Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with tacrolimus
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Kiuchi T et al. | Experience of tacrolimus-based immunosuppression in living-related liver transplantation complicated with graft tuberculosis: interaction with rifampicin and side effects. | 1996 | Transplant. Proc. | pmid:8962229 |
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Braun F et al. | Clinical relevance of monitoring tacrolimus: comparison of microparticle enzyme immunoassay, enzyme-linked immunosorbent assay, and liquid chromatography mass spectrometry in renal transplant recipients converted from cyclosporine to tacrolimus. | 1996 | Transplant. Proc. | pmid:8962231 |
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Yussim A et al. | Conversion from cyclosporine to tacrolimus in hepatic and renal transplantation. | 1996 | Transplant. Proc. | pmid:8962233 |
Golling M et al. | Tacrolimus reduction improves glucose metabolism and insulin secretion after liver transplantation. | 1996 | Transplant. Proc. | pmid:8962234 |
Platz KP et al. | Incidence and outcome of chronic rejection in CyA- and FK 506-treated patients. | 1996 | Transplant. Proc. | pmid:8962235 |
Mollison KW et al. | Discovery of FK 506 analogues that are nontoxic to mouse pancreatic beta cells in vitro but show diabetogenic potential when administered to the rat. | 1996 | Transplant. Proc. | pmid:8962236 |
Yokoyama I et al. | Decreased Fas antigen expression of cultured hepatocytes with FK 506. | 1996 | Transplant. Proc. | pmid:8962237 |
Mueller AR et al. | Long-term follow-up in hepatitis C patients with respect to immunosuppression. | 1996 | Transplant. Proc. | pmid:8962255 |
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Guérette B et al. | Increased interferon-gamma mRNA expression following alloincompatible myoblast transplantation is inhibited by FK506. | 1996 | Muscle Nerve | pmid:8965835 |
Sharkey J et al. | Tacrolimus (FK506) ameliorates skilled motor deficits produced by middle cerebral artery occlusion in rats. | 1996 | Stroke | pmid:8969794 |
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Taler SJ et al. | Role of steroid dose in hypertension early after liver transplantation with tacrolimus (FK506) and cyclosporine. | 1996 | Transplantation | pmid:8970613 |
Hisanaga Y et al. | Implication of nitric oxide synthase activity in the genesis of water immersion stress-induced gastric lesions in rats: the protective effects of FK506. | 1996 | Aliment. Pharmacol. Ther. | pmid:8971291 |
Corey HE et al. | Improved renal allograft survival in children treated with FK 506 (tacrolimus) rescue therapy. | 1996 | Pediatr. Nephrol. | pmid:8971888 |
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Blecher O et al. | A novel plant peptidyl-prolyl-cis-trans-isomerase (PPIase): cDNA cloning, structural analysis, enzymatic activity and expression. | 1996 | Plant Mol. Biol. | pmid:8980498 |
Odom A et al. | The immunosuppressant FK506 and its nonimmunosuppressive analog L-685,818 are toxic to Cryptococcus neoformans by inhibition of a common target protein. | 1997 | Antimicrob. Agents Chemother. | pmid:8980772 |
Nichterlein T et al. | Effects of FK-506 on the course of murine salmonellosis. | 1996 | J Chemother | pmid:8981186 |
Redmon JB et al. | Effects of tacrolimus (FK506) on human insulin gene expression, insulin mRNA levels, and insulin secretion in HIT-T15 cells. | 1996 | J. Clin. Invest. | pmid:8981925 |
Sempuku T et al. | Osteogenic potential of allogeneic rat marrow cells in porous hydroxyapatite ceramics: a histological study. | 1996 | J. Orthop. Res. | pmid:8982133 |
