| MeSH term | MeSH ID | Detail |
|---|---|---|
| Diabetes Mellitus, Type 1 | D003922 | 56 associated lipids |
| Dermatitis, Contact | D003877 | 59 associated lipids |
| Pain | D010146 | 64 associated lipids |
| Reperfusion Injury | D015427 | 65 associated lipids |
| Cystic Fibrosis | D003550 | 65 associated lipids |
| Liver Cirrhosis | D008103 | 67 associated lipids |
| Melanoma | D008545 | 69 associated lipids |
| Colitis | D003092 | 69 associated lipids |
| Hyperlipidemias | D006949 | 73 associated lipids |
| Leukemia | D007938 | 74 associated lipids |
tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Saikali JA et al. | Sirolimus may promote thrombotic microangiopathy. | 2003 | Am. J. Transplant. | pmid:12603218 |
| Carpenter PA and Sanders JE | Steroid-refractory graft-vs.-host disease: past, present and future. | 2003 | Pediatr Transplant | pmid:12603689 |
| Yoshikawa H et al. | Low-dose tacrolimus for intractable myasthenia gravis. | 2002 | J Clin Neurosci | pmid:12604270 |
| Onyewu C et al. | Ergosterol biosynthesis inhibitors become fungicidal when combined with calcineurin inhibitors against Candida albicans, Candida glabrata, and Candida krusei. | 2003 | Antimicrob. Agents Chemother. | pmid:12604527 |
| Kitayama T et al. | Facilitation of tacrolimus-induced heart-allograft acceptability by pretransplant host treatment with granulocyte colony-stimulating factor: interleukin-12-restricted suppression of intragraft monokine mRNA expression. | 2003 | Transplantation | pmid:12605126 |
| Egidi MF and Gaber AO | Outcomes of African-American kidney-transplant recipients treated with sirolimus, tacrolimus, and corticosteroids. | 2003 | Transplantation | pmid:12605133 |
| Padilla PI et al. | Interaction of FK506-binding protein 13 with brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1): effects of FK506. | 2003 | Proc. Natl. Acad. Sci. U.S.A. | pmid:12606707 |
| Goffin E et al. | Post-renal transplant syndrome of transient lower limb joint pain: description under a tacrolimus-based immunosuppression. | 2003 | Clin. Nephrol. | pmid:12608552 |
| Forbes A | Alternative immunomodulators. | 2003 | Eur J Gastroenterol Hepatol | pmid:12610318 |
| Eichenfield LF et al. | Atopic dermatitis and asthma: parallels in the evolution of treatment. | 2003 | Pediatrics | pmid:12612244 |
| Plath KE et al. | Calcineurin antagonists differentially affect mediator secretion, p38 mitogen-activated protein kinase and extracellular signal-regulated kinases from immunologically activated human basophils. | 2003 | Clin. Exp. Allergy | pmid:12614449 |
| Rikkers SM et al. | Topical tacrolimus treatment of atopic eyelid disease. | 2003 | Am. J. Ophthalmol. | pmid:12614745 |
| Erin N et al. | In vitro hypoxia and excitotoxicity in human brain induce calcineurin-Bcl-2 interactions. | 2003 | Neuroscience | pmid:12617962 |
| Leung DY and Boguniewicz M | Advances in allergic skin diseases. | 2003 | J. Allergy Clin. Immunol. | pmid:12618747 |
| [New treatment approach. Patients with neurodermatitis need less cortisone]. | 2003 | MMW Fortschr Med | pmid:12619368 | |
| Wyzgał J et al. | [Treatment of diabetes mellitus in patients after renal transplantation]. | 2002 | Pol. Merkur. Lekarski | pmid:12621776 |
| Pilecki T et al. | [Effect of immunosuppressive treatment on diurnal profile of blood pressure]. | 2002 | Pol. Merkur. Lekarski | pmid:12621780 |
| Tavadia S and Tillman D | Managing facial redness and rashes. | 2003 | Practitioner | pmid:12621802 |
