tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Ramachandran R et al. | Tacrolimus combined with corticosteroids versus Modified Ponticelli regimen in treatment of idiopathic membranous nephropathy: Randomized control trial. | 2016 | Nephrology (Carlton) | pmid:26205759 |
| Lee YJ et al. | Acquired Bilateral Dyspigmentation on Face and Neck: Clinically Appropriate Approaches. | 2016 | J. Korean Med. Sci. | pmid:27822947 |
| Hurabielle C et al. | Certolizumab pegol - A new therapeutic option for refractory disseminated pyoderma gangrenosum associated with Crohn's disease. | 2016 | J Dermatolog Treat | pmid:25909366 |
| Khan S et al. | Tacrolimus-loaded nanostructured lipid carriers for oral delivery - Optimization of production and characterization. | 2016 | Eur J Pharm Biopharm | pmid:27449630 |
| Muduma G et al. | Systematic Review and Meta-Analysis of Tacrolimus versus Ciclosporin as Primary Immunosuppression After Liver Transplant. | 2016 | PLoS ONE | pmid:27812112 |
| Prókai à et al. | Calcineurin-inhibition Results in Upregulation of Local Renin and Subsequent Vascular Endothelial Growth Factor Production in Renal Collecting Ducts. | 2016 | Transplantation | pmid:26502369 |
| Unver Dogan N et al. | Investigation of developmental toxicity and teratogenicity of cyclosporine A, tacrolimus and their combinations with prednisolone. | 2016 | Regul. Toxicol. Pharmacol. | pmid:26993750 |
| Siponen M et al. | Cathepsin K expression is increased in oral lichen planus. | 2016 | J. Oral Pathol. Med. | pmid:27152719 |
| Tomei P et al. | Everolimus-induced epithelial to mesenchymal transition (EMT) in bronchial/pulmonary cells: when the dosage does matter in transplantation. | 2016 | J. Nephrol. | pmid:27026415 |
| Chitvanich S et al. | Combination of non-ablative fractional photothermolysis and 0.1% tacrolimus ointment is efficacious for treating idiopathic guttate hypomelanosis. | 2016 | J Dermatolog Treat | pmid:26864301 |
| Garcovich S et al. | First report of hereditary Christ-Siemens-Touraine syndrome and non-segmental vitiligo association in a young adult: contraindication for vitiligo treatment. | 2016 | J Eur Acad Dermatol Venereol | pmid:25339629 |
| Ferjani H et al. | Combination of tacrolimus and mycophenolate mofetil induces oxidative stress and genotoxicity in spleen and bone marrow of Wistar rats. | 2016 | Mutat. Res. | pmid:27776691 |
| Klein OR et al. | Alternative-Donor Hematopoietic Stem Cell Transplantation with Post-Transplantation Cyclophosphamide for Nonmalignant Disorders. | 2016 | Biol. Blood Marrow Transplant. | pmid:26860634 |
| Jahnukainen T et al. | The second report of the Nordic Pediatric Renal Transplantation Registry 1997-2012: More infant recipients and improved graft survivals. | 2016 | Pediatr Transplant | pmid:26857893 |
| Fathy M et al. | Impact of CYP3A5 and MDR-1 gene polymorphisms on the dose and level of tacrolimus among living-donor liver transplanted patients: single center experience. | 2016 | Biomarkers | pmid:26856709 |
| Størset E et al. | Low-target tacrolimus in de novo standard risk renal transplant recipients: A single-centre experience. | 2016 | Nephrology (Carlton) | pmid:26854648 |
| Kanda Y et al. | A randomized controlled trial of cyclosporine and tacrolimus with strict control of blood concentrations after unrelated bone marrow transplantation. | 2016 | Bone Marrow Transplant. | pmid:26437063 |
| Ishida H et al. | A Prospective Randomized, Comparative Trial of High-Dose Mizoribine Versus Mycophenolate Mofetil in Combination With Tacrolimus and Basiliximab for Living Donor Renal Transplant: A Multicenter Trial. | 2016 | Exp Clin Transplant | pmid:27733107 |
| Tsunashima D et al. | Preparation of extended release solid dispersion formulations of tacrolimus using ethylcellulose and hydroxypropylmethylcellulose by solvent evaporation method. | 2016 | J. Pharm. Pharmacol. | pmid:26773717 |
