tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Donners MM et al. | Inflammation and restenosis: implications for therapy. | 2003 | Ann. Med. | pmid:14649334 |
| Sun L et al. | Cellular and molecular consequences of calcineurin A alpha gene deletion. | 2007 | Ann. N. Y. Acad. Sci. | pmid:17872390 |
| Shipston MJ et al. | Glucocorticoid negative feedback in pituitary corticotropes. Pivotal role for calcineurin inhibition of adenylyl cyclase. | 1994 | Ann. N. Y. Acad. Sci. | pmid:7529975 |
| Iwanaga Y et al. | Living donor islet transplantation, the alternative approach to overcome the obstacles limiting transplant. | 2006 | Ann. N. Y. Acad. Sci. | pmid:17130575 |
| Xu L et al. | Potential for pharmacology of ryanodine receptor/calcium release channels. | 1998 | Ann. N. Y. Acad. Sci. | pmid:10603942 |
| Bers DM et al. | Factors that control sarcoplasmic reticulum calcium release in intact ventricular myocytes. | 1998 | Ann. N. Y. Acad. Sci. | pmid:10603944 |
| Engelbrecht ME et al. | The effect of immunosuppressants on human leukocyte NADPH oxidase. | 1994 | Ann. N. Y. Acad. Sci. | pmid:7518204 |
| Zuany-Amorim C et al. | Modulation by rm interferon-gamma and CD4+ T-lymphocytes of allergic eosinophil accumulation in the mice peritoneal cavity. | 1994 | Ann. N. Y. Acad. Sci. | pmid:7518212 |
| Nagai H et al. | The role of interleukin-5 (IL-5) in allergic airway hyperresponsiveness in mice. | 1996 | Ann. N. Y. Acad. Sci. | pmid:8906215 |
| Clipstone NA and Crabtree GR | Calcineurin is a key signaling enzyme in T lymphocyte activation and the target of the immunosuppressive drugs cyclosporin A and FK506. | 1993 | Ann. N. Y. Acad. Sci. | pmid:7509131 |
| Takahara S | Efficacy of FK506 in renal transplantation. | 1993 | Ann. N. Y. Acad. Sci. | pmid:7509132 |
| Thomson AW et al. | Incidence of CD4+ IL-2R alpha+ and CD4+ CD45RA+ T-cells in progressive multiple sclerosis and the influence of short-term (3 months) FK 506 therapy. | 1993 | Ann. N. Y. Acad. Sci. | pmid:7509133 |
| Lemster B et al. | FK 506 inhibits cytokine gene and adhesion molecule expression in psoriatic skin lesions. | 1993 | Ann. N. Y. Acad. Sci. | pmid:7509134 |
| Tamura K et al. | Inhibitory effect of FK 506 on autoimmune thyroid disease in the PVG rat. | 1993 | Ann. N. Y. Acad. Sci. | pmid:7509135 |
| Ochiai T et al. | Combination of immunosuppressive drugs for organ transplantation. | 1993 | Ann. N. Y. Acad. Sci. | pmid:7509136 |
| Wiederrecht G et al. | The mechanism of action of FK-506 and cyclosporin A. | 1993 | Ann. N. Y. Acad. Sci. | pmid:7509138 |
| Lee RK and Wurtman RJ | Regulation of APP synthesis and secretion by neuroimmunophilin ligands and cyclooxygenase inhibitors. | 2000 | Ann. N. Y. Acad. Sci. | pmid:11193162 |
| Christensen BG | FK-506: its role in immunosuppression. | 1993 | Ann. N. Y. Acad. Sci. | pmid:7689803 |
| Kino T and Goto T | Discovery of FK-506 and update. | 1993 | Ann. N. Y. Acad. Sci. | pmid:7689804 |
| Parsons WH et al. | FK-506--a novel immunosuppressant. | 1993 | Ann. N. Y. Acad. Sci. | pmid:7689805 |
| Zenke G et al. | Molecular mechanisms of immunosuppression by cyclosporins. | 1993 | Ann. N. Y. Acad. Sci. | pmid:7689806 |
| Clardy J | Structural studies of complexed FK-506 binding protein. | 1993 | Ann. N. Y. Acad. Sci. | pmid:7689808 |
