| MeSH term | MeSH ID | Detail |
|---|---|---|
| Weight Loss | D015431 | 56 associated lipids |
| Dermatitis, Contact | D003877 | 59 associated lipids |
| Pain | D010146 | 64 associated lipids |
| Cystic Fibrosis | D003550 | 65 associated lipids |
| Reperfusion Injury | D015427 | 65 associated lipids |
| Liver Cirrhosis | D008103 | 67 associated lipids |
| Melanoma | D008545 | 69 associated lipids |
| Colitis | D003092 | 69 associated lipids |
| Hyperlipidemias | D006949 | 73 associated lipids |
| Leukemia | D007938 | 74 associated lipids |
tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Grinyó JM and Petruzzelli S | Once-daily LCP-Tacro MeltDose tacrolimus for the prophylaxis of organ rejection in kidney and liver transplantations. | 2014 | Expert Rev Clin Immunol | pmid:25407098 |
| Zaltzman JS et al. | A randomized cross-over comparison of short-term exposure of once-daily extended release tacrolimus and twice-daily tacrolimus on renal function in healthy volunteers. | 2014 | Transpl. Int. | pmid:25160518 |
| Misra DP et al. | Pulmonary co-infection with Nocardia and Aspergillus in a patient with adult-onset Still's disease receiving steroids and tacrolimus. | 2014 | BMJ Case Rep | pmid:25398925 |
| Weng LC et al. | Association between use of FK506 and prevalence of post-transplantation diabetes mellitus in kidney transplant patients. | 2014 | Transplant. Proc. | pmid:24656004 |
| Takahashi K et al. | Safety and efficacy of once-daily modified-release tacrolimus in kidney transplant recipients: interim analysis of multicenter postmarketing surveillance in Japan. | 2014 | Transplant. Proc. | pmid:24655975 |
| Kamburova EG et al. | Longitudinal analysis of T and B cell phenotype and function in renal transplant recipients with or without rituximab induction therapy. | 2014 | PLoS ONE | pmid:25393622 |
| Wu MJ et al. | Reduced variability of tacrolimus trough level in once-daily tacrolimus-based Taiwanese kidney transplant recipients with high-expressive genotype of cytochrome P450 3A5. | 2014 | Transplant. Proc. | pmid:24655974 |
| Jun H et al. | Experiences on conversion to once-daily Advagraf and sirolimus combination in stable kidney recipients. | 2014 | Transplant. Proc. | pmid:24655973 |
| Masutani K et al. | Protocol biopsy findings in living donor kidney transplant patients treated with once-daily or twice-daily tacrolimus formulation. | 2014 | Transplant. Proc. | pmid:24655972 |
| Tian SY et al. | Immunosuppressive therapies for the induction treatment of proliferative lupus nephritis: a systematic review and network metaanalysis. | 2014 | J. Rheumatol. | pmid:25225281 |
| Leung EK et al. | Clinical evaluation of the QMS® Tacrolimus immunoassay. | 2014 | Clin. Chim. Acta | pmid:24518359 |
| Qi R et al. | FK506 inhibits the mice glomerular mesangial cells proliferation by affecting the transforming growth factor-β and Smads signal pathways. | 2014 | Ren Fail | pmid:24512120 |
| Klawitter J et al. | Mycophenolate mofetil enhances the negative effects of sirolimus and tacrolimus on rat kidney cell metabolism. | 2014 | PLoS ONE | pmid:24497939 |
| Filler G | Finding the optimal therapeutic window for tacrolimus. | 2014 | Pediatr Transplant | pmid:25345999 |
| Thölking G et al. | The tacrolimus metabolism rate influences renal function after kidney transplantation. | 2014 | PLoS ONE | pmid:25340655 |
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| Lipson EJ et al. | Successful administration of ipilimumab to two kidney transplantation patients with metastatic melanoma. | 2014 | J. Clin. Oncol. | pmid:24493726 |
| Hinchliffe E et al. | Therapeutic drug monitoring of ciclosporin A and tacrolimus in heart lung transplant patients using dried blood spots. | 2014 | Ann. Clin. Biochem. | pmid:23939194 |
