tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Guy S et al. | Immunosuppression conversion for relief of side effects. | 1994 | Transplant. Proc. | pmid:7527956 |
| Knoop C et al. | FK 506 rescue therapy for irreversible airway rejection in heart-lung transplant recipients: report on five cases. | 1994 | Transplant. Proc. | pmid:7527957 |
| Yashima J et al. | Successful conversion from tacrolimus to cyclosporine after kidney transplantation. | 2000 | Transplant. Proc. | pmid:11119895 |
| Gibbs JF et al. | Outcome analysis of FK 506 therapy for acute and chronic rejection. | 1993 | Transplant. Proc. | pmid:7679823 |
| Nomoto S et al. | Cardiotoxicity of long-term intravenous administration of FK506 in rabbits: dose relationship and recovery after discontinuance. | 1994 | Transplant. Proc. | pmid:7513477 |
| Morphological characteristics of renal allografts showing renal dysfunction under FK 506 therapy: is graft biopsy available to reveal the morphological findings corresponding with FK 506 nephropathy? Japanese FK 506 Study Group. | 1993 | Transplant. Proc. | pmid:7679824 | |
| Kato H et al. | Spontaneous proliferation of peripheral blood mononuclear cells as an indicator for insufficient plasma levels of FK 506 in the early phase after liver transplantation. | 1994 | Transplant. Proc. | pmid:7513481 |
| Siekierka JJ et al. | Potential roles of other FK 506-binding proteins in mediating the effects of FK 506. | 1991 | Transplant. Proc. | pmid:1721256 |
| Morris RE | In vivo immunopharmacology of the macrolides FK 506 and rapamycin: toward the era of rational immunosuppressive drug discovery, development, and use. | 1991 | Transplant. Proc. | pmid:1721257 |
| Satomura K et al. | Pharmacokinetics of FK 506 in living-related liver transplantation. | 1996 | Transplant. Proc. | pmid:8623209 |
| Loss M et al. | Glucose and lipid metabolism in liver transplant patients under long-term tacrolimus (FK 506) monotherapy. | 1996 | Transplant. Proc. | pmid:8623210 |
| Shapiro R et al. | The side effects of FK 506 in humans. | 1990 | Transplant. Proc. | pmid:1689892 |
| Van Thiel DH et al. | Gastrointestinal and metabolic problems associated with immunosuppression with either CyA or FK 506 in liver transplantation. | 1990 | Transplant. Proc. | pmid:1689893 |
| Machado PG et al. | Use of reduced dose of OKT3 (2.5 mg) after renal transplantation. | 2002 | Transplant. Proc. | pmid:11959207 |
| Zervos XA et al. | Comparison of tacrolimus with neoral as primary immunosuppression in hepatitis C patients after liver transplantation. | 1998 | Transplant. Proc. | pmid:9636568 |
| Videla CO | Two-year experience with tacrolimus in renal transplantation after late conversion from cyclosporine therapy. | 2009 Jul-Aug | Transplant. Proc. | pmid:19715995 |
| Melo MJ et al. | Impact of conversion from Advagraf to twice-daily generic tacrolimus in kidney transplant recipients: a single-center study. | 2015 | Transplant. Proc. | pmid:26036484 |
| Santos T et al. | New Recipes With Known Ingredients: Combined Therapy of Everolimus and Low-dose Tacrolimus in De Novo Renal Allograft Recipients. | 2015 | Transplant. Proc. | pmid:26036483 |
| Viganó J et al. | Incidence of graft rejection in small bowel transplanted pigs after immunosuppression withdrawal. | 2006 Jul-Aug | Transplant. Proc. | pmid:16908291 |
| Higuchi K et al. | FK506 induces the atrophy of enteric ganglia in small bowel transplantation, which can be prevented by the neuropeptide bombesin. | 2006 Jul-Aug | Transplant. Proc. | pmid:16908293 |
| Koyamada N et al. | Strategy for chronic rejection in recipient of living-related liver transplantation. | 2000 | Transplant. Proc. | pmid:11120102 |
| Kaplinsky E et al. | Renal function improvement after conversion to proliferation signal inhibitors during long-term follow-up in heart transplant recipients. | 2012 | Transplant. Proc. | pmid:23146455 |
| Rilo HR et al. | Effect of intraportal human islet transplantation on kidney graft survival in simultaneous kidney-islet allografts. | 1993 | Transplant. Proc. | pmid:7680172 |
| Harihara Y et al. | Correlation between graft size and necessary tacrolimus dose after living-related liver transplantation. | 2000 | Transplant. Proc. | pmid:11120116 |
| Yilmaz A et al. | Severe angioedema caused by banana allergy under tacrolimus immunosuppression. | 2005 | Transplant. Proc. | pmid:16387091 |
