tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Bunnapradist S et al. | LCPT once-daily extended-release tacrolimus tablets versus twice-daily capsules: a pooled analysis of two phase 3 trials in important de novo and stable kidney transplant recipient subgroups. | 2016 | Transpl. Int. | pmid:26953629 |
| Velasco-Guardado A et al. | Potential protective effect of Helicobacter pylori on the development of gastrointestinal GvHD. | 2016 | Bone Marrow Transplant. | pmid:26950379 |
| Mehta RS et al. | Post-transplantation cyclophosphamide versus conventional graft-versus-host disease prophylaxis in mismatched unrelated donor haematopoietic cell transplantation. | 2016 | Br. J. Haematol. | pmid:26947769 |
| Kloster-Jensen K et al. | Treatment with Tacrolimus and Sirolimus Reveals No Additional Adverse Effects on Human Islets In Vitro Compared to Each Drug Alone but They Are Reduced by Adding Glucocorticoids. | 2016 | J Diabetes Res | pmid:26885529 |
| Rotenstein L et al. | Management of refractory autoimmune hemolytic anemia via allogeneic stem cell transplantation. | 2016 | Bone Marrow Transplant. | pmid:27272445 |
| Raschzok N et al. | The impact of directly acting antivirals on the enzymatic liver function of liver transplant recipients with recurrent hepatitis C. | 2016 | Transpl Infect Dis | pmid:27632190 |
| Shen X et al. | Calcineurin inhibitors cyclosporin A and tacrolimus protect against podocyte injury induced by puromycin aminonucleoside in rodent models. | 2016 | Sci Rep | pmid:27580845 |
| Nakamura H et al. | Usefulness of tacrolimus for refractory adult-onset still's disease: Report of six cases. | 2016 | Mod Rheumatol | pmid:25036233 |
| Khan S et al. | Tacrolimus-loaded nanostructured lipid carriers for oral delivery-in vivo bioavailability enhancement. | 2016 | Eur J Pharm Biopharm | pmid:27793753 |
| Thölking G et al. | Influence of tacrolimus metabolism rate on BKV infection after kidney transplantation. | 2016 | Sci Rep | pmid:27573493 |
| Andrews LM et al. | Consideration of the ethnic prevalence of genotypes in the clinical use of tacrolimus. | 2016 | Pharmacogenomics | pmid:27790923 |
| Tang J et al. | Cytokine Profile in Calcineurin Inhibitor-Induced Chronic Nephrotoxicity in Chinese Liver Transplant Recipients. | 2016 | Transplant. Proc. | pmid:27788813 |
| Högerle BA et al. | Challenging immunosuppression treatment in lung transplant recipients with kidney failure. | 2016 | Transpl. Immunol. | pmid:26892232 |
| Kolb M et al. | Risk Factors for Subtherapeutic Tacrolimus Levels after Conversion from Continuous Intravenous Infusion to Oral in Children after Allogeneic Hematopoietic Cell Transplantation. | 2016 | Biol. Blood Marrow Transplant. | pmid:26880117 |
| Kimura H et al. | Has widespread use of biologic and immunosuppressant therapy for ulcerative colitis affected surgical trends? Results of a questionnaire survey of surgical institutions in Japan. | 2016 | Surg. Today | pmid:26467558 |
| Törlén J et al. | A prospective randomized trial comparing cyclosporine/methotrexate and tacrolimus/sirolimus as graft-versus-host disease prophylaxis after allogeneic hematopoietic stem cell transplantation. | 2016 | Haematologica | pmid:27662016 |
| Žilinská Z et al. | Impact of Trough Levels of Tacrolimus on Kidney Function and Graft Survival in Short and Longer Periods After Renal Transplantation. | 2016 | Transplant. Proc. | pmid:27788794 |
| Gaballa S et al. | Results of a 2-arm, phase 2 clinical trial using post-transplantation cyclophosphamide for the prevention of graft-versus-host disease in haploidentical donor and mismatched unrelated donor hematopoietic stem cell transplantation. | 2016 | Cancer | pmid:27404668 |
| Chang KT et al. | Tacrolimus suppresses atopic dermatitis-associated cytokines and chemokines in monocytes. | 2016 | J Microbiol Immunol Infect | pmid:25315214 |
