| MeSH term | MeSH ID | Detail |
|---|---|---|
| Weight Loss | D015431 | 56 associated lipids |
| Dermatitis, Contact | D003877 | 59 associated lipids |
| Pain | D010146 | 64 associated lipids |
| Cystic Fibrosis | D003550 | 65 associated lipids |
| Reperfusion Injury | D015427 | 65 associated lipids |
| Liver Cirrhosis | D008103 | 67 associated lipids |
| Colitis | D003092 | 69 associated lipids |
| Melanoma | D008545 | 69 associated lipids |
| Hyperlipidemias | D006949 | 73 associated lipids |
| Leukemia | D007938 | 74 associated lipids |
tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| McCune TR et al. | Effects of tacrolimus on hyperlipidemia after successful renal transplantation: a Southeastern Organ Procurement Foundation multicenter clinical study. | 1998 | Transplantation | pmid:9448150 |
| Mentzer RM et al. | Tacrolimus as a rescue immunosuppressant after heart and lung transplantation. The U.S. Multicenter FK506 Study Group. | 1998 | Transplantation | pmid:9448154 |
| Ernst A et al. | Lung abcess complicating Legionella micdadei pneumonia in an adult liver transplant recipient: case report and review. | 1998 | Transplantation | pmid:9448158 |
| Cavaillé-Coll MW and Elashoff MR | Commentary on a comparison of tacrolimus and cyclosporine for immunosuppression after cadaveric renal transplantation. | 1998 | Transplantation | pmid:9448161 |
| Alaiti S et al. | Tacrolimus (FK506) ointment for atopic dermatitis: a phase I study in adults and children. | 1998 | J. Am. Acad. Dermatol. | pmid:9448208 |
| Morris-Stiff G et al. | Prospective randomized study comparing FK 506 (Prograft) and cyclosporine A (Neoral) as primary immunosuppression in cadaveric renal transplants at a single institution: interim report of the first 80 cases. | 1998 | Transplant. Proc. | pmid:9636525 |
| Woodle ES et al. | Meta-analysis of FK 506 and mycophenolate mofetil refractory rejection trials in renal transplantation. Refractory Rejection Meta-Analysis Study Group. | 1998 | Transplant. Proc. | pmid:9636526 |
| Undre NA et al. | Pharmacokinetics of FK 506 and mycophenolic acid after the administration of a FK 506-based regimen in combination with mycophenolate mofetil in kidney transplantation. | 1998 | Transplant. Proc. | pmid:9636527 |
| Kumar MS et al. | ATGAM versus OKT3 induction therapy in cadaveric kidney transplantation: patient and graft survival, CD3 subset, infection, and cost analysis. | 1998 | Transplant. Proc. | pmid:9636549 |
| Neylan JF | Effect of race and immunosuppression in renal transplantation: three-year survival results from a US multicenter, randomized trial. FK506 Kidney Transplant Study Group. | 1998 | Transplant. Proc. | pmid:9636551 |
| Burke GW et al. | Cholesterol control: long-term benefit of pancreas-kidney transplantation with FK 506 immunosuppression. | 1998 | Transplant. Proc. | pmid:9532153 |
| Büsing M et al. | Mycophenolate mofetil/tacrolimus/single-shot versus azathioprine/cyclosporine/ATG in pancreas-kidney transplantation: results of a prospective randomized single-center study. | 1998 | Transplant. Proc. | pmid:9532155 |
| Gruessner RW et al. | Mycophenolate mofetil and tacrolimus for induction and maintenance therapy after pancreas transplantation. | 1998 | Transplant. Proc. | pmid:9532156 |
| Corry RJ et al. | Tacrolimus without antilymphocyte induction therapy prevents pancreas loss from rejection in 123 consecutive patients. | 1998 | Transplant. Proc. | pmid:9532157 |
| Elmer DS et al. | Metabolic effects of FK 506 (tacrolimus) versus cyclosporine in portally drained pancreas allografts. | 1998 | Transplant. Proc. | pmid:9532159 |
