| MeSH term | MeSH ID | Detail |
|---|---|---|
| Diabetes Mellitus, Type 1 | D003922 | 56 associated lipids |
| Dermatitis, Contact | D003877 | 59 associated lipids |
| Pain | D010146 | 64 associated lipids |
| Cystic Fibrosis | D003550 | 65 associated lipids |
| Reperfusion Injury | D015427 | 65 associated lipids |
| Liver Cirrhosis | D008103 | 67 associated lipids |
| Melanoma | D008545 | 69 associated lipids |
| Colitis | D003092 | 69 associated lipids |
| Hyperlipidemias | D006949 | 73 associated lipids |
| Leukemia | D007938 | 74 associated lipids |
tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Schulz T et al. | [TAC/MMF/Pred/single shot ATG versus CsA/MMF/Pred single shot ATG after pancreas-/kidney transplantation (PNTX)--initial results of a prospective randomized study]. | 1998 | Langenbecks Arch Chir Suppl Kongressbd | pmid:14518229 |
| Gasser M et al. | [Selective immunosuppression with monoclonal antibodies against ICAM-1 and LFA-1 with FK 506 after experimental small intestine transplantation in the rat]. | 1998 | Langenbecks Arch Chir Suppl Kongressbd | pmid:14518324 |
| Mendez R | FK 506 and mycophenolate mofetil in renal transplant recipients: six-month results of a multicenter, randomized dose ranging trial. FK 506 MMF Dose-Ranging Kidney Transplant Study Group. | 1998 | Transplant. Proc. | pmid:9636522 |
| Vanrenterghem Y et al. | Co-administration of tacrolimus and mycophenolate mofetil in cadaveric renal transplant recipients. | 1998 | Transplant. Proc. | pmid:9636523 |
| Claesson K et al. | Lipoprotein patterns in renal transplant patients: a comparison between FK 506 and cyclosporine A patients. | 1998 | Transplant. Proc. | pmid:9636524 |
| Morris-Stiff G et al. | Prospective randomized study comparing FK 506 (Prograft) and cyclosporine A (Neoral) as primary immunosuppression in cadaveric renal transplants at a single institution: interim report of the first 80 cases. | 1998 | Transplant. Proc. | pmid:9636525 |
| Reich K et al. | Topical tacrolimus for pyoderma gangrenosum. | 1998 | Br. J. Dermatol. | pmid:9892935 |
| Woodle ES et al. | Meta-analysis of FK 506 and mycophenolate mofetil refractory rejection trials in renal transplantation. Refractory Rejection Meta-Analysis Study Group. | 1998 | Transplant. Proc. | pmid:9636526 |
| Kahl A et al. | First results with a quadruple therapy regimen including tacrolimus and mycophenolate mofetil in patients after combined pancreas and kidney transplantation. | 1998 | Transplant. Proc. | pmid:9532149 |
| Bruce DS et al. | Effects of tacrolimus, mycophenolate mofetil, and cyclosporine microemulsion on rejection incidence in synchronous pancreas-kidney transplantation. | 1998 | Transplant. Proc. | pmid:9532150 |
| Peddi VR et al. | Tacrolimus eliminates acute rejection as a major complication following simultaneous kidney and pancreas transplantation. | 1998 | Transplant. Proc. | pmid:9532151 |
| Burke GW et al. | Cholesterol control: long-term benefit of pancreas-kidney transplantation with FK 506 immunosuppression. | 1998 | Transplant. Proc. | pmid:9532153 |
| Büsing M et al. | Mycophenolate mofetil/tacrolimus/single-shot versus azathioprine/cyclosporine/ATG in pancreas-kidney transplantation: results of a prospective randomized single-center study. | 1998 | Transplant. Proc. | pmid:9532155 |
| Bekersky I et al. | Bioequivalence of a new strength tacrolimus capsule under development. | 1998 | Transplant. Proc. | pmid:9636591 |
| Cantarovich M et al. | Optimal time points for the prediction of the area-under-the-curve in liver transplant patients receiving tacrolimus. | 1998 | Transplant. Proc. | pmid:9636592 |
| Mueller AR et al. | Does initial graft function influence the outcome after liver transplantation? | 1998 | Transplant. Proc. | pmid:9636594 |
| Lang M et al. | Impact of immunosuppression in liver transplantation across a positive crossmatch. | 1998 | Transplant. Proc. | pmid:9636595 |
| Platz KP et al. | Indications for mycophenolate mofetil therapy in hepatitis C-patients undergoing liver transplantation. | 1998 | Transplant. Proc. | pmid:9636596 |
