| MeSH term | MeSH ID | Detail |
|---|---|---|
| Protoporphyria, Erythropoietic | D046351 | 1 associated lipids |
| Colitis, Collagenous | D046729 | 1 associated lipids |
| Hepatic Insufficiency | D048550 | 1 associated lipids |
| Diabetes Complications | D048909 | 4 associated lipids |
| Dyslipidemias | D050171 | 7 associated lipids |
| Atherosclerosis | D050197 | 85 associated lipids |
| Granulomatosis, Orofacial | D051261 | 2 associated lipids |
| Lymphohistiocytosis, Hemophagocytic | D051359 | 1 associated lipids |
| Renal Insufficiency | D051437 | 8 associated lipids |
| Delayed Graft Function | D051799 | 2 associated lipids |
tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Gruessner RW et al. | A prospective study of FK506 versus CsA and pig ATG in a porcine model of small bowel transplantation. | 1995 | Transplantation | pmid:7530871 |
| Todo S et al. | Abdominal multivisceral transplantation. | 1995 | Transplantation | pmid:7530873 |
| Shapiro R et al. | A prospective randomized trial of FK506-based immunosuppression after renal transplantation. | 1995 | Transplantation | pmid:7533343 |
| Cox KL et al. | An increased incidence of Epstein-Barr virus infection and lymphoproliferative disorder in young children on FK506 after liver transplantation. | 1995 | Transplantation | pmid:7533344 |
| McDiarmid SV et al. | FK506 (tacrolimus) compared with cyclosporine for primary immunosuppression after pediatric liver transplantation. Results from the U.S. Multicenter Trial. | 1995 | Transplantation | pmid:7533345 |
| Jain AB et al. | One thousand consecutive primary orthotopic liver transplants under FK 506: survival and adverse events. | 1995 | Transplant. Proc. | pmid:7533353 |
| Rucay P et al. | FK 506 as treatment of late acute rejection in liver transplant patients. | 1995 | Transplant. Proc. | pmid:7533354 |
| Schwartz M et al. | FK 506 in liver transplantation: correlation of whole blood levels with efficacy and toxicity. The US Multicenter FK 506 Dose Optimization. | 1995 | Transplant. Proc. | pmid:7533355 |
| Sakimoto H et al. | Prolonged survival of hamster-to-rat pancreas xenografts by FK 506 and splenectomy. | 1995 | Transplant. Proc. | pmid:7533394 |
| Celli S et al. | Mechanisms of protection from humoral rejection by a xenografted liver. | 1995 | Transplant. Proc. | pmid:7533395 |
| Kuroki H and Ikuta Y | Nerve regeneration of vascularized rat limb allograft and functional recovery of long-term graft survivals treated by short course of FK 506 or cyclosporine. | 1995 | Transplant. Proc. | pmid:7533405 |
| Ko S et al. | Significance of newly developed liposomal FK 506 in canine liver transplantation. | 1995 | Transplant. Proc. | pmid:7533406 |
| Fukuzaki T et al. | Induction of unresponsiveness to islet allografts with donor spleen cell inoculation followed by a single injection of FK 506. | 1995 | Transplant. Proc. | pmid:7533407 |
| Grochowicz PM et al. | Synergism of castanospermine and FK 506. | 1995 | Transplant. Proc. | pmid:7533408 |
| Itoh S and Navia MA | Structure comparison of native and mutant human recombinant FKBP12 complexes with the immunosuppressant drug FK506 (tacrolimus). | 1995 | Protein Sci. | pmid:8563622 |
| Swenson JM et al. | Immunosuppression switch in pediatric heart transplant recipients: cyclosporine to FK 506. | 1995 | J. Am. Coll. Cardiol. | pmid:7534779 |
| Sen J et al. | Expression and induction of nuclear factor-kappa B-related proteins in thymocytes. | 1995 | J. Immunol. | pmid:7534792 |
| Hodgkiss JP and Kelly JS | Only 'de novo' long-term depression (LTD) in the rat hippocampus in vitro is blocked by the same low concentration of FK506 that blocks LTD in the visual cortex. | 1995 | Brain Res. | pmid:8821755 |
| Komori T | [The change of lymphocyte subset and effect of FK506 in experimental small bowel transplantation of rats]. | 1995 | Nihon Geka Gakkai Zasshi | pmid:7534867 |
| Ellis D | Clinical use of tacrolimus (FK-506) in infants and children with renal transplants. | 1995 | Pediatr. Nephrol. | pmid:7577418 |