| Pulsipher MA et al. | The addition of sirolimus to tacrolimus/methotrexate GVHD prophylaxis in children with ALL: a phase 3 Children's Oncology Group/Pediatric Blood and Marrow Transplant Consortium trial. | 2014 | Blood | pmid:24497539 |
| Verma M et al. | Impact of single immunosuppressive drug withdrawal on lymphocyte immunoreactivity. | 2014 | J. Surg. Res. | pmid:24485875 |
| El-Sheikh AA et al. | Renal glucuronidation and multidrug resistance protein 2-/ multidrug resistance protein 4-mediated efflux of mycophenolic acid: interaction with cyclosporine and tacrolimus. | 2014 | Transl Res | pmid:24486136 |
| Carr L et al. | Calcineurin activity assay measurement by liquid chromatography-tandem mass spectrometry in the multiple reaction monitoring mode. | 2014 | Clin. Chem. | pmid:24281780 |
| Rehman S et al. | Effect of different tacrolimus levels on early outcomes after kidney transplantation. | 2014 | Ann. Transplant. | pmid:24509826 |
| Xie M et al. | Tacrolimus-related seizure after pediatric liver transplantation--a single-center experience. | 2014 | Pediatr Transplant | pmid:24283660 |
| Qin XL et al. | In vivo to in vitro effects of six bioactive lignans of Wuzhi tablet (Schisandra sphenanthera extract) on the CYP3A/P-glycoprotein-mediated absorption and metabolism of tacrolimus. | 2014 | Drug Metab. Dispos. | pmid:24195812 |
| Eid L et al. | Late acute rejection: incidence, risk factors, and effect on graft survival and function. | 2014 | Pediatr Transplant | pmid:24372967 |
| Peng ZG and Tian J | Higher Serum Trough Levels of Tacrolimus Increase 5-Year Allograft Survival in Antibody Positive Renal Transplant Patients. | 2014 | Clin Transpl | pmid:26281147 |
| Filler G et al. | Similar MPA exposure on modified release and regular tacrolimus. | 2014 | Ther Drug Monit | pmid:24365986 |
| Vavic N et al. | The influence of comedication on tacrolimus blood concentration in patients subjected to kidney transplantation: a retrospective study. | 2014 | Eur J Drug Metab Pharmacokinet | pmid:24356808 |
| Chen D et al. | Association of hemoglobin levels, CYP3A5, and NR1I3 gene polymorphisms with tacrolimus pharmacokinetics in liver transplant patients. | 2014 | Drug Metab. Pharmacokinet. | pmid:24351870 |
| Jain A et al. | Delayed introduction of tacrolimus postliver transplant with intravenous mycophenolate mofetil preserves renal function without incurring rejection. | 2014 | Transplantation | pmid:25285953 |
| Fukushima A et al. | Therapeutic effects of 0.1% tacrolimus eye drops for refractory allergic ocular diseases with proliferative lesion or corneal involvement. | 2014 | Br J Ophthalmol | pmid:24695688 |
| Cho A et al. | Calcineurin signaling regulates neural induction through antagonizing the BMP pathway. | 2014 | Neuron | pmid:24698271 |
| Hirai F et al. | Impact of CYP3A5 genetic polymorphisms on the pharmacokinetics and short-term remission in patients with ulcerative colitis treated with tacrolimus. | 2014 | J. Gastroenterol. Hepatol. | pmid:24033383 |
| Protic M et al. | The effectiveness and safety of rescue treatments in 108 patients with steroid-refractory ulcerative colitis with sequential rescue therapies in a subgroup of patients. | 2014 | J Crohns Colitis | pmid:24908178 |
| Hayashi K et al. | Delayed false elevation of circulating tacrolimus concentrations after cord blood transplantation in a patient with myelodysplastic syndrome. | 2014 | Intern. Med. | pmid:25400189 |
| Sugiyama K et al. | Immune monitoring with a lymphocyte adenosine triphosphate assay in kidney transplant recipients treated with a calcineurin inhibitor. | 2014 | Exp Clin Transplant | pmid:24907718 |
| Lankarani KB et al. | New onset diabetes and impaired fasting glucose after liver transplant: risk analysis and the impact of tacrolimus dose. | 2014 | Exp Clin Transplant | pmid:23902591 |
| Shlivko IL et al. | Morphological changes in skin of different phototypes under the action of topical corticosteroid therapy and tacrolimus. | 2014 | Skin Res Technol | pmid:23808907 |