| Watanabe K et al. | Synergistic effect of short-term fractionated lymphoid irradiation with initial high doses of FK506 on the induction of tolerance to kidney allografts in dogs. | 1998 | Transplant. Proc. | pmid:9474940 |
| Ghobrial RM et al. | Retransplantation for recurrent hepatitis C following tacrolimus or cyclosporine immunosuppression. | 1998 | Transplant. Proc. | pmid:9636597 |
| Yoshimura N et al. | Combination therapy of tacrolimus (FK506) with azathioprine and steroids in renal transplant recipients. | 1998 | Transplant. Proc. | pmid:9474949 |
| Takeuchi H et al. | Lymphocyte sensitivity to cyclosporine and tacrolimus in chronic renal failure patients and clinical significance in renal transplantation. | 1998 | Transplant. Proc. | pmid:9474950 |
| Hatori M et al. | Clinicopathologic examination of no-episode biopsies in well-functioning renal allografts. | 1998 | Transplant. Proc. | pmid:9474971 |
| Egawa H et al. | Lymphoproliferative disorders in patients undergoing living-related liver transplantation. | 1998 | Transplant. Proc. | pmid:9474982 |
| Murata M et al. | Unrelated donor bone marrow transplantation in Japanese patients is facilitated by the National Marrow Donor Program of the United States. | 1998 | Transplant. Proc. | pmid:9474987 |
| Yang J et al. | Small-molecule control of insulin and PDGF receptor signaling and the role of membrane attachment. | 1998 | Curr. Biol. | pmid:9427627 |
| Billaud EM et al. | Evidence for a pharmacokinetic interaction between itraconazole and tacrolimus in organ transplant patients. | 1998 | Br J Clin Pharmacol | pmid:9764970 |
| Onuma H et al. | A calcineurin inhibitor, FK506, blocks voltage-gated calcium channel-dependent LTP in the hippocampus. | 1998 | Neurosci. Res. | pmid:9678635 |
| Fisher NC et al. | Chronic renal failure following liver transplantation: a retrospective analysis. | 1998 | Transplantation | pmid:9679823 |
| Sanchez-Campos S et al. | Cholestasis and alterations of glutathione metabolism induced by tacrolimus (FK506) in the rat. | 1998 | Transplantation | pmid:9679826 |
| Denesyuk AI et al. | Analogous conformations of both binding and effector regions in cyclosporin A, FK506 and rapamycin. | 1998 | Comput. Chem. | pmid:9680690 |
| Redrup AC et al. | Differential regulation of IL-4 and IL-13 secretion by human basophils: their relationship to histamine release in mixed leukocyte cultures. | 1998 | J. Immunol. | pmid:9469459 |
| Kihira H et al. | Possible involvement of calcineurin in retinoic acid-induced inhibition of leukemic HL-60 cell proliferation. | 1998 | Int. J. Oncol. | pmid:9472103 |
| Daoud AJ et al. | A comparison of the safety and efficacy of mycophenolate mofetil, prednisone and cyclosporine and mycophenolate mofetil, and prednisone and tacrolimus. | 1998 | Transplant. Proc. | pmid:9865303 |
| Braun F et al. | How to handle mycophenolate mofetil in combination with tacrolimus? | 1998 | Transplant. Proc. | pmid:9865309 |
| Schorlemmer HU et al. | Long-term allograft survival and tolerance induction by the synergistic activity of malononitrilamides and tacrolimus. | 1998 | Transplant. Proc. | pmid:9865312 |
| Lai MM et al. | Cain, a novel physiologic protein inhibitor of calcineurin. | 1998 | J. Biol. Chem. | pmid:9660798 |
| Metcalfe SM et al. | In vitro transcription and translation of the tumour suppressor protein P53: qualitative and quantitative effects of FK506 and rapamycin. | 1998 | Transplant. Proc. | pmid:9865315 |
| Nagayasu T et al. | Expression of proliferating cell nuclear antigen in bronchial epithelium after lung transplantation in the rat. | 1998 | J. Heart Lung Transplant. | pmid:9662091 |
| Gross A et al. | Enforced dimerization of BAX results in its translocation, mitochondrial dysfunction and apoptosis. | 1998 | EMBO J. | pmid:9670005 |
| Kilian K et al. | FK-506 (tacrolimus) therapy for an unusual SLE-like disease. | 1998 | Transplant. Proc. | pmid:9865322 |
| Stockwell BR and Schreiber SL | TGF-beta-signaling with small molecule FKBP12 antagonists that bind myristoylated FKBP12-TGF-beta type I receptor fusion proteins. | 1998 | Chem. Biol. | pmid:9662508 |
