| MeSH term | MeSH ID | Detail |
|---|---|---|
| Diabetes Mellitus, Type 1 | D003922 | 56 associated lipids |
| Dermatitis, Contact | D003877 | 59 associated lipids |
| Pain | D010146 | 64 associated lipids |
| Reperfusion Injury | D015427 | 65 associated lipids |
| Cystic Fibrosis | D003550 | 65 associated lipids |
| Liver Cirrhosis | D008103 | 67 associated lipids |
| Melanoma | D008545 | 69 associated lipids |
| Colitis | D003092 | 69 associated lipids |
| Hyperlipidemias | D006949 | 73 associated lipids |
| Leukemia | D007938 | 74 associated lipids |
tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Swanson C et al. | FK 506-based immunosuppression in clinical pancreas transplantation. | 1995 | Transplant. Proc. | pmid:8539827 |
| Tesi RJ et al. | Conversion of pancreas transplants to FK 506 from CsA. | 1995 | Transplant. Proc. | pmid:8539828 |
| Burke GW et al. | Use of FK 506 in simultaneous pancreas/kidney transplantation: lack of impairment of glycemic or lipid metabolism. | 1995 | Transplant. Proc. | pmid:8539872 |
| Burke GW et al. | The use of FK506 in simultaneous pancreas/kidney transplantation: rescue, induction, and maintenance immunosuppression. | 1995 | Transplant. Proc. | pmid:8539874 |
| Wennberg L et al. | Immunosuppression with leflunomide and cyclosporine prevents pig-to-rat islet xenograft rejection. | 1995 | Transplant. Proc. | pmid:8539967 |
| Tai J et al. | In vivo function of pig islet xenografts in immunosuppressed diabetic mice. | 1995 | Transplant. Proc. | pmid:8539968 |
| Felldin M et al. | Rescue therapy with Tacrolimus (FK506) in renal transplant recipients--a multicenter analysis. | 1995 | Transplant. Proc. | pmid:8540032 |
| Bersztel A et al. | Deoxyspergualin is synergistic with cyclosporin A, but not with FK506 in a rat heart allograft transplantation model. | 1995 | Transplant. Proc. | pmid:8540095 |
| Monfar M et al. | Activation of pp70/85 S6 kinases in interleukin-2-responsive lymphoid cells is mediated by phosphatidylinositol 3-kinase and inhibited by cyclic AMP. | 1995 | Mol. Cell. Biol. | pmid:7528328 |
| Echigo Y et al. | Effects of cyclosporine and tacrolimus (FK 506) on acute pancreatitis in mice. | 1995 | Arch Surg | pmid:7528496 |
| Fukuzaki T et al. | A protocol with FK 506 for inducing unresponsiveness to murine islet allografts. | 1995 | Surgery | pmid:7531371 |
| Lemster BH et al. | IL-8/IL-8 receptor expression in psoriasis and the response to systemic tacrolimus (FK506) therapy. | 1995 | Clin. Exp. Immunol. | pmid:7531627 |
| Chaudhuri B et al. | The interaction between the catalytic A subunit of calcineurin and its autoinhibitory domain, in the yeast two-hybrid system, is disrupted by cyclosporin A and FK506. | 1995 | FEBS Lett. | pmid:7528690 |
| Timerman AP et al. | Characterization of an exchange reaction between soluble FKBP-12 and the FKBP.ryanodine receptor complex. Modulation by FKBP mutants deficient in peptidyl-prolyl isomerase activity. | 1995 | J. Biol. Chem. | pmid:7531689 |
| Richter A et al. | Growth inhibitory effects of FK506 and cyclosporin A independent of inhibition of calcineurin. | 1995 | Biochem. Pharmacol. | pmid:7531976 |
| Schwartz M et al. | FK 506 in liver transplantation: correlation of whole blood levels with efficacy and toxicity. The US Multicenter FK 506 Dose Optimization. | 1995 | Transplant. Proc. | pmid:7533355 |
| Yasuhara M et al. | Pharmacokinetics and pharmacodynamics of FK 506 in pediatric patients receiving living-related donor liver transplantations. | 1995 | Transplant. Proc. | pmid:7533356 |