| Mok MM et al. | Acute Phosphate Nephropathy: An Under-Recognized Complication Leading to Impaired Allograft Function After Renal Transplant. | 2016 | Nephrology (Carlton) | pmid:27730726 |
| Stocki P et al. | Inhibition of the FKBP family of peptidyl prolyl isomerases induces abortive translocation and degradation of the cellular prion protein. | 2016 | Mol. Biol. Cell | pmid:26764098 |
| Kawamura A et al. | Teratocarcinomas Arising from Allogeneic Induced Pluripotent Stem Cell-Derived Cardiac Tissue Constructs Provoked Host Immune Rejection in Mice. | 2016 | Sci Rep | pmid:26763872 |
| Suh SW et al. | Risk Factors for the Adverse Events after Conversion from Twice-Daily to Once-Daily Tacrolimus in Stable Liver Transplantation Patients. | 2016 | J. Korean Med. Sci. | pmid:27709847 |
| Yamamoto T et al. | Tacrolimus vs. anti-tumour necrosis factor agents for moderately to severely active ulcerative colitis: a retrospective observational study. | 2016 | Aliment. Pharmacol. Ther. | pmid:26762838 |
| Witt LJ et al. | Benefit of adjunctive tacrolimus in connective tissue disease-interstitial lung disease. | 2016 | Pulm Pharmacol Ther | pmid:26762710 |
| Bakardzhiev I et al. | Unilateral unique Lupus tumidus: pathogenetic mystery and diagnostic problem. | 2016 | Wien Med Wochenschr | pmid:26762262 |
| Kim JM et al. | Immunosuppression status of liver transplant recipients with hepatitis C affects biopsy-proven acute rejection. | 2016 | Clin Mol Hepatol | pmid:27729628 |
| Bogossian H et al. | Expression of NO Synthase Under Medication with Cyclosporine A, Mycophenolate Mofetil, and Tacrolimus during Development of Transplant Vasculopathy on Rat Cardiac Allograft. | 2016 | Cardiovasc Ther | pmid:26924260 |
| Michael M et al. | Outcomes of two-drug maintenance immunosuppression for pediatric renal transplantation: 10-yr follow-up in a single center. | 2016 | Pediatr Transplant | pmid:26916966 |
| Ueda Y et al. | Interstitial cystitis associated with primary Sjögren's syndrome successfully treated with a combination of tacrolimus and corticosteroid: A case report and literature review. | 2016 | Mod Rheumatol | pmid:24720552 |
| Treister N et al. | An Open-Label Phase II Randomized Trial of Topical Dexamethasone and Tacrolimus Solutions for the Treatment of Oral Chronic Graft-versus-Host Disease. | 2016 | Biol. Blood Marrow Transplant. | pmid:27590106 |
| Kabat-Koperska J et al. | The influence of exposure to immunosuppressive treatment during pregnancy on renal function and rate of apoptosis in native kidneys of female Wistar rats. | 2016 | Apoptosis | pmid:27586504 |
| Singh JA et al. | Treatments for Lupus Nephritis: A Systematic Review and Network Metaanalysis. | 2016 | J. Rheumatol. | pmid:27585688 |
| Jun H et al. | Clinical advantages including medication adherence with conversion to once-daily advagraf and sirolimus combination in stable kidney recipients. | 2016 | Int J Clin Pharmacol Ther | pmid:26709601 |
| Schmutz JL | [No increased risk of cancer under pimecrolimus]. | 2016 | Ann Dermatol Venereol | pmid:26708204 |
| Saito S et al. | Role of Paternal Antigen-Specific Treg Cells in Successful Implantation. | 2016 | Am. J. Reprod. Immunol. | pmid:26706630 |
| Valbuena H et al. | Comparing the effect of isotopically labeled or structural analog internal standards on the performance of a LC-MS/MS method to determine ciclosporin A, everolimus, sirolimus and tacrolimus in whole blood. | 2016 | Clin. Chem. Lab. Med. | pmid:26351941 |
| Kronbichler A et al. | Moderator's view: The use of calcineurin inhibitors in the treatment of lupus nephritis. | 2016 | Nephrol. Dial. Transplant. | pmid:27591329 |