| Schorlemmer HU and Kurrle R | Combination therapy of malononitrilamides and tacrolimus (FK 506) induced long-term xenograft survival. | 1998 | Transplant. Proc. | pmid:9865337 |
| Chelmicka-Schorr E et al. | Immunoaugmenting effect of FK 506 on experimental allergic encephalomyelitis in Lewis rats. | 1998 | J. Autoimmun. | pmid:9776710 |
| Trindade E et al. | Use of granulocyte macrophage colony stimulating factor in children after orthotopic liver transplantation. | 1998 | J. Hepatol. | pmid:9672183 |
| Weichert G and Sauder DN | Efficacy of tacrolimus (FK 506) in idiopathic treatment-resistant pyoderma gangrenosum. | 1998 | J. Am. Acad. Dermatol. | pmid:9777778 |
| Yamada H et al. | Simvastatin-tacrolimus and simvastatin-cyclosporin interactions in rats. | 1998 | Biopharm Drug Dispos | pmid:9673778 |
| Yardin C et al. | FK506 antagonizes apoptosis and c-jun protein expression in neuronal cultures. | 1998 | Neuroreport | pmid:9674596 |
| Hattori R et al. | FK 506 in cadaveric kidney transplantation from non-heart-beating donors. | 1998 | Transplant. Proc. | pmid:9838666 |
| Takeda M et al. | Immunologic factors contributing to acute rejection in lungs xenotransplanted between primates. | 1998 | Transplant. Proc. | pmid:9838670 |
| Cai Q et al. | Reduction of infarct size in isolated rat heart by CsA and FK506: possible role of phosphatase inhibition. | 1998 | Cardiovasc Drugs Ther | pmid:9926283 |
| Fukushima N et al. | Prolonged survival of pig cardiac xenografts in baboons by sequential cardiac transplantation. | 1998 | Transplant. Proc. | pmid:9838671 |
| Honoré P et al. | [Liver transplantation: experiences and results of a program at the University of Liege]. | 1998 | Rev Med Liege | pmid:9927867 |
| Tredger JM et al. | Therapeutic monitoring of tacrolimus (FK506) with the first- and second-generation microparticle enzyme immunoassays: performance and results in four patient populations. | 1998 | Ther Drug Monit | pmid:9631923 |
| Nishimura Y et al. | A trial to obtain donor-specific immunotolerance using a vascularized thymus allograft. | 1998 | Transplant. Proc. | pmid:9838684 |
| Stone JH et al. | Outcome of renal transplantation in ninety-seven cyclosporine-era patients with systemic lupus erythematosus and matched controls. | 1998 | Arthritis Rheum. | pmid:9704643 |
| Sanada O et al. | Establishment of chimerism in donors by intraportal injection of recipient-type bone marrow cells with concomitant administration of FK 506 before liver transplantation prolongs liver allograft survival in rats. | 1998 | Transplant. Proc. | pmid:9838689 |
| Ogawa T et al. | Osteoblastic differentiation is enhanced by rapamycin in rat osteoblast-like osteosarcoma (ROS 17/2.8) cells. | 1998 | Biochem. Biophys. Res. Commun. | pmid:9705862 |
| Khattab A et al. | Cyclosporins: lack of correlation between antischistosomal properties and inhibition of cyclophilin isomerase activity. | 1998 | Exp. Parasitol. | pmid:9709036 |
| White MH et al. | Randomized, double-blind clinical trial of amphotericin B colloidal dispersion vs. amphotericin B in the empirical treatment of fever and neutropenia. | 1998 | Clin. Infect. Dis. | pmid:9709879 |
| Perego C et al. | Evidence that SMS 201-995 enhances the immunosuppressive effect of FK506. | 1998 | Int. J. Immunopharmacol. | pmid:9818792 |
| Campo JV et al. | Tacrolimus toxic reaction associated with the use of nefazodone: paroxetine as an alternative agent. | 1998 | Arch. Gen. Psychiatry | pmid:9819077 |
| Shapiro R | Tacrolimus in pediatric renal transplantation: a review. | 1998 | Pediatr Transplant | pmid:10084728 |
| Budde K et al. | Long-term outcome of tacrolimus rescue therapy in late rejection after renal transplantation. | 1998 | Transplant. Proc. | pmid:9723280 |
| Schultz LW and Clardy J | Chemical inducers of dimerization: the atomic structure of FKBP12-FK1012A-FKBP12. | 1998 | Bioorg. Med. Chem. Lett. | pmid:9871618 |