| Fonseca E | [Topic calcineurin inhibitors]. | 2003 | Med Clin (Barc) | pmid:12623001 |
| Nishimuta K and Ito Y | Effects of metronidazole and tinidazole ointments on models for inflammatory dermatitis in mice. | 2003 | Arch. Dermatol. Res. | pmid:12624780 |
| Sobol JB et al. | Effects of delaying FK506 administration on neuroregeneration in a rodent model. | 2003 | J Reconstr Microsurg | pmid:12632311 |
| Tanghetti EA | Tacrolimus ointment 0.1% produces repigmentation in patients with vitiligo: results of a prospective patient series. | 2003 | Cutis | pmid:12635898 |
| Cavallo R et al. | B19 virus infection in renal transplant recipients. | 2003 | J. Clin. Virol. | pmid:12637086 |
| Mai I et al. | Impact of St John's wort treatment on the pharmacokinetics of tacrolimus and mycophenolic acid in renal transplant patients. | 2003 | Nephrol. Dial. Transplant. | pmid:12637655 |
| Korzets Z et al. | Myoclonic jerks in a post-transplant patient: is tacrolimus the sole culprit? | 2003 | Nephrol. Dial. Transplant. | pmid:12637662 |
| Mathis AS | Comment: delayed wound healing with sirolimus after liver transplant. | 2003 | Ann Pharmacother | pmid:12639183 |
| Ajiki T et al. | Generation of donor hematolymphoid cells after rat-limb composite grafting. | 2003 | Transplantation | pmid:12640301 |
| Grube E et al. | Drug eluting stents: initial experiences. | 2002 | Z Kardiol | pmid:12641014 |
| Klettner A and Herdegen T | The immunophilin-ligands FK506 and V-10,367 mediate neuroprotection by the heat shock response. | 2003 | Br. J. Pharmacol. | pmid:12642403 |
| Ben-Ari Z et al. | Comparison of tacrolimus with cyclosporin as primary immunosuppression in patients with hepatitis C virus infection after liver transplantation. | 2003 | Transplant. Proc. | pmid:12644067 |
| Aravot D et al. | A new immunosuppressive protocol for lung transplantation: early promising results. | 2003 | Transplant. Proc. | pmid:12644072 |
| Shitrit D et al. | Tacrolimus-induced hemolytic uremic syndrome case presentation in a lung transplant recipient. | 2003 | Transplant. Proc. | pmid:12644073 |
| Rahamimov R et al. | Rejection rate in living donor kidney transplantation with and without basiliximab in tacrolimus/mycophenolate mofetil-based protocol. | 2003 | Transplant. Proc. | pmid:12644082 |
| Wasserberg N et al. | Tacrolimus does not upregulate mucin gene expression after small bowel transplantation in rats. | 2003 | Transplant. Proc. | pmid:12644089 |
| Berman M et al. | Lipid metabolism and immunosuppressive therapy in heart transplant recipients. | 2003 | Transplant. Proc. | pmid:12644091 |
| Sahar G et al. | Glucose metabolism in heart transplant recipients treated with FK506 or cyclosporine. | 2003 | Transplant. Proc. | pmid:12644092 |
| Ruiz MC et al. | Effect of early versus delayed calcineurin inhibitor treatment on delayed graft function. | 2003 | Transplant. Proc. | pmid:12644096 |
| Vilalta R et al. | Rapamycin use and rapid withdrawal of calcineurin inhibitors in pediatric renal transplantation. | 2003 | Transplant. Proc. | pmid:12644102 |
| Ciancio G et al. | Efficacy and safety of daclizumab induction for primary kidney transplant recipients in combination with tacrolimus, mycophenolate mofetil, and steroids as maintenance immunosuppression. | 2003 | Transplant. Proc. | pmid:12644172 |
| Oetjen E et al. | Regulation of human insulin gene transcription by the immunosuppressive drugs cyclosporin A and tacrolimus at concentrations that inhibit calcineurin activity and involving the transcription factor CREB. | 2003 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:12644894 |