| Starzl TE et al. | Allograft and xenograft acceptance under FK-506 and other immunosuppressant treatment. | 1993 | Ann. N. Y. Acad. Sci. | pmid:7689809 |
| Reem GH et al. | FK-506 inhibits the IL-2-independent induction of the activation antigen CD 69. | 1993 | Ann. N. Y. Acad. Sci. | pmid:7689811 |
| Mollison KW et al. | Comparison of FK-506, rapamycin, ascomycin, and cyclosporine in mouse models of host-versus-graft disease and heterotopic heart transplantation. | 1993 | Ann. N. Y. Acad. Sci. | pmid:7689812 |
| Ponseti JM et al. | Tacrolimus for myasthenia gravis: a clinical study of 212 patients. | 2008 | Ann. N. Y. Acad. Sci. | pmid:18096852 |
| Paterson DL et al. | Could a herpesvirus mimic tacrolimus-induced leukoencephalopathy? | 1997 | Ann. Neurol. | pmid:9266742 |
| Caprariello AV et al. | Apoptosis of oligodendrocytes in the central nervous system results in rapid focal demyelination. | 2012 | Ann. Neurol. | pmid:23034912 |
| Keswani SC et al. | FK506 is neuroprotective in a model of antiretroviral toxic neuropathy. | 2003 | Ann. Neurol. | pmid:12509848 |
| Dawson TM | Immunosuppressants, immunophilins, and the nervous system. | 1996 | Ann. Neurol. | pmid:8871573 |
| Small SL et al. | Immunosuppression-induced leukoencephalopathy from tacrolimus (FK506) | 1996 | Ann. Neurol. | pmid:8871576 |
| Roberts WK et al. | A destructive feedback loop mediated by CXCL10 in central nervous system inflammatory disease. | 2015 | Ann. Neurol. | pmid:26224283 |
| Wijdicks EF et al. | FK506-induced neurotoxicity in liver transplantation. | 1994 | Ann. Neurol. | pmid:7512320 |
| Nelson M et al. | Direct revascularization is superior for rat parathyroid allotransplantation with FK506. | 2005 | Ann. Otol. Rhinol. Laryngol. | pmid:15825570 |
| Gerster JC et al. | Gout in liver transplant patients receiving tacrolimus. | 2004 | Ann. Rheum. Dis. | pmid:15194597 |
| Igarashi T et al. | Central nervous system toxicity related to FK506 in patients with Behçet's disease. | 1994 | Ann. Rheum. Dis. | pmid:7517134 |
| Villaverde V et al. | Leg bone pain syndrome in a kidney transplant patient treated with tacrolimus (FK506) | 1999 | Ann. Rheum. Dis. | pmid:10577370 |
| Duddridge M and Powell RJ | Treatment of severe and difficult cases of systemic lupus erythematosus with tacrolimus. A report of three cases. | 1997 | Ann. Rheum. Dis. | pmid:9462174 |
| Lightman S et al. | Pegylated interferon-α-2b reduces corticosteroid requirement in patients with Behçet's disease with upregulation of circulating regulatory T cells and reduction of Th17. | 2015 | Ann. Rheum. Dis. | pmid:25269831 |
| Lampropoulos CE and D' Cruz DP | Topical tacrolimus treatment in a patient with dermatomyositis. | 2005 | Ann. Rheum. Dis. | pmid:16100347 |
| Mok CC et al. | Tacrolimus versus mycophenolate mofetil for induction therapy of lupus nephritis: a randomised controlled trial and long-term follow-up. | 2016 | Ann. Rheum. Dis. | pmid:25550339 |
| Lerut JP et al. | Is minimal, [almost] steroid-free immunosuppression a safe approach in adult liver transplantation? Long-term outcome of a prospective, double blind, placebo-controlled, randomized, investigator-driven study. | 2014 | Ann. Surg. | pmid:25379858 |
| Schlegel A et al. | Hypothermic Oxygenated Perfusion (HOPE) downregulates the immune response in a rat model of liver transplantation. | 2014 | Ann. Surg. | pmid:25243553 |
