| MeSH term | MeSH ID | Detail |
|---|---|---|
| Weight Loss | D015431 | 56 associated lipids |
| Dermatitis, Contact | D003877 | 59 associated lipids |
| Pain | D010146 | 64 associated lipids |
| Cystic Fibrosis | D003550 | 65 associated lipids |
| Reperfusion Injury | D015427 | 65 associated lipids |
| Liver Cirrhosis | D008103 | 67 associated lipids |
| Melanoma | D008545 | 69 associated lipids |
| Colitis | D003092 | 69 associated lipids |
| Hyperlipidemias | D006949 | 73 associated lipids |
| Leukemia | D007938 | 74 associated lipids |
tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Butcher SP et al. | Neuroprotective actions of FK506 in experimental stroke: in vivo evidence against an antiexcitotoxic mechanism. | 1997 | J. Neurosci. | pmid:9278529 |
| Vaden SL | Cyclosporine and tacrolimus. | 1997 | Semin. Vet. Med. Surg. Small Anim. | pmid:9283240 |
| Ellouk-Achard S et al. | Implication of CYP 3A in the toxicity of cyclosporin G (CsG), cyclosporin A (CsA) and FK506 on rat hepatocytes in primary culture. | 1997 | Arch. Toxicol. | pmid:9209689 |
| Hatanaka H and Shimomura K | [Immunosuppressive activity of a microbial product]. | 1997 | Nippon Yakurigaku Zasshi | pmid:9503409 |
| Devine SM et al. | The outcome of unrelated donor bone marrow transplantation in patients with hematologic malignancies using tacrolimus (FK506) and low dose methotrexate for graft-versus-host disease prophylaxis. | 1997 | Biol. Blood Marrow Transplant. | pmid:9209738 |
| Su Y et al. | Cyclosporin A but not FK506 inhibits thyroid hormone-induced apoptosis in tadpole intestinal epithelium. | 1997 | FASEB J. | pmid:9212079 |
| Maeda T | [Experimental study of the effectiveness of immunosuppression therapy using FK506 and 15-deoxyspergualin in concordant xenotransplantation]. | 1997 | Nihon Kyobu Geka Gakkai Zasshi | pmid:9217381 |
| duBell WH et al. | Effect of the immunosupressant FK506 on excitation-contraction coupling and outward K+ currents in rat ventricular myocytes. | 1997 | J. Physiol. (Lond.) | pmid:9218211 |
| de-la-Serna-Higuera C et al. | Tacrolimus-induced bone marrow suppression. | 1997 | Lancet | pmid:9291912 |
| Yoshikawa H et al. | Fc gammaRIII-mediated regulation of hematopoiesis in murine bone marrow cells by interleukin-3 and CD95 (Fas/Apo-1). | 1997 | Blood | pmid:9292524 |
| Jain A et al. | Pregnancy after liver transplantation under tacrolimus. | 1997 | Transplantation | pmid:9293865 |
| Fletcher L | Specific neuroimmunophilin ligands to treat neurodegenerative disease. | 1997 | Mol Med Today | pmid:9449119 |
| Lauerma AI et al. | Absorption of topical tacrolimus (FK506) in vitro through human skin: comparison with cyclosporin A. | 1997 | Skin Pharmacol. | pmid:9449161 |
| Alak AM | Measurement of tacrolimus (FK506) and its metabolites: a review of assay development and application in therapeutic drug monitoring and pharmacokinetic studies. | 1997 | Ther Drug Monit | pmid:9200777 |
| Saitoh O et al. | Cyclosporine A inhibits interleukin-8 production in a human colon epithelial cell line (HT-29). | 1997 | J. Gastroenterol. | pmid:9349985 |
| Hebebrand D et al. | Nerve xenograft transplantation. Immunosuppression with FK-506 and RS-61443. | 1997 | J Hand Surg Br | pmid:9222906 |
| Kageyama M et al. | FK506-binding proteins regulate smooth muscle contractility by altering neurotransmitter release. | 1997 | Eur. J. Pharmacol. | pmid:9314039 |