| Lang M et al. | Impact of immunosuppression in liver transplantation across a positive crossmatch. | 1998 | Transplant. Proc. | pmid:9636595 |
| Platz KP et al. | Indications for mycophenolate mofetil therapy in hepatitis C-patients undergoing liver transplantation. | 1998 | Transplant. Proc. | pmid:9636596 |
| Ghobrial RM et al. | Retransplantation for recurrent hepatitis C following tacrolimus or cyclosporine immunosuppression. | 1998 | Transplant. Proc. | pmid:9636597 |
| Nakamura M et al. | Clinical and radiological features of two cases of tacrolimus-related posterior leukoencephalopathy in living related liver transplantation. | 1998 | Transplant. Proc. | pmid:9636600 |
| Charco R et al. | Hypercholesterolemia in long-term survivors of liver transplantation: a comparison between cyclosporine and FK 506. | 1998 | Transplant. Proc. | pmid:9636605 |
| Hatori M et al. | Clinicopathologic examination of no-episode biopsies in well-functioning renal allografts. | 1998 | Transplant. Proc. | pmid:9474971 |
| Egawa H et al. | Lymphoproliferative disorders in patients undergoing living-related liver transplantation. | 1998 | Transplant. Proc. | pmid:9474982 |
| Murata M et al. | Unrelated donor bone marrow transplantation in Japanese patients is facilitated by the National Marrow Donor Program of the United States. | 1998 | Transplant. Proc. | pmid:9474987 |
| Resch B et al. | FK 506 and successful pregnancy in a patient after renal transplantation. | 1998 | Transplant. Proc. | pmid:9474990 |
| Furlan V et al. | Interaction between tacrolimus and itraconazole in a heart-lung transplant recipient. | 1998 | Transplant. Proc. | pmid:9474996 |
| Yang J et al. | Small-molecule control of insulin and PDGF receptor signaling and the role of membrane attachment. | 1998 | Curr. Biol. | pmid:9427627 |
| Sanchez-Campos S et al. | Cholestasis and alterations of glutathione metabolism induced by tacrolimus (FK506) in the rat. | 1998 | Transplantation | pmid:9679826 |
| Denesyuk AI et al. | Analogous conformations of both binding and effector regions in cyclosporin A, FK506 and rapamycin. | 1998 | Comput. Chem. | pmid:9680690 |
| Van Leent EJ et al. | Effectiveness of the ascomycin macrolactam SDZ ASM 981 in the topical treatment of atopic dermatitis. | 1998 | Arch Dermatol | pmid:9681343 |
| Hultsch T et al. | Direct evidence that FK506 inhibition of FcepsilonRI-mediated exocytosis from RBL mast cells involves calcineurin. | 1998 | Arch. Dermatol. Res. | pmid:9681677 |
| Grupp C et al. | Haemolytic uraemic syndrome (HUS) during treatment with cyclosporin A after renal transplantation--is tacrolimus the answer? | 1998 | Nephrol. Dial. Transplant. | pmid:9681701 |
| Maesaki S et al. | Synergic effects of tactolimus and azole antifungal agents against azole-resistant Candida albican strains. | 1998 | J. Antimicrob. Chemother. | pmid:10052898 |
| Metcalfe SM et al. | In vitro transcription and translation of the tumour suppressor protein P53: qualitative and quantitative effects of FK506 and rapamycin. | 1998 | Transplant. Proc. | pmid:9865315 |
| Kilian K et al. | FK-506 (tacrolimus) therapy for an unusual SLE-like disease. | 1998 | Transplant. Proc. | pmid:9865322 |
| Stockwell BR and Schreiber SL | TGF-beta-signaling with small molecule FKBP12 antagonists that bind myristoylated FKBP12-TGF-beta type I receptor fusion proteins. | 1998 | Chem. Biol. | pmid:9662508 |
| Schorlemmer HU and Kurrle R | Combination therapy of malononitrilamides and tacrolimus (FK 506) induced long-term xenograft survival. | 1998 | Transplant. Proc. | pmid:9865337 |
