Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with tacrolimus
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Liao R et al. | Tacrolimus Protects Podocytes from Injury in Lupus Nephritis Partly by Stabilizing the Cytoskeleton and Inhibiting Podocyte Apoptosis. | 2015 | PLoS ONE | pmid:26161538 |
Kojima R et al. | Release mechanisms of tacrolimus-loaded PLGA and PLA microspheres and immunosuppressive effects of the microspheres in a rat heart transplantation model. | 2015 | Int J Pharm | pmid:26160668 |
Kanchongkittiphon W et al. | Child with atopic dermatitis. | 2015 | Ann. Allergy Asthma Immunol. | pmid:25528736 |
Meng QH et al. | Falsely elevated tacrolimus concentrations on the Dimension Xpand. | 2015 | Clin. Biochem. | pmid:26160209 |
Fischer L et al. | Three-year Outcomes in De Novo Liver Transplant Patients Receiving Everolimus With Reduced Tacrolimus: Follow-Up Results From a Randomized, Multicenter Study. | 2015 | Transplantation | pmid:26151607 |
Spolidorio LC et al. | The long-term administration of calcineurin inhibitors decreases antioxidant enzyme activity in the rat parotid and submandibular salivary glands. | 2015 | Life Sci. | pmid:26006038 |
Shamsudin N et al. | Objective assessment of vitiligo with a computerised digital imaging analysis system. | 2015 | Australas. J. Dermatol. | pmid:25367709 |
Velickovic-Radovanovic R et al. | Gender-dependent predictable pharmacokinetic method for tacrolimus exposure monitoring in kidney transplant patients. | 2015 | Eur J Drug Metab Pharmacokinet | pmid:24596067 |
Ali H et al. | Mycophenolate mofetil-based salvage as acute GVHD prophylaxis after early discontinuation of tacrolimus and/or sirolimus. | 2015 | Bone Marrow Transplant. | pmid:25365064 |
Lee SC et al. | Calcineurin orchestrates dimorphic transitions, antifungal drug responses and host-pathogen interactions of the pathogenic mucoralean fungus Mucor circinelloides. | 2015 | Mol. Microbiol. | pmid:26010100 |
Kedzierska K et al. | The effect of immunosuppressive therapy on renal cell apoptosis in native rat kidneys. | 2015 | Histol. Histopathol. | pmid:25029518 |
Seo YG et al. | Solid self-nanoemulsifying drug delivery system (SNEDDS) for enhanced oral bioavailability of poorly water-soluble tacrolimus: physicochemical characterisation and pharmacokinetics. | 2015 | J Microencapsul | pmid:26079598 |
Menotta M et al. | Label-free quantification of Tacrolimus in biological samples by atomic force microscopy. | 2015 | Anal. Chim. Acta | pmid:26073814 |
Sato K et al. | Late onset of progressive speech impairment due to tacrolimus-associated leukoencephalopathy after kidney transplantation. | 2015 | Int Urol Nephrol | pmid:26071870 |
Pulk RA et al. | Multigene predictors of tacrolimus exposure in kidney transplant recipients. | 2015 | Pharmacogenomics | pmid:26067485 |
Hu WX et al. | Glucocorticoid with or without additional immunosuppressant therapy for patients with lupus podocytopathy: a retrospective single-center study. | 2015 | Lupus | pmid:25819933 |
Considine A et al. | Performance of modified-release tacrolimus after conversion in liver transplant patients indicates potentially favorable outcomes in selected cohorts. | 2015 | Liver Transpl. | pmid:25312292 |
Taber DJ et al. | African-American race modifies the influence of tacrolimus concentrations on acute rejection and toxicity in kidney transplant recipients. | 2015 | Pharmacotherapy | pmid:26011276 |
Parody R et al. | GVHD prophylaxis with sirolimus-tacrolimus may overcome the deleterious effect on survival of HLA mismatch after reduced-intensity conditioning allo-SCT. | 2015 | Bone Marrow Transplant. | pmid:25310306 |