| Platz KP et al. | OKT3 vs FK 506 rescue management of acute steroid-resistant and chronic rejection. | 1995 | Transplant. Proc. | pmid:7533357 |
| Bierer BE | Mechanisms of action of immunosuppressive agents: cyclosporin A, FK506, and rapamycin. | 1995 | Proc. Assoc. Am. Physicians | pmid:8630742 |
| Porayko MK et al. | Comparing nephrotoxicity of FK 506 and cyclosporine regimens after liver transplantation: preliminary results from US Multicenter trial. U.S. Multicenter Liver Study Group. | 1995 | Transplant. Proc. | pmid:7533358 |
| Mueller AR et al. | The superior immunosuppressant according to diagnosis: FK 506 or cyclosporine A. | 1995 | Transplant. Proc. | pmid:7533359 |
| Abouljoud MS et al. | Hyperlipidemia after liver transplantation: long-term results of the FK506/cyclosporine A US Multicenter Trial. US Multicenter Study Group. | 1995 | Transplant. Proc. | pmid:7533360 |
| Bäckman L et al. | Whole-blood and plasma levels of FK 506 after liver transplantation: results from the US Multicenter Trial. FK506 Multicenter Study Group. | 1995 | Transplant. Proc. | pmid:7533361 |
| Söderdahl G et al. | FK 506 improves recovery of bile secretion following orthotopic liver transplantation in man. | 1995 | Transplant. Proc. | pmid:7533362 |
| Mor E et al. | Weight gain and lipid profile changes in liver transplant recipients: long-term results of the American FK506 Multicenter Study. | 1995 | Transplant. Proc. | pmid:7533363 |
| Hemenway CS et al. | vph6 mutants of Saccharomyces cerevisiae require calcineurin for growth and are defective in vacuolar H(+)-ATPase assembly. | 1995 | Genetics | pmid:8582630 |
| Fukuzaki T et al. | Induction of unresponsiveness to islet allografts with donor spleen cell inoculation followed by a single injection of FK 506. | 1995 | Transplant. Proc. | pmid:7533407 |
| Grochowicz PM et al. | Synergism of castanospermine and FK 506. | 1995 | Transplant. Proc. | pmid:7533408 |
| Itoh S and Navia MA | Structure comparison of native and mutant human recombinant FKBP12 complexes with the immunosuppressant drug FK506 (tacrolimus). | 1995 | Protein Sci. | pmid:8563622 |
| Tamura K et al. | Inhibition of insulin production by FK 506 is caused at the transcriptional level in pancreatic beta cell when FK BP-12 content is relatively high. | 1995 | Transplant. Proc. | pmid:7533409 |
| Kawano K et al. | Protective effect of FK 506 on hepatic injury following cold ischemic preservation and transplantation: influence on hepatic microcirculation. | 1995 | Transplant. Proc. | pmid:7533410 |
| Charters AR et al. | Developmental expression of FK506 binding proteins and calcineurin in rat brain. | 1995 | Biochem. Soc. Trans. | pmid:8566310 |
| Tanabe M et al. | Therapeutic synergism between low-dose FK 506 and antimetabolites in rat allogeneic heart transplantation. | 1995 | Transplant. Proc. | pmid:7533411 |
| Abu-Elmagd K et al. | The current status of hepatic transplantation at the University of Pittsburgh. | 1995 | Clin Transpl | pmid:8794262 |
| Masri MA | Comparative study of toxicity and efficacy of cyclosporine, cyclosporine G (OG37), FK 506, and rapamycin in BALB/c mice with fitted skin grafts. | 1995 | Transplant. Proc. | pmid:7533412 |
| Shapiro R et al. | The superiority of tacrolimus in renal transplant recipients -- the Pittsburgh experience. | 1995 | Clin Transpl | pmid:8794266 |
| Jiang H et al. | Immunosuppressive effects of FK 506 on rat renal allograft survival, in comparison with cyclosporine. | 1995 | Transplant. Proc. | pmid:7533413 |
