Am. J. Transplant. | pmid:12201367 |
| Shui C et al. | The immunosuppressant rapamycin, alone or with transforming growth factor-beta, enhances osteoclast differentiation of RAW264.7 monocyte-macrophage cells in the presence of RANK-ligand. | 2002 | Calcif. Tissue Int. | pmid:12202955 |
| Althoff EA and Cornish VW | A bacterial small-molecule three-hybrid system. | 2002 | Angew. Chem. Int. Ed. Engl. | pmid:12203581 |
| Hong F et al. | Cyclosporin A blocks muscle differentiation by inducing oxidative stress and inhibiting the peptidyl-prolyl-cis-trans isomerase activity of cyclophilin A: cyclophilin A protects myoblasts from cyclosporin A-induced cytotoxicity. | 2002 | FASEB J. | pmid:12207006 |
| Kirtschig G et al. | Successful treatment of erosive vulvovaginal lichen planus with topical tacrolimus. | 2002 | Br. J. Dermatol. | pmid:12207624 |
| Furst DE et al. | Efficacy of tacrolimus in rheumatoid arthritis patients who have been treated unsuccessfully with methotrexate: a six-month, double-blind, randomized, dose-ranging study. | 2002 | Arthritis Rheum. | pmid:12209503 |
| Udina E et al. | Bimodal dose-dependence of FK506 on the rate of axonal regeneration in mouse peripheral nerve. | 2002 | Muscle Nerve | pmid:12210363 |
| Nishikawa K and Terasaki PI | Annual trends and triple therapy--1991-2000. | 2001 | Clin Transpl | pmid:12211788 |
| Chang CT and Wu MS | Successful treatment of idiopathic membranous glomerulonephritis complicated with renal vein thrombosis with FK506. | 2002 | Ren Fail | pmid:12212832 |
| Curtis JJ | Hypertensinogenic mechanism of the calcineurin inhibitors. | 2002 | Curr. Hypertens. Rep. | pmid:12217256 |
| Huai Q et al. | Crystal structure of calcineurin-cyclophilin-cyclosporin shows common but distinct recognition of immunophilin-drug complexes. | 2002 | Proc. Natl. Acad. Sci. U.S.A. | pmid:12218175 |
| Uehara T et al. | A successful second unrelated BMT (UBMT) from a different unrelated donor to treat ALL that relapsed after the initial UBMT. | 2002 | Am. J. Hematol. | pmid:12221672 |
| Allen DM and Esterly NB | Significant systemic absorption of tacrolimus after topical application in a patient with lamellar ichthyosis. | 2002 | Arch Dermatol | pmid:12225004 |
| Neau-Cransac M et al. | Renal failure after liver transplantation: outcome after calcineurin inhibitor withdrawal. | 2002 | Clin Transplant | pmid:12225434 |
| Keevil BG et al. | Evaluation of a rapid micro-scale assay for tacrolimus by liquid chromatography-tandem mass spectrometry. | 2002 | Ann. Clin. Biochem. | pmid:12227855 |
| Spychala J and Mitchell BS | Cyclosporin A and FK506 decrease adenosine kinase activity and adenosine uptake in T-lymphocytes. | 2002 | J. Lab. Clin. Med. | pmid:12228764 |
| Jeanmart H et al. | Comparative study of cyclosporine and tacrolimus vs newer immunosuppressants mycophenolate mofetil and rapamycin on coronary endothelial function. | 2002 | J. Heart Lung Transplant. | pmid:12231370 |
| Tanaka K et al. | Neuroprotective and antioxidant properties of FKBP-binding immunophilin ligands are independent on the FKBP12 pathway in human cells. | 2002 | Neurosci. Lett. | pmid:12231433 |
| Hong Y et al. | Triptolide is a potent suppressant of C3, CD40 and B7h expression in activated human proximal tubular epithelial cells. | 2002 | Kidney Int. | pmid:12234299 |
| Iwasaki Y et al. | Neuroprotective actions of FK506 and cyclosporin A on motor neuron survival following neonatal axotomy. | 2002 | Neurol. Res. | pmid:12238623 |
| Höcherl K et al. | Cyclosporine A suppresses cyclooxygenase-2 expression in the rat kidney. | 2002 | J. Am. Soc. Nephrol. | pmid:12239231 |
| Emovon OE and Browne BJ | Tacrolimus and ciclosporin microemulsion in renal transplantation. | 2002 | Lancet | pmid:12241844 |
| Schieppati A et al. | Tacrolimus and ciclosporin microemulsion in renal transplantation. | 2002 | Lancet | pmid:12241845 |
| Bruijn JA and van der Woude FJ | Tacrolimus and ciclosporin microemulsion in renal transplantation. | 2002 | Lancet | pmid:12241846 |
| English RF et al. | Long-term comparison of tacrolimus- and cyclosporine-induced nephrotoxicity in pediatric heart-transplant recipients. | 2002 | Am. J. Transplant. | pmid:12243498 |
| Matsue H et al. | Contrasting impacts of immunosuppressive agents (rapamycin, FK506, cyclosporin A, and dexamethasone) on bidirectional dendritic cell-T cell interaction during antigen presentation. | 2002 | J. Immunol. | pmid:12244145 |