| Brooks E et al. | Population Pharmacokinetic Modelling and Bayesian Estimation of Tacrolimus Exposure: Is this Clinically Useful for Dosage Prediction Yet? | 2016 | Clin Pharmacokinet | pmid:27138787 |
| Rebora A | Tacrolimus and oral lichen planus. Possible absorption after mucosal application? | 2016 | J Eur Acad Dermatol Venereol | pmid:26372839 |
| Ohe M et al. | A case of lupus nephritis treated with clarithromycin, tacrolimus, and glucocorticoids. | 2016 | Kaohsiung J. Med. Sci. | pmid:27638410 |
| Jin H et al. | Clinical study of double dose of valsartan combined with tacrolimus in treatment of diabetic nephropathy. | 2016 | Eur Rev Med Pharmacol Sci | pmid:26813471 |
| Wang N et al. | Paclitaxel and Tacrolimus Coencapsulated Polymeric Micelles That Enhance the Therapeutic Effect of Drug-Resistant Ovarian Cancer. | 2016 | ACS Appl Mater Interfaces | pmid:26809267 |
| Pirojsakul K et al. | Management of sensitized pediatric patients prior to renal transplantation. | 2016 | Pediatr. Nephrol. | pmid:26801944 |
| Guo YW et al. | Successful treatment of ileal ulcers caused by immunosuppressants in two organ transplant recipients. | 2016 | World J. Gastroenterol. | pmid:27350740 |
| Sawada T et al. | Experimental Studies on Protective Effects of FK506 Against Hepatic Ischemia-Reperfusion Injury. | 2016 | J. Med. Invest. | pmid:27644569 |
| Gabriel D et al. | Improved topical delivery of tacrolimus: A novel composite hydrogel formulation for the treatment of psoriasis. | 2016 | J Control Release | pmid:27639683 |
| Chen CA et al. | Quantitative analysis of tissue inflammation and responses to treatment in immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome, and review of literature. | 2016 | J Microbiol Immunol Infect | pmid:26748735 |
| Yoshida T et al. | Oral tacrolimus oil formulations for enhanced lymphatic delivery and efficient inhibition of T-cell's interleukin-2 production. | 2016 | Eur J Pharm Biopharm | pmid:26748381 |
| Muñoz Gómez MM et al. | [Tacrolimus-induced gynecomastia in a patient with polymyositis]. | 2016 | Med Clin (Barc) | pmid:26678165 |
| Ferjani H et al. | Protective effect of mycophenolate mofetil against nephrotoxicity and hepatotoxicity induced by tacrolimus in Wistar rats. | 2016 | J. Physiol. Biochem. | pmid:26746208 |
| Vasu S et al. | Granulocyte Colony-Stimulating Factor-Mobilized Allografts Contain Activated Immune Cell Subsets Associated with Risk of Acute and Chronic Graft-versus-Host Disease. | 2016 | Biol. Blood Marrow Transplant. | pmid:26743340 |
| Yoo EC et al. | Developmental changes of MPA exposure in children. | 2016 | Pediatr. Nephrol. | pmid:26743220 |
| Yingfang F et al. | Pimecrolimus micelle exhibits excellent therapeutic effect for Keratoconjunctivitis Sicca. | 2016 | Colloids Surf B Biointerfaces | pmid:26731192 |
| Pouché L et al. | A candidate gene approach of the calcineurin pathway to identify variants associated with clinical outcomes in renal transplantation. | 2016 | Pharmacogenomics | pmid:26894651 |
| Radziejewski K and Balicki I | Comparative clinical evaluation of tacrolimus and cyclosporine eye drops for the treatment of canine keratoconjunctivitis sicca. | 2016 | Acta Vet. Hung. | pmid:27653428 |
| Sommerer C et al. | Design and rationale of the ATHENA study--A 12-month, multicentre, prospective study evaluating the outcomes of a de novo everolimus-based regimen in combination with reduced cyclosporine or tacrolimus versus a standard regimen in kidney transplant patients: study protocol for a randomised controlled trial. | 2016 | Trials | pmid:26888217 |
| Choi WJ et al. | Oral administration of Lactococcus chungangensis inhibits 2,4-dinitrochlorobenzene-induced atopic-like dermatitis in NC/Nga mice. | 2016 | J. Dairy Sci. | pmid:27289147 |