| Tamaki M et al. | Fungal meningitis caused by Lomentospora prolificans after allogeneic hematopoietic stem cell transplantation. | 2016 | Transpl Infect Dis | pmid:27258644 |
| Juvvadi PR et al. | Novel motif in calcineurin catalytic subunit is required for septal localization of calcineurin in Aspergillus fumigatus. | 2016 | FEBS Lett. | pmid:26864964 |
| Wang L et al. | Therapeutic advances for primary biliary cholangitis: the old and the new. | 2016 | Eur J Gastroenterol Hepatol | pmid:26862931 |
| Ben Fredj N et al. | Modeling of Tacrolimus Exposure in Kidney Transplant According to Posttransplant Time Based on Routine Trough Concentration Data. | 2016 | Exp Clin Transplant | pmid:27506258 |
| Miyata Y et al. | Pharmacokinetics of a Once-Daily Dose of Tacrolimus Early After Liver Transplantation: With Special Reference to CYP3A5 and ABCB1 Single Nucleotide Polymorphisms. | 2016 | Ann. Transplant. | pmid:27503662 |
| Hirsch HH et al. | BK Polyomavirus Replication in Renal Tubular Epithelial Cells Is Inhibited by Sirolimus, but Activated by Tacrolimus Through a Pathway Involving FKBP-12. | 2016 | Am. J. Transplant. | pmid:26639422 |
| Orr C et al. | Quantifying Insulin Therapy Requirements to Preserve Islet Graft Function Following Islet Transplantation. | 2016 | Cell Transplant | pmid:25853639 |
| Thomas KS et al. | Clinical outcomes and response of patients applying topical therapy for pyoderma gangrenosum: A prospective cohort study. | 2016 | J. Am. Acad. Dermatol. | pmid:27502313 |
| Yaowakulpatana K et al. | Impact of CYP3A5 polymorphism on trough concentrations and outcomes of tacrolimus minimization during the early period after kidney transplantation. | 2016 | Eur. J. Clin. Pharmacol. | pmid:26635230 |
| Shuker N et al. | Pretransplant Tacrolimus Dose Requirements Predict Early Posttransplant Dose Requirements in Blood Group AB0-Incompatible Kidney Transplant Recipients. | 2016 | Ther Drug Monit | pmid:26630539 |
| Turrión-Merino L et al. | A Case Series of 4 Patients With Peristomal Pyoderma Gangrenosum: Review of Risk Factors and Treatment Response. | 2016 | Actas Dermosifiliogr | pmid:26626501 |
| Saliba F et al. | Corticosteroid-Sparing and Optimization of Mycophenolic Acid Exposure in Liver Transplant Recipients Receiving Mycophenolate Mofetil and Tacrolimus: A Randomized, Multicenter Study. | 2016 | Transplantation | pmid:27454919 |
| Liu XX et al. | Limited Sampling Strategy for the Estimation of Tacrolimus Area Under the Concentration-Time Curve in Chinese Adult Liver Transplant Patients. | 2016 | Pharmacology | pmid:27449772 |
| Chan SW et al. | Associations of the CYP3A5*3 and CYP3A4*1G polymorphisms with the pharmacokinetics of oral midazolam and the urinary 6β-hydroxycortisol/cortisol ratio as markers of CYP3A activity in healthy male Chinese. | 2016 | J Clin Pharm Ther | pmid:27511886 |
| Gastaca M et al. | Favorable longterm outcomes of liver transplant recipients treated de novo with once-daily tacrolimus: Results of a single-center cohort. | 2016 | Liver Transpl. | pmid:27434676 |
| Genvigir FD et al. | Influence of the CYP3A4/5 genetic score and ABCB1 polymorphisms on tacrolimus exposure and renal function in Brazilian kidney transplant patients. | 2016 | Pharmacogenet. Genomics | pmid:27434656 |
| Ogura Y et al. | Early Conversion From Twice-Daily Tacrolimus to Prolonged-Release Tacrolimus in Liver Transplantation: A Single-Center Experience. | 2016 | Ann. Transplant. | pmid:27432248 |
| Qi XM et al. | FK506 reduces albuminuria through improving podocyte nephrin and podocin expression in diabetic rats. | 2016 | Inflamm. Res. | pmid:26566632 |
| Seo J et al. | Therapeutic advantage of inhaled tacrolimus-bound albumin nanoparticles in a bleomycin-induced pulmonary fibrosis mouse model. | 2016 | Pulm Pharmacol Ther | pmid:26768967 |
