| MeSH term | MeSH ID | Detail |
|---|---|---|
| Weight Loss | D015431 | 56 associated lipids |
| Dermatitis, Contact | D003877 | 59 associated lipids |
| Pain | D010146 | 64 associated lipids |
| Cystic Fibrosis | D003550 | 65 associated lipids |
| Reperfusion Injury | D015427 | 65 associated lipids |
| Liver Cirrhosis | D008103 | 67 associated lipids |
| Colitis | D003092 | 69 associated lipids |
| Melanoma | D008545 | 69 associated lipids |
| Hyperlipidemias | D006949 | 73 associated lipids |
| Leukemia | D007938 | 74 associated lipids |
tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Li Q et al. | Development and validation of a sensitive LC-MS/MS method for determination of tacrolimus on dried blood spots. | 2013 | Biomed. Chromatogr. | pmid:22893355 |
| Vassal O et al. | [Bacterial parotitis in an immunocompromised patient in adult ICU]. | 2013 | Ann Fr Anesth Reanim | pmid:23948025 |
| Yoshikawa Y et al. | [Pre-evening meal administration of tacrolimus improved refractory ocular symptoms in two young children with latent general myasthenia gravis]. | 2013 | No To Hattatsu | pmid:23951946 |
| Preidl RH et al. | Clopidogrel reduces post-transplant obliterative bronchiolitis. | 2013 | Transpl. Int. | pmid:23952051 |
| Wimmer CD et al. | Impact of cyclosporine versus tacrolimus on the incidence of de novo malignancy following liver transplantation: a single center experience with 609 patients. | 2013 | Transpl. Int. | pmid:23952102 |
| Mignogna MD et al. | Clinical behaviour and long-term therapeutic response in orofacial granulomatosis patients treated with intralesional triamcinolone acetonide injections alone or in combination with topical pimecrolimus 1%. | 2013 | J. Oral Pathol. Med. | pmid:22784292 |
| Ladizinski B et al. | Frontal fibrosing alopecia: a retrospective review of 19 patients seen at Duke University. | 2013 | J. Am. Acad. Dermatol. | pmid:23375454 |
| Naora Y et al. | Expression analysis of XPhyH-like during development and tail regeneration in Xenopus tadpoles: possible role of XPhyH-like expressing immune cells in impaired tail regenerative ability. | 2013 | Biochem. Biophys. Res. Commun. | pmid:23313512 |
| Nonaka K et al. | Intractable membranous lupus nephritis showing selective improvement of subepithelial deposits with tacrolimus therapy: a case report. | 2013 | Clin. Nephrol. | pmid:22541676 |
| Dumortier J et al. | Conversion from twice daily tacrolimus to once daily tacrolimus in long-term stable liver transplant recipients: a single-center experience with 394 patients. | 2013 | Liver Transpl. | pmid:23483701 |
| Provenzani A et al. | Pharmacogenetic considerations for optimizing tacrolimus dosing in liver and kidney transplant patients. | 2013 | World J. Gastroenterol. | pmid:24409044 |
| Brown RS et al. | Topical tacrolimus with custom trays in the treatment of severe oral chronic graft-versus-host disease refractory to a potent topical steroid therapy: a case report. | 2013 | Oral Surg Oral Med Oral Pathol Oral Radiol | pmid:23102802 |
| Giannelli V et al. | Conversion from twice-daily to once-daily Tacrolimus administration in liver transplant patient: results of long term follow-up. | 2013 | Eur Rev Med Pharmacol Sci | pmid:24174352 |
| van den Hoogen MW et al. | Insulin requirement after a renal transplant in patients with type 2 diabetes: the choice of calcineurin inhibitors. | 2013 | Exp Clin Transplant | pmid:23432070 |
| Westland T et al. | Treatment of atopic keratoconjunctivitis in patients with atopic dermatitis: is ocular application of tacrolimus an option? | 2013 | J Eur Acad Dermatol Venereol | pmid:23106347 |
| Shi Y et al. | Influence of CYP3A4, CYP3A5 and MDR-1 polymorphisms on tacrolimus pharmacokinetics and early renal dysfunction in liver transplant recipients. | 2013 | Gene | pmid:23107770 |