| Rejto PA and Verkhivker GM | Mean field analysis of FKBP12 complexes with FK506 and rapamycin: implications for a role of crystallographic water molecules in molecular recognition and specificity. | 1997 | Proteins | pmid:9223178 |
| Reynolds KA et al. | Biosynthesis of the shikimate-derived starter unit of the immunosuppressant ascomycin: stereochemistry of the 1,4-conjugate elimination. | 1997 | J. Antibiot. | pmid:9315087 |
| Birnbaum AH et al. | Recurrence of autoimmune hepatitis in children after liver transplantation. | 1997 | J. Pediatr. Gastroenterol. Nutr. | pmid:9226522 |
| Alarcón CM and Heitman J | FKBP12 physically and functionally interacts with aspartokinase in Saccharomyces cerevisiae. | 1997 | Mol. Cell. Biol. | pmid:9315655 |
| Scott JE et al. | Dynamic equilibrium between calcineurin and kinase activities regulates the phosphorylation state and localization of the nuclear factor of activated T-cells. | 1997 | Biochem. J. | pmid:9182723 |
| Goodyear N et al. | The 37 kDa immunophilin has uracil DNA glycosylase but not rotamase activity. | 1997 | Clin. Biochem. | pmid:9316745 |
| Suzuki N et al. | In vivo mechanisms for the inhibition of T lymphocyte activation by long-term therapy with tacrolimus (FK-506): experience in patients with Behçet's disease. | 1997 | Arthritis Rheum. | pmid:9182928 |
| Rudi J et al. | Prevalence of serum antibodies to Helicobacter pylori and to CagA protein in liver transplant recipients. | 1997 | Am. J. Gastroenterol. | pmid:9317070 |
| Odom A et al. | Calcineurin is required for virulence of Cryptococcus neoformans. | 1997 | EMBO J. | pmid:9184205 |
| Kesten S et al. | Tacrolimus as rescue therapy for bronchiolitis obliterans syndrome. | 1997 | J. Heart Lung Transplant. | pmid:9322139 |
| Nishinaka H et al. | Graft persistence effectively induces and maintains donor-specific unresponsiveness. | 1997 | J. Surg. Res. | pmid:9184673 |
| Cardoso CM et al. | Uncoupling of Ca2+ transport ATPase in muscle and blood platelets by diacylglycerol analogues and cyclosporin A antagonism. | 1997 | Biochem. J. | pmid:9581558 |
| Ko WJ et al. | Hypomagnesia and arrhythmia corrected by replacing cyclosporine with FK506 in a heart transplant recipient. | 1997 | J. Heart Lung Transplant. | pmid:9322151 |
| Miwa S et al. | Effect of anti-intercellular adhesion molecule-1 and anti-leukocyte function associated antigen-1 monoclonal antibodies on rat-to-mouse cardiac xenograft rejection. | 1997 | Surgery | pmid:9186469 |
| Arbustini E et al. | Acute rejection and heart infection rates in FK 506- versus cyclosporine A-treated heart transplant recipients: an endomyocardial biopsy pathologic study. | 1997 | J. Heart Lung Transplant. | pmid:9322152 |
| Fujino H et al. | Stimulatory roles of muscarinic acetylcholine receptors on T cell antigen receptor/CD3 complex-mediated interleukin-2 production in human peripheral blood lymphocytes. | 1997 | Mol. Pharmacol. | pmid:9187267 |
| Denecker G et al. | Differential role of calcium in tumour necrosis factor-mediated apoptosis and secretion of granulocyte-macrophage colony-stimulating factor in a T cell hybridoma. | 1997 | Cytokine | pmid:9325011 |
| Hausen B and Morris RE | Review of immunosuppression for lung transplantation. Novel drugs, new uses for conventional immunosuppressants, and alternative strategies. | 1997 | Clin. Chest Med. | pmid:9187827 |
| Fujita T et al. | Prolonged survival of rat skin allograft by treatment with FK506 ointment. | 1997 | Transplantation | pmid:9326422 |
