| MeSH term | MeSH ID | Detail |
|---|---|---|
| Ataxia Telangiectasia | D001260 | 6 associated lipids |
| Ataxia | D001259 | 20 associated lipids |
| Ascites | D001201 | 25 associated lipids |
| Arthritis, Juvenile | D001171 | 8 associated lipids |
| Arthritis, Infectious | D001170 | 8 associated lipids |
| Arthritis, Experimental | D001169 | 24 associated lipids |
| Arthritis | D001168 | 41 associated lipids |
| Arteriosclerosis | D001161 | 86 associated lipids |
| Arterial Occlusive Diseases | D001157 | 12 associated lipids |
| Arm Injuries | D001134 | 1 associated lipids |
tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Kuroki H et al. | Effect of FK 506 and donor-specific blood transfusion on the rat composite tissue limb allograft and the mechanism of long-term graft survival. | 1993 | Transplant. Proc. | pmid:7679833 |
| Azhderian EM et al. | Nucleus associated FK 506 binding proteins with potential relevance to FK 506 immunosuppression. | 1993 | Transplant. Proc. | pmid:7679834 |
| Porayko MK et al. | Nephrotoxicity of FK 506 and cyclosporine when used as primary immunosuppression in liver transplant recipients. | 1993 | Transplant. Proc. | pmid:7679835 |
| Shapiro R et al. | Randomized trial of FK 506/prednisone vs FK 506/azathioprine/prednisone after renal transplantation: preliminary report. | 1993 | Transplant. Proc. | pmid:7679836 |
| Propper DJ et al. | Effects of the immunosuppressive macrolides rapamycin and FK 506 in high responder rats presensitized to major histocompatibility complex antigens. | 1993 | Transplant. Proc. | pmid:7679837 |
| Stock PG et al. | Standard sequential immunosuppression with Minnesota antilymphoblast globulin and cyclosporine vs FK 506: a comparison of early nephrotoxicity. | 1993 | Transplant. Proc. | pmid:7679838 |
| Tabasco-Minguillan J et al. | Long-term insulin requirement after liver transplantation with FK 506 in American veterans. | 1993 | Transplant. Proc. | pmid:7679839 |
| Klintmalm GB et al. | Use of Prograf (FK 506) as rescue therapy for refractory rejection after liver transplantation. US Multicenter FK 506 Liver Study Group. | 1993 | Transplant. Proc. | pmid:7679840 |
| Gunji Y et al. | Pathologic characteristics of vasculitis in renal transplant recipient dogs receiving immunosuppressive agents, FK 506, rapamycin, or RS-61443. | 1993 | Transplant. Proc. | pmid:7679841 |
| Gregory CR et al. | Effects of treatment with cyclosporine, FK 506, rapamycin, mycophenolic acid, or deoxyspergualin on vascular muscle proliferation in vitro and in vivo. | 1993 | Transplant. Proc. | pmid:7679842 |
| Zeevi A et al. | Comparative in vitro studies on the immunosuppressive effects of purine and pyrimidine synthesis inhibitors. | 1993 | Transplant. Proc. | pmid:7679843 |
| Piekoszewski W and Jusko WJ | Plasma protein binding of tacrolimus in humans. | 1993 | J Pharm Sci | pmid:7680714 |
| Ning YM and Sánchez ER | Potentiation of glucocorticoid receptor-mediated gene expression by the immunophilin ligands FK506 and rapamycin. | 1993 | J. Biol. Chem. | pmid:7681058 |
| Saeki T et al. | Human P-glycoprotein transports cyclosporin A and FK506. | 1993 | J. Biol. Chem. | pmid:7681059 |
| Dutz JP et al. | A role for calcineurin in degranulation of murine cytotoxic T lymphocytes. | 1993 | J. Immunol. | pmid:7681074 |
| Takeguchi N et al. | Inhibition of the multidrug efflux pump in isolated hepatocyte couplets by immunosuppressants FK506 and cyclosporine. | 1993 | Transplantation | pmid:7681229 |
| Valdivia LA et al. | Successful hamster-to-rat liver xenotransplantation under FK506 immunosuppression induces unresponsiveness to hamster heart and skin. | 1993 | Transplantation | pmid:7681230 |
| Fujimura A et al. | Chronopharmacokinetic study of a new immunosuppressive agent, FK 506, in mice. | 1993 | Jpn. J. Pharmacol. | pmid:7681489 |