| Bismuth H | Comparison of FK 506- and cyclosporine-based immunosuppression: FK 506 therapy significantly reduces the incidence of acute, steroid-resistant, refractory, and chronic rejection whilst possessing a comparable safety profile. European FK 506 Multicenter Liver Study Group. | 1995 | Transplant. Proc. | pmid:7533415 |
| Ochiai T et al. | Japanese multicenter studies of FK 506 in renal transplantation. Japanese FK 506 Study Group. | 1995 | Transplant. Proc. | pmid:7533419 |
| Saito S et al. | The pattern of rejection and susceptibility to different kinds of immunosuppression after combined liver, duodenum, and pancreas transplantation in swine--immunosuppressive drugs versus ex vivo immunomodulation of the allograft. | 1995 | Transplant. Proc. | pmid:7533420 |
| Komori T | [The change of lymphocyte subset and effect of FK506 in experimental small bowel transplantation of rats]. | 1995 | Nihon Geka Gakkai Zasshi | pmid:7534867 |
| Woo J et al. | Combined effects of FK506 (tacrolimus) and cyclophosphamide on atypical B220+ T cells, cytokine gene expression and disease activity in MRL/MpJ-lpr/lpr mice. | 1995 | Clin. Exp. Immunol. | pmid:7535208 |
| Jusko WJ et al. | Pharmacokinetics of tacrolimus in liver transplant patients. | 1995 | Clin. Pharmacol. Ther. | pmid:7535213 |
| Hadley S et al. | Major infectious complications after orthotopic liver transplantation and comparison of outcomes in patients receiving cyclosporine or FK506 as primary immunosuppression. | 1995 | Transplantation | pmid:7535482 |
| Bakhtiar R and Stearns RA | Studies on non-covalent associations of immunosuppressive drugs with serum albumin using pneumatically assisted electrospray ionization mass spectrometry. | 1995 | Rapid Commun. Mass Spectrom. | pmid:7535601 |
| Yamamoto M et al. | Cyclosporin A and FK506 reverse anthracycline resistance by altering the cell cycle. | 1995 | Anticancer Drugs | pmid:7579561 |
| O'Gorman MA et al. | Proximal renal tubular acidosis secondary to FK506 in pediatric liver transplant patients. | 1995 | Clin Transplant | pmid:7579739 |
| Kanamaru A et al. | FK506 treatment of graft-versus-host disease developing or exacerbating during prophylaxis and therapy with cyclosporin and/or other immunosuppressants. Japanese FK506 BMT Study Group. | 1995 | Bone Marrow Transplant. | pmid:7581086 |
| Antoni FA et al. | Calcineurin feedback inhibition of agonist-evoked cAMP formation. | 1995 | J. Biol. Chem. | pmid:7499291 |
| Koehler MT et al. | FK506 (tacrolimus) in the treatment of steroid-resistant acute graft-versus-host disease in children undergoing bone marrow transplantation. | 1995 | Bone Marrow Transplant. | pmid:7581088 |
| Arnold JC and Theilmann L | [Comparison between tacrolimus (FK 506) and cyclosporin in immunosuppressive therapy after liver transplantation]. | 1995 | Z Gastroenterol | pmid:7502559 |
| Reisman L et al. | Modulation of interleukin-1 secretion by immunosuppressive drugs, alone and in combination. | 1995 | Transpl. Immunol. | pmid:7551978 |
| Osman A et al. | Schistosoma mansoni: characterization of p50, an immunophilin. | 1995 | Exp. Parasitol. | pmid:7537219 |
| Woo J et al. | Effects of FK 506 on chimerism and the induction of donor-specific unresponsiveness following fully allogeneic bone marrow transplantation in mice. | 1995 | Transpl. Immunol. | pmid:7551985 |
| Tanida I et al. | Cooperation of calcineurin and vacuolar H(+)-ATPase in intracellular Ca2+ homeostasis of yeast cells. | 1995 | J. Biol. Chem. | pmid:7537264 |
| Kelly PA et al. | Tacrolimus: a new immunosuppressive agent. | 1995 | Am J Health Syst Pharm | pmid:7552894 |
| Koch K et al. | The C-32 triacetyl-L-rhamnose derivative of ascomycin: a potent, orally active macrolactone immunosuppressant. | 1995 | J. Med. Chem. | pmid:7537331 |