| Lai WJ et al. | Is sirolimus a safe alternative to reduce or eliminate calcineurin inhibitors in chronic allograft nephropathy in kidney transplantation? | 2004 | Transplant. Proc. | pmid:15518744 |
| Kohnle M et al. | Conversion from cyclosporine to tacrolimus in renal transplant recipients with gum hyperplasia. | 1999 | Transplant. Proc. | pmid:10576043 |
| Barten MJ et al. | Pharmacodynamic monitoring of the conversion of cyclosporine to tacrolimus in heart and lung transplant recipients. | 2005 | Transplant. Proc. | pmid:16387162 |
| Chueh SC et al. | Pharmacokinetic variability of sirolimus in Taiwanese renal transplant recipients. | 2004 | Transplant. Proc. | pmid:15518745 |
| Blanc P et al. | Antiproliferative effect of FK 506 and cyclosporine on adult human hepatocytes in culture. | 1991 | Transplant. Proc. | pmid:1721288 |
| Ueno M et al. | Immunosuppressive effect in combination therapy of cyclosporine A, FK 506, and 15-deoxyspergualin on pancreatic islet xenotransplantation. | 1992 | Transplant. Proc. | pmid:1373546 |
| van Hooff JP et al. | Tacrolimus and glucose metabolism. | 1999 | Transplant. Proc. | pmid:10576044 |
| D'Silva M et al. | Immunosuppressive effect of RS-61443 on rat cardiac allograft survival in combination with leflunomide or FK 506. | 1996 | Transplant. Proc. | pmid:8623467 |
| Meçule A et al. | Once daily tacrolimus formulation: monitoring of plasma levels, graft function, and cardiovascular risk factors. | 2010 | Transplant. Proc. | pmid:20534290 |
| Burke GW et al. | Use of tacrolimus and mycophenolate mofetil for pancreas-kidney transplantation with or without OKT3 induction. | 1998 | Transplant. Proc. | pmid:9636627 |
| Gruessner RW | Antibody induction therapy in pancreas transplantation. | 1998 | Transplant. Proc. | pmid:9636632 |
| Bakar F et al. | Low-density lipoprotein oxidizability and the alteration of its fatty acid content in renal transplant recipients treated with cyclosporine/tacrolimus. | 2009 | Transplant. Proc. | pmid:19545695 |
| Marcén R et al. | Effects of the new immunosuppressive agents on the occurrence of malignancies after renal transplantation. | 2010 | Transplant. Proc. | pmid:20970609 |
| Mueller AR et al. | Association between hepatitis and rejection: upregulation of cytokines and extracellular matrix parameters. | 1997 | Transplant. Proc. | pmid:9365585 |
| Platz KP et al. | FK 506 and mycofenolate mofetil rescue for acute steroid-resistant and chronic rejection after liver transplantation. | 1997 | Transplant. Proc. | pmid:9365598 |
| Villamil F et al. | Long-term outcomes in liver transplant patients with hepatic C infection receiving tacrolimus or cyclosporine. | 2006 | Transplant. Proc. | pmid:17112875 |
| Deardon DJ et al. | Small bowel tonometry: a possible technique for detecting early small bowel allograft dysfunction. | 1993 | Transplant. Proc. | pmid:7505502 |
| Demetris AJ et al. | Hematolymphoid cell trafficking, microchimerism, and GVH reactions after liver, bone marrow, and heart transplantation. | 1993 | Transplant. Proc. | pmid:7505503 |
| Ohtsuka S et al. | Mechanism of antibody production in guinea pig to rat discordant xenotransplant: establishment of a simple model by intravenous injection of discordant splenocytes. | 1994 | Transplant. Proc. | pmid:7518130 |
| Todo S et al. | Intestinal transplantation at the University of Pittsburgh. | 1994 | Transplant. Proc. | pmid:7518136 |
| Mucha K et al. | 36-month follow-up of 75 renal allograft recipients treated with steroids, tacrolimus, and azathioprine or mycophenolate mofetil. | 2003 | Transplant. Proc. | pmid:14529880 |
| Loss M et al. | Influence of long-term cyclosporine or FK 506 therapy on glucose and lipid metabolism in stable liver graft recipients. | 1995 | Transplant. Proc. | pmid:7533365 |
| Ushigome H et al. | Two cases of tacrolimus-induced alopecia following kidney transplantation. | 1999 | Transplant. Proc. | pmid:10578326 |
| Woodle ES et al. | FK 506 rescue therapy: the rapidity of rejection reversal is related to the subsequent development of CMV disease. | 1993 | Transplant. Proc. | pmid:7682360 |
| Lang T et al. | Distinct patterns of Th2 cytokine production during immune activation in pediatric liver allograft recipients. | 1995 | Transplant. Proc. | pmid:7533367 |
