tacrolimus

Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.

Cross Reference

Introduction

To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with tacrolimus?

tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with tacrolimus

MeSH term MeSH ID Detail
Mite Infestations D008924 1 associated lipids
Feline Infectious Peritonitis D016766 1 associated lipids
Fox-Fordyce Disease D005588 2 associated lipids
Primary Graft Dysfunction D055031 1 associated lipids
Sleep Apnea, Central D020182 1 associated lipids
Protoporphyria, Erythropoietic D046351 1 associated lipids
Digestive System Diseases D004066 3 associated lipids
Pancreatitis, Graft D055589 1 associated lipids
Candidiasis, Invasive D058365 2 associated lipids
Intestinal Volvulus D045822 1 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with tacrolimus

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with tacrolimus?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with tacrolimus?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with tacrolimus?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with tacrolimus?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with tacrolimus?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with tacrolimus

Download all related citations
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Authors Title Published Journal PubMed Link
van der Schaft J et al. First experience with extended release tacrolimus in the treatment of adult patients with severe, difficult to treat atopic dermatitis: Clinical efficacy, safety and dose finding. 2016 J. Dermatol. Sci. pmid:26547110
Parody R et al. GvHD prophylaxis with tacrolimus plus sirolimus after reduced intensity conditioning allogeneic transplantation: results of a multicenter study. 2016 Bone Marrow Transplant. pmid:27295268
Muduma G et al. Indirect treatment comparison of belatacept versus tacrolimus from a systematic review of immunosuppressive therapies for kidney transplant patients. 2016 Curr Med Res Opin pmid:26907083
Sato Y et al. Acute encephalitis with refractory, repetitive partial seizures: Pathological findings and a new therapeutic approach using tacrolimus. 2016 Brain Dev. pmid:26906012
Fu LF et al. Improvement of FK506 production by synthetic biology approaches. 2016 Biotechnol. Lett. pmid:27600954
Rodrigo E et al. Within-Patient Variability in Tacrolimus Blood Levels Predicts Kidney Graft Loss and Donor-Specific Antibody Development. 2016 Transplantation pmid:26703349
Zhang XS et al. FkbN and Tcs7 are pathway-specific regulators of the FK506 biosynthetic gene cluster in Streptomyces tsukubaensis L19. 2016 J. Ind. Microbiol. Biotechnol. pmid:27757551
Hellström VC et al. Malignancies in transplanted patients: Multidisciplinary evaluation and switch to mTOR inhibitors after kidney transplantation - experiences from a prospective, clinical, observational study. 2016 Acta Oncol pmid:26824275
Kim HY et al. Tracking protein-protein interaction and localization in living cells using a high-affinity molecular binder. 2016 Biochem. Biophys. Res. Commun. pmid:26820537
Zeng W et al. Hyaluronic acid-coated niosomes facilitate tacrolimus ocular delivery: Mucoadhesion, precorneal retention, aqueous humor pharmacokinetics, and transcorneal permeability. 2016 Colloids Surf B Biointerfaces pmid:26820107
Joko T et al. Therapeutic Effect of 0.1% Topical Tacrolimus for Childhood Interstitial Keratitis Refractory to Cyclosporine. 2016 J Nippon Med Sch pmid:26960587
Snell GI et al. ABO incompatible renal transplantation following lung transplantation. 2016 Transpl. Immunol. pmid:27663090
Malachowski SJ et al. Annular Lichenoid Dermatitis of Youth: A Chronic Case Managed Using Pimecrolimus. 2016 Pediatr Dermatol pmid:27653808
Juillerat A et al. Design of chimeric antigen receptors with integrated controllable transient functions. 2016 Sci Rep pmid:26750734
Prakash A et al. Crystal structure of the FK506 binding domain of human FKBP25 in complex with FK506. 2016 Protein Sci. pmid:26749369
Hu X et al. Chimeric Allografts Induced by Short-Term Treatment With Stem Cell-Mobilizing Agents Result in Long-Term Kidney Transplant Survival Without Immunosuppression: A Study in Rats. 2016 Am. J. Transplant. pmid:26749344
Cameron AM et al. Chimeric Allografts Induced by Short-Term Treatment With Stem Cell Mobilizing Agents Result in Long-Term Kidney Transplant Survival Without Immunosuppression: II, Study in Miniature Swine. 2016 Am. J. Transplant. pmid:26748958
Karagüzel G et al. Vitamin D status and the effects of oral vitamin D treatment in children with vitiligo: A prospective study. 2016 Clin Nutr ESPEN pmid:28531780
Abdel-Kahaar E et al. Analytical Validation and Cross-Validation of an NFAT-Regulated Gene Expression Assay for Pharmacodynamic Monitoring of Therapy With Calcineurin Inhibitors. 2016 Ther Drug Monit pmid:27661400
