Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with tacrolimus
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Wang M et al. | Enteric polymer based on pH-responsive aliphatic polycarbonate functionalized with vitamin E to facilitate oral delivery of tacrolimus. | 2015 | Biomacromolecules | pmid:25714622 |
Gallon L et al. | Differential Effects of Calcineurin and Mammalian Target of Rapamycin Inhibitors on Alloreactive Th1, Th17, and Regulatory T Cells. | 2015 | Transplantation | pmid:25905982 |
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Chen KH et al. | De novo cancer avoidance after renal transplantation: A case-control study on low-dose sirolimus combined with a calcineurin inhibitor. | 2015 | J. Formos. Med. Assoc. | pmid:25843527 |
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Gajzlerska W et al. | Use of three-carbon chain compounds as biosynthesis precursors to enhance tacrolimus production in Streptomyces tsukubaensis. | 2015 | N Biotechnol | pmid:25152525 |
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Yu Z et al. | IL-15 is decreased upon CsA and FK506 treatment of acute rejection following heart transplantation in mice. | 2015 | Mol Med Rep | pmid:25333459 |
Selk A | A Survey of Experts Regarding the Treatment of Adult Vulvar Lichen Sclerosus. | 2015 | J Low Genit Tract Dis | pmid:25853633 |
Hurst AL et al. | Supra-therapeutic tacrolimus concentrations associated with concomitant nicardipine in pediatric liver transplant recipients. | 2015 | Pediatr Transplant | pmid:25850753 |
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Wang L et al. | Gq signaling causes glomerular injury by activating TRPC6. | 2015 | J. Clin. Invest. | pmid:25844902 |
Bowman LJ et al. | Tacrolimus-Induced Cardiomyopathy in an Adult Renal Transplant Recipient. | 2015 | Pharmacotherapy | pmid:26616582 |
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Aouam K et al. | Influence of combined CYP3A4 and CYP3A5 single-nucleotide polymorphisms on tacrolimus exposure in kidney transplant recipients: a study according to the post-transplant phase. | 2015 | Pharmacogenomics | pmid:26615671 |
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Girdlestone J et al. | Enhancement of the immunoregulatory potency of mesenchymal stromal cells by treatment with immunosuppressive drugs. | 2015 | Cytotherapy | pmid:26276002 |
Suzuki N et al. | In vivo regulation of erythropoiesis by chemically inducible dimerization of the erythropoietin receptor intracellular domain. | 2015 | PLoS ONE | pmid:25790231 |
Ross A and Kirsner RS | JID VisualDx Quiz: April 2015. | 2015 | J. Invest. Dermatol. | pmid:25785952 |
Tavira B et al. | ABCB1 (MDR-1) pharmacogenetics of tacrolimus in renal transplanted patients: a Next Generation Sequencing approach. | 2015 | Clin. Chem. Lab. Med. | pmid:25781547 |
Heneberg P et al. | Pimecrolimus Is a Potent Inhibitor of Allergic Reactions to Hymenopteran Venom Extracts and Birch Pollen Allergen In Vitro. | 2015 | PLoS ONE | pmid:26562153 |
Plischke M et al. | Late Conversion of Kidney Transplant Recipients from Ciclosporin to Tacrolimus Improves Graft Function: Results from a Randomized Controlled Trial. | 2015 | PLoS ONE | pmid:26270340 |
Yang CJ et al. | Differential Large-Amplitude Breathing Motions in the Interface of FKBP12-Drug Complexes. | 2015 | Biochemistry | pmid:26561008 |
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Fan J et al. | Donor IL-18 rs5744247 polymorphism as a new biomarker of tacrolimus elimination in Chinese liver transplant patients during the early post-transplantation period: results from two cohort studies. | 2015 | Pharmacogenomics | pmid:25712187 |
Morales E et al. | A case of thrombotic micro-angiopathy after heart transplantation successfully treated with eculizumab. | 2015 | Transpl. Int. | pmid:25712140 |
Buschow SI et al. | To target or not to target viral antigens in HBV related HCC? | 2015 | J. Hepatol. | pmid:25711422 |