High KP and Washburn RG | Invasive aspergillosis in mice immunosuppressed with cyclosporin A, tacrolimus (FK506), or sirolimus (rapamycin). | 1997 | J. Infect. Dis. | pmid:8985226 |
Yoshikai Y et al. | Clonal expansion of superantigen-reactive T cells is resistant to FK506 in mice with AIDS. | 1997 | J. Virol. | pmid:8985410 |
pmid:8986461 | ||||
Shapiro R et al. | Tacrolimus in pediatric renal transplantation. | 1996 | Transplantation | pmid:8990356 |
Przepiorka D et al. | Allogeneic transplantation for advanced leukemia: improved short-term outcome with blood stem cell grafts and tacrolimus. | 1996 | Transplantation | pmid:8990368 |
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Ericzon BG et al. | Secretion and composition of bile after human liver transplantation: studies on the effects of cyclosporine and tacrolimus. | 1997 | Transplantation | pmid:9000664 |
Kelly PA et al. | Ciprofloxacin does not block the antiproliferative effect of tacrolimus. | 1997 | Transplantation | pmid:9000686 |
Nair SC et al. | Molecular cloning of human FKBP51 and comparisons of immunophilin interactions with Hsp90 and progesterone receptor. | 1997 | Mol. Cell. Biol. | pmid:9001212 |
Pirenne J et al. | Donor-specific unmodified bone marrow transfusion does not facilitate intestinal engraftment after bowel transplantation in a porcine model. | 1997 | Surgery | pmid:9001555 |
Felldin M et al. | Rescue therapy with tacrolimus (FK 506) in renal transplant recipients--a Scandinavian multicenter analysis. | 1997 | Transpl. Int. | pmid:9002146 |
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Matsui A et al. | Apparently increased trough levels of tacrolimus caused by acute infantile diarrhea in two infants with biliary atresia after liver transplantation. | 1996 | Acta Paediatr Jpn | pmid:9002314 |
DeCenzo MT et al. | FK506-binding protein mutational analysis: defining the active-site residue contributions to catalysis and the stability of ligand complexes. | 1996 | Protein Eng. | pmid:9005438 |
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Ishizuka T et al. | Rapamycin potentiates dexamethasone-induced apoptosis and inhibits JNK activity in lymphoblastoid cells. | 1997 | Biochem. Biophys. Res. Commun. | pmid:9016789 |
Richardson D et al. | The successful conversion to Tacrolimus (FK506) of a renal transplant recipient with cyclosporin-induced haemolytic-uraemic syndrome. | 1996 | Nephrol. Dial. Transplant. | pmid:9017633 |
Sano Y et al. | Effect of a single injection of high-dose FK506 on lung transplantation in rats. | 1996 | Surg. Today | pmid:9017963 |
Villalba L and Adams EM | Update on therapy for refractory dermatomyositis and polymyositis. | 1996 | Curr Opin Rheumatol | pmid:9018458 |
Jordan ML et al. | Tacrolimus rescue therapy for renal allograft rejection--five-year experience. | 1997 | Transplantation | pmid:9020321 |
Mazariegos GV et al. | Weaning of immunosuppression in liver transplant recipients. | 1997 | Transplantation | pmid:9020325 |
Marks WH et al. | Asialoglycoprotein/asialoglycoprotein receptor (AGP-AGPr) interaction is an important mechanism for the uptake of FK506 by hepatocytes. | 1997 | Transplantation | pmid:9020333 |
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Aiko S et al. | Effects of cyclosporine or FK506 in chronic colitis. | 1997 | J. Pharmacol. Exp. Ther. | pmid:9023326 |
Budde K et al. | Differing proteinuria control with cyclosporin and tacrolimus. | 1997 | Lancet | pmid:9024386 |
Lo Russo A et al. | Cyclosporin A potentiates receptor-activated [Ca2+]c increase. | 1997 Jan-May | J. Recept. Signal Transduct. Res. | pmid:9029487 |
Iwasaki K et al. | Binding of tacrolimus (FK506) with human plasma proteins re-evaluation and effect of mycophenolic acid. | 1996 | Res. Commun. Mol. Pathol. Pharmacol. | pmid:9029671 |