| Nishinaka Y et al. | Protective effect of FK506 on ischemia/reperfusion-induced myocardial damage in canine heart. | 1993 | J. Cardiovasc. Pharmacol. | pmid:7681507 |
| Luan S et al. | Immunosuppressants implicate protein phosphatase regulation of K+ channels in guard cells. | 1993 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7681590 |
| Deardon DJ et al. | Small bowel tonometry: a possible technique for detecting early small bowel allograft dysfunction. | 1993 | Transplant. Proc. | pmid:7505502 |
| Demetris AJ et al. | Hematolymphoid cell trafficking, microchimerism, and GVH reactions after liver, bone marrow, and heart transplantation. | 1993 | Transplant. Proc. | pmid:7505503 |
| Pancer Z et al. | cDNA cloning of a putative protochordate FK506-binding protein. | 1993 | Biochem. Biophys. Res. Commun. | pmid:7505578 |
| Fischer S et al. | A mechanism for rotamase catalysis by the FK506 binding protein (FKBP). | 1993 | Biochemistry | pmid:7505615 |
| Thomson AW et al. | ICAM-1 and E-selectin expression in lesional biopsies of psoriasis patients responding to systemic FK 506 therapy. | 1993 | Autoimmunity | pmid:7505632 |
| López-Gil JA and GarcÃa Sáiz M | [FK506: an immunosuppressor for the '90's?]. | 1993 | Med Clin (Barc) | pmid:7505871 |
| Kagayama A et al. | Oral absorption of FK506 in rats. | 1993 | Pharm. Res. | pmid:7505939 |
| Kim YI et al. | Augmentation of hepatocyte proliferation by immunosuppressant pretherapy is associated with up-regulation of malondialdehyde production. | 1993 | Res Exp Med (Berl) | pmid:7506444 |
| Hytiroglou P et al. | FK506 versus cyclosporine as primary immunosuppressive agent for orthotopic liver allograft recipients. Histologic and immunopathologic observations. | 1993 | Transplantation | pmid:7506452 |
| Ishizuka J et al. | Effects of FK506 and cyclosporine on dynamic insulin secretion from isolated dog pancreatic islets. | 1993 | Transplantation | pmid:7506454 |
| Muthukkumar S et al. | Elevation of cytosolic calcium is sufficient to induce growth inhibition in a B cell lymphoma. | 1993 | Eur. J. Immunol. | pmid:7691606 |
| Wesselborg S et al. | Triggering via the alternative CD2 pathway induces apoptosis in activated human T lymphocytes. | 1993 | Eur. J. Immunol. | pmid:7691614 |
| Schulz BS et al. | Increased expression of epidermal IL-8 receptor in psoriasis. Down-regulation by FK-506 in vitro. | 1993 | J. Immunol. | pmid:7691948 |
| Nagata K et al. | Failure of FK-506, a new immunosuppressant, to prevent cerebral vasospasm in a canine two-hemorrhage model. | 1993 | J. Neurosurg. | pmid:7692019 |
| Lhoëst G et al. | Isolation and identification by FAB mass spectrometry and NMR spectroscopy of a demethylated metabolite of FK506 from erythromycin-induced rabbit liver microsomes. | 1993 | Pharm Acta Helv | pmid:7692454 |
| Izumi S and Okuhara M | [FK506 and kifunensine, new immunomodulators of microbial origin]. | 1993 | Tanpakushitsu Kakusan Koso | pmid:7692469 |
| Wakugami T et al. | Effect of FK506 on the development of diabetes in BB rats in comparison with that of cyclosporin. | 1993 | Tohoku J. Exp. Med. | pmid:7692621 |
| Hill CC et al. | Penile prosthesis surgery in the immunosuppressed patient. | 1993 | Transplantation | pmid:7692633 |
| Roberts JP et al. | Reversal of chronic rejection after treatment failure with FK506 and RS61443. | 1993 | Transplantation | pmid:7692634 |
| McCauley J et al. | Pilot trial of FK 506 in the management of steroid-resistant nephrotic syndrome. | 1993 | Nephrol. Dial. Transplant. | pmid:7508098 |
| Nishikawa T et al. | Kinetic analysis of molecular interconversion of immunosuppressant FK506 by high-performance liquid chromatography. | 1993 | Pharm. Res. | pmid:7508108 |
| Iwasaki K et al. | Effects of twenty-three drugs on the metabolism of FK506 by human liver microsomes. | 1993 | Res. Commun. Chem. Pathol. Pharmacol. | pmid:7508138 |
