tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Provenzani A et al. | Pharmacogenetic considerations for optimizing tacrolimus dosing in liver and kidney transplant patients. | 2013 | World J. Gastroenterol. | pmid:24409044 |
| Liu F et al. | Tacrolimus dosage requirements in living donor liver transplant recipients with small-for-size grafts. | 2009 | World J. Gastroenterol. | pmid:19701975 |
| Schott E et al. | Development of ulcerative colitis in a patient with multiple sclerosis following treatment with interferon beta 1a. | 2007 | World J. Gastroenterol. | pmid:17659718 |
| Jia JJ et al. | ''Minimizing tacrolimus'' strategy and long-term survival after liver transplantation. | 2014 | World J. Gastroenterol. | pmid:25170223 |
| Hao JC et al. | Effect of low-dose tacrolimus with mycophenolate mofetil on renal function following liver transplantation. | 2014 | World J. Gastroenterol. | pmid:25170222 |
| Kawakami K et al. | Effects of oral tacrolimus as a rapid induction therapy in ulcerative colitis. | 2015 | World J. Gastroenterol. | pmid:25684955 |
| Meier J and Sturm A | Current treatment of ulcerative colitis. | 2011 | World J. Gastroenterol. | pmid:21912469 |
| Kiyama T et al. | Tacrolimus enhances colon anastomotic healing in rats. | 2002 Sep-Oct | Wound Repair Regen | pmid:12406167 |
| Gupta AS et al. | Pyoderma Gangrenosum of the Scalp: A Rare Clinical Variant. | 2018 | Wounds | pmid:29481333 |
| Zhou YN et al. | Effect of amlodipine on the pharmacokinetics of tacrolimus in rats. | 2013 | Xenobiotica | pmid:23312000 |
| Picard N | The pharmacokinetic interaction between mycophenolic acid and cyclosporine revisited: a commentary on "Mycophenolic acid glucuronide is transported by multidrug resistance-associated protein 2 and this transport is not inhibited by cyclosporine, tacrolimus or sirolimus". | 2013 | Xenobiotica | pmid:23339626 |
| Tata PN et al. | Species-dependent hepatic metabolism of immunosuppressive agent tacrolimus (FK-506). | 2009 | Xenobiotica | pmid:19604035 |
| Zhang S et al. | Effect of voriconazole and other azole antifungal agents on CYP3A activity and metabolism of tacrolimus in human liver microsomes. | 2012 | Xenobiotica | pmid:22106961 |
| Ogawa K et al. | A new approach to predicting human hepatic clearance of CYP3A4 substrates using monkey pharmacokinetic data. | 2013 | Xenobiotica | pmid:23153054 |
| Lu XF et al. | Use of a semi-physiological pharmacokinetic model to investigate the influence of itraconazole on tacrolimus absorption, distribution and metabolism in mice. | 2017 | Xenobiotica | pmid:27533047 |
| Lampen A et al. | Catalytic activities, protein- and mRNA-expression of cytochrome P450 isoenzymes in intestinal cell lines. | 1998 | Xenobiotica | pmid:9622846 |
| Jeong H and Chiou WL | Role of P-glycoprotein in the hepatic metabolism of tacrolimus. | 2006 | Xenobiotica | pmid:16507509 |
| Patel CG et al. | Mycophenolic acid glucuronide is transported by multidrug resistance-associated protein 2 and this transport is not inhibited by cyclosporine, tacrolimus or sirolimus. | 2013 | Xenobiotica | pmid:22934787 |
| Chitnis SD et al. | Concentration of tacrolimus and major metabolites in kidney transplant recipients as a function of diabetes mellitus and cytochrome P450 3A gene polymorphism. | 2013 | Xenobiotica | pmid:23278282 |
| Niioka T et al. | Effects of CYP3A5 polymorphism and the tacrolimus 12 h concentration on tacrolimus-induced acute renal dysfunction in patients with lupus nephritis. | 2015 | Xenobiotica | pmid:26189776 |