| Colombani PM et al. | Liver transplantation in infants younger than 1 year of age. | 1996 | Ann. Surg. | pmid:8645039 |
| Todo S et al. | Liver, kidney, and thoracic organ transplantation under FK 506. | 1990 | Ann. Surg. | pmid:1697743 |
| Stratta RJ et al. | Evolution in pancreas transplantation techniques: simultaneous kidney-pancreas transplantation using portal-enteric drainage without antilymphocyte induction. | 1999 | Ann. Surg. | pmid:10235529 |
| Shapiro R et al. | Kidney transplantation under a tolerogenic regimen of recipient pretreatment and low-dose postoperative immunosuppression with subsequent weaning. | 2003 | Ann. Surg. | pmid:14530723 |
| Fealy MJ et al. | Efficacy of rapamycin and FK 506 in prolonging rat hind limb allograft survival. | 1994 | Ann. Surg. | pmid:7507657 |
| Ozawa K et al. | An appraisal of pediatric liver transplantation from living relatives. Initial clinical experiences in 20 pediatric liver transplantations from living relatives as donors. | 1992 | Ann. Surg. | pmid:1280074 |
| Vivarelli M et al. | Liver transplantation for hepatocellular carcinoma under calcineurin inhibitors: reassessment of risk factors for tumor recurrence. | 2008 | Ann. Surg. | pmid:18948815 |
| Abu-Elmagd K et al. | Clinical intestinal transplantation: a decade of experience at a single center. | 2001 | Ann. Surg. | pmid:11524593 |
| Petruzzo P et al. | Outcomes after bilateral hand allotransplantation: a risk/benefit ratio analysis. | 2015 | Ann. Surg. | pmid:24646555 |
| Todo S et al. | Single-center experience with primary orthotopic liver transplantation with FK 506 immunosuppression. | 1994 | Ann. Surg. | pmid:7522431 |
| Jain A et al. | What have we learned about primary liver transplantation under tacrolimus immunosuppression? Long-term follow-up of the first 1000 patients. | 1999 | Ann. Surg. | pmid:10493490 |
| Lerut J et al. | Tacrolimus monotherapy in liver transplantation: one-year results of a prospective, randomized, double-blind, placebo-controlled study. | 2008 | Ann. Surg. | pmid:19092340 |
| Schneeberger S et al. | Upper-extremity transplantation using a cell-based protocol to minimize immunosuppression. | 2013 | Ann. Surg. | pmid:23001085 |
| Bartlett ST et al. | Equivalent success of simultaneous pancreas kidney and solitary pancreas transplantation. A prospective trial of tacrolimus immunosuppression with percutaneous biopsy. | 1996 | Ann. Surg. | pmid:8857849 |
| Todo S et al. | Intestinal transplantation in composite visceral grafts or alone. | 1992 | Ann. Surg. | pmid:1384443 |
| Sho M et al. | New insights into the interactions between T-cell costimulatory blockade and conventional immunosuppressive drugs. | 2002 | Ann. Surg. | pmid:12409674 |
| McCourtie AS et al. | Synergistic protection in lung ischemia-reperfusion injury with calcineurin and thrombin inhibition. | 2010 | Ann. Thorac. Surg. | pmid:20494024 |
| Laubach VE | Invited commentary. | 2010 | Ann. Thorac. Surg. | pmid:20494025 |
| Li S et al. | Intrathymic inoculation of donor bone marrow induces long-term acceptance of lung allografts. | 2003 | Ann. Thorac. Surg. | pmid:12537225 |