| Furuke K et al. | Suppression of adult T cell leukemia-derived factor/human thioredoxin induction by FK506 and cyclosporin A: a new mechanism of immune modulation via redox control. | 1995 | Int. Immunol. | pmid:7577807 |
| Shapiro R et al. | FK506 in pediatric kidney transplantation--primary and rescue experience. | 1995 | Pediatr. Nephrol. | pmid:7492486 |
| Mehta BA et al. | Two pathways of exocytosis of cytoplasmic granule contents and target cell killing by cytokine-induced CD3+ CD56+ killer cells. | 1995 | Blood | pmid:7579455 |
| Ito A et al. | Induction of tolerance in rat cardiac allograft model by intrathymic injection of donor bone marrow cells. | 1995 | Transplant. Proc. | pmid:7536974 |
| Coss MC et al. | Molecular cloning, DNA sequence analysis, and biochemical characterization of a novel 65-kDa FK506-binding protein (FKBP65). | 1995 | J. Biol. Chem. | pmid:7493967 |
| Hemenway C | FK506 in bone marrow transplantation. | 1995 | Blood | pmid:7579473 |
| Büttemeyer R et al. | Peripheral nerve allotransplant immunosuppressed with FK 506: preliminary results. | 1995 | Transplant. Proc. | pmid:7536979 |
| Lee MJ et al. | Physicochemical, pharmacokinetic and pharmacodynamic evaluation of liposomal tacrolimus (FK 506) in rats. | 1995 | Pharm. Res. | pmid:7494802 |
| Yamamoto M et al. | Cyclosporin A and FK506 reverse anthracycline resistance by altering the cell cycle. | 1995 | Anticancer Drugs | pmid:7579561 |
| Venkataramanan R et al. | Clinical pharmacokinetics of tacrolimus. | 1995 | Clin Pharmacokinet | pmid:8787947 |
| Arita S et al. | Effect of FK 506 in experimental pancreas transplantation. | 1995 | Transplant. Proc. | pmid:7536980 |
| Zhao Y and Iwata M | Cross-linking of the TCR-CD3 complex with CD4, CD8 or LFA-1 induces an anti-apoptotic signal in thymocytes: the signal is canceled by FK506. | 1995 | Int. Immunol. | pmid:7495746 |
| Aono T et al. | Minimal threshold of FK 506 for enhancing liver regeneration in thymectomized rats. | 1995 | Transplant. Proc. | pmid:7536981 |
| Saito T et al. | In situ dephosphorylation of tau by protein phosphatase 2A and 2B in fetal rat primary cultured neurons. | 1995 | FEBS Lett. | pmid:7498550 |
| Iwabuchi T et al. | Effects of immunosuppressive peptidyl-prolyl cis-trans isomerase (PPIase) inhibitors, cyclosporin A, FK506, ascomycin and rapamycin, on hair growth initiation in mouse: immunosuppression is not required for new hair growth. | 1995 | J. Dermatol. Sci. | pmid:7537082 |
| Antoni FA et al. | Calcineurin feedback inhibition of agonist-evoked cAMP formation. | 1995 | J. Biol. Chem. | pmid:7499291 |
| Yamamoto S et al. | Cross-species transplantation of photoreceptors with tacrolimus hydrate (FK506) treatment. | 1995 | Jpn. J. Ophthalmol. | pmid:8926639 |
| Griffith JP et al. | X-ray structure of calcineurin inhibited by the immunophilin-immunosuppressant FKBP12-FK506 complex. | 1995 | Cell | pmid:7543369 |
| Prud'homme GJ et al. | Effects of cyclosporin A, rapamycin, and FK520 on peripheral T-cell deletion and anergy. | 1995 | Cell. Immunol. | pmid:7543371 |
| Migita K et al. | FK506 augments activation-induced programmed cell death of T lymphocytes in vivo. | 1995 | J. Clin. Invest. | pmid:7543492 |
| Rodriguez Rilo HL et al. | Rapid hair regrowth in refractory alopecia universalis associated with autoimmune disease following liver transplantation and tacrolimus (FK506) therapy. | 1995 | Transplantation | pmid:7539169 |
| Lhoëst G et al. | The in vitro immunosuppressive activity of the C15-demethylated metabolite of FK-506 is governed by ring- and open-chain tautomerism effects. | 1995 | J. Pharmacol. Exp. Ther. | pmid:7543569 |
| Schleibner S et al. | FK 506 versus cyclosporin in the prevention of renal allograft rejection--European pilot study: six-week results. | 1995 | Transpl. Int. | pmid:7539270 |
| Textor SC et al. | Urinary endothelin and renal vasoconstriction with cyclosporine or FK506 after liver transplantation. | 1995 | Kidney Int. | pmid:7543625 |
| Ko S et al. | The enhanced immunosuppressive efficacy of newly developed liposomal FK506 in canine liver transplantation. | 1995 | Transplantation | pmid:7539553 |