| Takada K et al. | Distribution characteristics of immunosuppressants FK506 and cyclosporin A in the blood compartment. | 1993 | Biopharm Drug Dispos | pmid:7508273 |
| Jusko WJ and Kobayashi M | Therapeutic monitoring of tacrolimus (FK 506) | 1993 | Ther Drug Monit | pmid:7694395 |
| Kunz J and Hall MN | Cyclosporin A, FK506 and rapamycin: more than just immunosuppression. | 1993 | Trends Biochem. Sci. | pmid:7694398 |
| Bierer BE et al. | Cyclosporin A and FK506: molecular mechanisms of immunosuppression and probes for transplantation biology. | 1993 | Curr. Opin. Immunol. | pmid:7694595 |
| White DJ | Immunosuppression for heart transplantation. | 1993 | Br. J. Biomed. Sci. | pmid:7694717 |
| Blaehr H et al. | Acute effects of FK506 and cyclosporine A on cultured human proximal tubular cells. | 1993 | Eur. J. Pharmacol. | pmid:7683267 |
| Kadmon M et al. | Inhibition by cyclosporin A of adenosine triphosphate-dependent transport from the hepatocyte into bile. | 1993 | Gastroenterology | pmid:7683296 |
| Denesyuk AI et al. | Structural similarity of the binding sites of cyclophilin A-cyclosporin A and FKBP-FK506 systems. | 1993 | Biochem. Biophys. Res. Commun. | pmid:7683466 |
| Waschulewski IH et al. | Effects of the immunosuppressants cyclosporin A and FK 506 on exocytosis in the rat exocrine pancreas in vitro. | 1993 | Br. J. Pharmacol. | pmid:7683567 |
| Ohtake M et al. | Enhanced liver regeneration in rats treated with 15-deoxyspergualin alone and in combination with FK 506. | 1993 | Gastroenterol. Jpn. | pmid:7683616 |
| Takeda Y et al. | Stimulation of endothelin mRNA and secretion in human endothelial cells by FK 506. | 1993 | J. Cardiovasc. Pharmacol. | pmid:7509973 |
| Soldin SJ et al. | Immunophilin receptors for immunosuppressive drugs. | 1993 | Ther Drug Monit | pmid:7510077 |
| McMichael J et al. | Computer-guided concentration-controlled trials in autoimmune disorders. | 1993 | Ther Drug Monit | pmid:7510078 |
| Lemster B et al. | Blood lymphocytes of autoimmune disease patients receiving FK506 exhibit normal ex vivo cytokine gene expression and proliferative responses. | 1993 | Immunol. Lett. | pmid:7510265 |
| Parent SA et al. | Calcineurin-dependent growth of an FK506- and CsA-hypersensitive mutant of Saccharomyces cerevisiae. | 1993 | J. Gen. Microbiol. | pmid:7510323 |
| Partaledis JA and Berlin V | The FKB2 gene of Saccharomyces cerevisiae, encoding the immunosuppressant-binding protein FKBP-13, is regulated in response to accumulation of unfolded proteins in the endoplasmic reticulum. | 1993 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7685904 |
| Sykes K et al. | Proline isomerases function during heat shock. | 1993 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7685914 |
| Suzuki S et al. | Neutrophil infiltration as an important factor in liver ischemia and reperfusion injury. Modulating effects of FK506 and cyclosporine. | 1993 | Transplantation | pmid:7685932 |
| McDiarmid SV et al. | Differences in oral FK506 dose requirements between adult and pediatric liver transplant patients. | 1993 | Transplantation | pmid:7685933 |
| Moutabarrik A et al. | Use of FK 506 in kidney transplantation. | 1993 | Transplant. Proc. | pmid:7685946 |
| Moutabarrik A et al. | Effect of FK 506 and cyclosporine on the expression of IL-6 and its receptor on stimulated monocytes. | 1993 | Transplant. Proc. | pmid:7685949 |
| Takaya S et al. | Use of prostaglandin E1 in crossmatch-negative liver transplant recipients treated with FK 506. | 1993 | Transplant. Proc. | pmid:7685953 |
| Murphy MP and Morris RE | Brequinar sodium effectively and potently suppresses allograft rejection in a heterotopic mouse heart transplant model. | 1993 | Transplant. Proc. | pmid:7685955 |
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| Henke W and Jung K | Comparison of the effects of the immunosuppressive agents FK 506 and cyclosporin A on rat kidney mitochondria. | 1993 | Biochem. Pharmacol. | pmid:7690566 |