| Chelmicka-Schorr E et al. | Immunoaugmenting effect of FK 506 on experimental allergic encephalomyelitis in Lewis rats. | 1998 | J. Autoimmun. | pmid:9776710 |
| Trindade E et al. | Use of granulocyte macrophage colony stimulating factor in children after orthotopic liver transplantation. | 1998 | J. Hepatol. | pmid:9672183 |
| Ahlmén J et al. | Positive effects of tacrolimus in a case of CIDP. | 1998 | Transplant. Proc. | pmid:9865344 |
| Weichert G and Sauder DN | Efficacy of tacrolimus (FK 506) in idiopathic treatment-resistant pyoderma gangrenosum. | 1998 | J. Am. Acad. Dermatol. | pmid:9777778 |
| Yamada H et al. | Simvastatin-tacrolimus and simvastatin-cyclosporin interactions in rats. | 1998 | Biopharm Drug Dispos | pmid:9673778 |
| Yokoyama I et al. | Immunosuppressant effect on Fas antigen expression and p53 of an experimental tumor. | 1998 | Transplant. Proc. | pmid:9865346 |
| Motamedi H and Shafiee A | The biosynthetic gene cluster for the macrolactone ring of the immunosuppressant FK506. | 1998 | Eur. J. Biochem. | pmid:9780228 |
| Yardin C et al. | FK506 antagonizes apoptosis and c-jun protein expression in neuronal cultures. | 1998 | Neuroreport | pmid:9674596 |
| Mollison KW et al. | Discovery of ascomycin analogs with potent topical but weak systemic activity for treatment of inflammatory skin diseases. | 1998 | Curr. Pharm. Des. | pmid:10197049 |
| Gerauer K et al. | Long-term cardiac allograft survival in mice treated with malononitrilamide 715. | 1998 | Transplant. Proc. | pmid:9865349 |
| Maestri M et al. | [Treatment of the nephrotoxicity of immunosuppressive drugs with insulin-like growth factor-I]. | 1998 | Minerva Chir | pmid:9780630 |
| Salowe SP and Hermes JD | Competitive and slow-binding inhibition of calcineurin by drug x immunophilin complexes. | 1998 | Arch. Biochem. Biophys. | pmid:9675023 |
| Medh RD et al. | Agonist-specific modulation of glucocorticoid receptor-mediated transcription by immunosuppressants. | 1998 | Mol. Cell. Endocrinol. | pmid:9685211 |
| Tsuzuki S et al. | FK506 (tacrolimus) inhibits extravasation of lymphoid cells by abrogating VLA-4/VCAM-1 mediated transendothelial migration. | 1998 | FEBS Lett. | pmid:9688583 |
| Fukushima N et al. | Prolonged survival of pig cardiac xenografts in baboons by sequential cardiac transplantation. | 1998 | Transplant. Proc. | pmid:9838671 |
| Nishimura Y et al. | A trial to obtain donor-specific immunotolerance using a vascularized thymus allograft. | 1998 | Transplant. Proc. | pmid:9838684 |
| Sanada O et al. | Establishment of chimerism in donors by intraportal injection of recipient-type bone marrow cells with concomitant administration of FK 506 before liver transplantation prolongs liver allograft survival in rats. | 1998 | Transplant. Proc. | pmid:9838689 |
| Ogawa T et al. | Osteoblastic differentiation is enhanced by rapamycin in rat osteoblast-like osteosarcoma (ROS 17/2.8) cells. | 1998 | Biochem. Biophys. Res. Commun. | pmid:9705862 |
| Sho M et al. | Simultaneous inoculation of donor lymphocyte subsets with transplantation in a rat cardiac allograft model. | 1998 | Transplant. Proc. | pmid:9838696 |
| Khattab A et al. | Cyclosporins: lack of correlation between antischistosomal properties and inhibition of cyclophilin isomerase activity. | 1998 | Exp. Parasitol. | pmid:9709036 |
| Navarro-AntolÃn J et al. | CsA and FK506 up-regulate eNOS expression: role of reactive oxygen species and AP-1. | 1998 | Kidney Int. Suppl. | pmid:9839278 |