Hollis IB et al. | Medication management of cardiac allograft vasculopathy after heart transplantation. | 2015 | Pharmacotherapy | pmid:26011142 |
Chen YB et al. | Phase II Trial of Tandem High-Dose Chemotherapy with Autologous Stem Cell Transplantation Followed by Reduced-Intensity Allogeneic Stem Cell Transplantation for Patients with High-Risk Lymphoma. | 2015 | Biol. Blood Marrow Transplant. | pmid:26009261 |
Ribero S et al. | Efficacy of topical tacrolimus for oral lichen planus: real-life experience in a retrospective cohort of patients with a review of the literature. | 2015 | J Eur Acad Dermatol Venereol | pmid:25308924 |
Revollo J | Update on the clinical utility of once-daily tacrolimus in the management of transplantation. | 2015 | Drug Des Devel Ther | pmid:26005334 |
Qasim W et al. | Immunotherapy of HCC metastases with autologous T cell receptor redirected T cells, targeting HBsAg in a liver transplant patient. | 2015 | J. Hepatol. | pmid:25308176 |
Chan TM | Treatment of severe lupus nephritis: the new horizon. | 2015 | Nat Rev Nephrol | pmid:25421826 |
Ozbek OY and Ozcay F | Long-term outcome of food allergy after liver transplantation in children. | 2015 | Pediatr Transplant | pmid:25882294 |
Mistry NP et al. | Formulation and evaluation of tacrolimus-loaded galactosylated Poly(lactic-co-glycolic acid) nanoparticles for liver targeting. | 2015 | J. Pharm. Pharmacol. | pmid:25944126 |
Andreu F et al. | Development of a population PK model of tacrolimus for adaptive dosage control in stable kidney transplant patients. | 2015 | Ther Drug Monit | pmid:25254416 |
Fussner LA et al. | Cardiovascular disease after liver transplantation: When, What, and Who Is at Risk. | 2015 | Liver Transpl. | pmid:25880971 |
Banhara PB et al. | Tubular dysfunction in renal transplant patients using sirolimus or tacrolimus. | 2015 | Clin. Nephrol. | pmid:25943142 |
Abuabara K et al. | Atopic dermatitis disease control and age: A cohort study. | 2015 | J. Allergy Clin. Immunol. | pmid:25935107 |
Bonanni A et al. | Low-dose ofatumumab for rituximab-resistant nephrotic syndrome. | 2015 | BMJ Case Rep | pmid:26376698 |
Clark SL et al. | Making every drop count for pediatric kidney transplant patients. | 2015 | Hosp Pediatr | pmid:25934814 |
de Sandes-Freitas TV et al. | Subclinical Lesions and Donor-Specific Antibodies in Kidney Transplant Recipients Receiving Tacrolimus-Based Immunosuppressive Regimen Followed by Early Conversion to Sirolimus. | 2015 | Transplantation | pmid:25929604 |
Ikitimur B et al. | Long-Term Impact of Different Immunosuppressive Drugs on QT and PR Intervals in Renal Transplant Patients. | 2015 | Ann Noninvasive Electrocardiol | pmid:25367596 |
Ganetsky A et al. | Lack of a significant pharmacokinetic interaction between maraviroc and tacrolimus in allogeneic HSCT recipients. | 2015 | J. Antimicrob. Chemother. | pmid:25881619 |
Goldthorpe H et al. | Occlusive lung arterial lesions in endothelial-targeted, fas-induced apoptosis transgenic mice. | 2015 | Am. J. Respir. Cell Mol. Biol. | pmid:25879383 |
Liang GB et al. | Impact of immunosuppressive agents on the expression of indoleamine 2,3-dioxygenase, heme oxygenase-1 and interleukin-7 in mesangial cells. | 2015 | Mol Med Rep | pmid:25936769 |
Chapron B et al. | Reversible, time-dependent inhibition of CYP3A-mediated metabolism of midazolam and tacrolimus by telaprevir in human liver microsomes. | 2015 | J Pharm Pharm Sci | pmid:25877445 |
Seo YG et al. | Preparation and pharmaceutical evaluation of new tacrolimus-loaded solid self-emulsifying drug delivery system. | 2015 | Arch. Pharm. Res. | pmid:25134927 |
Ott M et al. | Suppression of TDO-mediated tryptophan catabolism in glioblastoma cells by a steroid-responsive FKBP52-dependent pathway. | 2015 | Glia | pmid:25132599 |