| Rahnama-Moghadam S et al. | Vesicular eruption in a 2-year-old boy. | 2016 | J Fam Pract | pmid:27565104 |
| Haasova M et al. | Immunosuppressive therapy for kidney transplantation in children and adolescents: systematic review and economic evaluation. | 2016 | Health Technol Assess | pmid:27557331 |
| Bapur Erduran F and Adışen E | Comparison of the efficacy of 308-nm excimer lamp monotherapy with topical tacrolimus or clobetasol 17-propionate combination therapies in localized vitiligo. | 2016 | Photodermatol Photoimmunol Photomed | pmid:27552312 |
| Badr R et al. | Assessment of global ischemic/reperfusion and Tacrolimus administration on CA1 region of hippocampus: gene expression profiles of BAX and BCL2 genes. | 2016 | Bratisl Lek Listy | pmid:27546370 |
| Tsuji T et al. | Therapeutic approach to mite-induced intractable dermatitis using novel immunomodulator FTY720 ointment (fingolimod) in NC/Nga mice. | 2016 | Allergol Int | pmid:26666476 |
| Speckmann T et al. | Npas4 Transcription Factor Expression Is Regulated by Calcium Signaling Pathways and Prevents Tacrolimus-induced Cytotoxicity in Pancreatic Beta Cells. | 2016 | J. Biol. Chem. | pmid:26663079 |
| Fang YP et al. | What is the discrepancy between drug permeation into/across intact and diseased skins? Atopic dermatitis as a model. | 2016 | Int J Pharm | pmid:26657274 |
| Thao le Q et al. | Pharmaceutical potential of tacrolimus-loaded albumin nanoparticles having targetability to rheumatoid arthritis tissues. | 2016 | Int J Pharm | pmid:26657273 |
| Ishiwata Y et al. | Effects of Miconazole Oral Gel on Blood Concentrations of Tacrolimus and Cyclosporine: A Retrospective Observational Study. | 2016 | Ther Drug Monit | pmid:27559841 |
| Lee C et al. | Treatment of bleomycin-induced pulmonary fibrosis by inhaled tacrolimus-loaded chitosan-coated poly(lactic-co-glycolic acid) nanoparticles. | 2016 | Biomed. Pharmacother. | pmid:26898446 |
| Bargnoux AS et al. | Evaluation of the New Siemens Tacrolimus Assay on the Dimension EXL Integrated Chemistry System Analyzer: Comparison With an Ultra-Performance Liquid Chromatography-Tandem Mass Spectrometry Method. | 2016 | Ther Drug Monit | pmid:27494947 |
| Arai K et al. | A Case Report of Drug-Induced Thrombocytopenia after Living Donor Liver Transplantation. | 2016 | Kobe J Med Sci | pmid:27492209 |
| Ren H et al. | Phosphatase inhibition increases AQP2 accumulation in the rat IMCD apical plasma membrane. | 2016 | Am. J. Physiol. Renal Physiol. | pmid:27488997 |
| Albeiroti S et al. | Evaluation of 2 Batched Pretreatment Systems for the Measurement of Whole Blood Tacrolimus on the ARCHITECT Immunoassay Analyzer. | 2016 | Lab Med | pmid:27474776 |
| Yu H et al. | Risk factors for new-onset diabetes mellitus after living donor kidney transplantation in Korea - a retrospective single center study. | 2016 | BMC Nephrol | pmid:27473469 |
| Woolner K and Sauder M | Periorbital erythema following alcohol ingestion during treatment with topical tacrolimus. | 2016 | CMAJ | pmid:26598374 |
| Park JS et al. | A rapid and sensitive method to determine tacrolimus in rat whole blood using liquid-liquid extraction with mild temperature ultrasonication and LC-MS/MS. | 2016 | Arch. Pharm. Res. | pmid:26589688 |
| Filler G et al. | Minimum mycophenolic acid levels are associated with donor-specific antibody formation. | 2016 | Pediatr Transplant | pmid:26589470 |
| Dabrowska-Zamojcin E et al. | CCL2 gene polymorphism is associated with post-transplant diabetes mellitus. | 2016 | Int. Immunopharmacol. | pmid:26802601 |
| Yoshida S et al. | Treatment with DHA/EPA ameliorates atopic dermatitis-like skin disease by blocking LTB4 production. | 2016 | J. Med. Invest. | pmid:27644556 |
| Ashizuka S et al. | Adrenomedullin Therapy in Patients with Refractory Ulcerative Colitis: A Case Series. | 2016 | Dig. Dis. Sci. | pmid:26470867 |