| Zhang X et al. | The effect of calcineurin inhibitors in the induction and maintenance treatment of lupus nephritis: a systematic review and meta-analysis. | 2016 | Int Urol Nephrol | pmid:26781720 |
| Ayyala RS et al. | Imaging findings in a child with calcineurin inhibitor-induced pain syndrome after bone marrow transplant for beta thalassemia major. | 2016 | Pediatr Radiol | pmid:27324395 |
| Miura K et al. | Development of the Intestinal Transplantation Model With Major Histocompatibility Complex Inbred CLAWN Miniature Swine. | 2016 | Transplant. Proc. | pmid:27320612 |
| Lee HK et al. | Expression of Endoplasmic Reticulum-Mediated Stress Proteins in FK506-Treated T-Lymphocytes. | 2016 | Transplant. Proc. | pmid:27320607 |
| Asavakarn S et al. | Systematic Pharmaceutical Educational Approach to Enhance Drug Adherence in Liver Transplant Recipients. | 2016 | Transplant. Proc. | pmid:27320587 |
| Limsrichamrern S et al. | Correlation of Hematocrit and Tacrolimus Level in Liver Transplant Recipients. | 2016 | Transplant. Proc. | pmid:27320581 |
| Lien YH | Top 10 Things Primary Care Physicians Should Know About Maintenance Immunosuppression for Transplant Recipients. | 2016 | Am. J. Med. | pmid:26714210 |
| Mo S et al. | Improvement of FK506 Production in the High-Yielding Strain Streptomyces sp. RM7011 by Engineering the Supply of Allylmalonyl-CoA Through a Combination of Genetic and Chemical Approach. | 2016 | J. Microbiol. Biotechnol. | pmid:26502733 |
| Yesilipek MA et al. | Haploidentical hematopoietic stem cell transplantation with post-transplant high-dose cyclophosphamide in high-risk children: A single-center study. | 2016 | Pediatr Transplant | pmid:26707539 |
| Wilkes SR et al. | How Clinically Relevant Are Treatment Comparisons of Topical Calcineurin Inhibitor Trials for Atopic Eczema? | 2016 | J. Invest. Dermatol. | pmid:27265005 |
| Miura M et al. | Inter-laboratory Variability of Current Immunoassay Methods for Tacrolimus among Japanese Hospitals. | 2016 | Biol. Pharm. Bull. | pmid:27263473 |
| Weiner SM | [Combination of tacrolimus and MMF for treatment of proliferative lupus nephritis]. | 2016 | Z Rheumatol | pmid:27259912 |
| Sobiak J et al. | Pharmacokinetics of mycophenolate sodium co-administered with tacrolimus in the first year after renal transplantation. | 2016 | Eur J Drug Metab Pharmacokinet | pmid:25663618 |
| Gaynor JJ et al. | Lower tacrolimus trough levels are associated with subsequently higher acute rejection risk during the first 12 months after kidney transplantation. | 2016 | Transpl. Int. | pmid:26442829 |
| Sharma P et al. | Protein Phosphatase 1-α Regulates AS160 Ser588 and Thr642 Dephosphorylation in Skeletal Muscle. | 2016 | Diabetes | pmid:27246912 |
| Prytuła A et al. | Factors associated with 1,25-dihydroxyvitamin D3 concentrations in liver transplant recipients: a prospective observational longitudinal study. | 2016 | Endocrine | pmid:26433738 |
| Hannun P et al. | Efficacy and Safety of Elective Conversion From Sotrastaurin (STN) to Tacrolimus (TAC) or Mycophenolate (MPS) in Stable Kidney Transplant Recipients. | 2016 | Ther Drug Monit | pmid:26919549 |
| Medeiros M et al. | Are Tacrolimus Pharmacokinetics Affected by Nephrotic Stage? | 2016 | Ther Drug Monit | pmid:27167176 |
| Nitta D et al. | Successful Pregnancy and Delivery in a Heart Transplantation Recipient. | 2016 | Int Heart J | pmid:27150004 |
| Jovanović M and Golušin Z | Nonsteroidal Topical Immunomodulators in Allergology and Dermatology. | 2016 | Biomed Res Int | pmid:27144167 |
| Ban YH et al. | The biosynthetic pathway of FK506 and its engineering: from past achievements to future prospects. | 2016 | J. Ind. Microbiol. Biotechnol. | pmid:26342319 |
| Romano C et al. | Management of Acute Severe Colitis in Children With Ulcerative Colitis in the Biologics Era. | 2016 | Pediatrics | pmid:27244779 |