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Jia N et al. | Collapsing focal segmental glomerulosclerosis following long-term treatment with oral ibandronate: case report and review of literature. | 2015 | BMC Cancer | pmid:26197890 |
Duong SQ et al. | Transition from brand to generic tacrolimus is associated with a decrease in trough blood concentration in pediatric heart transplant recipients. | 2015 | Pediatr Transplant | pmid:26497983 |
Kawano N et al. | Successful Secondary Umbilical Cord Blood Transplantation for Graft Failure in Acute Myelogenous Leukemia, Treated with Modified One-Day Conditioning Regimen, and Graft-Versus-Host Disease Prophylaxis Consisting of Mycophenolate and Tacrolimus. | 2015 | J Clin Exp Hematop | pmid:26490521 |
Li ZQ et al. | Efficacy and safety of tacrolimus vs. cyclophosphamide for idiopathic membranous nephropathy: A meta-analysis of Chinese adults. | 2015 | J. Huazhong Univ. Sci. Technol. Med. Sci. | pmid:26489612 |
Jóźwiak-Bębenista M et al. | The cyclic AMP effects and neuroprotective activities of PACAP and VIP in cultured astrocytes and neurons exposed to oxygen-glucose deprivation. | 2015 | Pharmacol Rep | pmid:25712659 |
Pucci N et al. | Tacrolimus vs. cyclosporine eyedrops in severe cyclosporine-resistant vernal keratoconjunctivitis: A randomized, comparative, double-blind, crossover study. | 2015 | Pediatr Allergy Immunol | pmid:25712437 |
Kim KW et al. | The effect of mammalian target of rapamycin inhibition on T helper type 17 and regulatory T cell differentiation in vitro and in vivo in kidney transplant recipients. | 2015 | Immunology | pmid:24974886 |
Yessayan L et al. | Race, Calcineurin Inhibitor Exposure, and Renal Function After Solid Organ Transplantation. | 2015 | Transplant. Proc. | pmid:26707323 |
Yoon NY et al. | Topical glucocorticoid or pimecrolimus treatment suppresses thymic stromal lymphopoietin-related allergic inflammatory mechanism in an oxazolone-induced atopic dermatitis murine model. | 2015 | Arch. Dermatol. Res. | pmid:25786383 |
Tanaka M et al. | Corticosteroid and tacrolimus treatment in neuromyelitis optica related disorders. | 2015 | Mult. Scler. | pmid:25662352 |
Van der Perren A et al. | FK506 reduces neuroinflammation and dopaminergic neurodegeneration in an α-synuclein-based rat model for Parkinson's disease. | 2015 | Neurobiol. Aging | pmid:25660193 |
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Stefanović NZ et al. | Potential role of tacrolimus in erythrocytes' antioxidative capacity in long-term period after renal transplantation. | 2015 | Eur J Pharm Sci | pmid:25657088 |
Petruzzo P et al. | Outcomes after bilateral hand allotransplantation: a risk/benefit ratio analysis. | 2015 | Ann. Surg. | pmid:24646555 |
Polańska A et al. | Monitoring of therapy in atopic dermatitis--observations with the use of high-frequency ultrasonography. | 2015 | Skin Res Technol | pmid:24894324 |
Okechuku G et al. | Anorexia nervosa in a pediatric renal transplant recipient and its reversal with cyclosporine. | 2015 | Pediatr Transplant | pmid:25661468 |
Kume K et al. | Screening for a gene deletion mutant whose temperature sensitivity is suppressed by FK506 in budding yeast and its application for a positive screening for drugs inhibiting calcineurin. | 2015 | Biosci. Biotechnol. Biochem. | pmid:25614218 |
Garnock-Jones KP | Tacrolimus prolonged release (Envarsus®): a review of its use in kidney and liver transplant recipients. | 2015 | Drugs | pmid:25613762 |
Li CJ and Li L | Tacrolimus in preventing transplant rejection in Chinese patients--optimizing use. | 2015 | Drug Des Devel Ther | pmid:25609922 |
Uemoto S et al. | Early coupled up-regulation of interleukin-12 receptor beta-1 in CD8+ central memory and effector T cells for better clinical outcomes in liver transplant recipients. | 2015 | Clin. Exp. Immunol. | pmid:25603847 |