| Murase N et al. | Hamster-to-rat heart and liver xenotransplantation with FK506 plus antiproliferative drugs. | 1993 | Transplantation | pmid:7682735 |
| Abu-Elmagd K et al. | Recent advances in hepatic transplantation at the University of Pittsburgh. | 1993 | Clin Transpl | pmid:7522528 |
| Ueki M et al. | Diabetogenic effects of FK506 on renal subcapsular islet isografts in rat. | 1993 | Diabetes Res. Clin. Pract. | pmid:7688276 |
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| Morkawa K et al. | Immunosuppressive property of bromocriptine on human B lymphocyte function in vitro. | 1993 | Clin. Exp. Immunol. | pmid:7688676 |
| Yamaoka K et al. | Cyclosporin A and FK506 block the negative signaling mediated by surface IgM cross-linking in normal human mature B cells. | 1993 | Immunol. Lett. | pmid:7688712 |
| Smith DF et al. | Two FKBP-related proteins are associated with progesterone receptor complexes. | 1993 | J. Biol. Chem. | pmid:7688746 |
| Jacobs JC et al. | Pyoderma gangrenosum in infancy. | 1993 | J. Am. Acad. Dermatol. | pmid:7688775 |
| Garrity GM et al. | Genetic relationships among actinomycetes that produce the immunosuppressant macrolides FK506, FK520/FK523 and rapamycin. | 1993 | J. Ind. Microbiol. | pmid:7688970 |
| Hoof T et al. | Reversal of multidrug resistance in Chinese hamster ovary cells by the immunosuppressive agent rapamycin. | 1993 | Eur. J. Pharmacol. | pmid:7689059 |
| Parsons WH et al. | FK-506--a novel immunosuppressant. | 1993 | Ann. N. Y. Acad. Sci. | pmid:7689805 |
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| Reem GH et al. | FK-506 inhibits the IL-2-independent induction of the activation antigen CD 69. | 1993 | Ann. N. Y. Acad. Sci. | pmid:7689811 |
| Mollison KW et al. | Comparison of FK-506, rapamycin, ascomycin, and cyclosporine in mouse models of host-versus-graft disease and heterotopic heart transplantation. | 1993 | Ann. N. Y. Acad. Sci. | pmid:7689812 |
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| Lieberman R | FK506, artificial intelligence and pharmacoeconomics. | 1993 | J Clin Pharmacol | pmid:7690045 |
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| Jiang H et al. | Anti-tumor-promoting action of FK506, a potent immunosuppressive agent. | 1993 | Carcinogenesis | pmid:7678785 |
| Naito M et al. | Enhancement of cellular accumulation of cyclosporine by anti-P-glycoprotein monoclonal antibody MRK-16 and synergistic modulation of multidrug resistance. | 1993 | J. Natl. Cancer Inst. | pmid:7678867 |
| Barthelmess IB and Tropschug M | FK506-binding protein of Neurospora crassa (NcFKBP) mediates sensitivity to the immunosuppressant FK506; resistant mutants identify two loci. | 1993 | Curr. Genet. | pmid:7679056 |
| Fingar DC et al. | Dissociation of pp70 ribosomal protein S6 kinase from insulin-stimulated glucose transport in 3T3-L1 adipocytes. | 1993 | J. Biol. Chem. | pmid:7679106 |
| Griffiths EJ and Halestrap AP | Protection by Cyclosporin A of ischemia/reperfusion-induced damage in isolated rat hearts. | 1993 | J. Mol. Cell. Cardiol. | pmid:7512654 |
| McCaffrey PG et al. | NF-ATp, a T lymphocyte DNA-binding protein that is a target for calcineurin and immunosuppressive drugs. | 1993 | J. Biol. Chem. | pmid:7679116 |
| Armitage JM et al. | Pediatric lung transplantation. The years 1985 to 1992 and the clinical trial of FK 506. | 1993 | J. Thorac. Cardiovasc. Surg. | pmid:7679172 |
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| Langrehr JM et al. | Clinical course, morphology, and treatment of chronically rejecting small bowel allografts. | 1993 | Transplantation | pmid:7679526 |
| Uemoto S et al. | Experience with FK506 in living-related liver transplantation. | 1993 | Transplantation | pmid:7679528 |