Alak AM et al. | A highly sensitive enzyme-linked immunosorbent assay for the determination of tacrolimus in atopic dermatitis patients. | 1997 | Ther Drug Monit | pmid:9029754 |
Padhi ID et al. | Interaction between tacrolimus and erythromycin. | 1997 | Ther Drug Monit | pmid:9029762 |
Markus PM et al. | Allogeneic hepatocyte transplantation using FK 506. | 1997 Jan-Feb | Cell Transplant | pmid:9040958 |
Tsuchida Y et al. | Limb allografts in rats treated with anti-ICAM-1 and anti-LFA-1 monoclonal antibodies. | 1997 | J Reconstr Microsurg | pmid:9044184 |
Wang W et al. | c-Rel is a target of pentoxifylline-mediated inhibition of T lymphocyte activation. | 1997 | Immunity | pmid:9047238 |
Steiner JP et al. | Neurotrophic immunophilin ligands stimulate structural and functional recovery in neurodegenerative animal models. | 1997 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9050897 |
Seidel ER and Ragan VL | Inhibition by rapamycin of ornithine decarboxylase and epithelial cell proliferation in intestinal IEC-6 cells in culture. | 1997 | Br. J. Pharmacol. | pmid:9051292 |
Bagnis C et al. | Comparative acute nephrotoxicity of FK-506 and ciclosporin in an isolated in situ autoperfused rat kidney model. | 1997 | Am. J. Nephrol. | pmid:9057948 |
Ivery MT and Weiler L | Modeling the interaction between FK506 and FKBP12: a mechanism for formation of the calcineurin inhibitory complex. | 1997 | Bioorg. Med. Chem. | pmid:9061187 |
Garcia-Morales R et al. | The effects of chimeric cells following donor bone marrow infusions as detected by PCR-flow assays in kidney transplant recipients. | 1997 | J. Clin. Invest. | pmid:9062371 |
Göthel SF et al. | An internal FK506-binding domain is the catalytic core of the prolyl isomerase activity associated with the Bacillus subtilis trigger factor. | 1997 | Eur. J. Biochem. | pmid:9063446 |
Motamedi H et al. | Structural organization of a multifunctional polyketide synthase involved in the biosynthesis of the macrolide immunosuppressant FK506. | 1997 | Eur. J. Biochem. | pmid:9063448 |
Guckelberger O et al. | Cardiovascular risk factors in long-term follow-up after orthotopic liver transplantation. | 1997 | Clin Transplant | pmid:9067697 |
Singh N et al. | Clinical spectrum of invasive cryptococcosis in liver transplant recipients receiving tacrolimus. | 1997 | Clin Transplant | pmid:9067698 |
Victor RG et al. | Mechanism of Ca(2+)-dependent inactivation of L-type Ca2+ channels in GH3 cells: direct evidence against dephosphorylation by calcineurin. | 1997 | J. Membr. Biol. | pmid:9070464 |
Grobecker HF et al. | Cyclosporine A-induced hypertension in SHR and WKY: role of the sympatho-adrenal system. | 1995 | Clin Exp Pharmacol Physiol Suppl | pmid:9072458 |
Guo Z et al. | In vivo effects of leflunomide on normal pancreatic islet and syngeneic islet graft function. | 1997 | Transplantation | pmid:9075844 |
Ciancio G et al. | Use of intravenous FK506 to treat acute rejection in simultaneous pancreas-kidney transplant recipients on maintenance oral FK506. | 1997 | Transplantation | pmid:9075856 |
Mirza DF et al. | Reduced acute rejection after liver transplantation with Neoral-based triple immunosuppression. | 1997 | Lancet | pmid:9078209 |
Yoshikawa H et al. | FK506 prevents induction of rat experimental autoimmune myasthenia gravis. | 1997 | J. Autoimmun. | pmid:9080295 |
de Paulis A et al. | Human synovial mast cells. II. Heterogeneity of the pharmacologic effects of antiinflammatory and immunosuppressive drugs. | 1997 | Arthritis Rheum. | pmid:9082935 |