| Fealy MJ et al. | Association of down-regulation of cytokine activity with rat hind limb allograft survival. | 1995 | Transplantation | pmid:7539555 |
| Kinoshita I et al. | Myoblast allotransplantation in primates. | 1995 | Muscle Nerve | pmid:7544871 |
| Monsour HP et al. | Renal insufficiency and hypertension as long-term complications in liver transplantation. | 1995 | Semin. Liver Dis. | pmid:7544917 |
| Varela E | [Small bowel transplantation]. | 1995 | Acta Gastroenterol. Latinoam. | pmid:7544939 |
| Taler SJ et al. | Loss of nocturnal blood pressure fall after liver transplantation during immunosuppressive therapy. | 1995 | Am. J. Hypertens. | pmid:7544983 |
| Morris RE and Brown BW | Tacrolimus for prevention of liver allograft rejection: clinical trials and tribulations. | 1995 | Lancet | pmid:7475764 |
| Starzl TE et al. | Randomised trialomania? The multicentre liver transplant trials of tacrolimus. | 1995 | Lancet | pmid:7475777 |
| Teague S | Lessons from molecular matchmakers. | 1995 | Nat. Struct. Biol. | pmid:7545076 |
| Milad M et al. | Interaction of the progesterone receptor with binding proteins for FK506 and cyclosporin A. | 1995 | Mol. Endocrinol. | pmid:7476967 |
| Zhang J and Steiner JP | Nitric oxide synthase, immunophilins and poly(ADP-ribose) synthetase: novel targets for the development of neuroprotective drugs. | 1995 | Neurol. Res. | pmid:7477744 |
| Jindal RM and Popescu I | Renal dysfunction associated with liver transplantation. | 1995 | Postgrad Med J | pmid:7479462 |
| Yeh WC et al. | Identification and characterization of an immunophilin expressed during the clonal expansion phase of adipocyte differentiation. | 1995 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7479941 |
| Spencer DM et al. | A general strategy for producing conditional alleles of Src-like tyrosine kinases. | 1995 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7568222 |
| Holsinger LJ et al. | Signal transduction in T lymphocytes using a conditional allele of Sos. | 1995 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7568223 |
| Faerman CH and Karplus PA | Consensus preferred hydration sites in six FKBP12-drug complexes. | 1995 | Proteins | pmid:8539241 |
| Groth CG | Immunosuppressive regimens of tomorrow. | 1995 | Transplant. Proc. | pmid:8539797 |
| Sekigawa I et al. | Inhibitory effect of the immunosuppressant FK506 on apoptotic cell death induced by HIV-1 gp120. | 1995 | J. Clin. Immunol. | pmid:8576317 |
| Hariharan S et al. | Conversion from cyclosporine to tacrolimus after pancreas transplantation. | 1995 | Transplant. Proc. | pmid:8539799 |
| Henley SE et al. | Lipids following pancreas transplantation in recipients receiving FK 506. | 1995 | Transplant. Proc. | pmid:8539809 |
| Stratta RJ et al. | Preliminary experience with FK 506 in pancreas transplant recipients. | 1995 | Transplant. Proc. | pmid:8539823 |
| DÃaz M et al. | [Tacrolimus (FK 506): an immunosuppression alternative in solid organ transplantation. (Part 2)]. | 1995 Apr-Jun | Rev Med Univ Navarra | pmid:7569553 |
| Hisatomi K et al. | Effect of dose of cyclosporine or FK506 and antithrombotic agents on cardiac allograft vascular disease in heterotopically transplanted hearts in rats. | 1995 Jan-Feb | J. Heart Lung Transplant. | pmid:7537098 |
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| Kawahara K et al. | Effects of deoxyspergualin on bronchial anastomosis healing in canine pulmonary allografts. | 1995 Jul-Aug | J. Heart Lung Transplant. | pmid:7578196 |
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| Okudaira H et al. | Enhanced production and gene expression of interleukin-5 in patients with bronchial asthma: possible management of atopic diseases by down-regulation of interleukin-5 gene transcription. | 1995 May-Jun | Int. Arch. Allergy Immunol. | pmid:7542077 |
| Su Q et al. | Nephrotoxicity of cyclosporin A and FK506: inhibition of calcineurin phosphatase. | 1995 May-Jun | Ren. Physiol. Biochem. | pmid:7542793 |