| MacDonald AS and Sketris IS | Tacrolimus in transplantation. | 1995 | Am J Health Syst Pharm | pmid:7552906 |
| Torii N et al. | An inhibitor for calcineurin, FK506, blocks induction of long-term depression in rat visual cortex. | 1995 | Neurosci. Lett. | pmid:7537357 |
| Holmes JA and Twentyman PR | The activity of deoxyspergualin in multidrug-resistant cells. | 1995 | Cancer Chemother. Pharmacol. | pmid:7554042 |
| Miyazawa H et al. | Hamster to rat kidney xenotransplantation. Effects of FK 506, cyclophosphamide, organ perfusion, and complement inhibition. | 1995 | Transplantation | pmid:7537396 |
| Pockley AG et al. | Effect of cyclosporin A, FK506 and rapamycin on proliferation and soluble IL-2 receptor release from mitogenically stimulated rat spleen cells. | 1995 | Biochem. Soc. Trans. | pmid:8654800 |
| Furlan V et al. | Interactions between FK506 and rifampicin or erythromycin in pediatric liver recipients. | 1995 | Transplantation | pmid:7537398 |
| Mañez R et al. | Anomalous pattern of IgG antibody response to primary cytomegalovirus infection after solid organ retransplantation. | 1995 | Transplantation | pmid:7537400 |
| Van Thiel DH et al. | Tacrolimus: a potential new treatment for autoimmune chronic active hepatitis: results of an open-label preliminary trial. | 1995 | Am. J. Gastroenterol. | pmid:7537444 |
| Textor SC et al. | Urinary endothelin and renal vasoconstriction with cyclosporine or FK506 after liver transplantation. | 1995 | Kidney Int. | pmid:7543625 |
| Dollinger MM et al. | Tacrolimus and cardiotoxicity in adult liver transplant recipients. | 1995 | Lancet | pmid:7543645 |
| Romero DF et al. | Rapamycin: a bone sparing immunosuppressant? | 1995 | J. Bone Miner. Res. | pmid:7543725 |
| Rebollo A et al. | Differential effect of rapamycin and cyclosporin A in proliferation in a murine T cell line expressing either intermediate or high affinity receptor for IL-2. | 1995 | Cytokine | pmid:7543780 |
| Lam E et al. | Isolation of a cDNA encoding a novel human FK506-binding protein homolog containing leucine zipper and tetratricopeptide repeat motifs. | 1995 | Gene | pmid:7543869 |
| Hisatomi K et al. | Changes in the mononuclear cell subpopulations of rat cardiac transplant recipients administered FK506 for the treatment of ongoing rejection. | 1995 | Surg. Today | pmid:7539647 |
| Minamoto A et al. | Suppression of corneal graft rejection by subconjunctival injection of FK-506 in a rat model of penetrating keratoplasty. | 1995 | Jpn. J. Ophthalmol. | pmid:7543958 |
| Ueda M et al. | A proposal of FK506 optimal dosing in living related liver transplantations. | 1995 | Transplantation | pmid:7544035 |
| Tamura K et al. | Transcriptional inhibition of insulin by FK506 and possible involvement of FK506 binding protein-12 in pancreatic beta-cell. | 1995 | Transplantation | pmid:7539960 |
| Muthukkumar S et al. | Rapamycin, a potent immunosuppressive drug, causes programmed cell death in B lymphoma cells. | 1995 | Transplantation | pmid:7544036 |
| Fisher A et al. | FK506 hepatotoxicity in liver allograft recipients. | 1995 | Transplantation | pmid:7539961 |
| Muraki T et al. | Antithrombotic effect of FK506 versus prothrombotic effect of cyclosporine in vivo. | 1995 | Transplantation | pmid:7544038 |
| Nash RA et al. | Tacrolimus (FK506) alone or in combination with methotrexate or methylprednisolone for the prevention of acute graft-versus-host disease after marrow transplantation from HLA-matched siblings: a single-center study. | 1995 | Blood | pmid:7540071 |