Ohashi Y et al. | Successful treatment of steroid-resistant severe acute GVHD with 24-h continuous infusion of FK506. | 1997 | Bone Marrow Transplant. | pmid:9085743 |
Oz HS and Hughes WT | Novel anti-Pneumocystis carinii effects of the immunosuppressant mycophenolate mofetil in contrast to provocative effects of tacrolimus, sirolimus, and dexamethasone. | 1997 | J. Infect. Dis. | pmid:9086147 |
Wagner K et al. | New-onset diabetes mellitus in pediatric thoracic organ recipients receiving tacrolimus-based immunosuppression. | 1997 | J. Heart Lung Transplant. | pmid:9087870 |
Yasutomi M et al. | Evaluation of tetrahydropyranyladriamycin as an immunosuppressant in concordant xenotransplantation. | 1997 | J. Heart Lung Transplant. | pmid:9087871 |
Morrissey PE et al. | Correlation of clinical outcomes after tacrolimus conversion for resistant kidney rejection or cyclosporine toxicity with pathologic staging by the Banff criteria. | 1997 | Transplantation | pmid:9089224 |
Kiuchi T et al. | A hepatic graft tuberculosis transmitted from a living-related donor. | 1997 | Transplantation | pmid:9089234 |
Krämer BK and Schweda F | Differing proteinuria control with cyclosporin and tacrolimus. | 1997 | Lancet | pmid:9093272 |
Maurer M et al. | Hair growth modulation by topical immunophilin ligands: induction of anagen, inhibition of massive catagen development, and relative protection from chemotherapy-induced alopecia. | 1997 | Am. J. Pathol. | pmid:9094998 |
Steiner JP et al. | Neurotrophic actions of nonimmunosuppressive analogues of immunosuppressive drugs FK506, rapamycin and cyclosporin A. | 1997 | Nat. Med. | pmid:9095176 |
Mori A et al. | Enhanced production and gene expression of IL-5 in bronchial asthma. Possible management of atopic diseases with IL-5 specific gene transcription inhibitor. | 1996 | Adv. Exp. Med. Biol. | pmid:9095279 |
Blau CA et al. | A proliferation switch for genetically modified cells. | 1997 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9096348 |
Bowman AR et al. | The role of testosterone in cyclosporine-induced osteopenia. | 1997 | J. Bone Miner. Res. | pmid:9101372 |
Taylor P et al. | Conformational polymorphism in peptidic and nonpeptidic drug molecules. | 1996 | Biopolymers | pmid:9101762 |
Guérette B et al. | Inflammatory damage following first-generation replication-defective adenovirus controlled by anti-LFA-1. | 1997 | J. Leukoc. Biol. | pmid:9103242 |
Mori A et al. | IL-2-induced IL-5 synthesis, but not proliferation, of human CD4+ T cells is suppressed by FK506. | 1997 | J. Immunol. | pmid:9103428 |
Hess DA et al. | The hydroxylamine of sulfamethoxazole synergizes with FK506 and cyclosporin A, inhibiting T-cell proliferation. | 1997 | J. Pharmacol. Exp. Ther. | pmid:9103542 |
Kawamura N et al. | Extremely high serum level of IgE during immunosuppressive therapy: paradoxical effect of cyclosporine A and tacrolimus. | 1997 | Int. Arch. Allergy Immunol. | pmid:9104801 |
Beals CR et al. | Nuclear localization of NF-ATc by a calcineurin-dependent, cyclosporin-sensitive intramolecular interaction. | 1997 | Genes Dev. | pmid:9106655 |
Lee JW et al. | Tacrolimus (FK506): validation of a sensitive enzyme-linked immunosorbent assay kit for and application to a clinical pharmacokinetic study. | 1997 | Ther Drug Monit | pmid:9108651 |
Holt DW and Johnston A | Tacrolimus quality assessment. | 1997 | Ther Drug Monit | pmid:9108659 |
Pirsch JD et al. | A comparison of tacrolimus (FK506) and cyclosporine for immunosuppression after cadaveric renal transplantation. FK506 Kidney Transplant Study Group. | 1997 | Transplantation | pmid:9112351 |
Hikita N et al. | Use of topical FK506 in a corneal graft rejection model in Lewis rats. | 1997 | Invest. Ophthalmol. Vis. Sci. | pmid:9112986 |