| Johannesson L et al. | Preclinical report on allogeneic uterus transplantation in non-human primates. | 2013 | Hum. Reprod. | pmid:23108346 |
| López E et al. | Immunophilins are involved in the altered platelet aggregation observed in patients with type 2 diabetes mellitus. | 2013 | Curr. Med. Chem. | pmid:23432586 |
| Chung BY et al. | The proactive treatment of atopic dermatitis with tacrolimus ointment in Korean patients: a comparative study between once-weekly and thrice-weekly applications. | 2013 | Br. J. Dermatol. | pmid:23110605 |
| Du J et al. | Long-term efficacy and safety of tacrolimus ointment in the treatment of vitiligo. | 2013 | J. Dermatol. | pmid:24111918 |
| Khanmoradi K et al. | Evaluating safety and efficacy of rabbit antithymocyte globulin induction in elderly kidney transplant recipients. | 2013 | Exp Clin Transplant | pmid:23432665 |
| Arora RB et al. | FK506 attenuates intracerebroventricular streptozotocin-induced neurotoxicity in rats. | 2013 | Behav Pharmacol | pmid:26057771 |
| De Simone C et al. | Tacrolimus 0.1% ointment in nail psoriasis: a randomized controlled open-label study. | 2013 | J Eur Acad Dermatol Venereol | pmid:22788697 |
| Pan F et al. | [Protective effect of tacrolimus postconditioning on oxidative stress injury provoked by spinal cord ischemia-reperfusion in rats]. | 2013 | Zhonghua Yi Xue Za Zhi | pmid:24548402 |
| Uchino M et al. | Topical tacrolimus therapy for antibiotic-refractory pouchitis. | 2013 | Dis. Colon Rectum | pmid:24022534 |
| de Jonge H et al. | Impact of CYP3A5 genotype on tacrolimus versus midazolam clearance in renal transplant recipients: new insights in CYP3A5-mediated drug metabolism. | 2013 | Pharmacogenomics | pmid:24024898 |
| Mesar I et al. | Rescue therapy with sirolimus in a renal transplant recipient with tacrolimus-induced hepatotoxicity. | 2013 | Ren Fail | pmid:24028307 |
| Shihab FS et al. | Effect of corticosteroid withdrawal on tacrolimus and mycophenolate mofetil exposure in a randomized multicenter study. | 2013 | Am. J. Transplant. | pmid:23167508 |
| Dong QE et al. | [Inhibitory effects of tacrolimus on effector T cells from patients with severe aplastic anemia]. | 2013 | Zhonghua Yi Xue Za Zhi | pmid:24028719 |
| Bayer J et al. | Effect of inhaled tacrolimus on ischemia reperfusion injury in rat lung transplant model. | 2013 | J. Thorac. Cardiovasc. Surg. | pmid:24029291 |
| Rojas LE et al. | Meta-analysis and systematic review of the effect of the donor and recipient CYP3A5 6986A>G genotype on tacrolimus dose requirements in liver transplantation. | 2013 | Pharmacogenet. Genomics | pmid:23873120 |
| Bourdeaux C et al. | Prope tolerance after pediatric liver transplantation. | 2013 | Pediatr Transplant | pmid:23171043 |
| Jones AC et al. | Phage p1-derived artificial chromosomes facilitate heterologous expression of the FK506 gene cluster. | 2013 | PLoS ONE | pmid:23874942 |
| Eurich D et al. | YKL-40-gene polymorphism affects acute cellular rejection and fibrosis progression after transplantation for hepatitis C virus-induced liver disease. | 2013 | J. Gastroenterol. Hepatol. | pmid:22989351 |
| Prucha H et al. | Pimecrolimus, a topical calcineurin inhibitor used in the treatment of atopic eczema. | 2013 | Expert Opin Drug Metab Toxicol | pmid:23876065 |
| Miwa Y et al. | Depression is improved when low-dose tacrolimus is given to rheumatoid arthritis patients showing an inadequate response to biologic agents. | 2013 | Mod Rheumatol | pmid:22990336 |
| Kim CH et al. | 850nm light-emitting-diode phototherapy plus low-dose tacrolimus (FK-506) as combination therapy in the treatment of Dermatophagoides farinae-induced atopic dermatitis-like skin lesions in NC/Nga mice. | 2013 | J. Dermatol. Sci. | pmid:23810774 |
| Chaabane A et al. | Limited sampling strategy of mycophenolic acid in adult kidney transplant recipients: influence of the post-transplant period and the pharmacokinetic profile. | 2013 | J Clin Pharmacol | pmid:23813362 |