| White MH et al. | Randomized, double-blind clinical trial of amphotericin B colloidal dispersion vs. amphotericin B in the empirical treatment of fever and neutropenia. | 1998 | Clin. Infect. Dis. | pmid:9709879 |
| Ruetz S | Yeast secretory vesicle system for expression and functional characterization of P-glycoproteins. | 1998 | Meth. Enzymol. | pmid:9711569 |
| Marsaud V et al. | Dexamethasone and triamcinolone acetonide accumulation in mouse fibroblasts is differently modulated by the immunosuppressants cyclosporin A, FK506, rapamycin and their analogues, as well as by other P-glycoprotein ligands. | 1998 | J. Steroid Biochem. Mol. Biol. | pmid:9712407 |
| Shapiro R | Tacrolimus in pediatric renal transplantation: a review. | 1998 | Pediatr Transplant | pmid:10084728 |
| Tacrolimus in the prevention of graft rejection: new indication. Helpful alternative to ciclosporin. | 1998 | Prescrire Int | pmid:10342948 | |
| Van Buren D et al. | Impact of Sandimmune, Neoral, and Prograf on rejection incidence and renal function in primary liver transplant recipients. | 1998 | Transplant. Proc. | pmid:9723299 |
| Takamatsu H et al. | Neuroprotective effects depend on the model of focal ischemia following middle cerebral artery occlusion. | 1998 | Eur. J. Pharmacol. | pmid:9874163 |
| Peeters P et al. | Economic evaluation of Neoral versus Sandimmune maintenance therapy for de novo liver transplant patients: results from an International Randomized Controlled Trial. Milton Study Group. | 1998 | Transplant. Proc. | pmid:9723301 |
| Murthy JN et al. | Tacrolimus metabolite cross-reactivity in different tacrolimus assays. | 1998 | Clin. Biochem. | pmid:9876892 |
| Rayes N et al. | Distribution of lymphocyte subtypes in liver transplant recipients with viral reinfection or de novo malignancy. | 1998 | Transplant. Proc. | pmid:9723303 |
| Naruse K et al. | Uni-axial cyclic stretch induces c-src activation and translocation in human endothelial cells via SA channel activation. | 1998 | FEBS Lett. | pmid:9877176 |
| Reggiani P et al. | Reduced acute rejection after liver transplantation with Neoral-based double immunosuppression. | 1998 | Transplant. Proc. | pmid:9723308 |
| Staruch MJ et al. | Distinctive calcineurin-dependent (FK506-sensitive) mechanisms regulate the production of the CC chemokines macrophage inflammatory protein (MIP)-1alpha, MIP-1beta, and RANTES vs IL-2 and TNF-alpha by activated human T cells. | 1998 | Cell. Immunol. | pmid:9878113 |
| Alberti D et al. | Conversion from tacrolimus to microemulsion formulation of cyclosporine in pediatric liver transplantation. | 1998 | Transplant. Proc. | pmid:9723310 |
| Madsen JR et al. | Tacrolimus (FK506) increases neuronal expression of GAP-43 and improves functional recovery after spinal cord injury in rats. | 1998 | Exp. Neurol. | pmid:9878202 |
| Herzberg GZ et al. | Usefulness of tacrolimus versus cyclosporine after pediatric heart transplantation. | 1998 | Am. J. Cardiol. | pmid:9723652 |
| Thielke J et al. | Pharmacokinetics of tacrolimus and cyclosporine in short-bowel syndrome. | 1998 | Liver Transpl Surg | pmid:9724482 |
| Paterson DL et al. | Infectious complications occurring in liver transplant recipients receiving mycophenolate mofetil. | 1998 | Transplantation | pmid:9753337 |
| Mihatsch MJ et al. | The side-effects of ciclosporine-A and tacrolimus. | 1998 | Clin. Nephrol. | pmid:9696431 |
| Woodle ES et al. | Liver transplantation in the first three months of life. | 1998 | Transplantation | pmid:9753340 |
