| MeSH term | MeSH ID | Detail |
|---|---|---|
| Mite Infestations | D008924 | 1 associated lipids |
| Feline Infectious Peritonitis | D016766 | 1 associated lipids |
| Fox-Fordyce Disease | D005588 | 2 associated lipids |
| Primary Graft Dysfunction | D055031 | 1 associated lipids |
| Sleep Apnea, Central | D020182 | 1 associated lipids |
| Protoporphyria, Erythropoietic | D046351 | 1 associated lipids |
| Digestive System Diseases | D004066 | 3 associated lipids |
| Pancreatitis, Graft | D055589 | 1 associated lipids |
| Candidiasis, Invasive | D058365 | 2 associated lipids |
| Intestinal Volvulus | D045822 | 1 associated lipids |
tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
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| Reedy JL et al. | Immunotherapy with tacrolimus (FK506) does not select for resistance to calcineurin inhibitors in Candida albicans isolates from liver transplant patients. | 2006 | Antimicrob. Agents Chemother. | pmid:16569889 |
| Kontoyiannis DP et al. | Calcineurin inhibitor agents interact synergistically with antifungal agents in vitro against Cryptococcus neoformans isolates: correlation with outcome in solid organ transplant recipients with cryptococcosis. | 2008 | Antimicrob. Agents Chemother. | pmid:18070977 |
| Steinbach WJ et al. | In vitro interactions between antifungals and immunosuppressants against Aspergillus fumigatus isolates from transplant and nontransplant patients. | 2004 | Antimicrob. Agents Chemother. | pmid:15561883 |
| Aoki Y and Kao PN | Erythromycin inhibits transcriptional activation of NF-kappaB, but not NFAT, through calcineurin-independent signaling in T cells. | 1999 | Antimicrob. Agents Chemother. | pmid:10543746 |
| Rivosecchi RM et al. | Effects of Isavuconazole on the Plasma Concentrations of Tacrolimus among Solid-Organ Transplant Patients. | 2017 | Antimicrob. Agents Chemother. | pmid:28674051 |
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| Pea F et al. | Drop in trough blood concentrations of tacrolimus after switching from nelfinavir to fosamprenavir in four HIV-infected liver transplant patients. | 2008 | Antivir. Ther. (Lond.) | pmid:18771060 |
| Ginestà MM et al. | Acute xenograft rejection, late xenograft rejection and long term survival xenografts in the hamster-to-rat heart transplantation model: histological characterisation under low-dose of FK506. | 2002 | APMIS | pmid:12583441 |
| Kuo WW et al. | Cardiomyoblast apoptosis induced by insulin-like growth factor (IGF)-I resistance is IGF-II dependent and synergistically enhanced by angiotensin II. | 2006 | Apoptosis | pmid:16699953 |
| Rapak A et al. | Apoptosis of lymphoma cells is abolished due to blockade of cytochrome c release despite Nur77 mitochondrial targeting. | 2007 | Apoptosis | pmid:17701362 |
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| Wang J et al. | Comparative proteomic and metabolomic analysis of Streptomyces tsukubaensis reveals the metabolic mechanism of FK506 overproduction by feeding soybean oil. | 2017 | Appl. Microbiol. Biotechnol. | pmid:28175948 |
| Ordóñez-Robles M et al. | Target genes of the Streptomyces tsukubaensis FkbN regulator include most of the tacrolimus biosynthesis genes, a phosphopantetheinyl transferase and other PKS genes. | 2016 | Appl. Microbiol. Biotechnol. | pmid:27357227 |
| Salehi-Najafabadi Z et al. | Characterisation of a γ-butyrolactone receptor of Streptomyces tacrolimicus: effect on sporulation and tacrolimus biosynthesis. | 2011 | Appl. Microbiol. Biotechnol. | pmid:21792593 |
| Ma D et al. | Manipulating the expression of SARP family regulator BulZ and its target gene product to increase tacrolimus production. | 2018 | Appl. Microbiol. Biotechnol. | pmid:29666890 |
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| Kim DH et al. | Mutational biosynthesis of tacrolimus analogues by fkbO deletion mutant of Streptomyces sp. KCTC 11604BP. | 2013 | Appl. Microbiol. Biotechnol. | pmid:23392766 |
| MartÃnez-Castro M et al. | Taxonomy and chemically semi-defined media for the analysis of the tacrolimus producer 'Streptomyces tsukubaensis'. | 2013 | Appl. Microbiol. Biotechnol. | pmid:22990582 |
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| Laffitte E and Panizzon RG | Is topical tacrolimus really an effective therapy for Hailey-Hailey disease? | 2004 | Arch Dermatol | pmid:15492199 |
| Choi CJ and Nghiem P | Tacrolimus ointment in the treatment of chronic cutaneous graft-vs-host disease: a case series of 18 patients. | 2001 | Arch Dermatol | pmid:11559218 |
| Lebwohl M et al. | Proven efficacy of tacrolimus for facial and intertriginous psoriasis. | 2005 | Arch Dermatol | pmid:16172314 |
| Gorman CR and White SW | Rosaceiform dermatitis as a complication of treatment of facial seborrheic dermatitis with 1% pimecrolimus cream. | 2005 | Arch Dermatol | pmid:16172323 |
| Heffernan MP et al. | 0.1% tacrolimus ointment in the treatment of discoid lupus erythematosus. | 2005 | Arch Dermatol | pmid:16172325 |
| Lally A et al. | Penile pyoderma gangrenosum treated with topical tacrolimus. | 2005 | Arch Dermatol | pmid:16172330 |
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| Singh MN et al. | Solitary cutaneous nodule in an immunocompromised patient. | 2007 | Arch Dermatol | pmid:18087016 |
| Sardana K et al. | Effect of tacrolimus on vitiligo in absence of UV radiation exposure. | 2007 | Arch Dermatol | pmid:17224558 |
| Ward KM et al. | Eyelash trichomegaly associated with systemic tacrolimus. | 2006 | Arch Dermatol | pmid:16490862 |
| Ostovari N et al. | Lack of efficacy of tacrolimus in the treatment of vitiligo in the absence of UV-B exposure. | 2006 | Arch Dermatol | pmid:16490866 |
| Chapman MS et al. | 0.1% tacrolimus ointment for the treatment of intertrigo. | 2005 | Arch Dermatol | pmid:15967933 |
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| Sugiura H et al. | Long-term efficacy of tacrolimus ointment for recalcitrant facial erythema resistant to topical corticosteroids in adult patients with atopic dermatitis. | 2000 | Arch Dermatol | pmid:10926750 |
| Byrd JA et al. | Recalcitrant symptomatic vulvar lichen planus: response to topical tacrolimus. | 2004 | Arch Dermatol | pmid:15210463 |
| Passeron T et al. | Treatment of oral erosive lichen planus with 1% pimecrolimus cream: a double-blind, randomized, prospective trial with measurement of pimecrolimus levels in the blood. | 2007 | Arch Dermatol | pmid:17438179 |
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