| Ma MK et al. | Significant reduction of Tacrolimus trough level after conversion from twice daily Prograf to once daily Advagraf in Chinese renal transplant recipients with or without concomitant diltiazem treatment. | 2013 | Ren Fail | pmid:23815459 |
| Klintmalm G and O'Farrelly C | Taking the rap: multiple effects of blocking mammalian target of rapamycin. | 2013 | Hepatology | pmid:22767219 |
| Rickels MR et al. | Improvement in insulin sensitivity after human islet transplantation for type 1 diabetes. | 2013 | J. Clin. Endocrinol. Metab. | pmid:24085506 |
| Renner B et al. | Cyclosporine induces endothelial cell release of complement-activating microparticles. | 2013 | J. Am. Soc. Nephrol. | pmid:24092930 |
| Faralli JA et al. | Dexamethasone increases αvβ3 integrin expression and affinity through a calcineurin/NFAT pathway. | 2013 | Biochim. Biophys. Acta | pmid:24100160 |
| Michel S et al. | Renal recovery after conversion to an everolimus-based immunosuppression in early and late heart transplant recipients: a 12-month analysis. | 2013 | Exp Clin Transplant | pmid:24128136 |
| Kim Y et al. | Patients with persistent new-onset diabetes after transplantation have greater weight gain after kidney transplantation. | 2013 | J. Korean Med. Sci. | pmid:24133345 |
| Niu YJ et al. | Establishment of tacrolimus-induced diabetes in rat model and assessment of clinical treatments for post-transplant diabetes mellitus in liver transplant recipients. | 2013 | Clin. Lab. | pmid:24133918 |
| Azevedo LS et al. | Seroconversion of 2009 pandemic influenza A (H1N1) vaccination in kidney transplant patients and the influence of different risk factors. | 2013 | Transpl Infect Dis | pmid:24134688 |
| Landy J et al. | Oral tacrolimus as maintenance therapy for refractory ulcerative colitis--an analysis of outcomes in two London tertiary centres. | 2013 | J Crohns Colitis | pmid:23623737 |
| Vichyanond P and Kosrirukvongs P | Use of cyclosporine A and tacrolimus in treatment of vernal keratoconjunctivitis. | 2013 | Curr Allergy Asthma Rep | pmid:23625179 |
| Wang Y et al. | Micelles of methoxy poly(ethylene glycol)-poly(epsilon-caprolactone) as a novel drug delivery vehicle for tacrolimus. | 2013 | J Biomed Nanotechnol | pmid:23627041 |
| Wei H et al. | Effects of traditional chinese medicine Wuzhi capsule on pharmacokinetics of tacrolimus in rats. | 2013 | Drug Metab. Dispos. | pmid:23628674 |
| Rickels MR et al. | Improvement in β-cell secretory capacity after human islet transplantation according to the CIT07 protocol. | 2013 | Diabetes | pmid:23630300 |
| Axelsson J et al. | Scavengers of reactive oxygen species, paracalcitol, RhoA, and Rac-1 inhibitors and tacrolimus inhibit angiotensin II-induced actions on glomerular permeability. | 2013 | Am. J. Physiol. Renal Physiol. | pmid:23657856 |
| Pan F et al. | Tacolimus postconditioning alleviates apoptotic cell death in rats after spinal cord ischemia-reperfusion injury via up-regulating protein-serine-threonine kinases phosphorylation. | 2013 | J. Huazhong Univ. Sci. Technol. Med. Sci. | pmid:24337847 |
| Harikishore A et al. | Adamantyl derivative as a potent inhibitor of Plasmodium FK506 binding protein 35. | 2013 | ACS Med Chem Lett | pmid:24900611 |
| Selden NR et al. | Central nervous system stem cell transplantation for children with neuronal ceroid lipofuscinosis. | 2013 | J Neurosurg Pediatr | pmid:23581634 |
| Yao W et al. | Aβ induces acute depression of excitatory glutamatergic synaptic transmission through distinct phosphatase-dependent mechanisms in rat CA1 pyramidal neurons. | 2013 | Brain Res. | pmid:23583290 |
| Hill JA et al. | Genetic and genomic architecture of the evolution of resistance to antifungal drug combinations. | 2013 | PLoS Genet. | pmid:23593013 |