Abudou M et al. | Immunosuppressants for the prophylaxis of corneal graft rejection after penetrating keratoplasty. | 2015 | Cochrane Database Syst Rev | pmid:26313245 |
Söderlund C and Rådegran G | Immunosuppressive therapies after heart transplantation--The balance between under- and over-immunosuppression. | 2015 | Transplant Rev (Orlando) | pmid:25812489 |
Zegarska J et al. | Mycophenolic Acid Metabolites Acyl-Glucuronide and Glucoside Affect the Occurrence of Infectious Complications and Bone Marrow Dysfunction in Liver Transplant Recipients. | 2015 | Ann. Transplant. | pmid:26313036 |
Naito T et al. | ABCB1 genetic variant and its associated tacrolimus pharmacokinetics affect renal function in patients with rheumatoid arthritis. | 2015 | Clin. Chim. Acta | pmid:25817604 |
Lee JR et al. | Gut microbiota and tacrolimus dosing in kidney transplantation. | 2015 | PLoS ONE | pmid:25815766 |
Dave V et al. | Managing psychosis in a renal transplant recipient with bipolar affective disorder and allograft rejection. | 2015 | Nephrology (Carlton) | pmid:25807849 |
Honda Y et al. | Disseminated Mycobacterium mantenii infection with multiple purulent cutaneous lesions. | 2015 | Acta Derm. Venereol. | pmid:25881714 |
Stevens RB et al. | A randomized 2×2 factorial trial, part 1: single-dose rabbit antithymocyte globulin induction may improve renal transplantation outcomes. | 2015 | Transplantation | pmid:25083614 |
La Placa M et al. | Disfiguring papular sarcoidosis of the face: dramatic improvement with pimecrolimus. | 2015 | J Eur Acad Dermatol Venereol | pmid:25073484 |
Helmschrott M et al. | Advantageous effects of immunosuppression with tacrolimus in comparison with cyclosporine A regarding renal function in patients after heart transplantation. | 2015 | Drug Des Devel Ther | pmid:25759566 |
Mlih M et al. | Na(+)/H (+) exchanger isoform 1 induced osteopontin expression in cardiomyocytes involves NFAT3/Gata4. | 2015 | Mol. Cell. Biochem. | pmid:25758355 |
Ravaioli M et al. | Immunosuppression Modifications Based on an Immune Response Assay: Results of a Randomized, Controlled Trial. | 2015 | Transplantation | pmid:25757214 |
Bis DM et al. | Characterization of the nocardiopsin biosynthetic gene cluster reveals similarities to and differences from the rapamycin and FK-506 pathways. | 2015 | Chembiochem | pmid:25755076 |
Rahman Z et al. | Comparison of X-ray powder diffraction and solid-state nuclear magnetic resonance in estimating crystalline fraction of tacrolimus in sustained-release amorphous solid dispersion and development of discriminating dissolution method. | 2015 | J Pharm Sci | pmid:25753829 |
Devine SM et al. | Phase II Study of Allogeneic Transplantation for Older Patients With Acute Myeloid Leukemia in First Complete Remission Using a Reduced-Intensity Conditioning Regimen: Results From Cancer and Leukemia Group B 100103 (Alliance for Clinical Trials in Oncology)/Blood and Marrow Transplant Clinical Trial Network 0502. | 2015 | J. Clin. Oncol. | pmid:26527780 |
Pennington CA et al. | Evaluation of a Weight-based Rabbit Anti-thymocyte Globulin Induction Dosing Regimen for Kidney Transplant Recipients. | 2015 | Pharmacotherapy | pmid:26234282 |
Zhu L et al. | Adrenergic stimulation sensitizes TRPV1 through upregulation of cystathionine β-synthetase in a rat model of visceral hypersensitivity. | 2015 | Sci Rep | pmid:26527188 |
Staatz CE et al. | Tacrolimus pharmacokinetics after kidney transplantation--Influence of changes in haematocrit and steroid dose. | 2015 | Br J Clin Pharmacol | pmid:26235203 |