| Bennett WM | The nephrotoxicity of immunosuppressive drugs. | 1995 | Clin. Nephrol. | pmid:7540121 |
| Moro A et al. | Secretion by Trypanosoma cruzi of a peptidyl-prolyl cis-trans isomerase involved in cell infection. | 1995 | EMBO J. | pmid:7540135 |
| Zweifach A and Lewis RS | Slow calcium-dependent inactivation of depletion-activated calcium current. Store-dependent and -independent mechanisms. | 1995 | J. Biol. Chem. | pmid:7540169 |
| Teague S | Lessons from molecular matchmakers. | 1995 | Nat. Struct. Biol. | pmid:7545076 |
| Ito T et al. | Immunosuppressive agents induce the reduction of local pancreatic blood flow. | 1995 | Pancreas | pmid:7545292 |
| Han CW et al. | Differential effects of the immunosuppressants cyclosporin A, FK506 and KM2210 on cytokine gene expression. | 1995 | Bone Marrow Transplant. | pmid:7545487 |
| Hattori Y and Nakanishi N | Effects of cyclosporin A and FK506 on nitric oxide and tetrahydrobiopterin synthesis in bacterial lipopolysaccharide-treated J774 macrophages. | 1995 | Cell. Immunol. | pmid:7545550 |
| Yeh WC et al. | Identification and characterization of an immunophilin expressed during the clonal expansion phase of adipocyte differentiation. | 1995 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7479941 |
| Han JW et al. | Rapamycin, wortmannin, and the methylxanthine SQ20006 inactivate p70s6k by inducing dephosphorylation of the same subset of sites. | 1995 | J. Biol. Chem. | pmid:7545671 |
| Yeh WC et al. | Rapamycin inhibits clonal expansion and adipogenic differentiation of 3T3-L1 cells. | 1995 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7479942 |
| Ruff VA and Leach KL | Direct demonstration of NFATp dephosphorylation and nuclear localization in activated HT-2 cells using a specific NFATp polyclonal antibody. | 1995 | J. Biol. Chem. | pmid:7545680 |
| Shaw KT et al. | Immunosuppressive drugs prevent a rapid dephosphorylation of transcription factor NFAT1 in stimulated immune cells. | 1995 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7479966 |
| Matsuo S and Okamoto K | Enhancement of FK-506 activities by ganglioside (GM3) in vivo. | 1995 | Life Sci. | pmid:7545772 |
| Annesley TM et al. | Stability of tacrolimus (FK 506) and cyclosporin G in whole blood. | 1995 | Ther Drug Monit | pmid:7482690 |
| Jain AB et al. | Capillary blood versus arterial or venous blood for tacrolimus monitoring in liver transplantation. | 1995 | Transplantation | pmid:7545836 |
| Lampen A et al. | Metabolism of the immunosuppressant tacrolimus in the small intestine: cytochrome P450, drug interactions, and interindividual variability. | 1995 | Drug Metab. Dispos. | pmid:8689938 |
| Lake JR et al. | The impact of immunosuppressive regimens on the cost of liver transplantation--results from the U.S. FK506 multicenter trial. | 1995 | Transplantation | pmid:7482713 |
| Bolman RM | Advantage--FK 506: reduced chronic rejection for lung transplant recipients. | 1995 | Ann. Thorac. Surg. | pmid:7545888 |
| Mathew A et al. | Reversal of steroid-resistant rejection in renal allograft recipients using FK506. | 1995 | Transplantation | pmid:7482730 |
| Sakane T et al. | [A phase II study of FK506 (tacrolimus) on refractory uveitis associated with Behçet's disease and allied conditions]. | 1995 | Ryumachi | pmid:8594659 |
| Henley SE et al. | Lipids following pancreas transplantation in recipients receiving FK 506. | 1995 | Transplant. Proc. | pmid:8539809 |
| Stratta RJ et al. | Preliminary experience with FK 506 in pancreas transplant recipients. | 1995 | Transplant. Proc. | pmid:8539823 |