| Chen-Woan M et al. | Diminished lymphocyte growth from endomyocardial biopsies from cardiac transplant patients on FK 506 immunosuppression. | 1991 | Transplant. Proc. | pmid:1721320 |
| Li J et al. | Regulatory effect of FK506 on CD152 and PD-1 in the liver allorecipients. | 2008 | Transplant. Proc. | pmid:18589137 |
| Yang YJ et al. | Sirolimus-based immunosuppressive therapy in liver transplant recipient with tacrolimus-related chronic renal insufficiency. | 2008 | Transplant. Proc. | pmid:18589147 |
| Shibutani S et al. | FK 506 abrogates induction of regulatory cells after intratracheal delivery of alloantigen. | 2002 | Transplant. Proc. | pmid:12176432 |
| Signorell J et al. | Recurrent non-melanoma skin cancer: remission of field cancerization after conversion from calcineurin inhibitor- to proliferation signal inhibitor-based immunosuppression in a cardiac transplant recipient. | 2010 | Transplant. Proc. | pmid:21094874 |
| Hayes D et al. | Aerosolized tacrolimus: a case report in a lung transplant recipient. | 2010 | Transplant. Proc. | pmid:21094875 |
| Bouchta NB et al. | Conversion from tacrolimus to cyclosporin is associated with a significant improvement of glucose metabolism in patients with new-onset diabetes mellitus after renal transplantation. | 2005 | Transplant. Proc. | pmid:15919485 |
| Kumano K et al. | Role of endothelin in FK 506-induced renal hypoperfusion in rats. | 1995 | Transplant. Proc. | pmid:7533423 |
| Green M et al. | Infectious complications of pediatric liver transplantation under FK 506. | 1991 | Transplant. Proc. | pmid:1721352 |
| Altaca G et al. | Effect of low-dose calcineurin inhibitors on acute rejection and graft survival. | 2002 | Transplant. Proc. | pmid:12270320 |
| Torre-Cisneros J et al. | The spectrum of aspergillosis in liver transplant patients: comparison of FK 506 and cyclosporine immunosuppression. | 1991 | Transplant. Proc. | pmid:1721353 |
| Tanabe K et al. | Outcome of kidney transplantation from non-heart-beating donors followed by tacrolimus immunosuppression in japan. | 2002 | Transplant. Proc. | pmid:12176493 |
| Squifflet JP et al. | Safe withdrawal of corticosteroids or mycophenolate mofetil: results of a large, prospective, multicenter, randomized study. | 2002 | Transplant. Proc. | pmid:12176495 |
| Ko WJ et al. | Clinical trial of FK506 in heart transplant patients in Taiwan: report of 7 cases with immunosuppression switch from cyclosporine to FK506. | 1998 | Transplant. Proc. | pmid:9838474 |
| Cho JH et al. | Chronic rejection in pediatric liver transplantation. | 1997 Feb-Mar | Transplant. Proc. | pmid:9123078 |
| Spada M et al. | Bacterial translocation is enhanced in pig intestinal transplantation when the colon is included in the graft. | 1996 | Transplant. Proc. | pmid:8907997 |
| Hara Y et al. | Heterotopic rat heart transplantation to the iliac vessels. | 1994 | Transplant. Proc. | pmid:7520632 |
| Takayama K et al. | Nonmuscle myosin heavy chain and nuclear factor-kappa B expression in pig-to-primate xenotransplanted hearts. | 2000 | Transplant. Proc. | pmid:10936372 |
| McCauley J et al. | Changes in renal function after liver transplantation under FK 506. | 1991 | Transplant. Proc. | pmid:1721385 |
| Boots JM et al. | Risk of adrenal insufficiency with steroid maintenance therapy in renal transplantation. | 2002 | Transplant. Proc. | pmid:12176541 |
| Lee S et al. | Mycophenolic acid trough level measurements and clinical outcomes in kidney transplantation recipients on a fixed dose (1.5 g/d) of mycophenolate mofetil in Korea. | 2010 | Transplant. Proc. | pmid:20430174 |
| Klupp J et al. | Mycophenolate mofetil in combination with tacrolimus versus Neoral after liver transplantation. | 1999 Feb-Mar | Transplant. Proc. | pmid:10083497 |
| Kim JM et al. | Preemptive therapy in adult liver transplant recipients in CMV-endemic area. | 2010 | Transplant. Proc. | pmid:20430182 |
| Yang HC et al. | Tacrolimus/"low-dose" mycophenolate mofetil versus microemulsion cyclosporine/"low-dose" mycophenolate mofetil after kidney transplantation--1-year follow-up of a prospective, randomized clinical trial. | 1999 Feb-Mar | Transplant. Proc. | pmid:10083501 |
| Alessiani M et al. | Morphological and functional changes in small-bowel allografts of pigs under combined tacrolimus and mycophenolate mofetil immunosuppression. | 1997 Feb-Mar | Transplant. Proc. | pmid:9123483 |