| Khanna AK | The immunosuppressive agent tacrolimus induces p21WAF/CIP1WAF1/CIP1 via TGF-beta secretion. | 2003 | Biochem. Biophys. Res. Commun. | pmid:12646197 |
| Nakai A et al. | Windows of therapeutic opportunity on fetal growth retardation induced by transient intrauterine ischemia in rats. | 2002 | J Nippon Med Sch | pmid:12646985 |
| Goffin E et al. | Evaluation of bone mineral density after renal transplantation under a tacrolimus-based immunosuppression: a pilot study. | 2003 | Clin. Nephrol. | pmid:12653262 |
| Afzali B and Goldsmith DJ | Successful retransplantation using rapamycin in a patient with previous calcineurin inhibitor-induced posterior leukoencephalopathy syndrome. | 2003 | Clin. Nephrol. | pmid:12653269 |
| Steele BW et al. | A longitudinal replicate study of immunosuppressive drugs: a College of American Pathologists study. | 2003 | Arch. Pathol. Lab. Med. | pmid:12653570 |
| Fujimoto N et al. | Facial lichen striatus: successful treatment with tacrolimus ointment. | 2003 | Br. J. Dermatol. | pmid:12653755 |
| Ueda M et al. | Successful treatment of amyopathic dermatomyositis with topical tacrolimus. | 2003 | Br. J. Dermatol. | pmid:12653761 |
| Watsky KL | Erosive perianal lichen planus responsive to tacrolimus. | 2003 | Int. J. Dermatol. | pmid:12653920 |
| Jensen S et al. | Tacrolimus-based immunosuppression with steroid withdrawal in pediatric kidney transplantation--4-year experience at a moderate-volume center. | 2003 | Pediatr Transplant | pmid:12654052 |
| Ojogho O et al. | Mycophenolate mofetil without antibody induction in cadaver vs. living donor pediatric renal transplantation. | 2003 | Pediatr Transplant | pmid:12654055 |
| Pownall ME et al. | An inducible system for the study of FGF signalling in early amphibian development. | 2003 | Dev. Biol. | pmid:12654294 |
| Gohda T et al. | Effect of single-dose administration of FK-506 on allogeneic limb transplantation in rats: is there an optimal timing of its administration? | 2003 | Plast. Reconstr. Surg. | pmid:12655211 |
| Willis C et al. | Bayesian forecasting and prediction of tacrolimus concentrations in pediatric liver and adult renal transplant recipients. | 2003 | Ther Drug Monit | pmid:12657909 |
| Homayoun H et al. | The effects of FK506 on the development and expression of morphine tolerance and dependence in mice. | 2003 | Behav Pharmacol | pmid:12658072 |
| Smith KD et al. | Delayed graft function and cast nephropathy associated with tacrolimus plus rapamycin use. | 2003 | J. Am. Soc. Nephrol. | pmid:12660339 |
| Aw MM et al. | Basiliximab (Simulect) for the treatment of steroid-resistant rejection in pediatric liver transpland recipients: a preliminary experience. | 2003 | Transplantation | pmid:12660504 |
| Charpentier B et al. | A three-arm study comparing immediate tacrolimus therapy with antithymocyte globulin induction therapy followed by tacrolimus or cyclosporine A in adult renal transplant recipients. | 2003 | Transplantation | pmid:12660513 |
| Cho YM et al. | High incidence of tacrolimus-associated posttransplantation diabetes in the Korean renal allograft recipients according to American Diabetes Association criteria. | 2003 | Diabetes Care | pmid:12663584 |
| Ellis CN et al. | Cost-effectiveness analysis of tacrolimus ointment versus high-potency topical corticosteroids in adults with moderate to severe atopic dermatitis. | 2003 | J. Am. Acad. Dermatol. | pmid:12664019 |