| Rejto PA and Verkhivker GM | Molecular anchors with large stability gaps ensure linear binding free energy relationships for hydrophobic substituents. | 1998 | Pac Symp Biocomput | pmid:9697196 |
| Radkowski M et al. | Detection of hepatitis C virus replication in peripheral blood mononuclear cells after orthotopic liver transplantation. | 1998 | Transplantation | pmid:9753352 |
| [Tacrolimus in kidney transplantation. Bürgenstock, Switzerland, 20 March 1998]. | 1998 | Dtsch. Med. Wochenschr. | pmid:9697633 | |
| Xu Q et al. | Molecular characterization of a plant FKBP12 that does not mediate action of FK506 and rapamycin. | 1998 | Plant J. | pmid:9753776 |
| Miura S et al. | Effect of tacrolimus on the outcome of renal transplantation with donor-specific blood transfusion. | 1998 | Transplant. Proc. | pmid:9636492 |
| Cetinkale O et al. | Involvement of neutrophils in ischemia-reperfusion injury of inguinal island skin flaps in rats. | 1998 | Plast. Reconstr. Surg. | pmid:9655420 |
| Preston R et al. | FK 506 as primary immunosuppressive therapy in renal transplantation. | 1998 | Transplant. Proc. | pmid:9636493 |
| Jensik SC | Tacrolimus (FK 506) in kidney transplantation: three-year survival results of the US multicenter, randomized, comparative trial. FK 506 Kidney Transplant Study Group. | 1998 | Transplant. Proc. | pmid:9636494 |
| Luo Z et al. | Calcineurin inhibitors and cardiac hypertrophy. | 1998 | Nat. Med. | pmid:9771723 |
| Takahashi K et al. | Tacrolimus therapy for ABO-incompatible kidney transplantation. | 1998 | Transplant. Proc. | pmid:9636495 |
| Gómez J et al. | The Bcl-2 gene is differentially regulated by IL-2 and IL-4: role of the transcription factor NF-AT. | 1998 | Oncogene | pmid:9771966 |
| Braun F et al. | Primary low-dose tacrolimus immunosuppressive prophylaxis for high-risk kidney transplant recipients. | 1998 | Transplant. Proc. | pmid:9636496 |
| Fellermann K et al. | Steroid-unresponsive acute attacks of inflammatory bowel disease: immunomodulation by tacrolimus (FK506). | 1998 | Am. J. Gastroenterol. | pmid:9772045 |
| Tanabe K et al. | Long-term results of living kidney transplantation under tacrolimus immunosuppression: a single-center experience. | 1998 | Transplant. Proc. | pmid:9636497 |
| Reddy SS and Holley JL | Nocardiosis in a recently transplanted renal patient. | 1998 | Clin. Nephrol. | pmid:9725785 |
| Mollison KW et al. | Nephrotoxicity studies of the immunosuppressants tacrolimus (FK506) and ascomycin in rat models. | 1998 | Toxicology | pmid:9570331 |
| Garcia-Cozar FJ et al. | Two-site interaction of nuclear factor of activated T cells with activated calcineurin. | 1998 | J. Biol. Chem. | pmid:9727000 |
| Araki T et al. | Post-ischemic alterations in [3H]FK506 binding in the gerbil and rat brains. | 1998 | Metab Brain Dis | pmid:9570636 |
| Snyder SH et al. | Immunophilins in the nervous system. | 1998 | Neuron | pmid:9728910 |
| Finney NS | Enantioselective epoxide hydrolysis: catalysis involving microbes, mammals and metals. | 1998 | Chem. Biol. | pmid:9571210 |
| Matsuda T et al. | Involvement of calcineurin in Ca2+ paradox-like injury of cultured rat astrocytes. | 1998 | J. Neurochem. | pmid:9572286 |
| Bassing CH et al. | FKBP12 is not required for the modulation of transforming growth factor beta receptor I signaling activity in embryonic fibroblasts and thymocytes. | 1998 | Cell Growth Differ. | pmid:9543388 |
| Lopez-Ilasaca M et al. | Effects of FK506-binding protein 12 and FK506 on autophosphorylation of epidermal growth factor receptor. | 1998 | J. Biol. Chem. | pmid:9545268 |