| Sugita M et al. | Pharmacologic modulation of alveolar liquid clearance in transplanted lungs by phentolamine and FK506. | 2009 | Ann. Thorac. Surg. | pmid:19699927 |
| Moffatt-Bruce S | Invited commentary. | 2009 | Ann. Thorac. Surg. | pmid:19699928 |
| Thyagarajan GK et al. | FK506-induced fulminant leukoencephalopathy after single-lung transplantation. | 1997 | Ann. Thorac. Surg. | pmid:9386723 |
| Leshnower BG et al. | Cyclosporine preserves mitochondrial morphology after myocardial ischemia/reperfusion independent of calcineurin inhibition. | 2008 | Ann. Thorac. Surg. | pmid:18805178 |
| Chambers DJ | Invited commentary. | 2008 | Ann. Thorac. Surg. | pmid:18805179 |
| Nathan M et al. | Cyclosporin A but not FK-506 protects against dopamine-induced apoptosis in the stunned heart. | 2005 | Ann. Thorac. Surg. | pmid:15854943 |
| Hirai T et al. | A short course of FK506 can induce limited donor-specific graft acceptance. | 1994 | Ann. Thorac. Surg. | pmid:7520685 |
| Armitage JM et al. | Clinical trial of FK 506 immunosuppression in adult cardiac transplantation. | 1992 | Ann. Thorac. Surg. | pmid:1379032 |
| Oto T et al. | Calcineurin inhibitor-related cholestasis complicating lung transplantation. | 2010 | Ann. Thorac. Surg. | pmid:20417810 |
| Groetzner J et al. | Cardiac transplantation in pediatric patients: fifteen-year experience of a single center. | 2005 | Ann. Thorac. Surg. | pmid:15620914 |
| Inutsuka K et al. | Reconstruction of trachea and carina with immediate or cryopreserved allografts in dogs. | 1996 | Ann. Thorac. Surg. | pmid:8893587 |
| Bolman RM | Advantage--FK 506: reduced chronic rejection for lung transplant recipients. | 1995 | Ann. Thorac. Surg. | pmid:7545888 |
| Keenan RJ et al. | Clinical trial of tacrolimus versus cyclosporine in lung transplantation. | 1995 | Ann. Thorac. Surg. | pmid:7545889 |
| Muraki Y et al. | Impact of CYP3A5 genotype of recipients as well as donors on the tacrolimus pharmacokinetics and infectious complications after living-donor liver transplantation for Japanese adult recipients. | 2011 Oct-Dec | Ann. Transplant. | pmid:22210422 |
| Fox BD et al. | Tacrolimus Levels Are Not Associated with Risk of Malignancy in Lung Transplant Recipients. | 2017 | Ann. Transplant. | pmid:29133776 |
| Legris T et al. | Humoral immunity after kidney transplantation: impact of two randomized immunosuppressive protocols. | 2013 | Ann. Transplant. | pmid:24231646 |
| Gijsen VM et al. | Tacrolimus-induced nephrotoxicity and genetic variability: a review. | 2012 Apr-Jun | Ann. Transplant. | pmid:22743729 |
| Urbanowicz T et al. | Induction therapy, tacrolimus plasma concentration, and duration if intensive care unit stay are risk factors for peripheral leucopenia following heart transplantation. | 2014 | Ann. Transplant. | pmid:25274118 |
| Baron PW et al. | Post-Transplant Diabetes Mellitus After Kidney Transplant in Hispanics and Caucasians Treated with Tacrolimus-Based Immunosuppression. | 2017 | Ann. Transplant. | pmid:28533501 |
| Roan JN et al. | Dose-normalization for exposure to mycophenolic acid and the early clinical outcome in patients taking tacrolimus after heart transplantation. | 2013 | Ann. Transplant. | pmid:23792500 |
| Tanaka T et al. | Evaluation of immune function under conversion from Prograf to Advagraf in living donor liver transplantation. | 2013 | Ann. Transplant. | pmid:23792533 |