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| Mohri T et al. | Rapid adhesion and spread of non-adherent colon cancer Colo201 cells induced by the protein kinase inhibitors, K252a and KT5720 and suppression of the adhesion by the immunosuppressants FK506 and cyclosporin A. | 1998 | Cell Struct. Funct. | pmid:9872566 |
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| Fritsche L et al. | Late conversion to mycophenolate mofetil for chronic deterioration of renal allograft function. | 1998 | Transplant. Proc. | pmid:9723451 |
| Fornairon S et al. | Can we improve the results of simultaneous pancreas-kidney transplantation? | 1998 | Transplant. Proc. | pmid:9745580 |
| Hanack U et al. | Is there a different impact of cyclosporine versus tacrolimus on delayed graft function after kidney transplantation? | 1998 | Transplant. Proc. | pmid:9723477 |
| Ratanatharathorn V et al. | Phase III study comparing methotrexate and tacrolimus (prograf, FK506) with methotrexate and cyclosporine for graft-versus-host disease prophylaxis after HLA-identical sibling bone marrow transplantation. | 1998 | Blood | pmid:9746768 |
| Miyata Y et al. | Development of xenogeneic microchimerism correlated with graft outcome in hamster-to-rat heart xenotransplantation. | 1998 | Transplant. Proc. | pmid:9723548 |
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| Herzberg GZ et al. | Usefulness of tacrolimus versus cyclosporine after pediatric heart transplantation. | 1998 | Am. J. Cardiol. | pmid:9723652 |
| Thielke J et al. | Pharmacokinetics of tacrolimus and cyclosporine in short-bowel syndrome. | 1998 | Liver Transpl Surg | pmid:9724482 |
| Paterson DL et al. | Infectious complications occurring in liver transplant recipients receiving mycophenolate mofetil. | 1998 | Transplantation | pmid:9753337 |
| Mihatsch MJ et al. | The side-effects of ciclosporine-A and tacrolimus. | 1998 | Clin. Nephrol. | pmid:9696431 |
| Woodle ES et al. | Liver transplantation in the first three months of life. | 1998 | Transplantation | pmid:9753340 |
| Fritsche L et al. | Conversion to mycophenolate mofetil for chronic progressive deterioration of renal allograft function: first clinical experiences in 44 patients. | 1998 | Transplant. Proc. | pmid:9636481 |
| Miura S et al. | Effect of tacrolimus on the outcome of renal transplantation with donor-specific blood transfusion. | 1998 | Transplant. Proc. | pmid:9636492 |
| Cetinkale O et al. | Involvement of neutrophils in ischemia-reperfusion injury of inguinal island skin flaps in rats. | 1998 | Plast. Reconstr. Surg. | pmid:9655420 |
| Lamb ML and Jorgensen WL | Investigations of neurotrophic inhibitors of FK506 binding protein via Monte Carlo simulations. | 1998 | J. Med. Chem. | pmid:9767630 |
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| Bennett WM | The nephrotoxicity of new and old immunosuppressive drugs. | 1998 | Ren Fail | pmid:9768435 |
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| Gómez J et al. | The Bcl-2 gene is differentially regulated by IL-2 and IL-4: role of the transcription factor NF-AT. | 1998 | Oncogene | pmid:9771966 |
| Pizzolato GP et al. | Cerebral vasculitis during FK 506 treatment in a liver transplant patient. | 1998 | Neurology | pmid:9566415 |
| Fellermann K et al. | Steroid-unresponsive acute attacks of inflammatory bowel disease: immunomodulation by tacrolimus (FK506). | 1998 | Am. J. Gastroenterol. | pmid:9772045 |
| Salerno A et al. | The effect of cyclosporin A, FK506 and rapamycin on the murine contact sensitivity reaction. | 1998 | Clin. Exp. Immunol. | pmid:9566798 |
| Mollison KW et al. | Nephrotoxicity studies of the immunosuppressants tacrolimus (FK506) and ascomycin in rat models. | 1998 | Toxicology | pmid:9570331 |
| Araki T et al. | Post-ischemic alterations in [3H]FK506 binding in the gerbil and rat brains. | 1998 | Metab Brain Dis | pmid:9570636 |
| Finney NS | Enantioselective epoxide hydrolysis: catalysis involving microbes, mammals and metals. | 1998 | Chem. Biol. | pmid:9571210 |
| Davis EC et al. | Identification of tropoelastin as a ligand for the 65-kD FK506-binding protein, FKBP65, in the secretory pathway. | 1998 | J. Cell Biol. | pmid:9442105 |