| Kimsa M et al. | Transforming growth factor β-related genes in human retinal pigment epithelial cells after tacrolimus treatment. | 2016 | Pharmacol Rep | pmid:27372923 |
| GarcÃa-Delgado R et al. | Systemic Absorption of Topical Tacrolimus in Metastatic Crohn Disease With Skin Ulcers. | 2016 | Actas Dermosifiliogr | pmid:27372545 |
| Gray JM and Ameduri RK | Tacrolimus-associated hemolytic uremic syndrome in a pediatric heart transplant recipient. | 2016 | Pediatr Transplant | pmid:27371345 |
| Tanriover B et al. | Acute Rejection Rates and Graft Outcomes According to Induction Regimen among Recipients of Kidneys from Deceased Donors Treated with Tacrolimus and Mycophenolate. | 2016 | Clin J Am Soc Nephrol | pmid:27364616 |
| Ordóñez-Robles M et al. | Target genes of the Streptomyces tsukubaensis FkbN regulator include most of the tacrolimus biosynthesis genes, a phosphopantetheinyl transferase and other PKS genes. | 2016 | Appl. Microbiol. Biotechnol. | pmid:27357227 |
| Handisurya A et al. | Conversion from Tacrolimus to Cyclosporine A Improves Glucose Tolerance in HCV-Positive Renal Transplant Recipients. | 2016 | PLoS ONE | pmid:26735686 |
| Watanabe R et al. | Successful multi-target therapy using corticosteroid, tacrolimus, cyclophosphamide, and rituximab for rapidly progressive interstitial lung disease in a patient with clinically amyopathic dermatomyositis. | 2016 | Mod Rheumatol | pmid:25698368 |
| Vignali D et al. | IL-7 Mediated Homeostatic Expansion of Human CD4+CD25+FOXP3+ Regulatory T Cells After Depletion With Anti-CD25 Monoclonal Antibody. | 2016 | Transplantation | pmid:27306531 |
| Tsuji H et al. | Efficacy and Safety of Grapefruit Juice Intake Accompanying Tacrolimus Treatment in Connective Tissue Disease Patients. | 2016 | Intern. Med. | pmid:27301503 |
| Pizzo HP et al. | Sirolimus and tacrolimus coefficient of variation is associated with rejection, donor-specific antibodies, and nonadherence. | 2016 | Pediatr. Nephrol. | pmid:27286686 |
| Youssef M et al. | Asymptomatic papulonodular lesions in zosteriform distribution in an immunocompromised patient. | 2016 | Int. J. Dermatol. | pmid:26463835 |
| Ferjani H et al. | The evaluate and compare the effects of the Tacrolimus and Sirolimus on the intestinal system using an intestinal cell culture model. | 2016 | Toxicol. Mech. Methods | pmid:26460985 |
| Yamashita T et al. | Effects of CYP3A5 polymorphism on the pharmacokinetics of a once-daily modified-release tacrolimus formulation and acute kidney injury in hematopoietic stem cell transplantation. | 2016 | Cancer Chemother. Pharmacol. | pmid:27217047 |
| Tremblay S et al. | Absence of the Effect of Pretransplant Body Mass Index on Post Kidney Transplant Outcomes. | 2016 | Prog Transplant | pmid:27207408 |
| Sharma A et al. | Perioperative Desensitization Improves Outcomes Among Crossmatch Positive Recipients of Deceased Donor Renal Transplants. | 2016 | Prog Transplant | pmid:27207404 |
| Menninga NJ et al. | Restless Legs Syndrome Following Lung Transplantation: Prevalence and Relationship With Tacrolimus Exposure. | 2016 | Prog Transplant | pmid:27207403 |
| Nankivell BJ et al. | Calcineurin Inhibitor Nephrotoxicity Through the Lens of Longitudinal Histology: Comparison of Cyclosporine and Tacrolimus Eras. | 2016 | Transplantation | pmid:27306529 |
| Jebabli N et al. | Consequences of erroneous phone transmission of tacrolimus blood concentration: A case report. | 2016 | Therapie | pmid:27203160 |
| Sasaki T et al. | Characteristic features of tacrolimus-induced lung disease in rheumatoid arthritis patients. | 2016 | Clin. Rheumatol. | pmid:25644583 |
| Reeves TM et al. | Targeting Kv1.3 channels to reduce white matter pathology after traumatic brain injury. | 2016 | Exp. Neurol. | pmid:27302680 |