| Göthel SF et al. | An internal FK506-binding domain is the catalytic core of the prolyl isomerase activity associated with the Bacillus subtilis trigger factor. | 1997 | Eur. J. Biochem. | pmid:9063446 |
| Dumont FJ | FK506 enhances IL-13 production by T cells activated through CD3/CD28. | 1997 | Int. Arch. Allergy Immunol. | pmid:9363914 |
| Motamedi H et al. | Structural organization of a multifunctional polyketide synthase involved in the biosynthesis of the macrolide immunosuppressant FK506. | 1997 | Eur. J. Biochem. | pmid:9063448 |
| Taylor PJ et al. | Improved therapeutic drug monitoring of tacrolimus (FK506) by tandem mass spectrometry. | 1997 | Clin. Chem. | pmid:9365410 |
| Guckelberger O et al. | Cardiovascular risk factors in long-term follow-up after orthotopic liver transplantation. | 1997 | Clin Transplant | pmid:9067697 |
| Mueller AR et al. | Association between hepatitis and rejection: upregulation of cytokines and extracellular matrix parameters. | 1997 | Transplant. Proc. | pmid:9365585 |
| Singh N et al. | Clinical spectrum of invasive cryptococcosis in liver transplant recipients receiving tacrolimus. | 1997 | Clin Transplant | pmid:9067698 |
| Platz KP et al. | FK 506 and mycofenolate mofetil rescue for acute steroid-resistant and chronic rejection after liver transplantation. | 1997 | Transplant. Proc. | pmid:9365598 |
| Victor RG et al. | Mechanism of Ca(2+)-dependent inactivation of L-type Ca2+ channels in GH3 cells: direct evidence against dephosphorylation by calcineurin. | 1997 | J. Membr. Biol. | pmid:9070464 |
| Platz KP et al. | Indications for mycofenolate mofetil therapy after liver transplantation. | 1997 | Transplant. Proc. | pmid:9365601 |
| Demirbas A et al. | FK 506 in simultaneous pancreas/kidney transplantation: the University of Miami experience. | 1997 | Transplant. Proc. | pmid:9365608 |
| Ferron GM et al. | Population pharmacokinetics of sirolimus in kidney transplant patients. | 1997 | Clin. Pharmacol. Ther. | pmid:9129559 |
| Kliem V et al. | Long-term results after primary successful FK 506 treatment of steroid- and OKT3-resistant rejection in renal transplant recipients. | 1997 | Transplant. Proc. | pmid:9365627 |
| Weil SJ et al. | Chemotaxis of macrophages by a peritoneal fluid protein in women with endometriosis. | 1997 | Fertil. Steril. | pmid:9130891 |
| Xu M et al. | Effect of peritransplant FTY720 alone or in combination with posttransplant FK 506 in a rat model of cardiac allotransplantation. | 1997 | Transplant. Proc. | pmid:9365631 |
| Karlsson H et al. | Energy levels in resting and mitogen-stimulated human lymphocytes during treatment with FK506 or cyclosporin A in vitro. | 1997 | Biochim. Biophys. Acta | pmid:9131051 |
| Gavlik A et al. | Mycophenolate mofetil rescue therapy in liver transplant recipients: an extended follow-up. | 1997 | Transplant. Proc. | pmid:9365633 |
| Pratt WB | The role of the hsp90-based chaperone system in signal transduction by nuclear receptors and receptors signaling via MAP kinase. | 1997 | Annu. Rev. Pharmacol. Toxicol. | pmid:9131255 |
| Niederstadt C et al. | Effect of FK506 on magnesium homeostasis after renal transplantation. | 1997 | Transplant. Proc. | pmid:9365709 |
| Paterson DL et al. | Could a herpesvirus mimic tacrolimus-induced leukoencephalopathy? | 1997 | Ann. Neurol. | pmid:9266742 |
| Yoshimoto T et al. | [Leukoencephalopathy probably caused by tacrolimus hydrate after stem cell transplantation in a girl with MDS 7 monosomy]. | 1997 | Rinsho Ketsueki | pmid:9267167 |