Kannegieter NM et al. Conversion to Once-Daily Tacrolimus Results in Increased p38MAPK Phosphorylation in T Lymphocytes of Kidney Transplant Recipients. 2016 Ther Drug Monit pmid:26606072
El-Asmar J et al. Clotrimazole troches induce supratherapeutic blood levels of sirolimus and tacrolimus in an allogeneic hematopoietic cell-transplant recipient resulting in acute kidney injury. 2016 Hematol Oncol Stem Cell Ther pmid:26684920
Yang EM et al. Tacrolimus for children with refractory nephrotic syndrome: a one-year prospective, multicenter, and open-label study of Tacrobell®, a generic formula. 2016 World J Pediatr pmid:26684309
Gojowy D et al. High Frequency of Arterial Hypertension in Patients After Liver Transplantation. 2016 Transplant. Proc. pmid:27496479
Wilusz M et al. Effects of Immunosuppressive Drugs on Serum Fatty Acids of Phospholipids Fraction in Renal Transplant Recipients. 2016 Transplant. Proc. pmid:27496457
Kociszewska-Najman B et al. Congenital Infections in Neonates of Women With Liver or Kidney Transplants. 2016 Transplant. Proc. pmid:27496446
O'Donnell JC et al. Transient Oxygen/Glucose Deprivation Causes a Delayed Loss of Mitochondria and Increases Spontaneous Calcium Signaling in Astrocytic Processes. 2016 J. Neurosci. pmid:27383588
Saito B et al. Umbilical cord blood transplantation for adults using tacrolimus with two-day very-short-term methotrexate for graft-versus-host disease prophylaxis. 2016 Leuk. Res. pmid:27376545
Matsui K et al. Betamethasone, but Not Tacrolimus, Suppresses the Development of Th2 Cells Mediated by Langerhans Cell-Like Dendritic Cells. 2016 Biol. Pharm. Bull. pmid:27374298
Zarrinpar A et al. Individualizing liver transplant immunosuppression using a phenotypic personalized medicine platform. 2016 Sci Transl Med pmid:27053773
Deininger KM et al. CYP3A pharmacogenetics and tacrolimus disposition in adult heart transplant recipients. 2016 Clin Transplant pmid:27314545
de Mesquita Coutinho PR et al. Effects of tacrolimus and erythropoietin in experimental spinal cord lesion in rats: functional and histological evaluation. 2016 Spinal Cord pmid:26481712
Berryhill A et al. Cysteamine in renal transplantation: A report of two patients with nephropathic cystinosis and the successful re-initiation of cysteamine therapy during the immediate post-transplant period. 2016 Pediatr Transplant pmid:26477696
M Kotowski M et al. The influence of the tumor necrosis factor-alpa-308G>A polymorphism on the efficacy of immunosuppressive therapy in patients after kidney transplantation. 2016 J. Physiol. Pharmacol. pmid:28195062
Kyaw TH et al. A 45-Year-Old Woman With 3 Weeks of Cough and Night Sweats. 2016 Chest pmid:26965979
Golubovic B et al. Population Pharmacokinetic Approach of Immunosuppressive Therapy in Kidney Transplant Patients. 2016 Curr. Med. Chem. pmid:26687831
Fields JA et al. Neuroprotective effects of the immunomodulatory drug FK506 in a model of HIV1-gp120 neurotoxicity. 2016 J Neuroinflammation pmid:27220536
Metzker M et al. Analytical evaluation of a real-time PCR-based DNA demethylation assay to assess the frequency of naturally occurring regulatory T cells in peripheral blood. 2016 Clin. Biochem. pmid:27220060
Tanzi MG et al. Pharmacokinetics of prolonged-release tacrolimus and implications for use in solid organ transplant recipients. 2016 Clin Transplant pmid:27220013
Jia W et al. The calcineruin inhibitor cyclosporine a synergistically enhances the susceptibility of Candida albicans biofilms to fluconazole by multiple mechanisms. 2016 BMC Microbiol. pmid:27316338
Narain S and Furie R Update on clinical trials in systemic lupus erythematosus. 2016 Curr Opin Rheumatol pmid:27314466
Wen Y et al. Effect of the knockdown of Cabin1 on p53 in glomerular podocyte. 2016 J. Recept. Signal Transduct. Res. pmid:26400065
Azzi J et al. Targeted Delivery of Immunomodulators to Lymph Nodes. 2016 Cell Rep pmid:27134176
Rodríguez-Ausín P et al. Topical tacrolimus 0.03% for the treatment of ocular psoriasis. 2016 Arch Soc Esp Oftalmol pmid:27130870
Chauvet V et al. [Removal of senescent cells: towards a better future?] 2016 Med Sci (Paris) pmid:28008848
Giussani A et al. Posterior reversible encephalopathy syndrome after kidney transplantation in pediatric recipients: Two cases. 2016 Pediatr Transplant pmid:26607205
Labroo P et al. Controlled Delivery of FK506 to Improve Nerve Regeneration. 2016 Shock pmid:27058050
Wang YY et al. Characterization of Discrete Phosphopantetheinyl Transferases in Streptomyces tsukubaensis L19 Unveils a Complicate Phosphopantetheinylation Network. 2016 Sci Rep pmid:27052100
Kawahara T et al. Cyclosporine A and tacrolimus inhibit urothelial tumorigenesis. 2016 Mol. Carcinog. pmid:25594762
Sinangil A et al. New-Onset Diabetes After Kidney Transplantation and Pretransplant Hypomagnesemia. 2016 Prog Transplant pmid:27136250
Lee WS et al. Efficacy and safety of low-dose tacrolimus for active rheumatoid arthritis with an inadequate response to methotrexate. 2016 Korean J. Intern. Med. pmid:26961485