| Schellekens J et al. | The Maastricht Transplant Center: clinical setting and epitope searches in HLA class II molecules: does the structural localization of a polymorphic site contribute to its immunogenicity? | 2014 | Transpl. Immunol. | pmid:25240735 |
| Deng Z et al. | [Early diagnosis and comprehensive treatments of post-transplantation lymphoproliferative disorder after pediatric liver transplantation]. | 2014 | Zhonghua Er Ke Za Zhi | pmid:25224233 |
| Tanaka H et al. | Efficacy of mizoribine-tacrolimus-based induction therapy for pediatric lupus nephritis. | 2014 | Lupus | pmid:24651669 |
| Xu C et al. | Tacrolimus reversibly reduces insulin secretion, induces insulin resistance, and causes islet cell damage in rats. | 2014 | Int J Clin Pharmacol Ther | pmid:24755137 |
| Ichinose K et al. | [Rare case of systemic lupus erythematosus with encapsulating peritoneal sclerosis during hemodialysis]. | 2014 | Nihon Jinzo Gakkai Shi | pmid:24730352 |
| Jacobo-Cabral CO et al. | Limustin®, a non-innovator tacrolimus formulation, yields reduced drug exposure in pediatric renal transplant recipients. | 2014 | Pediatr Transplant | pmid:25156476 |
| Werk AN et al. | Identification and characterization of a defective CYP3A4 genotype in a kidney transplant patient with severely diminished tacrolimus clearance. | 2014 | Clin. Pharmacol. Ther. | pmid:24126681 |
| Carcas-Sansuán AJ et al. | Conversion from Prograf to Advagraf in stable paediatric renal transplant patients and 1-year follow-up. | 2014 | Pediatr. Nephrol. | pmid:23907143 |
| Gajanayake T et al. | A single localized dose of enzyme-responsive hydrogel improves long-term survival of a vascularized composite allograft. | 2014 | Sci Transl Med | pmid:25122638 |
| Thorat A et al. | Effects of converting tacrolimus formulation from twice-daily to once-daily in liver transplantation recipients. | 2014 | Biomed Res Int | pmid:25121091 |
| Griffith RD et al. | Cells to surgery quiz: September 2014. | 2014 | J. Invest. Dermatol. | pmid:25120152 |
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| Van der Hauwaert C et al. | Expression profiles of genes involved in xenobiotic metabolism and disposition in human renal tissues and renal cell models. | 2014 | Toxicol. Appl. Pharmacol. | pmid:25036895 |
| ZivÄić-Ćosić S et al. | Immune reactivity of renal transplant recipients receiving interleukin-2 receptor antagonists during the early posttransplant period. | 2014 | Int Urol Nephrol | pmid:23515930 |
| Hadjipanagi D et al. | Genetic polymorphisms in warfarin and tacrolimus-related genes VKORC1, CYP2C9 and CYP3A5 in the Greek-Cypriot population. | 2014 | BMC Res Notes | pmid:24593903 |
| Helenius-Hietala J et al. | Oral mucosal health in liver transplant recipients and controls. | 2014 | Liver Transpl. | pmid:24142471 |
| Demmers MW et al. | Substantial proliferation of human renal tubular epithelial cell-reactive CD4+CD28null memory T cells, which is resistant to tacrolimus and everolimus. | 2014 | Transplantation | pmid:24157471 |
| Tsuchida T et al. | The development of humanized liver with Rag1 knockout rats. | 2014 | Transplant. Proc. | pmid:24815157 |
| Li Q et al. | Proniosome-derived niosomes for tacrolimus topical ocular delivery: in vitro cornea permeation, ocular irritation, and in vivo anti-allograft rejection. | 2014 | Eur J Pharm Sci | pmid:24905830 |
| Shimizu M et al. | Treatment of refractory polyarticular juvenile idiopathic arthritis with tacrolimus. | 2014 | Rheumatology (Oxford) | pmid:25065006 |
| Dai YJ et al. | Effect of pharmacological intervention on MIP-1α, MIP-1β and MCP-1 expression in patients with psoriasis vulgaris. | 2014 | Asian Pac J Trop Med | pmid:25063291 |
| Oda K and Yamano K | Effect of telaprevir on the metabolism and hepatic uptake of tacrolimus (FK506). | 2014 | Biopharm Drug Dispos | pmid:25059890 |