| Altaca G et al. | Effect of low-dose calcineurin inhibitors on acute rejection and graft survival. | 2002 | Transplant. Proc. | pmid:12270320 |
| Colak T et al. | Effect of conversion from cyclosporine to tacrolimus on lipid profiles in renal transplant recipients. | 2002 | Transplant. Proc. | pmid:12270321 |
| Nanni G et al. | Lack of correlation between serum levels of mycophenolate mofetil and kidney transplant outcome in tacrolimus-based immunosupression. | 2002 | Transplant. Proc. | pmid:12270323 |
| Pape L et al. | Long-term stable glomerular filtration rate achieved with tacrolimus in pediatric renal transplantation. | 2002 | Transplant. Proc. | pmid:12270367 |
| Fischereder M et al. | Gynaecomastia following solid organ transplantation. | 2002 | Transplant. Proc. | pmid:12270376 |
| Dahmen U et al. | Onset of liver regeneration after subtotal resection is inhibited by the use of new immunosuppressive drugs. | 2002 | Transplant. Proc. | pmid:12270412 |
| Barten MJ et al. | Pharmacodynamics of the immunosuppressive effects of the combination of tacrolimus with mycophenolate mofetil. | 2002 | Transplant. Proc. | pmid:12270442 |
| Strassburg A et al. | Basiliximab reduces acute liver allograft rejection in pediatric patients. | 2002 | Transplant. Proc. | pmid:12270443 |
| Weimer R et al. | Effects of three immunosuppressive regimens on CD4 helper function, B cell monocyte and cytokine responses in renal transplant recipients: 4-month follow-up of a prospective randomized study. | 2002 | Transplant. Proc. | pmid:12270445 |
| Tangsinmankong N et al. | Different mechanisms are utilized by HIV-1 Nef and staphylococcal enterotoxin A to control and regulate interleukin-10 production. | 2002 | Immunol. Lett. | pmid:12270545 |
| Uchino H et al. | Differential neuroprotection by cyclosporin A and FK506 following ischemia corresponds with differing abilities to inhibit calcineurin and the mitochondrial permeability transition. | 2002 | Neurobiol. Dis. | pmid:12270685 |
| Ghoshal AK and Soldin SJ | IMx tacrolimus II assay: is it reliable at low blood concentrations? A comparison with tandem MS/MS. | 2002 | Clin. Biochem. | pmid:12270769 |
| Fleischer AB et al. | Tacrolimus ointment for the treatment of atopic dermatitis is not associated with an increase in cutaneous infections. | 2002 | J. Am. Acad. Dermatol. | pmid:12271302 |
| Morrison L et al. | An open trial of topical tacrolimus for erosive oral lichen planus. | 2002 | J. Am. Acad. Dermatol. | pmid:12271312 |
| Kalthoff FS et al. | Pimecrolimus inhibits up-regulation of OX40 and synthesis of inflammatory cytokines upon secondary T cell activation by allogeneic dendritic cells. | 2002 | Clin. Exp. Immunol. | pmid:12296857 |
| Edwards PC and Kelsch R | Oral lichen planus: clinical presentation and management. | 2002 | J Can Dent Assoc | pmid:12323106 |
| Neal JW and Clipstone NA | Calcineurin mediates the calcium-dependent inhibition of adipocyte differentiation in 3T3-L1 cells. | 2002 | J. Biol. Chem. | pmid:12351639 |
| Calò LA et al. | Oxidative stress in kidney transplant patients with calcineurin inhibitor-induced hypertension: effect of ramipril. | 2002 | J. Cardiovasc. Pharmacol. | pmid:12352326 |
| Garton T | Nefazodone and cyp450 3a4 interactions with cyclosporine and tacrolimus1. | 2002 | Transplantation | pmid:12352898 |
| Yamauchi A et al. | Neurotoxicity induced by tacrolimus after liver transplantation: relation to genetic polymorphisms of the ABCB1 (MDR1) gene. | 2002 | Transplantation | pmid:12352921 |
| Brown NW et al. | Mycophenolic acid and mycophenolic acid glucuronide pharmacokinetics in pediatric liver transplant recipients: effect of cyclosporine and tacrolimus comedication. | 2002 | Ther Drug Monit | pmid:12352931 |
| Staatz CE et al. | Comparison of an ELISA and an LC/MS/MS method for measuring tacrolimus concentrations and making dosage decisions in transplant recipients. | 2002 | Ther Drug Monit | pmid:12352932 |
| Ambo M | Relapsing Kaposi's varicelliform eruption and herpes simplex following facial tacrolimus treatment for atopic dermatitis. | 2002 | Acta Derm. Venereol. | pmid:12353724 |
| Jin L and Harrison SC | Crystal structure of human calcineurin complexed with cyclosporin A and human cyclophilin. | 2002 | Proc. Natl. Acad. Sci. U.S.A. | pmid:12357034 |
| Hariharan S | Case 2: strategies to minimize the use of calcineurin inhibitors (CNIs). | 2002 | Transplantation | pmid:12357988 |