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| Schreiber SL and Crabtree GR | Immunophilins, ligands, and the control of signal transduction. | 1995-1996 | Harvey Lect. | pmid:9127988 |
| Pham SM et al. | A prospective trial of tacrolimus (FK 506) in clinical heart transplantation: intermediate-term results. | 1996 | J. Thorac. Cardiovasc. Surg. | pmid:8614136 |
| Fukushima N et al. | Histological findings in heart grafts after orthotopic pig to baboon cardiac transplantation. | 1996 | Transplant. Proc. | pmid:8623400 |
| Takeda M et al. | Methotrexate in rescue therapy for xenotransplanted lungs in primates. | 1996 | Transplant. Proc. | pmid:8623402 |
| DiGiuseppe JA et al. | Tacrolimus-related posttransplant lymphoproliferative disorder presenting as autoimmune hemolytic anemia. | 1996 | Arch. Pathol. Lab. Med. | pmid:8629906 |
| Chudek J et al. | [The role of endothelin in the physiology and pathophysiology of the circulatory system and kidneys]. | 1996 | Pol. Arch. Med. Wewn. | pmid:9139279 |
| Tanida I et al. | Yeast Cls2p/Csg2p localized on the endoplasmic reticulum membrane regulates a non-exchangeable intracellular Ca2+ pool cooperatively with calcineurin. | 1996 | FEBS Lett. | pmid:8566225 |
| Corrigan CJ et al. | Glucocorticoid resistant asthma: T-lymphocyte steroid metabolism and sensitivity to glucocorticoids and immunosuppressive agents. | 1996 | Eur. Respir. J. | pmid:8902470 |
| Sakane T and Miura K | [Research for basic and clinical aspects of Behcet's disease--recent advance and future--]. | 1996 | Nippon Rinsho | pmid:8904250 |
| Lang T et al. | Production of IL-4 and IL-10 does not lead to immune quiescence in vascularized human organ grafts. | 1996 | Transplantation | pmid:8824477 |
| Matsuda H et al. | Interactions of FK506 (tacrolimus) with clinically important drugs. | 1996 | Res. Commun. Mol. Pathol. Pharmacol. | pmid:8824931 |
| Hisanaga Y et al. | Implication of nitric oxide synthase activity in the genesis of water immersion stress-induced gastric lesions in rats: the protective effects of FK506. | 1996 | Aliment. Pharmacol. Ther. | pmid:8971291 |
| Jonas S et al. | Indications for tacrolimus anti-rejection therapy in liver allograft recipients. | 1996 | Transpl. Int. | pmid:8959817 |
| Gruessner RW et al. | Use of FK 506 in pancreas transplantation. | 1996 | Transpl. Int. | pmid:8959841 |
| Tanaka M et al. | Reduction of immunosuppressive agents after living related donor liver transplantation. | 1996 | Transplant. Proc. | pmid:8769268 |
| Randhawa PS et al. | Microvascular changes in renal allografts associated with FK506 (Tacrolimus) therapy. | 1996 | Am. J. Surg. Pathol. | pmid:8772784 |
| Kershner RP and Fitzsimmons WE | Relationship of FK506 whole blood concentrations and efficacy and toxicity after liver and kidney transplantation. | 1996 | Transplantation | pmid:8878385 |
| Nolan TJ and Schad GA | Tacrolimus allows autoinfective development of the parasitic nematode Strongyloides stercoralis. | 1996 | Transplantation | pmid:8878405 |
| Okada K et al. | Effect of FK 506 administered topically versus intramuscularly on suppression of the corneal immune reaction in rats. | 1996 | Ophthalmologica | pmid:8738464 |
| Wagner K et al. | Experimental and clinical experience with the use of tacrolimus (FK506) in kidney transplantation. | 1996 | Clin. Nephrol. | pmid:8738666 |
| McMichael J et al. | Computer-guided randomized concentration-controlled trials of tacrolimus in autoimmunity: multiple sclerosis and primary biliary cirrhosis. | 1996 | Ther Drug Monit | pmid:8857564 |
| Bartlett ST et al. | Equivalent success of simultaneous pancreas kidney and solitary pancreas transplantation. A prospective trial of tacrolimus immunosuppression with percutaneous biopsy. | 1996 | Ann. Surg. | pmid:8857849 |
| Pullicino P et al. | Posterior leucoencephalopathy syndrome. | 1996 | Lancet | pmid:8684128 |
| Pirenne J et al. | Combined transplantation of small and large bowel. FK506 versus cyclosporine A in a porcine model. | 1996 | Transplantation | pmid:8685944 |
| Villalba L and Adams EM | Update on therapy for refractory dermatomyositis and polymyositis. | 1996 | Curr Opin Rheumatol | pmid:9018458 |