| Abud TB et al. | A Clinical Trial Comparing the Safety and Efficacy of Topical Tacrolimus versus Methylprednisolone in Ocular Graft-versus-Host Disease. | 2016 | Ophthalmology | pmid:27086024 |
| Nijhoff MF et al. | Glycemic Stability Through Islet-After-Kidney Transplantation Using an Alemtuzumab-Based Induction Regimen and Long-Term Triple-Maintenance Immunosuppression. | 2016 | Am. J. Transplant. | pmid:26288226 |
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| Anuradha D and Parsad | FK506 regulates pigmentation by maturing the melanosome and facilitating their transfer to keratinocytes. | 2016 | Dermatol Ther | pmid:27093927 |
| Krejci K et al. | Clinical experience of conversion from cyclosporine to tacrolimus prolonged-release in stabilized kidney transplant patients. | 2016 | Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub | pmid:27174195 |
| Fujii S et al. | Prior activation of inositol 1,4,5-trisphosphate receptors suppresses the subsequent induction of long-term potentiation in hippocampal CA1 neurons. | 2016 | Learn. Mem. | pmid:27084928 |
| Han SS et al. | Monitoring the Intracellular Tacrolimus Concentration in Kidney Transplant Recipients with Stable Graft Function. | 2016 | PLoS ONE | pmid:27082871 |
| Muduma G et al. | A cost-utility analysis of prolonged-release tacrolimus relative to immediate-release tacrolimus and ciclosporin in liver transplant recipients in the UK. | 2016 | J Med Econ | pmid:27172118 |
| Tannuri AC et al. | Prognostic factors for the evolution and reversibility of chronic rejection in pediatric liver transplantation. | 2016 | Clinics (Sao Paulo) | pmid:27166772 |
| Tariciotti L et al. | Everolimus and Advagraf Ab Initio in Combined Liver and Kidney Transplant With Donor-Specific Antibodies: A Case Report. | 2016 | Transplant. Proc. | pmid:27932158 |
| Ikeda M et al. | Successful Second Allogeneic Stem Cell Transplantation From a Sibling Donor for Relapse of Myelodysplastic Syndrome in a Recipient of a Renal Transplant From His Mother: Case Report. | 2016 | Transplant. Proc. | pmid:27932152 |
| Alagoz S et al. | Gangliocytoma Presenting With Tacrolimus Neurotoxicity in a Renal Transplant Recipient: Case Report. | 2016 | Transplant. Proc. | pmid:27932167 |
| Kolonko A et al. | Successful Preemptive Kidney Transplantation With Rituximab Induction in a Patient With Focal Segmental Glomerulosclerosis and Massive Nephrotic Syndrome: A Case Report. | 2016 | Transplant. Proc. | pmid:27932154 |
| Rodriguez Cubillo B et al. | Risk Factors of Recurrence of Diabetic Nephropathy in Renal Transplants. | 2016 | Transplant. Proc. | pmid:27932117 |
| Wakamatsu A et al. | Role of calcineurin (CN) in kidney glomerular podocyte: CN inhibitor ameliorated proteinuria by inhibiting the redistribution of CN at the slit diaphragm. | 2016 | Physiol Rep | pmid:27009276 |
| Sugitani A et al. | Unusual case of tacrolimus vascular toxicity after deceased donor renal transplantation. | 2016 | Nephrology (Carlton) | pmid:27004749 |
| Thölking G et al. | Tacrolimus Concentration/Dose Ratio is Associated with Renal Function After Liver Transplantation. | 2016 | Ann. Transplant. | pmid:27003330 |
| Krämer BK et al. | Efficacy and safety of tacrolimus compared with ciclosporin-A in renal transplantation: 7-year observational results. | 2016 | Transpl. Int. | pmid:26565071 |
| Janicki JJ et al. | Potential Effect of Liposomes and Liposome-Encapsulated Botulinum Toxin and Tacrolimus in the Treatment of Bladder Dysfunction. | 2016 | Toxins (Basel) | pmid:26999210 |
| Pallet N et al. | Long-Term Clinical Impact of Adaptation of Initial Tacrolimus Dosing to CYP3A5 Genotype. | 2016 | Am. J. Transplant. | pmid:26990694 |
| Oddis CV | Update on the pharmacological treatment of adult myositis. | 2016 | J. Intern. Med. | pmid:27098592 |