| Singh N et al. | Invasive fungal infections in liver transplant recipients receiving tacrolimus as the primary immunosuppressive agent. | 1997 | Clin. Infect. Dis. | pmid:9114144 |
| Woodle ES et al. | Reversal of accelerated renal allograft rejection with FK 506. | 1997 | Clin Transplant | pmid:9267710 |
| Eum SY et al. | Inhibition by the immunosuppressive agent FK-506 of antigen-induced airways eosinophilia and bronchial hyperreactivity in mice. | 1997 | Br. J. Pharmacol. | pmid:9117088 |
| Ahsan N et al. | Pure red cell aplasia due to parvovirus B19 infection in solid organ transplantation. | 1997 | Clin Transplant | pmid:9267713 |
| Jacobson PA et al. | Stability of tacrolimus in an extemporaneously compounded oral liquid. | 1997 | Am J Health Syst Pharm | pmid:9117806 |
| Singh N et al. | Bloodstream infections in liver transplant recipients receiving tacrolimus. | 1997 | Clin Transplant | pmid:9267715 |
| Boucek MM et al. | The Registry of the International Society of Heart and Lung Transplantation: first official pediatric report--1997. | 1997 | J. Heart Lung Transplant. | pmid:9436131 |
| Guo Z et al. | In vivo effects of leflunomide on normal pancreatic islet and syngeneic islet graft function. | 1997 | Transplantation | pmid:9075844 |
| Gruessner RW | Tacrolimus in pancreas transplantation: a multicenter analysis. Tacrolimus Pancreas Transplant Study Group. | 1997 | Clin Transplant | pmid:9267719 |
| Ciancio G et al. | Use of intravenous FK506 to treat acute rejection in simultaneous pancreas-kidney transplant recipients on maintenance oral FK506. | 1997 | Transplantation | pmid:9075856 |
| Sherrington PD et al. | TLiSA1 (PTA1) activation antigen implicated in T cell differentiation and platelet activation is a member of the immunoglobulin superfamily exhibiting distinctive regulation of expression. | 1997 | J. Biol. Chem. | pmid:9268302 |
| Mirza DF et al. | Reduced acute rejection after liver transplantation with Neoral-based triple immunosuppression. | 1997 | Lancet | pmid:9078209 |
| Danovitch GM | Cyclosporin or tacrolimus: which agent to choose? | 1997 | Nephrol. Dial. Transplant. | pmid:9269630 |
| Yoshikawa H et al. | FK506 prevents induction of rat experimental autoimmune myasthenia gravis. | 1997 | J. Autoimmun. | pmid:9080295 |
| Filler G et al. | Pharmacokinetics of tacrolimus (FK 506) in children and adolescents with renal transplants. | 1997 | Nephrol. Dial. Transplant. | pmid:9269646 |
| Yokoyama I et al. | Fas antigen expression of hepatocytes and its modification by immunosuppressants. | 1997 | Dig. Dis. Sci. | pmid:9440622 |
| Sperr WR et al. | Inhibition of allergen-induced histamine release from human basophils by cyclosporine A and FK-506. | 1997 | Int. Arch. Allergy Immunol. | pmid:9303333 |
| Azuma H et al. | Atypical Epstein-Barr virus infection during and after intermittent FK506 therapy. | 1997 | Acta Paediatr Jpn | pmid:9141259 |
| Izuishi K et al. | Effects of an immunosuppressive agent, tacrolimus (FK-506), on the activities of cytochrome P-450-linked monooxygenase systems in rat liver microsomes. | 1997 | Int. J. Biochem. Cell Biol. | pmid:9304807 |
| Tsuchida Y et al. | Vascularized bone marrow allotransplantation in rats prolongs a simultaneous skin allograft. | 1997 | Transplant. Proc. | pmid:9142252 |
| Costa A et al. | Small bowel myoelectrical activity after transplantation in pigs: motility versus ACR score. | 1997 | Transplant. Proc. | pmid:9142281 |
| Homey B et al. | A local lymph node assay to analyse immunosuppressive effects of topically applied drugs. | 1997 | Eur. J. Pharmacol. | pmid:9163567 |