| Galvao FH et al. | Experimental animal model of graft-versus-host disease (GVHD) after small-bowel transplantation: characteristics of the model and application to developing treatment strategies. | 1997 Feb-Mar | Transplant. Proc. | pmid:9123488 |
| Kimura O et al. | Influence of bombesin on the intestinal mucosal immunologic response under immunosuppression. | 2000 | Transplant. Proc. | pmid:10995942 |
| Yamashita T et al. | Prolongation of pancreaticoduodenal allograft survival in rats by treatment with FK 506. | 1991 | Transplant. Proc. | pmid:1721414 |
| Fukuzaki T et al. | Induction of tolerance to islet allografts with preoperative donor spleen cell injection and a short course of FK 506 treatment. | 1991 | Transplant. Proc. | pmid:1721415 |
| Degawa H et al. | Blocking of ICAM-1 and LFA-1 in rat liver transplantation. | 1996 | Transplant. Proc. | pmid:8658695 |
| Watanabe K et al. | Immunosuppressive effect of bactobolamine in rat liver allotransplantation. | 1996 | Transplant. Proc. | pmid:8658697 |
| Yamanaka K et al. | Induction Immunosuppressive Therapy With Everolimus and Low-Dose Tacrolimus Extended-Release Preserves Good Renal Function at 1Â Year After Kidney Transplantation. | 2016 | Transplant. Proc. | pmid:27234735 |
| Dette K et al. | Daclizumab and ATG versus ATG in combination with tacrolimus, mycophenolate mofetil, and steroids in simultaneous [correction of simultaneus] pancreas-kidney transplantation: analysis of early outcome. | 2002 | Transplant. Proc. | pmid:12176624 |
| Navaneethan SD et al. | Tacrolimus-associated hypomagnesemia in renal transplant recipients. | 2006 | Transplant. Proc. | pmid:16797291 |
| Zaltzman J et al. | Tacrolimus, MMF, steroid, and ALG immunotherapy for high immunological risk renal transplant recipients. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267183 |
| Burrows L et al. | Conversion to tacrolimus to ameliorate cyclosporine toxicity in kidney recipients. | 1998 | Transplant. Proc. | pmid:9723378 |
| Fabrega AJ et al. | FK 506 enhances the beneficial effects of donor-specific blood transfusion on allograft survival in rats. | 1991 | Transplant. Proc. | pmid:1721447 |
| Viebahn R et al. | Simulation of hypoxic and preservation injury in human hepatocyte cultures: influence of FK 506 and cyclosporine. | 1993 | Transplant. Proc. | pmid:7689278 |
| Wang CH et al. | Therapeutic drug monitoring of tacrolimus in cardiac transplant recipients: a comparison with cyclosporine neoral. | 2004 | Transplant. Proc. | pmid:15561257 |
| Heffron TG et al. | Daclizumab induction in liver transplant recipients. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267408 |
| Rabkin JM et al. | Pharmacoeconomic study of tacrolimus-based versus cyclosporine-based immunosuppressive therapy following liver transplantation. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267411 |
| Uber PA et al. | Ethnic disparities in the pharmacologic characteristics of tacrolimus in heart transplantation. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267428 |
| Nakai T et al. | Immunologic changes in heterotopic and orthotopic small bowel transplantation in rats. | 1999 | Transplant. Proc. | pmid:10500761 |
| Krüger B et al. | Different effects of cyclosporine or tacrolimus on hepatocyte acute phase proteins. | 1998 | Transplant. Proc. | pmid:9636399 |
| McAlister VC | Liposomal tacrolimus: drug migration within blood compartments. | 1998 | Transplant. Proc. | pmid:9636404 |
| Zhang J et al. | Value of CYP3A5 genotyping on determining initial dosages of tacrolimus for Chinese renal transplant recipients. | 2010 | Transplant. Proc. | pmid:21094797 |
| Gotsman I et al. | Effect of peripheral immune tolerance on liver-associated lymphocytes expressing NK1.1. | 2000 | Transplant. Proc. | pmid:10856569 |
| Soh KS et al. | Simultaneous liver and kidney transplantation from different living donors. | 2012 | Transplant. Proc. | pmid:22410057 |
| Blume C et al. | Conversion from cyclosporine to tacrolimus prevents transplant function loss due to acute steroid-resistant or chronic rejection in renal allograft recipients. | 2001 Nov-Dec | Transplant. Proc. | pmid:11750357 |
| Busque S et al. | Conversion from Neoral (cyclosporine) to tacrolimus of kidney transplant recipients for gingival hyperplasia or hypertrichosis. | 1998 | Transplant. Proc. | pmid:9636507 |