Vanhove T et al. | Response to 'Tacrolimus pharmacokinetics after kidney transplantation--Influence of changes in haematocrit and steroid dose'. | 2015 | Br J Clin Pharmacol | pmid:26235051 |
Ceulemans LJ et al. | Nonsteroidal anti-inflammatory drug-induced intestinal graft loss 12 years after transplantation. | 2015 | Transplantation | pmid:25695790 |
Vardas PN et al. | Identification and management of atypical hemolytic uremic syndrome immediately post-heart transplantation. | 2015 | J Card Surg | pmid:25693626 |
Hanifin JM | A Reassuring Rejoinder Against Malignant Influences of Topical Calcineurin Use in Children. | 2015 | JAMA Dermatol | pmid:25692944 |
Margolis DJ et al. | Association Between Malignancy and Topical Use of Pimecrolimus. | 2015 | JAMA Dermatol | pmid:25692459 |
Shuker N et al. | Intra-patient variability in tacrolimus exposure: causes, consequences for clinical management. | 2015 | Transplant Rev (Orlando) | pmid:25687818 |
Fan DM et al. | Successful ABO-incompatible living-related intestinal transplantation: a 2-year follow-up. | 2015 | Am. J. Transplant. | pmid:25808777 |
BlažiÄ M et al. | Roles of the crotonyl-CoA carboxylase/reductase homologues in acetate assimilation and biosynthesis of immunosuppressant FK506 in Streptomyces tsukubaensis. | 2015 | Microb. Cell Fact. | pmid:26466669 |
Stevens RB et al. | A Randomized 2x2 Factorial Clinical Trial of Renal Transplantation: Steroid-Free Maintenance Immunosuppression with Calcineurin Inhibitor Withdrawal after Six Months Associates with Improved Renal Function and Reduced Chronic Histopathology. | 2015 | PLoS ONE | pmid:26465152 |
Cai W et al. | Limited sampling strategy for predicting area under the concentration-time curve for mycophenolic Acid in Chinese adults receiving mycophenolate mofetil and tacrolimus early after renal transplantation. | 2015 | Ther Drug Monit | pmid:25525761 |
Matsushima M et al. | [A case of anti-PL7 antibody positive myositis and a clinical and pathological review of the anti-synthetase syndrome]. | 2015 | Rinsho Shinkeigaku | pmid:26458569 |
Almeida-Corrêa S et al. | Calcineurin inhibition blocks within-, but not between-session fear extinction in mice. | 2015 | Learn. Mem. | pmid:25691516 |
Leneghan D and Bell A | Immunophilin-protein interactions in Plasmodium falciparum. | 2015 | Parasitology | pmid:26156578 |
Van Driest SL and Webber SA | Pharmacogenomics: personalizing pediatric heart transplantation. | 2015 | Circulation | pmid:25645611 |
Detroyer D et al. | Resolution of diffuse skin and systemic Kaposi's sarcoma in a renal transplant recipient after introduction of everolimus: a case report. | 2015 | Transpl Infect Dis | pmid:25645490 |
Luo X et al. | Evaluation of 6β-Hydroxycortisol and 6β-Hydroxycortisone as Biomarkers for Cytochrome P450 3A Activity: Insight into Their Predictive Value for Estimating Oral Immunosuppressant Metabolism. | 2015 | J Pharm Sci | pmid:26150050 |
Chen QJ et al. | Tacrolimus decreases insulin sensitivity without reducing fasting insulin concentration: a 2-year follow-up study in kidney transplant recipients. | 2015 | Ren Fail | pmid:25644968 |
Garcia MF et al. | Behavioral measures to reduce non-adherence in renal transplant recipients: a prospective randomized controlled trial. | 2015 | Int Urol Nephrol | pmid:26377496 |
Herbst S et al. | Phagocytosis-dependent activation of a TLR9-BTK-calcineurin-NFAT pathway co-ordinates innate immunity to Aspergillus fumigatus. | 2015 | EMBO Mol Med | pmid:25637383 |
Joneja U and Uppal G | Pseudo-Pelger-Huët anomaly in a patient on tacrolimus. | 2015 | Blood | pmid:26371350 |
Ustundag UV et al. | The effects of tacrolimus on the activity and expression of tissue factor in the rat ovary with ischemia-reperfusion induced injury. | 2015 | Reprod Biol | pmid:26370456 |