| Klupp J et al. | Mycophenolate mofetil added to immunosuppression after liver transplantation--first results. | 1997 | Transpl. Int. | pmid:9163864 |
| McKee M et al. | Initial experience with FK506 (tacrolimus) in pediatric renal transplant recipients. | 1997 | J. Pediatr. Surg. | pmid:9165452 |
| Uno T et al. | The pharmacokinetics of water-in-oil-in-water-type multiple emulsion of a new tacrolimus formulation. | 1997 | Lipids | pmid:9168461 |
| Jiang H et al. | Distinct tissue and cellular distribution of two major isoforms of calcineurin. | 1997 | Mol. Immunol. | pmid:9393969 |
| Mignat C | Clinically significant drug interactions with new immunosuppressive agents. | 1997 | Drug Saf | pmid:9113494 |
| Schweda F et al. | Tacrolimus treatment for steroid- and cyclosporin-resistant minimal-change nephrotic syndrome. | 1997 | Nephrol. Dial. Transplant. | pmid:9394341 |
| Sabatini DM et al. | Neural roles of immunophilins and their ligands. | 1997 | Mol. Neurobiol. | pmid:9396011 |
| Su Y et al. | Thyroid hormone induces apoptosis in primary cell cultures of tadpole intestine: cell type specificity and effects of extracellular matrix. | 1997 | J. Cell Biol. | pmid:9396758 |
| Bielefeldt K et al. | Tacrolimus (FK506) modulates calcium release and contractility of intestinal smooth muscle. | 1997 | Cell Calcium | pmid:9502200 |
| Yamaguchi Y et al. | Enhanced expression of cytokine-induced neutrophil chemoattractant in rat hepatic allografts during acute rejection. | 1997 | Hepatology | pmid:9397996 |
| Gruessner AC and Sutherland DE | Pancreas transplants for United States (US) and non-US cases as reported to the International Pancreas Transplant Registry (IPTR) and to the United Network for Organ Sharing (UNOS). | 1997 | Clin Transpl | pmid:9919390 |
| Odorico JS et al. | Advances in pancreas transplantation: the University of Wisconsin experience. | 1997 | Clin Transpl | pmid:9919400 |
| Katznelson S et al. | Clinical aspects of sensitization. | 1997 | Clin Transpl | pmid:9919412 |
| Pirenne J et al. | Donor-specific unmodified bone marrow transfusion does not facilitate intestinal engraftment after bowel transplantation in a porcine model. | 1997 | Surgery | pmid:9001555 |
| Felldin M et al. | Rescue therapy with tacrolimus (FK 506) in renal transplant recipients--a Scandinavian multicenter analysis. | 1997 | Transpl. Int. | pmid:9002146 |
| Becker G et al. | Rescue therapy with tacrolimus in simultaneous pancreas/kidney transplantation. | 1997 | Transpl. Int. | pmid:9002152 |
| Odom A et al. | The immunosuppressant FK506 and its nonimmunosuppressive analog L-685,818 are toxic to Cryptococcus neoformans by inhibition of a common target protein. | 1997 | Antimicrob. Agents Chemother. | pmid:8980772 |
| High KP and Washburn RG | Invasive aspergillosis in mice immunosuppressed with cyclosporin A, tacrolimus (FK506), or sirolimus (rapamycin). | 1997 | J. Infect. Dis. | pmid:8985226 |
| Testa G and Klintmalm GB | Cyclosporine and tacrolimus: the mainstay of immunosuppressive therapy for solid organ transplantation. | 1997 | Clin Liver Dis | pmid:15562576 |
| Noguchi N et al. | Cyclic ADP-ribose binds to FK506-binding protein 12.6 to release Ca2+ from islet microsomes. | 1997 | J. Biol. Chem. | pmid:9013543 |
| Ishizuka T et al. | Rapamycin potentiates dexamethasone-induced apoptosis and inhibits JNK activity in lymphoblastoid cells. | 1997 | Biochem. Biophys. Res. Commun. | pmid:9016789 |