| Freeman AK et al. | Tacrolimus ointment for the treatment of psoriasis on the face and intertriginous areas. | 2003 | J. Am. Acad. Dermatol. | pmid:12664020 |
| Stratta RJ et al. | Improving results in solitary pancreas transplantation with portal-enteric drainage, thymoglobin induction, and tacrolimus/mycophenolate mofetil-based immunosuppression. | 2003 | Transpl. Int. | pmid:12664209 |
| Ohmori I et al. | Downregulation of interleukin-12p35 and upregulation of interleukin-12p40 mRNA expression in heart allografts by blood transfusion from granulocyte colony-stimulating factor-treated donors. | 2003 | Cytokine | pmid:12668156 |
| Niedner R | [Topical corticosteroids versus topical inhibitors of calcineurin]. | 2003 | Hautarzt | pmid:12669205 |
| Blankenship JR et al. | Teaching old drugs new tricks: reincarnating immunosuppressants as antifungal drugs. | 2003 | Curr Opin Investig Drugs | pmid:12669381 |
| Agostinho P and Oliveira CR | Involvement of calcineurin in the neurotoxic effects induced by amyloid-beta and prion peptides. | 2003 | Eur. J. Neurosci. | pmid:12670307 |
| Xiao T et al. | Both IL-4 and IL-13 inhibit the TNF-alpha and IFN-gamma enhanced MDC production in a human keratinocyte cell line, HaCaT cells. | 2003 | J. Dermatol. Sci. | pmid:12670721 |
| Sharma SK et al. | Inhibition of calcineurin facilitates the induction of memory for sensitization in Aplysia: requirement of mitogen-activated protein kinase. | 2003 | Proc. Natl. Acad. Sci. U.S.A. | pmid:12672952 |
| Zawadzka M and Kaminska B | Immunosuppressant FK506 affects multiple signaling pathways and modulates gene expression in astrocytes. | 2003 | Mol. Cell. Neurosci. | pmid:12676530 |
| Tamura S et al. | The site-specific transport and metabolism of tacrolimus in rat small intestine. | 2003 | J. Pharmacol. Exp. Ther. | pmid:12676880 |
| Muromoto R et al. | Daxx enhances Fas-mediated apoptosis in a murine pro-B cell line, BAF3. | 2003 | FEBS Lett. | pmid:12681512 |
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| Gajjar NA et al. | FK506 vs. cyclosporin. Pathologic findings in 1067 endomyocardial biopsies. | 2003 Mar-Apr | Cardiovasc. Pathol. | pmid:12684161 |
| Pai MP and Allen S | Voriconazole inhibition of tacrolimus metabolism. | 2003 | Clin. Infect. Dis. | pmid:12684931 |
| Lecointre K et al. | In vitro effects of tacrolimus on human cytochrome P450. | 2002 | Fundam Clin Pharmacol | pmid:12685503 |
| Nagano K et al. | A murine model of enterohemorrhagic Escherichia coli O157:H7 infection to assess immunopotentiating activity of drugs on mucosal immunity: effect of drugs. | 2003 | J. Pharmacol. Sci. | pmid:12686745 |
| Kniepeiss D et al. | Sirolimus and mycophenolate mofetil after liver transplantation. | 2003 | Transpl. Int. | pmid:12687325 |
| Pennesi M et al. | Effective tacrolimus treatment in a child suffering from severe nephrotic syndrome. | 2003 | Pediatr. Nephrol. | pmid:12687465 |
| Zheng H et al. | Tacrolimus dosing in pediatric heart transplant patients is related to CYP3A5 and MDR1 gene polymorphisms. | 2003 | Am. J. Transplant. | pmid:12694072 |
| Ellis C et al. | International Consensus Conference on Atopic Dermatitis II (ICCAD II): clinical update and current treatment strategies. | 2003 | Br. J. Dermatol. | pmid:12694268 |
| Hodgson TA et al. | Topical tacrolimus: a novel therapeutic intervention for recalcitrant labial pemphigus vulgaris. | 2003 Mar-Apr | Eur J Dermatol | pmid:12695129 |
| Shimono T et al. | MR imaging with quantitative diffusion mapping of tacrolimus-induced neurotoxicity in organ transplant patients. | 2003 | Eur Radiol | pmid:12695819 |