Oda K et al. | In vitro-in vivo extrapolations to evaluate the effect of concomitant drugs on tacrolimus (FK506) exposure. | 2015 | Biopharm Drug Dispos | pmid:25600613 |
Overk CR et al. | Differential calcium alterations in animal models of neurodegenerative disease: Reversal by FK506. | 2015 | Neuroscience | pmid:26341908 |
de Jonge H et al. | Progressive decline in tacrolimus clearance after renal transplantation is partially explained by decreasing CYP3A4 activity and increasing haematocrit. | 2015 | Br J Clin Pharmacol | pmid:26114223 |
Kallscheuer N et al. | Single-Domain Peptidyl-Prolyl cis/trans Isomerase FkpA from Corynebacterium glutamicum Improves the Biomass Yield at Increased Growth Temperatures. | 2015 | Appl. Environ. Microbiol. | pmid:26341203 |
Rojas-Vega L et al. | Increased phosphorylation of the renal Na+-Cl- cotransporter in male kidney transplant recipient patients with hypertension: a prospective cohort. | 2015 | Am. J. Physiol. Renal Physiol. | pmid:26336164 |
Sánchez-Lázaro I et al. | Association of SNPs with the efficacy and safety of immunosuppressant therapy after heart transplantation. | 2015 | Pharmacogenomics | pmid:26107754 |
Teixeira Mdo C et al. | Influence of post-transplant immunosuppressive therapy on gastrointestinal transit using biomagnetic method: a pilot study. | 2015 | Dig. Dis. Sci. | pmid:25146844 |
Schnitzbauer AA et al. | Delayed bottom-up and amended simple method of dosing with once-daily tacrolimus application to achieve stable trough levels in liver transplantation. | 2015 | Ann. Transplant. | pmid:25553853 |
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Aruch DB and Renteria A | Simultaneous PRES and TMA secondary to tacrolimus after allogeneic bone marrow transplant. | 2015 | Blood | pmid:26287041 |
Coilly A et al. | Once-daily prolonged release tacrolimus in liver transplantation: Experts' literature review and recommendations. | 2015 | Liver Transpl. | pmid:26264233 |
Minami-Hori M et al. | Periorbital lupus profundus successfully treated with oral tacrolimus plus low-dose prednisolone. | 2015 | J. Dermatol. | pmid:25544984 |
Pagliarello C et al. | Calcipotriol/betamethasone dipropionate ointment compared with tacrolimus ointment for the treatment of erosive pustular dermatosis of the scalp: a split-lesion comparison. | 2015 | Eur J Dermatol | pmid:25786341 |
Xing J et al. | Association between interleukin-18 promoter variants and tacrolimus pharmacokinetics in Chinese renal transplant patients. | 2015 | Eur. J. Clin. Pharmacol. | pmid:25487141 |
Gong N et al. | Immunoregulatory effects of sirolimus vs. tacrolimus treatment in kidney allograft recipients. | 2015 | Cell. Immunol. | pmid:26205091 |
Chamani G et al. | Efficacy of tacrolimus and clobetasol in the treatment of oral lichen planus: a systematic review and meta-analysis. | 2015 | Int. J. Dermatol. | pmid:26204904 |
Muduma G et al. | Evaluating the economic implications of non-adherence and antibody-mediated rejection in renal transplant recipients: the role of once-daily tacrolimus in the UK. | 2015 | J Med Econ | pmid:26201252 |
Mizuno K et al. | Dexamethasone but not tacrolimus suppresses TNF-α-induced thymic stromal lymphopoietin expression in lesional keratinocytes of atopic dermatitis model. | 2015 | J. Dermatol. Sci. | pmid:26198442 |
Niioka T et al. | Effects of CYP3A5 polymorphism and the tacrolimus 12 h concentration on tacrolimus-induced acute renal dysfunction in patients with lupus nephritis. | 2015 | Xenobiotica | pmid:26189776 |
Rathi M et al. | Conversion from tacrolimus to cyclosporine in patients with new-onset diabetes after renal transplant: an open-label randomized prospective pilot study. | 2015 | Transplant. Proc. | pmid:26036543 |
Mohsin N et al. | Pharmacokinetics of mycophenolate mofetil in Omani patients on cyclosporine or tacrolimus. | 2015 | Transplant. Proc. | pmid:26036534 |
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