Fukushima D et al. | Epstein-Barr virus--associated posttransplantation lymphoproliferative disorder with tacrolimus metabolism deterioration in infants after living-donor liver transplantation. | 2015 | Transplantation | pmid:24846306 |
Kawahara T et al. | Cyclosporine A and tacrolimus inhibit bladder cancer growth through down-regulation of NFATc1. | 2015 | Oncotarget | pmid:25638160 |
Tohme FA et al. | Conversion to a sirolimus-based regimen is associated with lower incidence of BK viremia in low-risk kidney transplant recipients. | 2015 | Transpl Infect Dis | pmid:25582442 |
Dagher M et al. | Overweight, central obesity, and cardiometabolic risk factors in pediatric liver transplantation. | 2015 | Pediatr Transplant | pmid:25581506 |
Kita A et al. | Imp2, the PSTPIP homolog in fission yeast, affects sensitivity to the immunosuppressant FK506 and membrane trafficking in fission yeast. | 2015 | Biochem. Biophys. Res. Commun. | pmid:25580011 |
Cortina G et al. | De novo tacrolimus-induced thrombotic microangiopathy in the early stage after renal transplantation successfully treated with conversion to everolimus. | 2015 | Pediatr. Nephrol. | pmid:25577332 |
Annunziato RA et al. | Can transition to adult care for transplant recipients be improved by intensified services while patients are still in pediatrics? | 2015 | Prog Transplant | pmid:26308783 |
Pape E et al. | Management of Tacrolimus-Telaprevir Drug-Drug Interaction in a Liver Transplant Patient With Hepatitis C Virus: Practical Considerations. | 2015 | Transplantation | pmid:26308424 |
Kurita T et al. | The efficacy of tacrolimus in patients with interstitial lung diseases complicated with polymyositis or dermatomyositis. | 2015 | Rheumatology (Oxford) | pmid:24764266 |
Cavalié M et al. | Maintenance therapy of adult vitiligo with 0.1% tacrolimus ointment: a randomized, double blind, placebo-controlled study. | 2015 | J. Invest. Dermatol. | pmid:25521460 |
Reddy YN et al. | Is there a genetic predisposition to new-onset diabetes after kidney transplantation? | 2015 | Saudi J Kidney Dis Transpl | pmid:26586047 |
Yu Y et al. | Investigation into the interchangeability of generic formulations using immunosuppressants and a broad selection of medicines. | 2015 | Eur. J. Clin. Pharmacol. | pmid:26062932 |
Lim SW et al. | Inhibition of dipeptidyl peptidase IV protects tacrolimus-induced kidney injury. | 2015 | Lab. Invest. | pmid:26237274 |
Vaeth M et al. | Selective NFAT targeting in T cells ameliorates GvHD while maintaining antitumor activity. | 2015 | Proc. Natl. Acad. Sci. U.S.A. | pmid:25583478 |
Millner L et al. | A clinical approach to solving discrepancies in therapeutic drug monitoring results for patients on sirolimus or tacrolimus: Towards personalized medicine, immunosuppression and pharmacogenomics. | 2015 | Clin. Chim. Acta | pmid:26232156 |
Li JL et al. | Interactive effects of CYP3A4, CYP3A5, MDR1 and NR1I2 polymorphisms on tracrolimus trough concentrations in early postrenal transplant recipients. | 2015 | Pharmacogenomics | pmid:26228923 |
Namvaran F et al. | The Effect of Tacrolimus on Reactive Oxygen Species and Total Antioxidant Status in Pancreatic Beta Cell Line. | 2015 | Exp Clin Transplant | pmid:25431882 |
Li YX and Dijkers PF | Specific calcineurin isoforms are involved in Drosophila toll immune signaling. | 2015 | J. Immunol. | pmid:25429067 |
Allison SJ | Lupus nephritis: Multitarget induction therapy for LN. | 2015 | Nat Rev Nephrol | pmid:25421833 |
Tan ES et al. | Effective treatment of scrotal lichen simplex chronicus with 0.1% tacrolimus ointment: an observational study. | 2015 | J Eur Acad Dermatol Venereol | pmid:24666218 |