| Guthery SL et al. | Determination of risk factors for Epstein-Barr virus-associated posttransplant lymphoproliferative disorder in pediatric liver transplant recipients using objective case ascertainment. | 2003 | Transplantation | pmid:12698085 |
| Jain A et al. | The absence of chronic rejection in pediatric primary liver transplant patients who are maintained on tacrolimus-based immunosuppression: a long-term analysis. | 2003 | Transplantation | pmid:12698091 |
| Egashira K et al. | Pomelo-induced increase in the blood level of tacrolimus in a renal transplant patient. | 2003 | Transplantation | pmid:12698101 |
| Hu H et al. | Effect of immunosuppressants on T-cell subsets observed in vivo using carboxy-fluorescein diacetate succinimidyl ester labeling. | 2003 | Transplantation | pmid:12698107 |
| Mulligan MS and Wood DE | Optimizing lung transplant immunosuppression: beyond calcineurin inhibition. | 2003 | J. Thorac. Cardiovasc. Surg. | pmid:12698139 |
| Zuckermann A et al. | Cyclosporine A versus tacrolimus in combination with mycophenolate mofetil and steroids as primary immunosuppression after lung transplantation: one-year results of a 2-center prospective randomized trial. | 2003 | J. Thorac. Cardiovasc. Surg. | pmid:12698153 |
| Sokol DK et al. | Tacrolimus (FK506)-induced mutism after liver transplant. | 2003 | Pediatr. Neurol. | pmid:12699871 |
| Lübbe J and Saurat JH | [A monograph on topical tacrolimus (Protopic]. | 2003 | Ann Dermatol Venereol | pmid:12700537 |
| Giordani F et al. | Tacrolimus (FK506) reduces ischemia-induced hippocampal damage in rats: a 7- and 30-day study. | 2003 | Braz. J. Med. Biol. Res. | pmid:12700828 |
| Tanaka K et al. | Immunosuppressive (FK506) and non-immunosuppressive (GPI1046) immunophilin ligands activate neurotrophic factors in the mouse brain. | 2003 | Brain Res. | pmid:12706270 |
| Mehr SE et al. | Inhibition by immunophilin ligands of morphine-induced tolerance and dependence in guinea pig ileum. | 2003 | Eur. J. Pharmacol. | pmid:12706476 |
| Mayer DF and Kushwaha SS | Transplant immunosuppressant agents and their role in autoimmune rheumatic diseases. | 2003 | Curr Opin Rheumatol | pmid:12707574 |
| Szeto CC et al. | Tacrolimus in resistant primary membranous nephropathy--a report of 3 cases. | 2003 | Clin. Nephrol. | pmid:12708570 |
| Lee MH et al. | Enhanced interleukin-4 production in CD4+ T cells and elevated immunoglobulin E levels in antigen-primed mice by bisphenol A and nonylphenol, endocrine disruptors: involvement of nuclear factor-AT and Ca2+. | 2003 | Immunology | pmid:12709020 |
| Van Rijen MM et al. | Mycophenolic acid is a potent inhibitor of the expression of tumour necrosis factor- and tumour necrosis factor-receptor superfamily costimulatory molecules. | 2003 | Immunology | pmid:12709024 |
| Kowalski R et al. | Immune cell function testing: an adjunct to therapeutic drug monitoring in transplant patient management. | 2003 | Clin Transplant | pmid:12709071 |
| Kemper MJ et al. | Neuropsychologic side-effects of tacrolimus in pediatric renal transplantation. | 2003 | Clin Transplant | pmid:12709079 |
| Gauthier C et al. | Functional similarities and differences between Candida albicans Cdr1p and Cdr2p transporters. | 2003 | Antimicrob. Agents Chemother. | pmid:12709320 |
| Castanedo-Cazares JP et al. | Repigmentation of chronic vitiligo lesions by following tacrolimus plus ultraviolet-B-narrow-band. | 2003 | Photodermatol Photoimmunol Photomed | pmid:12713553 |