| Tszyrsznic W et al. | Two rapid ultra performance liquid chromatography/tandem mass spectrometry (UPLC/MS/MS) methods with common sample pretreatment for therapeutic drug monitoring of immunosuppressants compared to immunoassay. | 2013 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:23584041 |
| Lee Sr et al. | Angiotensinogen polymorphisms and post-transplantation diabetes mellitus in Korean renal transplant subjects. | 2013 | Kidney Blood Press. Res. | pmid:23594830 |
| Santoro AB et al. | CYP3A5 genotype, but not CYP3A4*1b, CYP3A4*22, or hematocrit, predicts tacrolimus dose requirements in Brazilian renal transplant patients. | 2013 | Clin. Pharmacol. Ther. | pmid:23588314 |
| Riegersperger M et al. | Effect of conversion from ciclosporin to tacrolimus on endothelial progenitor cells in stable long-term kidney transplant recipients. | 2013 | Transplantation | pmid:23594858 |
| De Simone P et al. | Everolimus with reduced tacrolimus in liver transplantation. | 2013 | Am. J. Transplant. | pmid:23601137 |
| Kumar AJ et al. | Pilot study of prophylactic ex vivo costimulated donor leukocyte infusion after reduced-intensity conditioned allogeneic stem cell transplantation. | 2013 | Biol. Blood Marrow Transplant. | pmid:23635453 |
| Israni AK et al. | Tacrolimus trough levels after month 3 as a predictor of acute rejection following kidney transplantation: a lesson learned from DeKAF Genomics. | 2013 | Transpl. Int. | pmid:23879408 |
| Casanova JR et al. | Rapid hippocampal network adaptation to recurring synchronous activity--a role for calcineurin. | 2013 | Eur. J. Neurosci. | pmid:23879713 |
| Huang D et al. | Genome-scale metabolic network guided engineering of Streptomyces tsukubaensis for FK506 production improvement. | 2013 | Microb. Cell Fact. | pmid:23705993 |
| Ban YH et al. | Characterization of FK506 biosynthetic intermediates involved in post-PKS elaboration. | 2013 | J. Nat. Prod. | pmid:23706030 |
| Sanz-Marco E et al. | Treatment of refractory dry eye associated with graft versus host disease with 0.03% tacrolimus eyedrops. | 2013 | J Ocul Pharmacol Ther | pmid:23947579 |
| Pamuk F et al. | Effects of tacrolimus and nifedipine, alone or in combination, on gingival tissues. | 2013 | J. Periodontol. | pmid:23289868 |
| Eguchi R et al. | FK506 induces endothelial dysfunction through attenuation of Akt and ERK1/2 independently of calcineurin inhibition and the caspase pathway. | 2013 | Cell. Signal. | pmid:23707520 |
| Fitzgerald RT et al. | Isolated leptomeningeal enhancement in tacrolimus-associated posterior reversible encephalopathy syndrome. | 2013 | Pediatr. Neurol. | pmid:23290027 |
| van Maarseveen EM et al. | Pretransplantation pharmacokinetic curves of tacrolimus in HIV-infected patients on ritonavir-containing cART: a pilot study. | 2013 | Transplantation | pmid:23250333 |
| Hou Q et al. | Pharmacokinetic interaction between tacrolimus and berberine in a child with idiopathic nephrotic syndrome. | 2013 | Eur. J. Clin. Pharmacol. | pmid:23765408 |
| Shivaswamy V et al. | Metformin improves immunosuppressant induced hyperglycemia and exocrine apoptosis in rats. | 2013 | Transplantation | pmid:23250335 |
| Eun SC et al. | Prolongation of the rat composite tissue allograft survival by the combination of tolerogenic immature dendritic cells and short-term treatment with FK506. | 2013 | Transplant. Proc. | pmid:23769045 |
| Xu H et al. | Simultaneous bone marrow and composite tissue transplantation in rats treated with nonmyeloablative conditioning promotes tolerance. | 2013 | Transplantation | pmid:23250336 |
| Han N et al. | Prediction of the tacrolimus population pharmacokinetic parameters according to CYP3A5 genotype and clinical factors using NONMEM in adult kidney transplant recipients. | 2013 | Eur. J. Clin. Pharmacol. | pmid:22660440 |