| Kuypers DR | Influence of interactions between immunosuppressive drugs on therapeutic drug monitoring. | 2008 | Ann. Transplant. | pmid:18806728 |
| Figurski MJ et al. | Pharmacokinetic monitoring of mycophenolic acid in heart transplant patients: correlation the side-effects and rejections with pharmacokinetic parameters. | 2012 Jan-Mar | Ann. Transplant. | pmid:22466911 |
| Acott P and Babel N | BK virus replication following kidney transplant: does the choice of immunosuppressive regimen influence outcomes? | 2012 Jan-Mar | Ann. Transplant. | pmid:22466913 |
| Baran DA and Galin ID | "One size fits all": immunosuppression in cardiac transplantation. | 2003 | Ann. Transplant. | pmid:12848376 |
| Zahn A et al. | Mycophenolate mofetil combination therapy improves survival after liver transplantation. A single-center retrospective analysis. | 2013 | Ann. Transplant. | pmid:24088725 |
| WÅ‚odarczyk Z et al. | Freedom from rejection and stable kidney function are excellent criteria for steroid withdrawal in tacrolimus-treated kidney transplant recipients. | 2002 | Ann. Transplant. | pmid:12465429 |
| Park S et al. | Reduced Tacrolimus Trough Level Is Reflected by Estimated Glomerular Filtration Rate (eGFR) Changes in Stable Renal Transplantation Recipients: Results of the OPTIMUM Phase 3 Randomized Controlled Study. | 2018 | Ann. Transplant. | pmid:29891834 |
| Jannot M et al. | Early conversion from twice-daily tacrolimus to once-daily extended formulation in renal transplant patients before hospital discharge. | 2014 | Ann. Transplant. | pmid:24999809 |
| Urbanowicz T et al. | Comparison of conventional tacrolimus versus prolong release formula as initial therapy in heart transplantation. | 2014 | Ann. Transplant. | pmid:24949728 |
| Hošková L et al. | Comparison of Cystatin C and NGAL in Early Diagnosis of Acute Kidney Injury After Heart Transplantation. | 2016 | Ann. Transplant. | pmid:27226081 |
| Abdel Halim M et al. | Toxic tacrolimus blood levels with rifampin administration in a renal transplant recipient. | 2010 Jan-Mar | Ann. Transplant. | pmid:20305320 |
| Wu P et al. | Polymorphisms in CYP3A5*3 and MDR1, and haplotype modulate response to plasma levels of tacrolimus in Chinese renal transplant patients. | 2011 Jan-Mar | Ann. Transplant. | pmid:21436775 |
| Malinowski M et al. | The influence of commonly used immunosuppressive drugs on the small bowel functions - a comparative experimental study. | 2009 Apr-Jun | Ann. Transplant. | pmid:19487793 |
| Kitazawa F et al. | Pharmacokinetic Interaction Between Tacrolimus and Fentanyl in Patients Receiving Allogeneic Hematopoietic Stem Cell Transplantation. | 2017 | Ann. Transplant. | pmid:28947731 |
| Hirano Y et al. | Prolonged Administration of Twice-Daily Bolus Intravenous Tacrolimus in the Early Phase After Lung Transplantation. | 2017 | Ann. Transplant. | pmid:28798289 |
| Duvoux C et al. | Sustained virological response to antiviral therapy in a randomized trial of cyclosporine versus tacrolimus in liver transplant patients with recurrent hepatitis C infection. | 2015 | Ann. Transplant. | pmid:25588713 |
| Mijal J et al. | Formation of synapses between dendritic cells and lymphocytes in skin lymph in an allogeneic reaction. | 2002 | Ann. Transplant. | pmid:12854345 |