| O'Regan JA et al. | Tacrolimus trough-level variability predicts long-term allograft survival following kidney transplantation. | 2016 | J. Nephrol. | pmid:26374111 |
| Pirmez R et al. | Acne keloidalis nuchae in renal transplant patients receiving tacrolimus and sirolimus. | 2016 | Australas. J. Dermatol. | pmid:27124649 |
| Matsukawa T et al. | Reduced-dose methotrexate in combination with tacrolimus was associated with rapid engraftment and recovery from oral mucositis without affecting the incidence of GVHD. | 2016 | Int. J. Hematol. | pmid:27119977 |
| Alvarez-ElÃas AC et al. | CYP3A5 Genotype and Time to Reach Tacrolimus Therapeutic Levels in Renal Transplant Children. | 2016 | Transplant. Proc. | pmid:27110018 |
| Reiner J et al. | After Intestinal Transplantation Kidney Function Is Impaired by Downregulation of Epithelial Ion Transporters in the Ileum. | 2016 | Transplant. Proc. | pmid:27109987 |
| Peng L et al. | Comparison of different therapies in high-risk patients with idiopathic membranous nephropathy. | 2016 | J. Formos. Med. Assoc. | pmid:26315481 |
| Ruangkanchanasetr P et al. | Beta Cell Function and Insulin Resistance After Conversion from Tacrolimus Twice-Daily to Extended-Release Tacrolimus Once-Daily in Stable Renal Transplant Recipients. | 2016 | Ann. Transplant. | pmid:27980321 |
| Castagna L et al. | Tacrolimus compared with cyclosporine A after haploidentical T-cell replete transplantation with post-infusion cyclophosphamide. | 2016 | Bone Marrow Transplant. | pmid:26595078 |
| Cai SC et al. | Topical calcineurin inhibitors in eczema and cancer association: A cohort study. | 2016 | J Dermatolog Treat | pmid:27049893 |
| Aldoss I et al. | Cytogenetics Does Not Impact Outcomes in Adult Patients with Acute Lymphoblastic Leukemia Undergoing Allogeneic Hematopoietic Cell Transplantation. | 2016 | Biol. Blood Marrow Transplant. | pmid:27044907 |
| Yamamoto T et al. | Editorial: tacrolimus vs. anti-tumour necrosis factor agents for moderately to severely active ulcerative colitis--authors' reply. | 2016 | Aliment. Pharmacol. Ther. | pmid:27040167 |
| Taylor KM and Sparrow MP | Editorial: tacrolimus vs. anti-tumour necrosis factor agents for moderately to severely active ulcerative colitis. | 2016 | Aliment. Pharmacol. Ther. | pmid:27040166 |
| Imamura CK et al. | Impact of cytochrome P450 2C19 polymorphisms on the pharmacokinetics of tacrolimus when coadministered with voriconazole. | 2016 | J Clin Pharmacol | pmid:26239045 |
| Lonowski S et al. | Vitiligo: a potential autoimmune sequela of DRESS syndrome. | 2016 | Br. J. Dermatol. | pmid:27038429 |
| Wang Y et al. | Preparation, characterization and in vivo evaluation of amorphous tacrolimus nanosuspensions produced using CO2-assisted in situ nanoamorphization method. | 2016 | Int J Pharm | pmid:27034003 |
| Jimbo H et al. | Telangiectatic lichen sclerosus on the cheek successfully treated with topical tacrolimus. | 2016 | Eur J Dermatol | pmid:27033557 |
| Albano L et al. | Dosing of Enteric-Coated Mycophenolate Sodium Under Routine Conditions: An Observational, Multicenter Study in Kidney Transplantation. | 2016 | Ann. Transplant. | pmid:27122116 |
| GarcÃa-Bello JA et al. | Effect of Immunosuppressive Therapy on Cardiovascular Risk Factor Prevalence in Kidney-Transplanted Children: Comparative Study. | 2016 | Transplant. Proc. | pmid:27110020 |
| Gu C et al. | Triptolide Reduces the Required Dose of Tacrolimus by Attenuating Inflammation, Enhancing Immunosuppression, and Increasing Donor Chimerism in a Heterotopic Hindlimb Transplantation Model. | 2016 | Plast. Reconstr. Surg. | pmid:27879593 |
| Carrillo-Ibarra S et al. | The Oxidative and Inflammatory State in Patients with Acute Renal Graft Dysfunction Treated with Tacrolimus. | 2016 | Oxid Med Cell Longev | pmid:27872679 |