| Oteo I et al. | Tacrolimus pharmacokinetics in the early post-liver transplantation period and clinical applicability via Bayesian prediction. | 2013 | Eur. J. Clin. Pharmacol. | pmid:22660442 |
| Sarkar S et al. | Tacrolimus induced diabetic ketoacidosis in nephrotic syndrome. | 2013 | Indian J Pediatr | pmid:22660906 |
| Bashratyan R et al. | Insulinoma-released exosomes activate autoreactive marginal zone-like B cells that expand endogenously in prediabetic NOD mice. | 2013 | Eur. J. Immunol. | pmid:23817982 |
| Zlatic SA et al. | Chemical-genetic disruption of clathrin function spares adaptor complex 3-dependent endosome vesicle biogenesis. | 2013 | Mol. Biol. Cell | pmid:23761069 |
| Yin H et al. | Enhancing pancreatic Beta-cell regeneration in vivo with pioglitazone and alogliptin. | 2013 | PLoS ONE | pmid:23762423 |
| López E et al. | FKBP52 is involved in the regulation of SOCE channels in the human platelets and MEG 01 cells. | 2013 | Biochim. Biophys. Acta | pmid:23228564 |
| Tie X et al. | NFAT1 is highly expressed in, and regulates the invasion of, glioblastoma multiforme cells. | 2013 | PLoS ONE | pmid:23762456 |
| Knops N et al. | From gut to kidney: transporting and metabolizing calcineurin-inhibitors in solid organ transplantation. | 2013 | Int J Pharm | pmid:23711732 |
| Mourer JS et al. | Impact of late calcineurin inhibitor withdrawal on ambulatory blood pressure and carotid intima media thickness in renal transplant recipients. | 2013 | Transplantation | pmid:23715049 |
| Nagaraja P et al. | Role of insulin resistance indices in predicting new-onset diabetes after kidney transplantation. | 2013 | Transpl. Int. | pmid:23230898 |
| Fujita Y et al. | Analysis of cytochrome P450 gene polymorphism in a lupus nephritis patient in whom tacrolimus blood concentration was markedly elevated after administration of azole antifungal agents. | 2013 | J Clin Pharm Ther | pmid:22971159 |
| Musso CG et al. | Furosemide test in stage III-chronic kidney disease and kidney transplant patients on tacrolimus. | 2013 | Int Urol Nephrol | pmid:23233031 |
| Yang CH et al. | Effect of tacrolimus on myocardial infarction is associated with inflammation, ROS, MAP kinase and Akt pathways in mini-pigs. | 2013 | J. Atheroscler. Thromb. | pmid:22972310 |
| Sofue T et al. | Excess fluid distribution affects tacrolimus absorption in peritoneal dialysis patients. | 2013 | Clin. Exp. Nephrol. | pmid:23269423 |
| Inoue T et al. | The efficacy of oral tacrolimus in patients with moderate/severe ulcerative colitis not receiving concomitant corticosteroid therapy. | 2013 | Intern. Med. | pmid:23291669 |
| Sommers CD et al. | Analyses of marketplace tacrolimus drug product quality: bioactivity, NMR and LC-MS. | 2013 | J Pharm Biomed Anal | pmid:23917038 |
| Barbas AS et al. | Posterior reversible encephalopathy syndrome independently associated with tacrolimus and sirolimus after multivisceral transplantation. | 2013 | Am. J. Transplant. | pmid:23331705 |
| Noll BD et al. | Validation of an LC-MS/MS method to measure tacrolimus in rat kidney and liver tissue and its application to human kidney biopsies. | 2013 | Ther Drug Monit | pmid:23921430 |
| Rice SA et al. | Topical tacrolimus 0.1% ointment for treatment of cutaneous Crohn's Disease. | 2013 | BMC Res Notes | pmid:23331739 |
| Kanda J et al. | Pre-engraftment syndrome after myeloablative dual umbilical cord blood transplantation: risk factors and response to treatment. | 2013 | Bone Marrow Transplant. | pmid:23334274 |
| Gül FC et al. | The comparison of the impact of ghrelin and tacrolimus on vitreous cytokine levels in an experimental uveitis model. | 2013 | Graefes Arch. Clin. Exp. Ophthalmol. | pmid:23334350 |
| Martina MR et al. | The precise chemical-physical nature of the pharmacore in FK506 binding protein inhibition: ElteX, a New class of nanomolar FKBP12 ligands. | 2013 | J. Med. Chem. | pmid:23301792 |