| Lapteva M et al. | Polymeric micelle nanocarriers for the cutaneous delivery of tacrolimus: a targeted approach for the treatment of psoriasis. | 2014 | Mol. Pharm. | pmid:25057896 |
| Uesugi M et al. | Impact of cytochrome P450 3A5 polymorphism in graft livers on the frequency of acute cellular rejection in living-donor liver transplantation. | 2014 | Pharmacogenet. Genomics | pmid:24911663 |
| Di Stasio D et al. | Oral lichen planus: a narrative review. | 2014 | Front Biosci (Elite Ed) | pmid:24896212 |
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| Al-Harbi NO et al. | Olmesartan attenuates tacrolimus-induced biochemical and ultrastructural changes in rat kidney tissue. | 2014 | Biomed Res Int | pmid:24987695 |
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| Carbajal R et al. | Case report: boldo (Peumus boldus) and tacrolimus interaction in a renal transplant patient. | 2014 | Transplant. Proc. | pmid:24981811 |
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| Nath PR et al. | Immunophilins control T lymphocyte adhesion and migration by regulating CrkII binding to C3G. | 2014 | J. Immunol. | pmid:25225668 |
| Zhu H et al. | Tacrolimus promotes hepatocellular carcinoma and enhances CXCR4/SDF‑1α expression in vivo. | 2014 | Mol Med Rep | pmid:24912495 |
| Van Laecke S et al. | The effect of magnesium supplements on early post-transplantation glucose metabolism: a randomized controlled trial. | 2014 | Transpl. Int. | pmid:24909487 |
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| Savikko J et al. | Different effects of tacrolimus and cyclosporine on PDGF induction and chronic allograft injury: evidence for improved kidney graft outcome. | 2014 | Transpl. Immunol. | pmid:25158212 |
| Lebel MJ et al. | Increase in de novo food allergies after pediatric liver transplantation: tacrolimus vs. cyclosporine immunosuppression. | 2014 | Pediatr Transplant | pmid:25156571 |
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| Kim YE and Eun SC | Effect of FK506 ointment (Protopic) on rat skin allograft model. | 2014 | Transplant. Proc. | pmid:24815165 |
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| Kurbalija V et al. | Time-series analysis in the medical domain: a study of Tacrolimus administration and influence on kidney graft function. | 2014 | Comput. Biol. Med. | pmid:24813681 |
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| Osmola-Mańkowska A et al. | Topical tacrolimus vs medium-dose ultraviolet A1 phototherapy in the treatment of atopic dermatitis - a preliminary study in relation to parameters of the epidermal barrier function and high-frequency ultrasonography. | 2014 | Eur Rev Med Pharmacol Sci | pmid:25555886 |
| Dipchand AI et al. | Myocyte growth, repair, and oxidative stress following pediatric heart transplantation. | 2014 | Pediatr Transplant | pmid:25118092 |
| Upadhyay V et al. | Rapid and sensitive UPLC-MS-MS determination of tacrolimus in Wistar rats and human blood. | 2014 | J Chromatogr Sci | pmid:23264321 |
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| Shipkova M et al. | Multi-center analytical evaluation of a novel automated tacrolimus immunoassay. | 2014 | Clin. Biochem. | pmid:24721684 |
| Lin BW et al. | Effect of 0.025% FK-506 eyedrops on botulinum toxin B-induced mouse dry eye. | 2014 | Invest. Ophthalmol. Vis. Sci. | pmid:25491293 |
| Hošková L et al. | Tacrolimus-induced hypertension and nephrotoxicity in Fawn-Hooded rats are attenuated by dual inhibition of renin-angiotensin system. | 2014 | Hypertens. Res. | pmid:24718302 |
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| Fernandes MB et al. | Supplementation with omega-3 polyunsaturated fatty acids and experimental tacrolimus-induced nephrotoxicity. | 2014 | Exp Clin Transplant | pmid:25489802 |
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